Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MAKNVVITGATSGIGEAIARAYLEQGEDVVLTGRRIDRLEILKSEFAVSFPNQTVWTFPLDVTDMVMVKTVCSDILETIGRIDILVNNAGLALDLAPYQDYEELDMLTMLDTNVKGLMAVTHCFLPAMIKVNQGHIINMGSTAGIYAYAGAAVYSATKAAVKTFSDGLRIDTIATDIKVTTIQPGIVETDF---STVRFHGDKERAASVYQGIEALQAQDIADTVVYVTSQPRRVQITDMTIMANQQATGFMIHKK 3P19 Chain:A ((15-251)) MKKLVVITGASSGIGEAIARRFSEEGHPLLLLARRVERLK------ALNLPN--TLCAQVDVTDKYTFDTAITRAEKIYGPADAIVNNAGMML-LGQIDTQEANEWQRMFDVNVLGLLNGMQAVLAPMKARNCGTIINISSIAGKKTFPDHAAYCGTKFAVHAISENVREEVAASNVRVMTIAPSAVKTELLSHTTSQQIKDGYDAWRVDMG-GVLAADDVARAVLFAYQQPQNVCIREIALAPTKQ---------

General information: TITO was launched using: RESULT: Template: 3P19.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1283 -122581 -95.54 -523.85 target 2D structure prediction score : 0.65 Monomeric hydrophicity matching model chain A : 0.78 3D Compatibility (PKB) : -95.54 2D Compatibility (Sec. Struct. Predict.) : 0.65 1D Compatibility (Hydrophobicity) : 0.78 QMean score : 0.433

(partial model without unconserved sides chains): PDB file : Tito_3P19.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3P19-query.scw PDB file : Tito_Scwrl_3P19.pdb: