Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MHPIVIIGSGMAGYTLAREFRKLNPEQELVMICADDAVNYAKPTLS-NAFAGKKAPEQIPLGDAAKMSAQLNMRIEPFTWVKEILAERHELVLEKDGIISQQPYSKLILAVGANPIRLAIAGDG---SDDIHVVNSLIDYRSFRENLAQRKDKRVVILGAGLIGCEFANDLLHSEYDVTVIDLAPQPLGRLLPSHIASAFQQNLEEAGVKFTLGTTVEKVSKINNGED-YAVTLANGQTLVADIVLSAIGLQPNISLAQSANIQTSRGVITNSLLETNQADIYAIGDCAEVNGTL------LPYVMPIMQQARALAKTLSGQQTNVHYPAMPV-AVKTPAAPLTVLPAPVDVDVNWETEEF--DDGMLAKAIDNEGTLRGFVLLGATAGKQRLTLTKLVPDLIPAQA 1Q1W Chain:A ((4-380)) NDNVVIVGTGLAGVEVAFGLRASGWEGNIRLVGDATVIPHHLPPLSKAYLAGKATAESLYL-RTPDAYAAQNIQLLGGTQVTAINRDRQQVILSDG---RALDYDRLVLATGGRPRPLPVASGAVGKANNFRYLRTLEDAECIRRQLIA--DNRLVVIGGGYIGLEVAATAIKANMHVTLLDTAARVLERVTAPPVSAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGTRLPADLVIAGIGLIPNCELASAAGLQVDNGIVINEHMQTSDPLIMAVGDCARFHSQLYDRWVRIESVPNALEQARKIAAILCGKV-P-RDEAAPWFWSDQYEIGLKMVGLSEGYDRII-VRGSLAQPDFSVFYL-QGDRVLAVDTVNRP--------------------

General information: TITO was launched using: RESULT: Template: 1Q1W.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2048 -58033 -28.34 -159.87 target 2D structure prediction score : 0.62 Monomeric hydrophicity matching model chain A : 0.75 3D Compatibility (PKB) : -28.34 2D Compatibility (Sec. Struct. Predict.) : 0.62 1D Compatibility (Hydrophobicity) : 0.75 QMean score : 0.497

(partial model without unconserved sides chains): PDB file : Tito_1Q1W.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1Q1W-query.scw PDB file : Tito_Scwrl_1Q1W.pdb: