Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence WPLTADCNIYPKIGDKSVGWGSGFMGSVAHVRIEKVDYAVALWKRVCKAVKLEEL----PPGVEL-FAEPNTLRR---------NPQPVQRRGLVGREPLGGLELQE 1VDD Chain:C ((162-197)) ------------------------------------------------GAAISRIAYGVPVGGSLEYTDEVTLGRALTGRQTVS-----------------------

General information: TITO was launched using: RESULT: Template: 1VDD.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 9 -250 -27.78 -11.36 target 2D structure prediction score : 0.64 Monomeric hydrophicity matching model chain C : 0.55 3D Compatibility (PKB) : -27.78 2D Compatibility (Sec. Struct. Predict.) : 0.64 1D Compatibility (Hydrophobicity) : 0.55 QMean score : 0.588

(partial model without unconserved sides chains): PDB file : Tito_1VDD.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1VDD-query.scw PDB file : Tito_Scwrl_1VDD.pdb: