Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MRTRRLGQTLFSQPFLGEISMNLTIQEIAQAVGSECSALTKITNVEFDSRKITEGSLFVPLAGTR-DGHEFIQQAITNGASASFWSLPVEQAPKNFPVIPVADPLKAMQQLATYYLEKVGAEVVAITGSNGKTTTKDLTASVL----SEKYKTYKTQGNYNNNIGLPYTILHMPQDTEKIVLEMGMDHANEITELSLMAQPKAAAITMIGEAHIENLGSREGIAKAKMEITDGLVSDGLLVVPADEPLLTPLTATLV-QTVTTFGIGNGDVH---AEVTAKGKAQTDFVVEG----ETFTIPLPGSYNVTNALIAYTIGRFFGLSIPEIRQGLAHVSITQNRTEWLTAGNGAAILSDVYNANPTAMGLVLDTFKNLPTKGRRIAVLADMLELGKESLNMHAQMSEHIDPEKFAMIFLYGEQM-HALKEELNQKYPQLPVFYLEKEKNKLIDAIKQNLEATDSIMLKGSNSMGLFEVVEQLQQMK 4CVK Chain:A ((9-450)) ---------------------QLTVALDARLIGEDAV----FSAVSTDSRAIGPGELFIALSGPRFDGHDYLAEVAAKGAVAALVEREVA-AP--LPQLLVRDTRAALGRLGALNRRKFTGPLAAMTGSSGKTTVKEMLASILRTQAGDAESVLATRGNLNNDLGVPLTLLQLAPQHRSAVIELGASRIGEIAYTVELTRPHVAIITNA-------FGGPEKIVEAKGEILEGLAADGTAVLNLDDKAFDTWKARASGRPLLTFSLDRPQADFRAADLQRDARGCMGFRLQGVAGEAQVQLNLLGRHNVANALAAAAAAHALGVPLDGIVAGLQALQPVKGRAVAQLTASGLRVIDDSYNANPASMLAAIDILSGF--SGRTVLVLGDMG-----AEQAHREVGAYA-AGKVSALYAVGPLMAHAV-----QAFGATGRHF--ADQASLIGALATE-DPTTTILIKGSRSAAMDKVVAAL----

General information: TITO was launched using: RESULT: Template: 4CVK.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 2365 -26437 -11.18 -63.70 target 2D structure prediction score : 0.59 Monomeric hydrophicity matching model chain A : 0.77 3D Compatibility (PKB) : -11.18 2D Compatibility (Sec. Struct. Predict.) : 0.59 1D Compatibility (Hydrophobicity) : 0.77 QMean score : 0.542

(partial model without unconserved sides chains): PDB file : Tito_4CVK.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4CVK-query.scw PDB file : Tito_Scwrl_4CVK.pdb: