Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MRHLHHQTSQTKLWAVIPAAGSGSRFSKTELKQYQYIQDATVIEHTVKRLSQLPLTGYVLAIGKQDTFASTLSFQDKHKAHFCNGGVERVHSVLNALNYLSQIADEDDWVLVHDAARPCVTFECLNTLVKNAIETNQSAILAIPVRDTLKQVNQEQQIEKTVSRELLWQAQTPQIAKIGILKKAIETALKNNLTITDEASALESIGESVQVVMGRSDNIKITYPDDLELARLILQSQN 2PX7 Chain:A ((1-210)) ----------MEVSVLIPAAG--------GPKAFLQVGGRTLLEWTLAAFRDA--AEVLVALPPGAEPPKG--L----GAVFLEGGATRQASVARLLEAAS-----LPLVLVHDVARPFVSRGLVARVLEAAQR-SGAAVPVLPVPDTLMAPEG-EAYGRVVPREAFRLVQTPQGFFTALLREAHAYARRKGLEASDDAQLVQALGYPVALVEGEATAFKITHPQDLVLAEALARV--

General information: TITO was launched using: RESULT: Template: 2PX7.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1058 -124183 -117.38 -611.74 target 2D structure prediction score : 0.58 Monomeric hydrophicity matching model chain A : 0.74 3D Compatibility (PKB) : -117.38 2D Compatibility (Sec. Struct. Predict.) : 0.58 1D Compatibility (Hydrophobicity) : 0.74 QMean score : 0.408

(partial model without unconserved sides chains): PDB file : Tito_2PX7.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2PX7-query.scw PDB file : Tito_Scwrl_2PX7.pdb: