Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MRP---GKKSSSNKSRVMKNKYAHRSWLGAVCLLGCSLSYAAEEQFNDALNAANSGNTALLDQY--QLAMQNDVLGYYPEYWKLNTNLGFQSPTSIVSFAQRYPQSAMAEKLAADYVEEKVKQADFASAQPILPYVSNPDQAENCALAQVRAKSGDALVFAEYKDVWLATESQPESCIGLGRMMLSSPLMSTQDKQQRLWVQLRAGLSGQALATAQTLGLNLSLAQLNQIQANPLNYLWSAPKT--NDVDYAYLIFALGRLANNDLGNAFANVQRVAQGTPESVQKYLYR---TVAYIGGTTVMKNNFNREVLQYFDASYGYPLSPEEAEIYARQAIRFSAWESLIRAIDSMSVSQKQEDRWQYWLARATEQRGDSNSKNTAQCIYKKLAESGDDYHNLLAKDRLGVRYNHQPYNDEPTASDLRRLDQNIHFNRAFTLRRINVNPTYTNREWNWAVR------QAYLQHDDGLLLAAAK------RAHDMGWYDRAIYAADRTT-----NKHNDTYRYVTPHKTNVVSHSYNAGIDPAWAYGLMRQESRFVTSARSHVGAGGLMQIMPDTAKLIARQMGETYNPAALSEMNTNIRYGTFYLSMIQ------GQLSNNPVLATAGYNAGPNRARRWQPDYQPIEADQYTETIPLLETRDYVKHVMTNATHYGVILGQGAQSLIQRMKVIPTRSSP 5DO7 Chain:A ((34-650)) -EPHSLGILHASYSRQILKDVSLYVESGQIMCILGSS----------------GSGKTTLLDAMSGRLGRAGTFLG---EVYVNGRALRREQ------FQDCF-----------SYVLQSDTLLSSLTVRETLHYTAL------LAIRRGNPGSFQKKVEAVMAELSLSHVAD--------RLIGNYSLGGISTGERR-----RVSIAAQLLQ-------------------DPKVMLFDEPTTGLDCMTANQIVVLLVELARRN---------RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDC-GYPCPEHSN--------PFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKK----------SAICHKTLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAA-LLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLIS-----

General information: TITO was launched using: RESULT: Template: 5DO7.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2824 -37475 -13.27 -67.89 target 2D structure prediction score : 0.41 Monomeric hydrophicity matching model chain A : 0.64 3D Compatibility (PKB) : -13.27 2D Compatibility (Sec. Struct. Predict.) : 0.41 1D Compatibility (Hydrophobicity) : 0.64 QMean score : 0.126

(partial model without unconserved sides chains): PDB file : Tito_5DO7.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5DO7-query.scw PDB file : Tito_Scwrl_5DO7.pdb: