Modeling by threading (Tito software) Unconserved sides chains calculation (Scwrl software) Evaluation (QMean software) Input alignment information: Query sequence MLVIVITIIAIKGEGKHMASVLVVKGHPLTAEESRTVKALTSFLTSYKENHPDDEVTVLELYR--DDIPEIDEELLS-----GWEALRAGAEFTSLSESQQQKIARFNELTDQFLAADKIVIANALWNLNIPTKLKAWFDTVNVAGKTFRYTENGPEGLVTGKKALHIQSNGGVYNGQDFASQYVKGILNFVGIDQVDQLFIEGIDYDPDRADELMQNALDKAAALGKSF 2HPV Chain:D ((2-208)) ------------------SKLLVVKAHPLTKEESRSVRALETFLASYRETNPSDEIEILDVYAPETNMPEIDEELLSAWGALRAGAAFE-----TLSENQQQKVARFNELTDQFLSADKVVIANPMWNLNVPTRLKAWVDTINVAGKTFQYTAEGPKPLTSGKKALHIQSNGGFYEGKDFASQYIKAILNFIGVDQVDGLFIEGIDHFPDRAEELLNTAMTKATEYGKTF

General information: TITO was launched using: RESULT: Template: 2HPV.pdb Alignment : align.pir Tito was launched with SMD and SCWRL Tito text output Monomeric PKB - chain D - contact count / total energy / energy per contact / energy per residue : 912 -21184 -23.23 -105.92 target 2D structure prediction score : 0.71 Monomeric hydrophicity matching model chain D : 0.86 3D Compatibility (PKB) : -23.23 2D Compatibility (Sec. Struct. Predict.) : 0.71 1D Compatibility (Hydrophobicity) : 0.86 QMean score : 0.550

(partial model without unconserved sides chains): PDB file : Tito_2HPV.pdb: (Unconserved sides chains are recalculated) : Sequence: align-2HPV-query.scw PDB file : Tito_Scwrl_2HPV.pdb: