Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence WYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYY 2ROR Chain:A ((28-102)) WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFY

General information: TITO was launched using: RESULT: Template: 2ROR.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 269 -37072 -137.81 -494.29 target 2D structure prediction score : 0.75 Monomeric hydrophicity matching model chain A : 0.91 3D Compatibility (PKB) : -137.81 2D Compatibility (Sec. Struct. Predict.) : 0.75 1D Compatibility (Hydrophobicity) : 0.91 QMean score : 0.613

(partial model without unconserved sides chains): PDB file : Tito_2ROR.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2ROR-query.scw PDB file : Tito_Scwrl_2ROR.pdb: