Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MVAQIRIGQGMDVHAFEEGKFVTLAGVQIPHTHGLKAHSDGDVVLHALCDALLGALALGDIGQHFPDTDPEFKGADSRVLLKHVYQLILDRGYHLNNADITVACERPKLAKYNLEMRQSIADVLNVDLNQISIKATTTEKLGFTGRQEGILATATVLISH 3IEW Chain:C ((24-177)) ----FRIGQGYDVHQLVPGRPLIIGGVTIPYERGLLGHSDADVLLHAITDALFGAAALGDIGRHF----------DSRALLRECASRVAQAGFAIRNVDSTIIAQAPKLAPHIDAMRANIAADLDLPLDRVNVKAKTNEKLGYLGRGEGIEAQAAALV--

General information: TITO was launched using: RESULT: Template: 3IEW.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain C - contact count / total energy / energy per contact / energy per residue : 816 -118007 -144.62 -819.49 target 2D structure prediction score : 0.69 Monomeric hydrophicity matching model chain C : 0.81 3D Compatibility (PKB) : -144.62 2D Compatibility (Sec. Struct. Predict.) : 0.69 1D Compatibility (Hydrophobicity) : 0.81 QMean score : 0.537

(partial model without unconserved sides chains): PDB file : Tito_3IEW.pdb: (Unconserved sides chains are recalculated) : Sequence: align-3IEW-query.scw PDB file : Tito_Scwrl_3IEW.pdb: