Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MKRILIVTGQSGSGKSSALQVLE-DLGYYCIDNLPLAL--L----PEIVAKLDHE---N--------NLEQLALGVDVRSTRADMQEFDHVFEQLQKHGTVDVIYLTTQDQDLIARFSASR--RPHPLANRFKSLLQCIHEEKQLLIPIQ-FCATVHIDTTDKSVHDLKHILLSKLGQSDNLIVILQSFGYKHGIPLDADYVFDVRHLPNPHWDLELRRFSGLDEPVKQFLEASPQANEMFEDILHFLKKWLPAFAEGHRHYMTISIGCTGGQHRSVYMVDRLKQALEAEWSVQVLHREMKHWS 1E6C Chain:B ((1-170)) MTEPIFMVGARGCGMTTVGRELARALGYEFVDTDIFMQHTSGMTVADVVAAEGWPGFRRRESEALQAVATPNRVVATGGGMV----LLEQNRQFMRA--HGTVVYLFAPAEELALRLQASLQAHQRPTLTG-RPIAEEMEAVLREREALYQDVAHYVVDATQ-PPAAIVCELMQTMRL------------------------------------------------------------------------------------------------------------------------------

General information: TITO was launched using: RESULT: Template: 1E6C.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain B - contact count / total energy / energy per contact / energy per residue : 580 -10072 -17.36 -67.59 target 2D structure prediction score : 0.58 Monomeric hydrophicity matching model chain B : 0.58 3D Compatibility (PKB) : -17.36 2D Compatibility (Sec. Struct. Predict.) : 0.58 1D Compatibility (Hydrophobicity) : 0.58 QMean score : 0.541

(partial model without unconserved sides chains): PDB file : Tito_1E6C.pdb: (Unconserved sides chains are recalculated) : Sequence: align-1E6C-query.scw PDB file : Tito_Scwrl_1E6C.pdb: