Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKVQPNDYSKIYDIAVIGGGINGVGIANDAVGRGLSVFLCEK-DDLASHTSSASSKLIHGGLRY--------LEYKEFRLVREALAEREVLLAKAPHIIKPMRFIMPHRPHLRPAWLIRAG----LFFYDHLGKREKLLGSNRIYFKEDSP---LKPAI---TRGFEYSDCTVDDARLVVLNALQAKEKGAKVVTRKRCVKAYRQQELWYLELQSGAEFYQVRAKAIVNAAGPWVEEIISENLNLSSPYQIRLIQG-SHIVVPKLYDCHKAFIM---QNEDRRIVFAIPYLEKYTLIGTTD----------------QEYTGDPQKVEITDVEIDYLLTVTNSHFKKQLTRADIVSQYSGVRALCDDESDNPSAITRDYTLALQAEDKTTPLLSVFG---GKITTYRKLAEAALEHLAPFFNDMAEEWTADDPLPGAENWTTLEDLINQIKTRVSGISDSLANRWAHAYGTRVWNMLKERNAIEQLGQHFGHDLFECEVRYLCEYEWAHTAEDILWRRSKLGLAFDEKQVKVLEAYLSERRLKDDAA 3DME Chain:A ((6-368)) ------------DCIVIGAGVVGLAIARALAAGGHEVLVAEAAEGIGTGTSSRNSEVIHAGIYYPADSLKARLCVRGKHLLYEYCAARGV-------------------PHQRLGKLIVATSDAEASQLDSIARRAGANGVDDLQHIDGAAARRLEPALHCTAALVSPSTGIVDSHALMLAYQGDAESDGAQLVFHTPLIAGRVRPEGGFELDFGGAEPMTLSCRVLINAAG------------LHAPGLARRIEGIPRDSIPPEYLCKGSYFTLAGRAPFSRLIYPVPQHAGLGVHLTLDLGGQAKFGPDTEWIATEDYTLDPRRA-------DVFYAAVRSYWPA-LPDGALAPGYTGIR----PKISGPHEPAADFAIAGPASHGVAGLVNLYGIESPGLTASLAIAEETLARLA---------------------------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 3DME.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1724 -34065 -19.76 -106.12 target 2D structure prediction score : 0.48 Monomeric hydrophicity matching model chain A : 0.67 3D Compatibility (PKB) : -19.76 2D Compatibility (Sec. Struct. Predict.) : 0.48 1D Compatibility (Hydrophobicity) : 0.67 QMean score : 0.285

(partial model without unconserved sides chains): PDB file : Tito_3DME.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3DME-query.scw PDB file : Tito_Scwrl_3DME.pdb: