Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MCAAQMPPLAHIFRGTFVHSTWTCPME----VLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCFKPCEIRELSHHEF-FMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFAEEVYTRVVRRTLKNGTTTAC---YFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEYKETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETL----MGELGNIAKTRDLHIQSHISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAHCPNSNLSLSSGFLNVLEVLKHEVKIGLGTD-VAGGYSYSMLDAIRRAVMVSNILLINKVNEKSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDS-PIDLFYGDFFGDISEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV 4DZH Chain:A ((17-418)) ----------------LIEAGYVVPIEPHAVVLEDHAVAVSNGVIVAVLPTADARVR------FAPA--RTVSRPDAALMPGLVNAHTHNPMTLLRGVADDLPLMVWLQQHIWPVEAAVIGPEFVADGTTLAIAEMLRGGTTCVNENYFFADVQ-------AAVYKQHGFRALVGAVIID----FP-----TAWASSDDEYFARAGELHDQWRDDPLISTAFAPHAPYTVNDANFERVRMLADQLDMPVHLHTHETAQEVADSVAQY--GQRPLARLDRLGLVNDRLIAVHMTQLTEAEIHLCAERGVSVVHCPESNLKLASGFCPACALQRASVNLAIGTDGCASNNDLDMFSENRTAAILAKAV---ANDATALDAATTLRAATLGGARALGFGDRIGSIEVGKQADLVCVDLSALETQPL------------HHVLSQLIYAAGRHQVTDVWIAGK---------

General information: TITO was launched using: RESULT: Template: 4DZH.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2375 -43164 -18.17 -111.25 target 2D structure prediction score : 0.63 Monomeric hydrophicity matching model chain A : 0.72 3D Compatibility (PKB) : -18.17 2D Compatibility (Sec. Struct. Predict.) : 0.63 1D Compatibility (Hydrophobicity) : 0.72 QMean score : 0.430

(partial model without unconserved sides chains): PDB file : Tito_4DZH.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4DZH-query.scw PDB file : Tito_Scwrl_4DZH.pdb: