Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MTANIMTTLKNQITDALKTSMRAKDMATVTVLRSL---------QAAIKQIEVDERIELDDAQVLAVIEKQIKQR---KESIKAFEGAGRDDLASKEQAEAEVLSQFLPEAMTEEELDSLIEQTIAAQEATSMKDMGKVMNSLRPIIAGRADPAQVSAKIKAKLA 1EXR Chain:A ((34-125)) -----------------------------TVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLSLMARKMKEQDSEEELIEAFKVFDRDGNGLISAAELRHVMTNLGEKLTDDEVDEMI--------------------------------------------

General information: TITO was launched using: RESULT: Template: 1EXR.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 102 6766 66.33 84.58 target 2D structure prediction score : 0.71 Monomeric hydrophicity matching model chain A : 0.68 3D Compatibility (PKB) : 66.33 2D Compatibility (Sec. Struct. Predict.) : 0.71 1D Compatibility (Hydrophobicity) : 0.68 QMean score : 0.497

(partial model without unconserved sides chains): PDB file : Tito_1EXR.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1EXR-query.scw PDB file : Tito_Scwrl_1EXR.pdb: