@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00017_FPS_FU: (2014-08-09 )
ASGQLHRPQPQEHTSTSAAAGTWRLTQASESRHRLPHCSAAPSHQDHSAMGFGPELWCPKGHTELLRLQDSELRLLELMKKWMSQRAKSDREYAGMLHHMFSQLEKQEGLGHLRATDHSSQIGESWWVLASQTETLSQTLRRHAEELAAGPLAKLSILIRDKQQLRKVFSEQWQQLSQEYAWTTQQEVEKLKAQYRSLVRDSTQAKRKYQEASKDKEREKAKEKYVRSLSKLYALHNQYVLAVQAAALHHHHHYQRALPTLHESLYSLQQEMVLVLKEILGEYCSITSLVQEDVLAIHQKVAHAVEMIDPATEYSSFVQCHRYDSEVPPAVTFDESLLEEAENLEPGELQLNELTIESVQHSLTSIEEELLASRKAVSSKEQRVWELQVELRGEELALSPGERVHLLGKRQGLREAQQQLQGLVCAQAKLQAQRDMLANKLAELGSEEPPPALPLQEDRQSARSTDQERSGVTALKTIKNHISGIFSPRFSLPPPVPLIPEVQKPLCQQAWYHGAIPRSEVQELLKYSGDFLVRESQGKQEYVLSVLWDGQPRHFIIQAADNLYRLEDDGLPTIPLLIDHLLQSQRPITRKSGIVLTRAVLKDKWVLNHEDVLLGERIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPELKAKFLQEARILKQCNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSKGPRLKMKKLIKMMENAAAGMEYLESKHCIHRDLAARNCLVTEKNTLKISDFGMSRQEEDGVYASTGGMKQIPVKWTAPEALNYGWYSSESDVWSFGILLWEAFSLGAVPYANLSNQQTREAIEQGVRLEPPEQCPEDVYRLMQRCWEYDPHRRPSFGAVHQDLIAIRKRHR
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520....----.----..530......-.-540.......-----550.......-560.--.-...-...570.......580--------......--------..-.-------590.-.-----.....---------------600.......610....-...620.......630----.------.--......640...-....650.......660...-....670.......680........690.......700.------.-------.---.---....710.......720.......730.......740.-----.---.....750.......760-........770.......780.......790.......800.......810....-.-..820.......830.......840.......850.......860.......870.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
ASGQLHRPQPQEHTSTSAAA
G
T
W
R
LTQASESRHRLPHCSAAPSHQDHSAMGFGPELWCPKG
H
T
E
L
L
RLQDS
E
L
R
L
L
E
L
M
K
K
W
M
S
Q
RAKS
D
R
E
Y
A
G
M
L
H
H
M
F
S
Q
L
E
K
Q
EGLGHLRATDHSSQIG
E
S
W
W
V
L
AS
Q
T
E
T
L
S
Q
T
L
R
R
H
A
E
E
LAAGP
L
A
K
L
S
I
L
IR
D
K
Q
Q
L
R
K
V
F
S
E
Q
W
Q
Q
L
S
Q
E
YAWT
T
Q
Q
E
V
E
K
L
K
A
Q
Y
R
S
L
V
R
D
S
T
Q
A
K
R
K
Y
Q
E
ASK
D
K
E
R
E
K
A
K
E
K
Y
V
R
S
L
S
K
L
Y
A
L
H
N
Q
Y
V
L
A
V
Q
A
A
A
L
H
H
H
H
H
Y
Q
R
A
L
P
T
L
H
E
S
L
Y
S
L
Q
Q
E
M
V
L
V
L
K
E
I
L
G
E
Y
C
S
I
T
S
L
V
Q
E
D
V
L
A
I
H
Q
K
V
A
H
A
V
E
MIDP
A
T
E
Y
S
S
F
V
Q
C
HRYDSEVPPAVTF
D
E
S
L
L
E
E
A
ENLEPG
E
L
Q
L
N
E
L
T
I
E
S
V
Q
H
S
L
T
S
I
E
E
E
L
L
A
S
R
K
AVSSKE
Q
R
V
W
E
L
Q
V
E
L
RG
E
E
LALSPG
E
R
V
H
L
L
G
K
R
Q
G
L
R
E
A
Q
Q
Q
L
Q
G
L
V
C
A
Q
A
K
L
Q
A
Q
R
D
M
L
A
N
K
L
A
E
LGSEEPPPALP
L
Q
E
D
R
Q
S
ARST
D
Q
E
RSG
V
T
A
L
K
T
I
K
N
H
I
S
G
IFSPRFSLPPPVPLIP
E
V
Q
K
P
L
C
Q
Q
A
WYHGAI
P
R
S
E
V
Q
E
L
L
K
----Y----SG
D
F
L
V
RESQG-K-
Q
E
Y
V
L
S
V
L
WD-----GQP
R
H
F
I
I
QA-AD-
N
--
L
-
Y
RL-EDDGLP
T
I
P
L
L
I
D
H
----------
L
L
Q
SQR--------PI-T-------RKS
G
-
I
-----
V
L
T
R
A
---------------
V
LKDKWVLNH
E
D
V
L
L
G
E
-RIGRGN
F
G
E
V
FSGRL-----R------A--DNT
P
V
A
V
K
S
C
R
E
-TL
P
P
E
L
K
A
K
F
L
Q
E
A
R
I
L
K
QC-NHP
N
I
V
R
L
I
G
VCTQK-Q
P
I
Y
I
V
M
E
L
VQG
G
D
F
L
S
F
L
R
S-K------G-------P---
R
---
L
K
M
K
K
L
I
K
M
M
E
N
A
A
A
G
M
E
Y
L
E
S
K
H
C
I
H
R
D
L
A
ARN
C
L
VT-----E---K
N
T
L
K
I
SDFGMSRQEE-D-
G
V
Y
ASTGG
M
K
QI
P
V
K
WTAPEALNYGWYSSES
D
V
W
S
F
G
I
L
L
W
E
A
FSLGAVPYANLS-
N
-
Q
Q
T
R
E
A
I
EQGVRLE
P
P
EQ
C
P
E
D
V
Y
R
L
M
Q
R
C
WEYDPHRRPSF
G
A
V
H
Q
D
L
I
A
I
R
K
RHR
1
PsiBlast_PDB
99.54
79%
-99
- C1 -
3BKB
9
A:
[4-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
----
S
G
D
F
L
V
R
E
S
Q
G
-
K
-
Q
E
Y
V
L
S
V
L
W
D
-----
G
L
P
R
H
F
I
I
Q
S
-
L
D
-
N
--
L
-
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
----------
L
L
S
T
Q
Q
--------
P
L
-
T
-------
K
K
S
G
-
V
-----
V
L
H
R
A
---------------
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-----
R
------
A
--
D
N
T
L
V
A
V
K
S
C
R
E
-
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
------
G
-------
A
---
R
---
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
---
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
-
D
-
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
-
N
-
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-
35
HHSearch
74.71
37%
-83
- C1 -
1OPK
3
ABL1_MOUSE
A:
[100-477]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
----
S
GI--
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
Y
E
-----
G
R
V
Y
H
Y
R
I
N
T
-
A
S
D
G
--
K
L
Y
V
S
-
S
E
S
R
F
N
T
L
A
E
L
V
H
H
----------
H
S
T
V
A
D
--------
G
L
I
T
TLHYPAP
K
R
N
K
P
T
-----
I
Y
G
V
S
---------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
-
D
T
M
--
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N-----
R
-------
Q
---
E
---
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
----
3
PsiBlast_PDB
72.32
38%
-84
- C1 -
1OPL
2
ABL1_HUMAN
A:
[141-510]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
SG--
I
----
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
Y
E
-----
G
R
V
Y
H
Y
R
I
N
T
-
A
S
-
D
G
K
L
-
Y
V
S
-
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
VADGLIT
T
L
H
Y
P
A
--------
P
--
K
-------
R
N
K
P
-
T
-----
V
Y
G
V
S
---------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
37
HHSearch
72.16
34%
-97
- C1 -
2OZO
1
ZAP70_HUMAN
A:
[158-597]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
SGAQ
T
----
D
G
K
F
L
L
R
P
R
K
E
-
Q
-
G
T
Y
A
L
S
L
I
Y
G
-----
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
-
G
--
K
-
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
----------
L
K
L
K
A
D
GLIYCLKE
A
C
-
P
-------
N
---------------MDTSVFESPFSDPEE
L
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
-----
R
------
M
RK
K
Q
I
D
V
A
I
K
V
L
K
Q
-
G
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
------
R
-------
E
---
E
---
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
-----
N
---
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
---------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
----
5
PsiBlast_PDB
71.20
38%
-80
- C1 -
2FO0
4
ABL1_HUMAN
A:
[99-468]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
SG--
I
----
N
G
S
F
L
V
R
E
S
E
S
-
S
P
G
Q
R
S
I
S
L
R
Y
E
-----
G
R
V
Y
H
Y
R
I
N
T
-
A
S
-
D
G
K
L
-
Y
V
S
-
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
VADGLIT
T
L
H
Y
P
A
--------
P
--
K
-------
R
N
K
P
-
T
-----
V
Y
G
V
S
---------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
33
HHSearch
66.99
37%
-86
- C1 -
1QCF
1
HCK_HUMAN
A:
[65-442]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
----
A
PGNM
L
G
S
F
M
I
R
D
S
E
T
T
K
-
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
R
T
-
L
D
-
N
G
G
F
-
Y
I
S
-
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
----------
Y
K
K
G
N
D
--------
G
L
-
C
-------
Q
K
L
S
-
V
PCMSS
K
P
Q
K
P
---------------
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-----
N
---------
K
H
T
K
V
A
V
K
T
M
K
P
-
G
S
M
--
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
------
G
-------
S
---
K
---
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
-
D
-
N
E
Y
T
A
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
---
45
HHSearch
62.24
41%
-84
* C1 *
4AOJ
1
NTRK1_HUMAN
A:
[36-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
-----
H
NLLP------
K
M
L
V
A
V
K
A
L
K
E
-
A
-
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
-
H
------
G
-------
P
DPG
P
---
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
---
G
L
V
V
K
I
G
D
F
G
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
---
47
HHSearch
60.61
39%
-75
- C1 -
2IVS
5
RET_HUMAN
A:
[15-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
W
E
F
P
R
K
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
HLKG
R
------
A
--
G
Y
T
T
V
A
V
K
M
L
K
E
-
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
-
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
------
R
K
VGPGYL
R
---
A
---
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
---
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
-
D
S
Y
V
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
-
P
-
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
R
-
49
HHSearch
59.84
39%
-78
- C1 -
3ZBF
1
A:
[24-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--------
E
-------------
N
---------
L
P
A
---------------
F
P
R
-------
E
K
L
T
L
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
-----
V
DILGVG
S
--
G
E
I
K
V
A
V
K
T
L
K
K
-
G
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
-
E
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-
A
R
M
ATFY
G
-------
P
---
L
---
L
T
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
---
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
--------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
-
N
-
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
--
40
HHSearch
58.33
38%
-88
- C1 -
1U59
1
A:
[3-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
-----
R
---------
K
Q
I
D
V
A
I
K
V
L
K
Q
-
G
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
------
R
-------
E
---
E
---
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
N
---
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
-
D
S
Y
Y
T
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
----
43
HHSearch
58.09
38%
-87
- C1 -
4FYO
1
A:
[11-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
-----
Q
------
M
KK
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
--
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
--------------
R
---
H
---
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
T
---
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
-
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
--
13
PsiBlast_PDB
58.01
43%
-81
- C1 -
2G2I
2
ABL1_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
---
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
20
PsiBlast_PDB
57.87
43%
-80
- C1 -
3QRK
1
ABL1_HUMAN
A:
[11-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
48
HHSearch
57.82
43%
-75
- C1 -
2YFX
1
A:
[23-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
----------------
P
L
Q
V
A
V
K
T
L
P
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
------
R
PRPSQP-
S
---
S
---
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
-----
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
-------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
---
10
PsiBlast_PDB
57.38
43%
-85
- C1 -
3PYY
1
ABL1_HUMAN
A:
[19-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
----
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
12
PsiBlast_PDB
57.00
43%
-76
- C1 -
2G2H
1
ABL1_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
50
HHSearch
56.99
42%
-72
- C1 -
3L9P
4
A:
[65-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
-----
S
------
G
--
S
P
L
Q
V
A
V
K
T
L
P
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-
T
------
R
PRPSQP-
S
---
S
---
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
---
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-
R
-
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
---
7
PsiBlast_PDB
56.95
43%
-83
- C1 -
2Z60
1
ABL1_MOUSE
A:
[6-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
11
PsiBlast_PDB
56.74
43%
-81
- C1 -
2G2F
2
ABL1_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
9
PsiBlast_PDB
56.70
43%
-78
- C1 -
2F4J
1
ABL1_HUMAN
A:
[7-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
46
HHSearch
56.61
38%
-74
- C1 -
1T46
1
A:
[15-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
K
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
-----
Y
GLIKS-
D
--
A
A
M
T
V
A
V
K
M
L
K
P
-
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
------
R
-------
D
SFL
A
---
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
-----
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
-
N
D
S
N
Y
V
V
K
-
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
-
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
---
19
PsiBlast_PDB
56.55
43%
-79
- C1 -
3QRI
1
ABL1_HUMAN
A:
[11-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
22
Fugue
56.19
44%
-94
- C1 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
-----
R
G----------
N
K
V
A
V
K
C
I
K
------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
------
G
------------RSV
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
-----
E
---
D
N
V
A
K
V
S
D
F
G
-------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L--
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
15
PsiBlast_PDB
56.09
43%
-78
- C1 -
3UE4
1
ABL1_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
18
PsiBlast_PDB
55.88
43%
-83
- C1 -
2HIW
1
ABL1_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
16
PsiBlast_PDB
55.85
43%
-80
- C1 -
2HYY
1
ABL1_HUMAN
A:
[8-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
-D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
14
PsiBlast_PDB
55.68
43%
-80
- C1 -
2G1T
2
ABL1_HUMAN
A:
[8-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
6
PsiBlast_PDB
55.28
43%
-73
- C1 -
3OY3
1
ABL1_MOUSE
A:
[6-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
-
G
-
D
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------
8
PsiBlast_PDB
54.45
43%
-82
- C1 -
3IK3
1
ABL1_MOUSE
A:
[6-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-----
K
------
K
--
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
------
N
-------
R
---
Q
E--
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
---
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
Y
T
A
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
----------