Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKVLAFDTSSKALSLAILEDKQVLAETTINIKKNHSITLMPAIDFLMASLDWTPKDLDRIVVAEGPGSYTGLRIAVATAKTLAHTLNIELVGMSSL--LALVPYQQEGL--FIPLMDARRNNVYAGFYENAKPVM----AEAHLPFERVIELIKGASQVTFVGEVG-PFVEQIQKHLPRTDYKETLPNAAN---LALLAWDK-EADSLHDFVPNYLKRVEAEENWLKNHTESGESYIKRL 4Y0W Chain:A ((10-221)) --LLALDTSTEACSVALLHEGRALSHYEV-IPRLHAQRLLPMVRDLLDEAGVALSAVDAIAFGRGPGAFTGVRIAIGVVQGLAFALQRPVLAVSDLAILAQRAYREQGAERVAAAIDARMDEVYWGCYQLQQGEMRLAGSEAVLPPERVAVPWDAAAADWFGAGTGWGYVERMPQR-PVALDASLLPHAEDLLSLAGFAWARGEGVEAEQALPVYL------------------------

General information: TITO was launched using: RESULT: Template: 4Y0W.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain A - contact count / total energy / energy per contact / energy per residue : 1160 -62891 -54.22 -316.03 target 2D structure prediction score : 0.51 Monomeric hydrophicity matching model chain A : 0.76 3D Compatibility (PKB) : -54.22 2D Compatibility (Sec. Struct. Predict.) : 0.51 1D Compatibility (Hydrophobicity) : 0.76 QMean score : 0.408

(partial model without unconserved sides chains): PDB file : Tito_4Y0W.pdb: (Unconserved sides chains are recalculated) : Sequence: align-4Y0W-query.scw PDB file : Tito_Scwrl_4Y0W.pdb: