Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKLVTAIVKPFKLDDVREALSDIGVQGITVTEVKGFGRQKGHTELYRGAEYVVDFLPKVKIEIAISDEMVDAVIESITRVASTGKIGDGKIFLTNLEQVIRIRTGETGPDAV 4C3K Chain:C ((1-108)) MKKIEAIIRPFKLDEVKIALVNAGIVGMTVSEVRGFGRQ----------EYTVEFLQKLKLEIVVEDAQVDTVIDKIVAAARTGEIGDGKIFVSPVDQTIRIRTGEKN----

General information: TITO was launched using: RESULT: Template: 4C3K.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 357 -50056 -140.21 -510.77 target 2D structure prediction score : 0.58 Monomeric hydrophicity matching model chain C : 0.83 3D Compatibility (PKB) : -140.21 2D Compatibility (Sec. Struct. Predict.) : 0.58 1D Compatibility (Hydrophobicity) : 0.83 QMean score : 0.666

(partial model without unconserved sides chains): PDB file : Tito_4C3K.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4C3K-query.scw PDB file : Tito_Scwrl_4C3K.pdb: