@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00018_TEC_HU: (2014-08-10 )
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210-.......220.-.......230.......240.......250.......260-.-..-....270...-.-...280.......290.......300.......310.......320.......330.......340.......350....--------------...--360.......370..-.....380.......--390-.------.-.---......400..--.--.---...410.......420........430...-....440.......450.....-.---.------460.......470.......480.......490.......---500.......510....--..--.520...-....530.......540.......550.......560.......570-........580.......590.......600.......610.......620.......630
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
F
N
T
I
L
E
E
I
L
I
K
R
S
Q
QKKKTSPL
N
Y
K
E
R
L
F
V
L
T
K
S
M
L
T
Y
Y
EG
R
A
E
K
K
Y
R
KGFIDVS
K
I
K
C
V
E
I
VKNDD
G
V
I
PCQNKY
P
F
Q
V
V
HDA
N
T
L
Y
I
FAPSPQS
R
D
L
W
V
K
K
L
K
E
E
IKNNN
N
I
M
I
K
YHPKFWTDG
S
Y
Q
C
C
R
Q
T
E
KLAPG
C
E
K
Y
N
L
F
E
S
S
I
R
K
ALPPAPETKKRRPPPPIPLEEEDNSE
E
I
V
V
A
M
Y
D
FQAAEGHD
L
R
LERG
Q
E
Y
L
I
L
EKN-D
V
H
W
W
R
AR-DK-YGNEGYIPSNYVTGKKSNN
L
D
Q
Y
E
W
Y
C
RNM
N
R
S
K
A
E
Q
L
L
R
-S-ED-KEG
G
F
M
V
RDS-S-QP
G
L
Y
T
V
S
L
Y
T
KFGGEGSSG
F
R
H
Y
H
I
KETTTSP
K
K
Y
Y
L
A
EKHAFGS
I
P
E
I
I
E
Y
HKH
N
A
A
G
L
V
T
RLRY
P
V
S
VKGKNAPTTA--------------G
F
S
--
Y
E
KWEI
N
P
S
E
L
T
F
M
R
-
E
L
G
S
G
L
F
G
V
V
R
L
G
K
W
--
R
---
A
------
Q
-
Y
---
K
V
A
I
K
A
I
REGA--M--
C
---
E
E
D
F
I
E
E
A
K
V
M
M
KL-TH
P
K
L
V
Q
L
Y
G
VCTQQ-KP
I
Y
I
V
T
E
F
M
ER
G
C
L
L
N
F
L
R
Q
R-Q---G------HF
S
R
D
V
L
L
S
M
C
Q
D
V
C
E
G
M
E
Y
L
E
RNS
F
I
H
R
D
L
A
A
RNCLVSE---A
G
V
V
K
V
SDFG
M
A
R
Y
V
LD--DQ--YTSSSGA-KFPVKWC
P
P
E
VFNYSRFSSKS
D
V
W
S
F
G
V
L
M
W
E
V
F
TEGRM
P
F
E
KYT-N-
Y
E
V
V
T
M
V
TRGHRLYQPKLA
S
N
Y
V
Y
E
V
M
L
R
C
W
QEKPEGRP
S
F
E
D
L
L
R
T
I
D
E
L
V
E
C
E
E
TFGR
34
HHSearch
95.44
42%
-99
- C3 -
1OPK
3
ABL1_MOUSE
A:
[44-478]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
-
T
K
-
N
G
-
Q
G
W
V
P
S
N
Y
I
T
P
V
--
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
-
S
--
G
-
I
N
G
S
F
L
V
R
E
S
-
E
S
S
P
G
Q
R
S
I
S
L
R
Y
------
E
G
R
V
Y
H
Y
R
I
N
T
A
--
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
--
R
N
K
P
T
I
Y
--------------
G
V
S
PN
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
---
K
Y-----
S
-
L
---
T
V
A
V
K
T
L
K
E
D
T
--
M
--
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
---
Q
------
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
---
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
--
D
T
--
Y
T
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
-------
32
HHSearch
92.35
38%
-103
- C3 -
1QCF
1
HCK_HUMAN
A:
[7-443]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
S
--
G
E
W
W
K
A
R
S
L
A
-
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
--
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
-
A
P
G
N
-
M
L
G
S
F
M
I
R
D
S
E
T
-
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
-
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
--
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
---
K
P
Q
K
P
--------------
W
-
E
--
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
---
K
------
H
-
T
---
K
V
A
V
K
T
M
K
P
G
S
--
M
--
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
P
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
-
E
G
--
S
------
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
---
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
--
N
E
--
Y
T
A
R
E
G
A
-
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
-
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
------
33
HHSearch
91.32
39%
-100
- C3 -
2H8H
1
SRC_HUMAN
A:
[87-522]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
-
E
G
D
W
W
L
A
H
-
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
--
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
-
E
N
-
P
R
G
T
F
L
V
R
E
S
-
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
-
A
K
G
L
N
V
K
H
Y
K
I
R
K
--
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
---
S
K
P
Q
T
Q
--------------
G
L
A
--
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
---
G
------
T
-
T
---
R
V
A
I
K
T
L
K
P
G
T
--
M
--
S
---
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
P
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
-
T
G--
K
------
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
---
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
--
N
E
--
Y
T
A
R
Q
G
A
-
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
-
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
------
38
HHSearch
81.69
33%
-114
- C3 -
2OZO
1
ZAP70_HUMAN
A:
[155-599]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
-
S
-
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
Q
G
T
Y
A
L
S
L
I
Y
------
G
K
T
V
Y
H
Y
L
I
S
Q
D
--
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
---------MDTSVFESPFSDPE
E
L
K
--
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
M
RK
K
------
Q
-
I
---
D
V
A
I
K
V
L
K
Q
G
T
EK
A
--
D
---
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
--
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
-
R
---
E
------
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
---
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
-----------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
------
10
PsiBlast_PDB
79.55
66%
-120
- C3 -
4HCT
1
A:
[4-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
Q
--
Y
T
S
S
T
G
T
-
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
12
PsiBlast_PDB
78.94
66%
-122
- C3 -
4HCV
1
A:
[5-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
Q
--
Y
T
S
S
T
G
T
-
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
40
HHSearch
78.81
66%
-118
* C3 *
4HCU
1
A:
[5-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
Q
--
Y
T
S
S
T
G
T
-
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
------
4
PsiBlast_PDB
77.89
62%
-123
- C3 -
3PIX
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
---
G
------
Q
-
Y
---
D
V
A
I
K
M
I
K
E
G
S
--
M
--
S
---
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
E
--
Y
T
S
S
V
G
S
-
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
3
PsiBlast_PDB
77.79
66%
-121
- C3 -
3T9T
3
A:
[3-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
--
D
Q
--
Y
T
S
S
T
G
T
-
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
39
HHSearch
77.74
62%
-126
- C3 -
3GEN
1
A:
[16-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
---
F
G
V
V
K
Y
G
K
W
--
R
---
G
------
Q
-
Y
---
D
V
A
I
K
M
I
K
E
G
S
--
M
--
S
---
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
E
--
Y
T
S
S
V
G
S
-
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
8
PsiBlast_PDB
77.15
62%
-128
- C3 -
3PJ2
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
---
G
------
Q
-
Y
---
D
V
A
I
K
M
I
K
E
G
S
--
M
--
S
---
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
9
PsiBlast_PDB
75.81
62%
-126
- C3 -
3PJ3
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
---
G
------
Q
-
Y
---
D
V
A
I
K
M
I
--------------
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
------------------------
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
6
PsiBlast_PDB
75.56
62%
-127
- C3 -
3PIZ
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
---
G
------
Q
-
Y
---
D
V
A
I
K
M
I
---------
S
---
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
18
PsiBlast_PDB
75.55
66%
-119
- C3 -
3V8T
1
ITK_HUMAN
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
---
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
--------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
14
PsiBlast_PDB
75.50
66%
-114
- C3 -
1SNU
1
ITK_HUMAN
A:
[2-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
19
PsiBlast_PDB
75.48
66%
-121
- C3 -
3V8W
1
ITK_HUMAN
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
-
G
A
--
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
7
PsiBlast_PDB
75.45
62%
-129
- C3 -
3PJ1
2
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
---
G
V
V
K
Y
G
K
W
--
R
---
G
------
Q
-
Y
---
D
V
A
I
K
M
I
---------
S
---
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
-----------
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
17
PsiBlast_PDB
75.39
66%
-119
- C3 -
3V5L
1
ITK_HUMAN
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
------
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
--------
41
HHSearch
75.30
60%
-117
- C3 -
3SXS
1
A:
[1-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
-
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
--
K
---
G
------
Q
-
Y
---
D
V
A
V
K
M
I
K
E
G
S
--
M
--
S
---
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
-
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
-
G
---
K
------
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
--
D
Q
--
Y
V
S
S
V
G
T
-
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
-
N
-
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
-------
2
PsiBlast_PDB
75.02
62%
-125
- C3 -
3K54
1
A:
[16-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
---
G
------
Q
-
Y
---
D
V
A
I
K
M
I
K
--------------
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
13
PsiBlast_PDB
74.89
66%
-117
- C3 -
1SM2
1
ITK_HUMAN
A:
[2-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
E
G
A
--
M
--
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
16
PsiBlast_PDB
74.74
66%
-122
- C3 -
3V5J
1
ITK_HUMAN
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
R
E
G
------
S
---
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
-------
5
PsiBlast_PDB
74.55
62%
-119
- C3 -
3PIY
1
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
-
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
--
R
---
G
------
Q
-
Y
---
D
V
A
I
K
M
I
-------------
E
D
E
F
I
E
E
A
K
V
M
M
N
L
-
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
-
R
---
H
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
---
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--
D
E
--
Y
T
S
S
V
G
S
-
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
-
N
-
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-----
20
PsiBlast_PDB
72.47
67%
-122
- C3 -
3MJ1
1
A:
[4-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
-
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
--
L
---
N
------
K
-
D
---
K
V
A
I
K
T
I
------------------
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
-
R
---
G
------
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
-
N
-
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
------------
47
HHSearch
67.86
35%
-107
- C3 -
1T46
1
A:
[16-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
W
E
F
P
R
N
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
--
Y
---
G
LIKSD
A
A
-
M
---
T
V
A
V
K
M
L
K
P
S
A
--
H
--
L
T
E
-
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
I
G
-
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
-
R
---
D
SFL---
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
---
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
--
D
S
N-
Y
V
V
K
G
N
A
-
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
-
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
I
S
E
------
48
HHSearch
67.35
38%
-108
- C3 -
4AOJ
1
NTRK1_HUMAN
A:
[35-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
H
I
K
R
R
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
--
H
---
N
LLP---
K
-
M
---
L
V
A
V
K
A
L
K
E
A
S
--
E
S
-
A
---
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
-
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
-
G
PDP
G
------
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
-------------------
T
-
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
-----
22
Fugue
67.11
47%
-116
- C3 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
RG-------------
N
---
K
V
A
V
K
C
I
K
-----
N
--
D
---
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
--E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
-
G
----RS----
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
---
D
N
V
A
K
V
S
D
F
G
---------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L--
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
----
49
HHSearch
65.19
40%
-105
- C3 -
3KUL
2
EPHA8_HUMAN
A:
[43-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
I
E
A
S
R
I
H
I
E
K
-
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
--
R
---
V
PGQ
R
--
D
-
V
---
P
V
A
I
K
A
L
K
A
G
Y
--
T
--
E
R
Q
-
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
R
G
-
R
L
A
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
H
-
D
---
G
------
Q
F
T
I
M
Q
L
V
G
M
L
R
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
---
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
-----A-
A
Y
T
T
T
----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
M
T
-
N
-
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
C
P
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
S
V
L
D
A
L
I
R
S
P
E
----
50
HHSearch
64.56
40%
-101
- C3 -
2YFX
1
A:
[13-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
A
G
K
T
S
--------------
S
I
S
---
D
L
K
E
V
P
R
K
N
I
T
L
I
R
-
G
L
G
--
A
F
G
E
V
Y
E
G
Q
V
--------------P
L
---
Q
V
A
V
K
T
L
P
E
V
C
--
S
E
Q
D
---
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
-
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
-
R
---
P
RPSQPS
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
-
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
----
46
HHSearch
64.23
36%
-111
- C3 -
4FYO
1
A:
[11-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
---
M
KK
V
---
V
-
K
---
T
V
A
V
K
I
L
----------P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
A
E
--
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
--
N
---
R
------
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
---
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
--
D
E
NY
Y
K
A
-----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
---
43
HHSearch
62.96
36%
-109
- C3 -
1U59
1
A:
[3-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
----K-----
Q
-
I
---
D
V
A
I
K
V
L
K
Q
G
T
--
E
--
K
A
D
-
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
C
Q
A
E
--
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
-
R
---
E
------
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
---
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
DD
S
Y
--
Y
T
A
R
S
A
G
-
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
-
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
-----
52
HHSearch
61.46
34%
-116
- C3 -
3POZ
1
A:
[12-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
T
E
F
K
K
I
K
-
V
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
--
I
---
P
---------V
K
I
P
V
A
I
K
E
L
---------
A
---
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
-
D
N
P
H
V
C
R
L
L
G
I
C
L
T
S
--
T
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
H
-
K
---
D
------
N
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
---
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
--
E
E
K---------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
-
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
D
------