Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSELKQDQYWMQQAIELAKRGLYSTKPNPNVGCVIVKDNQVIGEGFHPRAGQPHAEVFALRQAGEQ---AQGATAYVTLEPCAHYGRTPPCAEALVKAQVKKVVVACPDPNPLVAGKGVQILKNAGIEVEIGICEDLAAQLNQGFLKAMSSGMPYVRLKVASSLDGRTAMASGESKWITGSAARQDVQHWRAISGAVITGIETVIADDCQLNVRPLHNVDIETVAQPKRVILDRRGRLPLT-AKILE-NPETVMVMGPYRQELADLGVIQL--EIQPLKTLLQTLSKQYQIYDVLIEAGATLSSAFLQEGLIDEMISYVAPTLLGQSARAMFNADFEYMAQQLRFKLLDVTQLDQDIRLRLIPTQEKV 2HXV Chain:A ((11-357)) ---HHMYETFMKRAIELAKKGLGRVNPNPPVGAVVVKDGRIIAEGFHPYFGGPHAERMAIESARKKGEDLRGATLIVTLEPCDHHGKTPPCTDLIIESGIKTVVIGTRDPNPV-SGNGVEKFRNHGIEVIEGVLEEEVKKLCEFFITYVTKKRPFVALKYASTLDGKIADHRGDSKWITDK-LRFKVHEMRNIYSAVLVGAGTVLKDNPQLTCRLKEG------RNPVRVILDRKGVLSGKVFRVFEENARVIVFTESEEAE-YPPHVEKALSD-CSVESILRNLYE-RDIDSVLVEGGSKVFSEFLDH--ADVVFGFYSTKIFGKGL-DVFSGYLSDVSVPPKFKVVNVEFSDSEFLVEMRPC----

General information: TITO was launched using: RESULT: Template: 2HXV.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1900 -15934 -8.39 -46.86 target 2D structure prediction score : 0.60 Monomeric hydrophicity matching model chain A : 0.79 3D Compatibility (PKB) : -8.39 2D Compatibility (Sec. Struct. Predict.) : 0.60 1D Compatibility (Hydrophobicity) : 0.79 QMean score : 0.478

(partial model without unconserved sides chains): PDB file : Tito_2HXV.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2HXV-query.scw PDB file : Tito_Scwrl_2HXV.pdb: