Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MDEVINVISKCITQLNLFVDGPAAHLSGTAAPTTIETIRKCIADHAYLFTDHRINGQRMWELVCSATFTVGEPRTPTTAATATATLLSLFRRLTDSVAASARAPEADILKHLVKLLRDAVKPPLVRGASPGQLRCLFQAAMRLLKLLLPLKKRADVQTECLHLLLALMQLSDLQEAHCAVVASGDEVAQVAKLCADICGAKHDVALRPQNASMQLLGCLCEQPAYVHALSGQLAERILKCFLDVARNLAQRAEVNQTLGEGLLRGLAGVLGSFPLRCEEDAPALTLINNIVLSALMLGETSTNYTFCLSALFLLRRRASDTLAPFTLLCAAEYSVALRSLWMHRNKDVRRETHAAAAVFWSALSSQLQQRCSSEVADANTTRNTAASHKLHSIVEFLLRSLDSSADPEASYALEALYHLLPAVAALSGPQALQTMSTRLEERVGGLLITASAQRTEALFQQVPYLLATLGQLLTLLPSVSPRQQAVVRELLDWVLLLYPHPKFYNREKTVPGIVLVIRALTHHPRAPHNTLPRLLSERTLELVGEAPGAAMMRLAGERISTEERLDRMATLWTRLLTTREESGAEAEAESKQRLSAAFYRACTGFCERARLEVIVKSNSEATLERILVDGVDGVQPSFPTHYSAFLSFVDFFVRLSEGLKGSGGVCRPPAEELTAWLEALVRGASAALHVSGFYTLLHRTVVGVEGVCPHSLTHQRPYTDASLASGNSDVTSDGHHENHLCVSPLLRHFLSTECLRRVHVYSDELLYQCAMCVVVGAALVGSEDRGELAGSRARACDDHRRLDAYVRAFKVVMTATPTSLQAESVAGSTNEVVCSFGSSPAILESNRQHALRVLEKKACRSPRWAAAVLPALTSALRSAEVVAAVRAPVQMLAARHGVAIAAELQHHSNEATFALLCRGEPASNGRRDSMPRWLATMQPVTVPLVPVDSALHIGYLVPLVSRLSLYGKHPAVRTAAAEVLYWCVVWVIGKKVNDWGSAVFPPLLSLASLARTSTGGSGGGGGSMVHQELHGLLMQAARWFGRSAGTPEEAELFVSVLLRGLGEREGTQRQVATEALFAYAIPPADEPQTVTPHFRAVIGRLVRMECGVSEWSRLGAAHCLHVMMRRLCKVRVPGLVCTVQAVAQGAVGCLRRCTEAPIWGAMETATCNEVQESLRWLGAYCHDIRQLENEEEQREADRFAADLVHAARAVLPALARRHTVCAITLLQTLPAVTHTNASARQVLLLSQELICEQQQRLGPAAVRSLDSTVGGCATLVALLQSGYGTETNKRAIAEAVTPVICTRADDCSVETELLRLLTVVLQAIVEEARVATHESRCISPHIVRWLLELVDVVPEQTHATHFSLLLTPTVIAQAARVMVAGAKVTVENCAGDVGEDATAGVPLRRCAPSSQLAPTARWCLELIEFLMRVAGQRRRGAQVIEDVLCAIRETSVFTVFTAASPARQLIDALSVGPSALVTGPVALAAALCQMEAPCSSGTTTLWMRIADSMKISPKTVVAMLLGLLRNSAALNATGGEEVCEGLLVLMLSEPDPALLRQHLRDLLASDAVQHNIFTSSSFAVSLEDGHGAVAVSPSSRSTSVLLSRAFDSVMNRCWQQASAALPTDRLVSALPSLTTVAMSEDALRSSSEAVSLFSLVGDWLAELQRRSLTSEHDKVLCRVCANLVAAEREMRQSTPTAAQDDGRGGARLAALLMLVQLIGPAIRTDTTLSSALCDLVLFVSKPANMCSLLASVDATEHVVWGFHVLAATMTPRPARRSLAVFPVDLRAVEMAFDFLNEVLNSALPLRWTELKTPREKTNGADVVRSGTALFAAVLPHKVQVLEVIAPLLAQESMPQRDTIVRQVHGALQALSVCQQALQLDACRCASRLLRDPRTHPGICDALTEHVLLPLLQASAEAVRLRLFEEEVRNWVTEAGRAPALGCFYMQTAAFSCLALMHRLCPLTELRGSISTAFTGRNPNTTGVELTLEVLKACRAAWQSPNTGGDDNSAEEADGDVGDSACADAPRRYRQAAFRCLLATLSQTQQAEKVFCRCFFQERSVAGWNGLFLVKRPGVAVTDLLDAVGEVQLWRDMDRCQVPELFAHLLRHFPSSSVTPGEPPEWVRHVVAVLRQPQLRLPVRMVFYEMICRHERFFGTFARCIFDGVADAVAAMAPSERAGKVIWELLALLTRWHREGSSRALAVGSAASLKALARYAAVHLAWEHSFTACEGSRALDPTSHKRLAELLEQFRRAQGAALAIRSTSQPLTAAEMKMLLSHPAYERHAALEVIYLITNACGCLGCTGDSREVVEVYDLLGAFLGASASPQLYHITARLVGLEHRLLSEAATREPSSAVRKLLRDALRGTVCAILSVCKSDKKFLEVLEAMQEDRSGDLVYQLLSRTDLLRRYSIRKDSEKLLTLRVLARAGTYVADNYDSIHVCLSGLLRGGQGEPLLGICTVVKNALPHMSMESVRHVLRDLCCLDVLQAMESAEPARIAFYKMGLAALRRWTVVREDQEKQDGGGSVSADAEAFLVRRGLRDASPAVQGAVLEYLDVHAQHVPDTMWGRLTCLFTAEDGASGDGHSGSGGWVRHVALLLLSLSKRSRDFANPTYFCPEALHSEGASPTLATSADTAAESSVAQRQPRSAPLFSEAVQCGSPAEAATANAACPITAALAQIYVPPALVPQPPHQQQQPLSGARRPRATGAWRLGAAPCAAATAVTRSWLRLESGDSEQENAVISAGVMASRQISATMQRNAAHGAALQAGRSVMNAPSAAPSLESNTAGRLSEVRLTLQSLLVPLQVLCLHEDEVAARVLIDLISNAAVASPVTSESPHIVSLCSALTSLLPKFQSGATTRQCELAKNPFTLFVALELLLHAQAAGWSSLASLDCAALVRLTSDVQAYGGSVPTAFLPVVDGTAHVVEKLLSSLQPSAARGVPTRPSLEFPALGWHAYHVAQRLRRHDDAACQAALQLFRATRRHEAPVIQLQGALDAMEVGGAAYSMRVIAKLLEDEEKEAAAAVATVASPATHVSGGAFALFAAREEVLRHYRSRASRLLLDWCGAASALQSATPVGAGGSGEVSVEGVRLRLRAQLQLMCNGAASAVTAEASTASRHRTGFEWGACLMANGRWLDCQLHAETSVDHLLESTASHYDSGGSSLVCGYLAANSLSQLADAAQVLRFVSTSAASSAGVALQTYLDTMPALVPLSGAYGSLFIDDVLLIRRLIIDYHVQSTGDLLGSLQFTDNERHKLVAQIHELLGTWTVQQCSELLLLPEKTSAIETIASKADHATLSEPTRCALELLKKRSSLFSIAVTPREASGASREEALAAFQKATGKDVQQRAAAGLLSPAAARQWAADVAQCEVEIFASIGSILSIPAGSAASVQKREIWVSTLKENLRDTIPSHVALL---NALEKLLPPVSRGDGTLADMGGDAKDAARASYITAATQSLWQLYANTFLWCAQAVGDRSMQVGSGGHLPVSARVPRLLSLFALPRVAEAAAQAQWRGTWEALVMLPTL----VWLPWATLLVNALLQTEHAVLARIL------------LRLCRERGQVLYYPINCA--WRSLADLGKRRNAGRAVDDDLTRELAELHKWHRSHRMALVAEFAAALDELVEPQHRLEVRLSEVESLVKQHEQCTRGGGGAQAEYLMAALQLYER-CKSDLMDPARWGRAQLYHRRAAQVLQELDRRNAF-SAEVLKSGEQFRSAKREALRQVAQTLSTLSTSASN-SATRSQELRLYSERLQHALGRSATAATTTTTQLGYTSDAAEPILQPVQPTHLLHTPPDAAQQCCTLVGVADRVLVLKSKRLPKKVDIYTSAG-ICTYMVKGGEDLRLDQRIQEVFTFANLCLLVSPRSRLSALTIRTYAVVPVSPLVGLICWVPRTTPLQELMKEATPPDAHDAVARFCRARGKPQEILPLYKTAHITGIPEQEYKDLVYCLRQSALVESLQSIATDHCSWLGARDAFLDTNAAASMASFVLGVGDRHAGNLLVDLLNSELVAIGFGLAFGDATRKLPVLELMPFRHTPQLQRVQGVLGDDVTRCRMRHVLHVLRAERQVVEGMVAALLMPDADAIGDEESRIAGHQLDVVRR-KLNLEHPAGIILRDVARNAYVTQDKDVWIGVKACLCERKRDENGEDADLTETALSALHQEDVFVQRLLRIASDPRVLGRAYAGWQAYM 5DFZ Chain:C ((4-875)) --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNITFCVSQDLDVPLKVKIKSLEGHKPLLKPSQKILNPELMLIGSNVFPSSDLIVSLQVFDKERNRNLTLPIYT----PYIPFRNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPFFNLETSIFNLKDCTLKRGFESLKFRYDVID----------HCEVVTDNKDQENLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIMNTNDPIEEKYRRLERASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNNKKALTKLLQSTNLREESERVEVLELMDSWAE--IDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAVCFENLSTFSDKSNSEFTIVDAVSPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSRNILNDQVRLINVLRECCETIKRLKDTTAKKMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVF--KSSLSPLKITFKTTLNQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVD----LKLTPYKILATGPQEGAIEFIPNDT---------------------------LASILSKYH--GILGYLKLHYPDENATLGVQG----------------WVLDNFVKSCAGYCVITYILGVGDRHLDNLLVTP-DGHFFHADFGYILGQDPKPFPPLMKLP----PQIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT-----------------------------------------------

General information: TITO was launched using: RESULT: Template: 5DFZ.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 3253 23146 7.12 30.58 target 2D structure prediction score : 0.50 Monomeric hydrophicity matching model chain C : 0.52 3D Compatibility (PKB) : 7.12 2D Compatibility (Sec. Struct. Predict.) : 0.50 1D Compatibility (Hydrophobicity) : 0.52 QMean score : 0.160

(partial model without unconserved sides chains): PDB file : Tito_5DFZ.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5DFZ-query.scw PDB file : Tito_Scwrl_5DFZ.pdb: