Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MESKGGVGSSNGSGGTSSNRHPLIGQLRPIFQELESATPQTLPSIILKLEYVIEEEKDALFHRNSIKSYTANARTFPNWLNAQLRHLFEQPQTHMAGVQVLRALLPVEYVELNEMTKLFSELLVRCVLETADYNTAVEGGEVWGLLLNNGSSVVEGIIINCLQFSLALLMRGGHDEIFLREDVSHRGVDSEATVRSAMSPLVDSSRQGENAVLTDDDRFPKATKLSGCIFIQQLVRRVPSTIAPHVHNILECLRRAILDSNKLVRVSGGDALFYTLTISYRSTDPKFYSRWQNTFLEDAERSVMYGSDVVLHGCLLAFNAVLSATASREAEGRAVGFSNQGRKHILQFWTFINDNLVSTSHNSDVRAEVLNALPLLAQYDSTTFKEISVKHVRALAAAVFVGTEGKDERAMVFQVLARLFTVLPSLVVPFLDFMMKYIEASLTPQPLRDRCPEAVTCFATLSSVEPNAVRPFLRPLLGPLFAGSVTEHFARDVAKICTAFPELRSTCLSKVLEATKEQLLRMRNRPRHTSASSETDHSAIVRSLNSLGSLDFTGYSTLQFLCDAVIRYVSDPHEEVRRSAIDLCFKLALSGCSQSPCERTAVGVVIHRGREHLGLVNTVIRKLVSAAVADTESDIRLHTLEHLSTEFDYSLALQDICTALFPALHD-HHQNRIAAVRLLGRLSSRNPSCILPMLRCVMVQCIMDIQLFHEPKRQEQAAVVLSAVVESAPAMARPYISSLLQDCVTRLQEENKPVPVITALLSLVGRLARYAEDDDVAVVAAIRPCVIRHILDSSSIQKKIEAIRALGDIIRTTKDVDVYETNPELLRVLLSALHGGFKETWPVRLDVLKLMGIIGAVDPVRAKEITRHLRDGGLSSSGAAAPAALQLSSSRGEEAIAQNVVKNVLGVLQLPCLSDDQCLCAVQVIANTLSLKEAASGCLTPMYRDILHTVVQQITLQAKIRENLFGVMTHIVYLYGQHIRPYLDELISTCVGFLPAAERGVLVEILCLLREMRRSLREEFSPSLSLVLPPLIQTVQADAAHSSEPVFAFLIEMGHLLDDHLHNVVPCVCEVASNPAYPVACRAAAADAIRHFARRLPRLVFHASRCVHCLCRVLKEMESHPLLFEQQPGASADAAQRRPAAELAAGGDTTASDVRSFVAVTLDAVRVVGRNLGSDFEKYTPLVFPLLDGYGQDGQDVKAFT-LSTLRTSGRVVAPENAQAQEEETAARYRVNTQQLAQRRKAALEDNFAQLRSILLARDRETEEEWNLWLKQLAVELLRSSPSNAHGFAFALAQLHEPFARQMLHSAFAVCYAEMEPRTKEAVRALLGNVLRSDRVPSEVLQELLNLSEYMERLEMRFNPKEGSHSTYAGLLFDLKTLMGSSERCNFYAKALHYVEIQFYEATYEYERNVMRGQVRPLPPEEWSKLVQWCEKSIYLCNLLGLRESAEGMLKYIQRNFSFLTGKPPSELPLMMDAQLLEKLQWWSQSLRAYEKGLQAEPNKFSNMVGLMRSLDNLGDYGRLLESWKLFYPRITRKEASELAPYGAHAAWLLRCWDDMEKITAYMTDEGYVGTTAVFYRAVLATHKLQFHDAVPVIQNCRKRLDSTLSALVAESYDRAYGLFVGIQQLSELEEFAFVADNPQG---LNHWQELWEKRLAAMA-YEGWPGTLANHTLVIPLAQELEMWLRFVSLSRVHGRDRTSRDILFELLGKQTIAAALEQPRLPQPPIALAACQHFYDINERERAVELLETYLKKMDQAAPSLLDIGGGQASLAMCHAKLASWLFTVAKKKRQNVDAHYREYIRHHLEKATSLDSTNGTIWHTWARFNHDLVTHRSRGAASE-----VRRDEHV------KHIVAAMDGYVRSVSCSQE-LEDMLGFLSLWFIHAALPQVQENAALQAEILQVSPTVWLKVLPQIIARLHSRDAVVSESVFQLLTIVAKAHPQALLYNLNVTLNSSVRGTESNTTEQMERKQAAQRLLGRIKEMHNHGRTMVKDAALVCQELVRCAVLWTELWFDELERAWFQWGRDKNAHNVFLVLQPLLEQLSH-PNTLAESHFVAEFGELLGGACEYVEKAASTGNNVYMEDAWNRFKTAVKRMDEQINGMNSLALQLVSPRLMQSGKDLSLVVPGQYNEGGVYPRIASFQSTLRVMNSKQHPRRLYMTGTDGVLYKFLLKGHEDLRLDERVMQLLAFVNTLLEKHSAIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQLIKDYRVHSKY-LSIEMNLMLSFNVDLDRLQVIQHVEPFEFALEQTEGADLANSLWMRAPSAESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSGRVVHIDFGDCFDVAQNRSAFPEKVPFRLTRMLVKAMEMGGIDGLFRHGCITVMGVLREEGSSILALLEAFVHDPLVSWWRDESEDGATASAAVASAAPSSSIPSAGAAAALGHYSQRAAYAAIGESFHKSRTAFASRTPASRSLAPRGRSFRAPQTSIASSPSAPPPLVSDRSSDILSNMSVNHTSEAKKVVNRIREKLEGREFAAWQLQASASAHAADDVGVAMKGQSEEDPMTSVSLGSAASAAPMASGEDGLSVQAQVSRLISEATSNENLCVHFQGWCPFW 5FVM Chain:A ((85-2469)) ----------------------NVKAFDLIFTKLN------------QLERVAASYELKSCLISLVS--TEYFQRFSNDINNKVFELIHDSNEKLGGVLAVDTLIDELPNQTSRLANYLRVLI--------DIEVMRAAATTLGKLAVLTSEFVEFEVKTCIEWLTQ----------EYRKHASLLIISSYPFVNSILDNIWRALRK---LVIRTDAAVTLGKCLTSSLTKKWVQRLFNG-----------CIHGTLLVYRQLVSLELK-----------------------DKYEEIYETTMKHRDNIIIRKEIYAIIPVLAADPKLFTQKYLDATMIHYLTLLLS-----------------------DKGPILVSIGDIAY------HIGPYLDAIVENLRDGLETKFKTRKEKDIFYCVSKLACAVRPLLAKYLNRGLLDASDHMQETLLVICEKISMEVTVNE------KLLNIICLVLSGEKFRPPGS------PTPMKSLSSETARAYRDQSLLRKTG---------TLDAMILRKALRMLSDIKPKYSLTEFIRRVIISYMEHDNMQVRKLAALTSCDLFV------------------KSLYALNVVSEVLSKLLTVAITDPVAEIRLEILKHLD-----RLSQPDNTKLLFMALNDEVFAIQMEAMKICGRLA------VIPSLRKTLIQLLTELKHSKMTRKKEECASLLCTLISSSSDVTKPYLEPVIEILL--------PSAVASTALKALGEISVVGGEDMLPFLDELMPLIIDTFQDQSNSFKRGAALKALGQLAASS--------YPELLGVLINIL------SQNIRRETVRLIGILGALDPYKHREVDVALLMQG--------------------EEYYPTVVIGVLMKILKDSIHHSTVIQAIMHIFQTMFLKQIIPGFILVMHP-------------PSLLELYFQQLSVLISIVKQHIRPHVTEIVDV-----------ISLTIISVIESLSRALEGEFNPHLPTILSLFLDVLE-NKKVVSVRILKSLVVFGPHLEEYVHLVLPTIIKLSSG-----NLKKAAIITIGRLSK----------------------------------NNALEMSSRIVQALVRVLNET------EYVKATMNTLSLLLLQLNIDFTVFIPVINKTLTIYDRLVAKLLNNEPLPTKIIIDKDFDLPNKEMDDVKVASK-KLPVNQMVLKNAWDCSQQ-------------RTKEDWQEWIRRLSIE----SSSHALRACSGLAGIYYPLARELFNASFA---QYQEDLIQSLCAALSST--------------LLNLVEFMEHDDKPLPI-------------SISTLGEYAQRCHAYAKALHYKELEFIE-----------------EPS-----TSTIESLITINNQLHQTDAAIGILKHAQQHH-----------DLQLKETWYEKLQRWDDALNAYNKREA------EVTIGKMRSLHALGEWDQLSELAADKWA--SSEVKRAIAPLAAGAAWGLAQWDRVEQYIEVMKPQS---PDKAFFDAILCLHRNNFEKAAEHIFSARDLLVTEMSAL----YNRAYGVVVRTQMVAELEEIIQYKKLPQGSERRAMIRKTWNKRLLGCQNVDVWQRVLKVRSLVIKPKQDMKVWIKFANLCRKSGRLGLAQKTLNTLLE-------------APPPVVYAQLKYMWATGSQKEALNHLISFTSRMAHDLGLQHHIEDYTKLLARCFLKQGEWRVSL----QPNWRLENPDAILGSYLLATHFDKTWYKAWHNWALANFEVTSSLTQRIKDDKVPPTLNANDNFPPELVQRHVVPAIKGFFHSIALSQSSLQDTLRLLTLWFKFGGIPEAAQAMHEGFGLIKI--DNWLEVIPQLISRIHQPNQTVSRSLLSLLADLGKAHPQALVYPLTVAIKS-------------DSVSRQRAALSIIDKMRMHSPKLVNQAELVSDELIRVAVLWHELWYEGLEDASRQFFGEHNTEKMFATLEPLHEMLKRGPETLREISFQNSFGRDLNDAYEWVLNYKRTKDINNLNQAWDIYYNVFRRISRKLPQLQTLDLQHVSPKLSAA-KDLELAVPGTYHAGKPIVRITHFEPVFTVISSKQRPRRVIIKGSDGKDYQYLLKSHEDIRQDNLVMQLFGLVNTLLQNDPESFQRHLNIQQYPAIPLSPKTGLLGWVPNSDTFHVLIREHREASKIPLNIEHRIMLQMAPDYDNLTLLQKVEVFTYALDNTKGQDLYKVLWLKSRSSESWLDRRTTYTRSLAVMSMVGYILGLGDRHPSNLMLDRITGKVVHIDFGDCFEAAILREKYPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMMVLRDNKESLMAILEAFAYDPLINWGFDLPTH-----------------------------------------------AVMEQTGIDLPLANPSELLRKGVISVEDAAKME-----------LQQKAEVRNARATLVLKRIADKLTGNDF---------------------------------------------PRCQELSVPDQVDKLIQQATSVENLCQHYIGWCS--

General information: TITO was launched using: RESULT: Template: 5FVM.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 9899 -179947 -18.18 -85.81 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain A : 0.71 3D Compatibility (PKB) : -18.18 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.71 QMean score : ?

(partial model without unconserved sides chains): PDB file : Tito_5FVM.pdb: (Unconserved sides chains are recalculated) : Sequence: align-5FVM-query.scw PDB file : Tito_Scwrl_5FVM.pdb: