Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MLYFMYRIIERRLSMKKKLVFPNLFWWGAASSGPQTEGQY---GKVHENVMDYWFKTHPEDFFDNVGPLVASNFFHTYTEDFHLMKEIGVNSFRTSIQWSRLIKNLETGEPDPKGIAFYNAIIEEAKKNQMDLVMNLHHFDLPVELLQKYGGWESKHVVELFVKFAKTAFTCFGDKVHYWTTFNEPMVIPEAGYLYAFHYPNLKGKGKEAVQVIYNLNLASAKVIQLYRSLELDG-KIGIILNLTPAYPRSNSPEDLEASRFTDDFFNKVFLNPAVKGTFPERLVKQLERDGVLWSHTEKELQLMKSNTVDFLGVNYYHPKRVQAQANPEEYQTPWMPDQYFKEYEWPERRMNPYRGWEIFPKAIYDIAMIVKEEYGNIPWFISENGMGVENEARFIDENGVIDDVYRIEFYEEHLRWLHKAIEEGSHCFGYHAWTAFDCWSWNNAYKNRYGFISVDLETQKRTIKSSGRWYRKVSDNNGFEVEIEE 4HZ6 Chain:A ((5-443)) --------------------FPEGFLWGAATSSYQIEGAWNEDGK-GESIWDR-FTRIPGKIKNGDSGDVACDHYHRYEQDLDLMRQLGLKTYRFSIAWAR-IQPDSSRQINQRGLDFYRRLVEGLHKRDILPMATLYHWDLP-QWVEDEGGWLSRESASRFAEYTHALVAALGDQIPLWVTHNEPMVTVWAGYHMGLFAPGLKDP-TLGGRVAHHLLLSHGQALQAFRALSPAGSQMGITLNFNTIYPVSAEPADVEAARRMHSFQNELFLEPLIRGQYNQATLMAYPN---LPEFIAPEDMQTISAPIDFLGVNYYNPMRVKSSPQP--------PGIEVVQVESPVTAM----GWEIAPEGLYDLLMGITRTYGKLPIYITENGAAFDDQP---DQSGQVNDPQRVGYFQGHIGAARRALADGVDLRGYYAWSLLDNFEWAEGYSKRFGIIYVDFETQQRTLKQSAQWYRDVIANNGLE-----

General information: TITO was launched using: RESULT: Template: 4HZ6.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2549 -27770 -10.89 -63.84 target 2D structure prediction score : 0.57 Monomeric hydrophicity matching model chain A : 0.76 3D Compatibility (PKB) : -10.89 2D Compatibility (Sec. Struct. Predict.) : 0.57 1D Compatibility (Hydrophobicity) : 0.76 QMean score : 0.487

(partial model without unconserved sides chains): PDB file : Tito_4HZ6.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4HZ6-query.scw PDB file : Tito_Scwrl_4HZ6.pdb: