Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTDTRENWTSRSGFIIAAVGSAVGLGNIWRFPYVAYENGGGAFLIPYLLALITAGLPLLFLDYAVGH----RSTGSPPKAYRALFKG--GETLGWWQVCVCIIIGLYYASVLTWA-GSYVYFSIGQMW----GSDPEGF------FFNTYLQTTKATGFDLQFVGHLFWPIVGIWAL--TLIILYGGVKKGVELSNKIFMPLLFILFTILVIQS--LRLPG--AVQGLNAFFTPNWSAMMDYKVWLAAYGHTFFSLSVGFGIMVTYASYLKPKTNLTGSGLIVGFANASTEILAG--IGIFAALGFMAHAAGTEVKDVVSGGIGLAFIAFPKIISSLGSGADLFGLLFFSSLFVAGISSMVSILEVPIAAMQDKLKWGRKKAVTIIGGGSALVSIILFSSVNAI---KLVDIVDHFINNIGIIGGALLSIISVAWFKRSALKELRDHVNRISTIQLGKGWDFTLTVITSLILLTTLCMTVFNLIKNGYDTYSMSLQGVFGWGSVIFCAVVAIVLSKMKDR 2QJU Chain:A ((1-462)) ----REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAIKFLVGLVPEPPP-TDPDSILRPFKEFLYSYIGVPK--GDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFGVANAVAIAK--AGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSS-IAIMQPMIAFLEDELKLSRKHAVLWTA------AIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTELIIFFWIFGA--DKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVV------------------------------------------

General information: TITO was launched using: RESULT: Template: 2QJU.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2439 -292877 -120.08 -677.95 target 2D structure prediction score : 0.62 Monomeric hydrophicity matching model chain A : 0.76 3D Compatibility (PKB) : -120.08 2D Compatibility (Sec. Struct. Predict.) : 0.62 1D Compatibility (Hydrophobicity) : 0.76 QMean score : 0.376

(partial model without unconserved sides chains): PDB file : Tito_2QJU.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2QJU-query.scw PDB file : Tito_Scwrl_2QJU.pdb: