Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDLEGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTNAVLFDGMGLAK 4HDC Chain:A ((4-194)) -----FITFEGPEGSGKTTVINEVYHRLV-KDYDVIMTREPGGVPTGEEIRKIVLEGN--DMDIRTEAMLFAASRREHLVLKVIPALKEGKVVLCDRYIDSSLAYQGYARGIGVEEVRALNEFAINGLYPDLTIYLNVSAEVGRERII----------DQEDLKFHEKVIEGYQEIIHNESQRFKSVNADQPLENVVEDT------------

General information: TITO was launched using: RESULT: Template: 4HDC.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 855 -68637 -80.28 -377.13 target 2D structure prediction score : 0.77 Monomeric hydrophicity matching model chain A : 0.83 3D Compatibility (PKB) : -80.28 2D Compatibility (Sec. Struct. Predict.) : 0.77 1D Compatibility (Hydrophobicity) : 0.83 QMean score : 0.532

(partial model without unconserved sides chains): PDB file : Tito_4HDC.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4HDC-query.scw PDB file : Tito_Scwrl_4HDC.pdb: