@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00067_CP2C9_: (2014-08-13 )
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
S
L
V
V
L
V
L
C
L
S
C
L
L
L
L
S
L
W
RQSSGRGKLPPGPT
P
L
P
V
I
G
N
I
L
Q
I
G
I
K
D
I
S
K
S
L
T
N
L
S
K
V
Y
G
P
V
F
T
L
YFGL
K
P
I
V
V
LH
G
Y
E
A
V
K
E
A
L
I
D
L
G
E
E
FSGRGIF
P
L
A
E
RANR
G
F
G
I
V
FSNG
K
K
W
K
E
I
R
R
F
S
L
M
T
L
R
NFGMGK
R
S
I
E
D
R
V
Q
E
E
A
R
C
L
V
E
E
L
R
K
TKASPCDP
T
F
I
L
GCA
P
C
N
V
I
C
S
I
I
F
HKRFDY
K
D
Q
Q
F
L
N
L
M
E
K
L
N
EN
I
K
ILSS
P
W
I
Q
I
CNNF
S
P
I
I
DYFPG
T
H
N
K
L
L
K
N
V
A
F
M
K
S
Y
I
L
E
K
V
K
E
H
Q
E
SMDMN
N
P
Q
D
F
I
D
C
F
L
M
K
M
E
K
E
KHNQPS
E
F
T
I
E
S
L
ENT
A
V
D
L
FGAGTET
T
S
T
T
L
R
Y
A
L
L
L
L
LKHP
E
V
T
A
K
V
Q
E
E
I
E
R
V
IGRNRSP
C
M
QDRSHMP
Y
T
D
A
V
V
H
E
V
Q
R
Y
I
D
LLPTSLP
H
A
V
T
C
D
I
K
F
R
N
Y
LIPKG
T
T
I
L
I
S
L
T
S
V
L
HDNKEFPNPEMFDPHHFLDEGGNF
K
K
S
K
Y
F
M
PFSAGK
R
I
C
V
G
E
A
L
A
G
M
E
L
F
L
F
L
T
S
I
L
QNFNLKSLVDPKNLDTTPVVNGFASV
P
P
F
Y
Q
L
C
F
IPV
21
PsiBlast_CBE
96.50
96%
-115
- C4 -
1OG5
2
CP2C9_HUMAN
B:
[11-471]
-----------------------------
P
P
G
P
T
P
L
P
V
I
G
N
I
L
Q
I
G
I
K
D
I
S
K
S
L
T
N
L
S
K
V
Y
G
P
V
F
T
L
Y
F
G
L
K
P
I
V
V
L
H
G
Y
E
A
V
K
E
A
L
I
D
L
G
E
E
F
S
G
R
G
I
F
P
L
A
E
R
A
N
R
G
F
G
I
V
F
S
N
G
K
K
W
K
E
I
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
I
I
F
H
K
R
F
D
Y
K
D
Q
Q
F
L
N
L
M
E
K
L
N
E
N
I
E
I
L
S
S
P
W
I
Q
V
Y
N
N
F
P
A
L
L
D
Y
F
P
G
T
H
N
K
L
L
K
N
V
A
F
M
K
S
Y
I
L
E
K
V
K
E
H
Q
E
S
M
D
M
N
N
P
Q
D
F
I
D
C
F
L
M
K
M
E
K
E
K
H
N
Q
P
S
E
F
T
I
E
S
L
E
N
T
A
V
D
L
F
G
A
G
T
E
T
T
S
T
T
L
R
Y
A
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
E
R
V
I
G
R
N
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
V
Q
R
Y
I
D
L
L
P
T
S
L
P
H
A
V
T
C
D
I
K
F
R
N
Y
L
I
P
K
G
T
T
I
L
I
S
L
T
S
V
L
H
D
N
K
E
F
P
N
P
E
M
F
D
P
H
H
F
L
D
E
G
G
N
F
K
K
S
K
Y
F
M
P
F
S
A
G
K
R
I
C
V
G
E
A
L
A
G
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
N
L
K
S
L
V
D
P
K
N
L
D
T
T
P
V
V
N
G
F
A
S
V
P
P
F
Y
Q
L
C
F
I
P
V
2
PsiBlast_PDB
96.41
96%
-115
- C4 -
1OG2
1
CP2C9_HUMAN
A:
[11-471]
-----------------------------
P
P
G
P
T
P
L
P
V
I
G
N
I
L
Q
I
G
I
K
D
I
S
K
S
L
T
N
L
S
K
V
Y
G
P
V
F
T
L
Y
F
G
L
K
P
I
V
V
L
H
G
Y
E
A
V
K
E
A
L
I
D
L
G
E
E
F
S
G
R
G
I
F
P
L
A
E
R
A
N
R
G
F
G
I
V
F
S
N
G
K
K
W
K
E
I
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
I
I
F
H
K
R
F
D
Y
K
D
Q
Q
F
L
N
L
M
E
K
L
N
E
N
I
E
I
L
S
S
P
W
I
Q
V
Y
N
N
F
P
A
L
L
D
Y
F
P
G
T
H
N
K
L
L
K
N
V
A
F
M
K
S
Y
I
L
E
K
V
K
E
H
Q
E
S
M
D
M
N
N
P
Q
D
F
I
D
C
F
L
M
K
M
E
K
E
K
H
N
Q
P
S
E
F
T
I
E
S
L
E
N
T
A
V
D
L
F
G
A
G
T
E
T
T
S
T
T
L
R
Y
A
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
E
R
V
I
G
R
N
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
V
Q
R
Y
I
D
L
L
P
T
S
L
P
H
A
V
T
C
D
I
K
F
R
N
Y
L
I
P
K
G
T
T
I
L
I
S
L
T
S
V
L
H
D
N
K
E
F
P
N
P
E
M
F
D
P
H
H
F
L
D
E
G
G
N
F
K
K
S
K
Y
F
M
P
F
S
A
G
K
R
I
C
V
G
E
A
L
A
G
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
N
L
K
S
L
V
D
P
K
N
L
D
T
T
P
V
V
N
G
F
A
S
V
P
P
F
Y
Q
L
C
F
I
P
V
1
PsiBlast_PDB
96.06
99%
-112
- C4 -
1R9O
3
CP2C9_HUMAN
A:
[9-473]
-------------------------
R
G
K
L
P
P
G
P
T
P
L
P
-----
L
Q
I
G
I
K
D
I
S
K
S
L
T
N
L
S
K
V
Y
G
P
V
F
T
L
Y
F
G
L
K
P
I
V
V
L
H
G
Y
E
A
V
K
E
A
L
I
D
L
G
E
E
F
S
G
R
G
I
F
P
L
A
E
R
A
N
R
G
F
G
I
V
F
S
N
G
K
K
W
K
E
I
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
I
I
F
H
K
R
F
D
Y
K
D
Q
Q
F
L
N
L
M
E
K
L
N
E
N
I
K
I
L
S
S
P
W
I
-------
P
I
I
D
Y
F
P
G
T
H
N
K
L
L
K
N
V
A
F
M
K
S
Y
I
L
E
K
V
K
E
H
Q
E
S
M
D
M
N
N
P
Q
D
F
I
D
C
F
L
M
K
M
E
K
E
K
H
N
Q
P
S
E
F
T
I
E
S
L
E
N
T
A
V
D
L
F
G
A
G
T
E
T
T
S
T
T
L
R
Y
A
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
E
R
V
I
G
R
N
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
V
Q
R
Y
I
D
L
L
P
T
S
L
P
H
A
V
T
C
D
I
K
F
R
N
Y
L
I
P
K
G
T
T
I
L
I
S
L
T
S
V
L
H
D
N
K
E
F
P
N
P
E
M
F
D
P
H
H
F
L
D
E
G
G
N
F
K
K
S
K
Y
F
M
P
F
S
A
G
K
R
I
C
V
G
E
A
L
A
G
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
N
L
K
S
L
V
D
P
K
N
L
D
T
T
P
V
V
N
G
F
A
S
V
P
P
F
Y
Q
L
C
F
I
P
I
22
PsiBlast_CBE
95.45
96%
-114
- C4 -
1OG2
1
CP2C9_HUMAN
B:
[11-471]
-----------------------------
P
P
G
P
T
P
L
P
V
I
G
N
I
L
Q
I
G
I
K
D
I
S
K
S
L
T
N
L
S
K
V
Y
G
P
V
F
T
L
Y
F
G
L
K
P
I
V
V
L
H
G
Y
E
A
V
K
E
A
L
I
D
L
G
E
E
F
S
G
R
G
I
F
P
L
A
E
R
A
N
R
G
F
G
I
V
F
S
N
G
K
K
W
K
E
I
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
I
I
F
H
K
R
F
D
Y
K
D
Q
Q
F
L
N
L
M
E
K
L
N
E
N
I
E
I
L
S
S
P
W
I
Q
V
Y
N
N
F
P
A
L
L
D
Y
F
P
G
T
H
N
K
L
L
K
N
V
A
F
M
K
S
Y
I
L
E
K
V
K
E
H
Q
E
S
M
D
M
N
N
P
Q
D
F
I
D
C
F
L
M
K
M
E
K
E
K
H
N
Q
P
S
E
F
T
I
E
S
L
E
N
T
A
V
D
L
F
G
A
G
T
E
T
T
S
T
T
L
R
Y
A
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
E
R
V
I
G
R
N
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
V
Q
R
Y
I
D
L
L
P
T
S
L
P
H
A
V
T
C
D
I
K
F
R
N
Y
L
I
P
K
G
T
T
I
L
I
S
L
T
S
V
L
H
D
N
K
E
F
P
N
P
E
M
F
D
P
H
H
F
L
D
E
G
G
N
F
K
K
S
K
Y
F
M
P
F
S
A
G
K
R
I
C
V
G
E
A
L
A
G
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
N
L
K
S
L
V
D
P
K
N
L
D
T
T
P
V
V
N
G
F
A
S
V
P
P
F
Y
Q
L
C
F
I
P
V
3
PsiBlast_PDB
95.10
96%
-111
- C4 -
1OG5
2
CP2C9_HUMAN
A:
[11-471]
-----------------------------
P
P
G
P
T
P
L
P
V
I
G
N
I
L
Q
I
G
I
K
D
I
S
K
S
L
T
N
L
S
K
V
Y
G
P
V
F
T
L
Y
F
G
L
K
P
I
V
V
L
H
G
Y
E
A
V
K
E
A
L
I
D
L
G
E
E
F
S
G
R
G
I
F
P
L
A
E
R
A
N
R
G
F
G
I
V
F
S
N
G
K
K
W
K
E
I
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
I
I
F
H
K
R
F
D
Y
K
D
Q
Q
F
L
N
L
M
E
K
L
N
E
N
I
E
I
L
S
S
P
W
I
Q
V
Y
N
N
F
P
A
L
L
D
Y
F
P
G
T
H
N
K
L
L
K
N
V
A
F
M
K
S
Y
I
L
E
K
V
K
E
H
Q
E
S
M
D
M
N
N
P
Q
D
F
I
D
C
F
L
M
K
M
E
K
E
K
H
N
Q
P
S
E
F
T
I
E
S
L
E
N
T
A
V
D
L
F
G
A
G
T
E
T
T
S
T
T
L
R
Y
A
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
E
R
V
I
G
R
N
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
V
Q
R
Y
I
D
L
L
P
T
S
L
P
H
A
V
T
C
D
I
K
F
R
N
Y
L
I
P
K
G
T
T
I
L
I
S
L
T
S
V
L
H
D
N
K
E
F
P
N
P
E
M
F
D
P
H
H
F
L
D
E
G
G
N
F
K
K
S
K
Y
F
M
P
F
S
A
G
K
R
I
C
V
G
E
A
L
A
G
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
N
L
K
S
L
V
D
P
K
N
L
D
T
T
P
V
V
N
G
F
A
S
V
P
P
F
Y
Q
L
C
F
I
P
V
5
PsiBlast_PDB
93.87
77%
-110
- C4 -
1PQ2
3
CP2C8_HUMAN
A:
[10-472]
---------------------------
K
L
P
P
G
P
T
P
L
P
I
I
G
N
M
L
Q
I
D
V
K
D
I
C
K
S
F
T
N
F
S
K
V
Y
G
P
V
F
T
V
Y
F
G
M
N
P
I
V
V
F
H
G
Y
E
A
V
K
E
A
L
I
D
N
G
E
E
F
S
G
R
G
N
S
P
I
S
Q
R
I
T
K
G
L
G
I
I
S
S
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
Q
K
R
F
D
Y
K
D
Q
N
F
L
T
L
M
K
R
F
N
E
N
F
R
I
L
N
S
P
W
I
Q
V
C
N
N
F
P
L
L
I
D
C
F
P
G
T
H
N
K
V
L
K
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
E
H
Q
A
S
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
K
D
N
Q
K
S
E
F
N
I
E
N
L
V
G
T
V
A
D
L
F
V
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
D
H
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
V
P
H
A
V
T
T
D
T
K
F
R
N
Y
L
I
P
K
G
T
T
I
M
A
L
L
T
S
V
L
H
D
D
K
E
F
P
N
P
N
I
F
D
P
G
H
F
L
D
K
N
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
I
C
A
G
E
G
L
A
R
M
E
L
F
L
F
L
T
T
I
L
Q
N
F
N
L
K
S
V
D
D
L
K
N
L
N
T
T
A
V
T
K
G
I
V
S
L
P
P
S
Y
Q
I
C
F
I
P
V
8
PsiBlast_PDB
93.31
77%
-112
- C4 -
2NNJ
3
CP2C8_HUMAN
A:
[10-472]
---------------------------
K
L
P
P
G
P
T
P
L
P
I
I
G
N
M
L
Q
I
D
V
K
D
I
C
K
S
F
T
N
F
S
K
V
Y
G
P
V
F
T
V
Y
F
G
M
N
P
I
V
V
F
H
G
Y
E
A
V
K
E
A
L
I
D
N
G
E
E
F
S
G
R
G
N
S
P
I
S
Q
R
I
T
K
G
L
G
I
I
S
S
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
Q
K
R
F
D
Y
K
D
Q
N
F
L
T
L
M
K
R
F
N
E
N
F
R
I
L
N
S
P
W
I
Q
V
C
N
N
F
P
L
L
I
D
C
F
P
G
T
H
N
K
V
L
K
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
E
H
Q
A
S
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
K
D
N
Q
K
S
E
F
N
I
E
N
L
V
G
T
V
A
D
L
F
V
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
D
H
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
V
P
H
A
V
T
T
D
T
K
F
R
N
Y
L
I
P
K
G
T
T
I
M
A
L
L
T
S
V
L
H
D
D
K
E
F
P
N
P
N
I
F
D
P
G
H
F
L
D
K
N
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
I
C
A
G
E
G
L
A
R
M
E
L
F
L
F
L
T
T
I
L
Q
N
F
N
L
K
S
V
D
D
L
K
N
L
N
T
T
A
V
T
K
G
I
V
S
L
P
P
S
Y
Q
I
C
F
I
P
V
25
PsiBlast_CBE
93.01
77%
-110
- C4 -
2NNH
5
CP2C8_HUMAN
B:
[10-472]
---------------------------
K
L
P
P
G
P
T
P
L
P
I
I
G
N
M
L
Q
I
D
V
K
D
I
C
K
S
F
T
N
F
S
K
V
Y
G
P
V
F
T
V
Y
F
G
M
N
P
I
V
V
F
H
G
Y
E
A
V
K
E
A
L
I
D
N
G
E
E
F
S
G
R
G
N
S
P
I
S
Q
R
I
T
K
G
L
G
I
I
S
S
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
Q
K
R
F
D
Y
K
D
Q
N
F
L
T
L
M
K
R
F
N
E
N
F
R
I
L
N
S
P
W
I
Q
V
C
N
N
F
P
L
L
I
D
C
F
P
G
T
H
N
K
V
L
K
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
E
H
Q
A
S
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
K
D
N
Q
K
S
E
F
N
I
E
N
L
V
G
T
V
A
D
L
F
V
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
D
H
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
V
P
H
A
V
T
T
D
T
K
F
R
N
Y
L
I
P
K
G
T
T
I
M
A
L
L
T
S
V
L
H
D
D
K
E
F
P
N
P
N
I
F
D
P
G
H
F
L
D
K
N
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
I
C
A
G
E
G
L
A
R
M
E
L
F
L
F
L
T
T
I
L
Q
N
F
N
L
K
S
V
D
D
L
K
N
L
N
T
T
A
V
T
K
G
I
V
S
L
P
P
S
Y
Q
I
C
F
I
P
V
7
PsiBlast_PDB
92.70
77%
-110
- C4 -
2NNI
3
CP2C8_HUMAN
A:
[10-472]
---------------------------
K
L
P
P
G
P
T
P
L
P
I
I
G
N
M
L
Q
I
D
V
K
D
I
C
K
S
F
T
N
F
S
K
V
Y
G
P
V
F
T
V
Y
F
G
M
N
P
I
V
V
F
H
G
Y
E
A
V
K
E
A
L
I
D
N
G
E
E
F
S
G
R
G
N
S
P
I
S
Q
R
I
T
K
G
L
G
I
I
S
S
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
Q
K
R
F
D
Y
K
D
Q
N
F
L
T
L
M
K
R
F
N
E
N
F
R
I
L
N
S
P
W
I
Q
V
C
N
N
F
P
L
L
I
D
C
F
P
G
T
H
N
K
V
L
K
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
E
H
Q
A
S
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
K
D
N
Q
K
S
E
F
N
I
E
N
L
V
G
T
V
A
D
L
F
V
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
D
H
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
V
P
H
A
V
T
T
D
T
K
F
R
N
Y
L
I
P
K
G
T
T
I
M
A
L
L
T
S
V
L
H
D
D
K
E
F
P
N
P
N
I
F
D
P
G
H
F
L
D
K
N
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
I
C
A
G
E
G
L
A
R
M
E
L
F
L
F
L
T
T
I
L
Q
N
F
N
L
K
S
V
D
D
L
K
N
L
N
T
T
A
V
T
K
G
I
V
S
L
P
P
S
Y
Q
I
C
F
I
P
V
26
PsiBlast_CBE
92.52
77%
-110
- C4 -
1PQ2
3
CP2C8_HUMAN
B:
[10-472]
---------------------------
K
L
P
P
G
P
T
P
L
P
I
I
G
N
M
L
Q
I
D
V
K
D
I
C
K
S
F
T
N
F
S
K
V
Y
G
P
V
F
T
V
Y
F
G
M
N
P
I
V
V
F
H
G
Y
E
A
V
K
E
A
L
I
D
N
G
E
E
F
S
G
R
G
N
S
P
I
S
Q
R
I
T
K
G
L
G
I
I
S
S
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
Q
K
R
F
D
Y
K
D
Q
N
F
L
T
L
M
K
R
F
N
E
N
F
R
I
L
N
S
P
W
I
Q
V
C
N
N
F
P
L
L
I
D
C
F
P
G
T
H
N
K
V
L
K
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
E
H
Q
A
S
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
K
D
N
Q
K
S
E
F
N
I
E
N
L
V
G
T
V
A
D
L
F
V
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
D
H
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
V
P
H
A
V
T
T
D
T
K
F
R
N
Y
L
I
P
K
G
T
T
I
M
A
L
L
T
S
V
L
H
D
D
K
E
F
P
N
P
N
I
F
D
P
G
H
F
L
D
K
N
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
I
C
A
G
E
G
L
A
R
M
E
L
F
L
F
L
T
T
I
L
Q
N
F
N
L
K
S
V
D
D
L
K
N
L
N
T
T
A
V
T
K
G
I
V
S
L
P
P
S
Y
Q
I
C
F
I
P
V
9
PsiBlast_PDB
92.52
77%
-110
- C4 -
2VN0
2
CP2C8_HUMAN
A:
[10-472]
---------------------------
K
L
P
P
G
P
T
P
L
P
I
I
G
N
M
L
Q
I
D
V
K
D
I
C
K
S
F
T
N
F
S
K
V
Y
G
P
V
F
T
V
Y
F
G
M
N
P
I
V
V
F
H
G
Y
E
A
V
K
E
A
L
I
D
N
G
E
E
F
S
G
R
G
N
S
P
I
S
Q
R
I
T
K
G
L
G
I
I
S
S
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
Q
K
R
F
D
Y
K
D
Q
N
F
L
T
L
M
K
R
F
N
E
N
F
R
I
L
N
S
P
W
I
Q
V
C
N
N
F
P
L
L
I
D
C
F
P
G
T
H
N
K
V
L
K
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
E
H
Q
A
S
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
K
D
N
Q
K
S
E
F
N
I
E
N
L
V
G
T
V
A
D
L
F
V
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
D
H
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
V
P
H
A
V
T
T
D
T
K
F
R
N
Y
L
I
P
K
G
T
T
I
M
A
L
L
T
S
V
L
H
D
D
K
E
F
P
N
P
N
I
F
D
P
G
H
F
L
D
K
N
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
I
C
A
G
E
G
L
A
R
M
E
L
F
L
F
L
T
T
I
L
Q
N
F
N
L
K
S
V
D
D
L
K
N
L
N
T
T
A
V
T
K
G
I
V
S
L
P
P
S
Y
Q
I
C
F
I
P
V
6
PsiBlast_PDB
92.48
77%
-108
- C4 -
2NNH
5
CP2C8_HUMAN
A:
[10-472]
---------------------------
K
L
P
P
G
P
T
P
L
P
I
I
G
N
M
L
Q
I
D
V
K
D
I
C
K
S
F
T
N
F
S
K
V
Y
G
P
V
F
T
V
Y
F
G
M
N
P
I
V
V
F
H
G
Y
E
A
V
K
E
A
L
I
D
N
G
E
E
F
S
G
R
G
N
S
P
I
S
Q
R
I
T
K
G
L
G
I
I
S
S
N
G
K
R
W
K
E
I
R
R
F
S
L
T
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
V
Q
E
E
A
H
C
L
V
E
E
L
R
K
T
K
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
V
F
Q
K
R
F
D
Y
K
D
Q
N
F
L
T
L
M
K
R
F
N
E
N
F
R
I
L
N
S
P
W
I
Q
V
C
N
N
F
P
L
L
I
D
C
F
P
G
T
H
N
K
V
L
K
N
V
A
L
T
R
S
Y
I
R
E
K
V
K
E
H
Q
A
S
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
K
D
N
Q
K
S
E
F
N
I
E
N
L
V
G
T
V
A
D
L
F
V
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
L
L
L
K
H
P
E
V
T
A
K
V
Q
E
E
I
D
H
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
H
M
P
Y
T
D
A
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
V
P
H
A
V
T
T
D
T
K
F
R
N
Y
L
I
P
K
G
T
T
I
M
A
L
L
T
S
V
L
H
D
D
K
E
F
P
N
P
N
I
F
D
P
G
H
F
L
D
K
N
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
I
C
A
G
E
G
L
A
R
M
E
L
F
L
F
L
T
T
I
L
Q
N
F
N
L
K
S
V
D
D
L
K
N
L
N
T
T
A
V
T
K
G
I
V
S
L
P
P
S
Y
Q
I
C
F
I
P
V
12
PsiBlast_PDB
92.46
74%
-113
- C4 -
1NR6
2
CP2C5_RABIT
A:
[9-469]
--------------------------
G
K
L
P
P
G
P
T
P
F
P
I
I
G
N
I
L
Q
I
D
A
K
D
I
S
K
S
L
T
K
F
S
E
C
Y
G
P
V
F
T
V
Y
L
G
M
K
P
T
V
V
L
H
G
Y
E
A
V
K
E
A
L
V
D
L
G
E
E
F
A
G
R
G
S
V
P
I
L
E
K
V
S
K
G
L
G
I
A
F
S
N
A
K
T
W
K
E
M
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
N
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
I
F
H
N
R
F
D
Y
K
D
E
E
F
L
K
L
M
E
S
L
H
E
N
V
E
L
L
G
T
P
W
L
Q
V
Y
N
N
F
P
A
L
L
D
Y
F
P
G
I
H
K
T
L
L
K
N
A
D
Y
I
K
N
F
I
M
E
K
V
K
E
H
Q
K
L
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
N
N
---
L
E
F
T
L
E
S
L
V
I
A
V
S
D
L
F
G
A
G
T
E
T
T
S
T
T
L
R
Y
S
L
L
L
L
L
K
H
P
E
V
A
A
R
V
Q
E
E
I
E
R
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
R
M
P
Y
T
D
A
V
I
H
E
I
Q
R
F
I
D
L
L
P
T
N
L
P
H
A
V
T
R
D
V
R
F
R
N
Y
F
I
P
K
G
T
D
I
I
T
S
L
T
S
V
L
H
D
E
K
A
F
P
N
P
K
V
F
D
P
G
H
F
L
D
E
S
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
M
C
V
G
E
G
L
A
R
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
K
L
Q
S
L
V
E
P
K
D
L
D
I
T
A
V
V
N
G
F
V
S
V
P
P
S
Y
Q
L
C
F
I
P
I
11
PsiBlast_PDB
91.38
74%
-110
- C4 -
1N6B
2
CP2C5_RABIT
A:
[9-469]
--------------------------
G
K
L
P
P
G
P
T
P
F
P
I
I
G
N
I
L
Q
I
D
A
K
D
I
S
K
S
L
T
K
F
S
E
C
Y
G
P
V
F
T
V
Y
L
G
M
K
P
T
V
V
L
H
G
Y
E
A
V
K
E
A
L
V
D
L
G
E
E
F
A
G
R
G
S
V
P
I
L
E
K
V
S
K
G
L
G
I
A
F
S
N
A
K
T
W
K
E
M
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
N
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
I
F
H
N
R
F
D
Y
K
D
E
E
F
L
K
L
M
E
S
L
H
E
N
V
E
L
L
G
T
P
W
L
Q
V
Y
N
N
F
P
A
L
L
D
Y
F
P
G
I
H
K
T
L
L
K
N
A
D
Y
I
K
N
F
I
M
E
K
V
K
E
H
Q
K
L
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
N
N
---
L
E
F
T
L
E
S
L
V
I
A
V
S
D
L
F
G
A
G
T
E
T
T
S
T
T
L
R
Y
S
L
L
L
L
L
K
H
P
E
V
A
A
R
V
Q
E
E
I
E
R
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
R
M
P
Y
T
D
A
V
I
H
E
I
Q
R
F
I
D
L
L
P
T
N
L
P
H
A
V
T
R
D
V
R
F
R
N
Y
F
I
P
K
G
T
D
I
I
T
S
L
T
S
V
L
H
D
E
K
A
F
P
N
P
K
V
F
D
P
G
H
F
L
D
E
S
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
M
C
V
G
E
G
L
A
R
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
K
L
Q
S
L
V
E
P
K
D
L
D
I
T
A
V
V
N
G
F
V
S
V
P
P
S
Y
Q
L
C
F
I
P
I
39
HHSearch
87.86
58%
-101
- C4 -
3E6I
2
CP2E1_HUMAN
A:
[10-470]
---------------------------
K
L
P
P
G
P
F
P
L
P
I
I
G
N
L
F
Q
L
E
L
K
N
I
P
K
S
F
T
R
L
A
Q
R
F
G
P
V
F
T
L
Y
V
G
S
Q
R
M
V
V
M
H
G
Y
K
A
V
K
E
A
L
L
D
Y
K
D
E
F
S
G
R
G
D
L
P
A
F
H
A
-
H
R
D
R
G
I
I
F
N
N
G
P
T
W
K
D
I
R
R
F
S
L
T
T
L
R
N
Y
G
-
G
K
Q
G
N
E
S
R
I
Q
R
E
A
H
F
L
L
E
A
L
R
K
T
Q
G
Q
P
F
D
P
T
F
L
I
G
C
A
P
C
N
V
I
A
D
I
L
F
R
K
H
F
D
Y
N
D
E
K
F
L
R
L
M
Y
L
F
N
E
N
F
H
L
L
S
T
P
W
L
Q
L
Y
N
N
F
P
S
F
L
H
Y
L
P
G
S
H
R
K
V
I
K
N
V
A
E
V
K
E
Y
V
S
E
R
V
K
E
H
H
Q
S
L
D
P
N
C
P
R
D
L
T
D
C
L
L
V
E
M
E
K
E
K
H
S
A
E
R
L
Y
T
M
D
G
I
T
V
T
V
A
D
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
I
L
M
K
Y
P
E
I
E
E
K
L
H
E
E
I
D
R
V
I
G
P
S
R
I
P
A
I
K
D
R
Q
E
M
P
Y
M
D
A
V
V
H
E
I
Q
R
F
I
T
L
V
P
S
N
L
P
H
E
A
T
R
D
T
I
F
R
G
Y
L
I
P
K
G
T
V
V
V
P
T
L
D
S
V
L
Y
D
N
Q
E
F
P
D
P
E
K
F
K
P
E
H
F
L
N
E
N
G
K
F
K
Y
S
D
Y
F
K
P
F
S
T
G
K
R
V
C
A
G
E
G
L
A
R
M
E
L
F
L
L
L
C
A
I
L
Q
H
F
N
L
K
P
L
V
D
P
K
D
I
D
L
S
P
I
H
I
G
F
G
C
I
P
P
R
Y
K
L
C
V
I
P
-
15
PsiBlast_PDB
86.62
58%
-103
- C4 -
3GPH
2
CP2E1_HUMAN
A:
[10-470]
---------------------------
K
L
P
P
G
P
F
P
L
P
I
I
G
N
L
F
Q
L
E
L
K
N
I
P
K
S
F
T
R
L
A
Q
R
F
G
P
V
F
T
L
Y
V
G
S
Q
R
M
V
V
M
H
G
Y
K
A
V
K
E
A
L
L
D
Y
K
D
E
F
S
G
R
G
D
L
P
-
A
F
H
A
H
R
D
R
G
I
I
F
N
N
G
P
T
W
K
D
I
R
R
F
S
L
T
T
L
R
N
Y
--
G
K
Q
G
N
E
S
R
I
Q
R
E
A
H
F
L
L
E
A
L
R
K
T
Q
G
Q
P
F
D
P
T
F
L
I
G
C
A
P
C
N
V
I
A
D
I
L
F
R
K
H
F
D
Y
N
D
E
K
F
L
R
L
M
Y
L
F
N
E
N
F
H
L
L
S
T
P
W
L
Q
L
Y
N
N
F
P
S
F
L
H
Y
L
P
G
S
H
R
K
V
I
K
N
V
A
E
V
K
E
Y
V
S
E
R
V
K
E
H
H
Q
S
L
D
P
N
C
P
R
D
L
T
D
C
L
L
V
E
M
E
K
E
K
H
S
A
E
R
L
Y
T
M
D
G
I
T
V
T
V
A
D
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
I
L
M
K
Y
P
E
I
E
E
K
L
H
E
E
I
D
R
V
I
G
P
S
R
I
P
A
I
K
D
R
Q
E
M
P
Y
M
D
A
V
V
H
E
I
Q
R
F
I
T
L
V
P
S
N
L
P
H
E
A
T
R
D
T
I
F
R
G
Y
L
I
P
K
G
T
V
V
V
P
T
L
D
S
V
L
Y
D
N
Q
E
F
P
D
P
E
K
F
K
P
E
H
F
L
N
E
N
G
K
F
K
Y
S
D
Y
F
K
P
F
S
T
G
K
R
V
C
A
G
E
G
L
A
R
M
E
L
F
L
L
L
C
A
I
L
Q
H
F
N
L
K
P
L
V
D
P
K
D
I
D
L
S
P
I
H
I
G
F
G
C
I
P
P
R
Y
K
L
C
V
I
P
-
17
PsiBlast_PDB
86.36
58%
-104
- C4 -
3LC4
2
CP2E1_HUMAN
A:
[10-470]
---------------------------
K
L
P
P
G
P
F
P
L
P
I
I
G
N
L
F
Q
L
E
L
K
N
I
P
K
S
F
T
R
L
A
Q
R
F
G
P
V
F
T
L
Y
V
G
S
Q
R
M
V
V
M
H
G
Y
K
A
V
K
E
A
L
L
D
Y
K
D
E
F
S
G
R
G
D
L
P
-
A
F
H
A
H
R
D
R
G
I
I
F
N
N
G
P
T
W
K
D
I
R
R
F
S
L
T
T
L
R
N
Y
G
M
G
---
N
E
S
R
I
Q
R
E
A
H
F
L
L
E
A
L
R
K
T
Q
G
Q
P
F
D
P
T
F
L
I
G
C
A
P
C
N
V
I
A
D
I
L
F
R
K
H
F
D
Y
N
D
E
K
F
L
R
L
M
Y
L
F
N
E
N
F
H
L
L
S
T
P
W
L
Q
L
Y
N
N
F
P
S
F
L
H
Y
L
P
G
S
H
R
K
V
I
K
N
V
A
E
V
K
E
Y
V
S
E
R
V
K
E
H
H
Q
S
L
D
P
N
C
P
R
D
L
T
D
C
L
L
V
E
M
E
K
E
K
H
S
A
E
R
L
Y
T
M
D
G
I
T
V
T
V
A
D
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
I
L
M
K
Y
P
E
I
E
E
K
L
H
E
E
I
D
R
V
I
G
P
S
R
I
P
A
I
K
D
R
Q
E
M
P
Y
M
D
A
V
V
H
E
I
Q
R
F
I
T
L
V
P
S
N
L
P
H
E
A
T
R
D
T
I
F
R
G
Y
L
I
P
K
G
T
V
V
V
P
T
L
D
S
V
L
Y
D
N
Q
E
F
P
D
P
E
K
F
K
P
E
H
F
L
N
E
N
G
K
F
K
Y
S
D
Y
F
K
P
F
S
T
G
K
R
V
C
A
G
E
G
L
A
R
M
E
L
F
L
L
L
C
A
I
L
Q
H
F
N
L
K
P
L
V
D
P
K
D
I
D
L
S
P
I
H
I
G
F
G
C
I
P
P
R
Y
K
L
C
V
I
P
-
10
PsiBlast_PDB
86.30
74%
-105
- C4 -
1DT6
1
CP2C5_RABIT
A:
[12-469]
-----------------------------
P
P
G
P
T
P
F
P
I
I
G
N
I
L
Q
I
D
A
K
D
I
S
K
S
L
T
K
F
S
E
C
Y
G
P
V
F
T
V
Y
L
G
M
K
P
T
V
V
L
H
G
Y
E
A
V
K
E
A
L
V
D
L
G
E
E
F
A
G
R
G
S
V
P
I
L
E
K
V
S
K
G
L
G
I
A
F
S
N
A
K
T
W
K
E
M
R
R
F
S
L
M
T
L
R
N
F
G
M
G
K
R
S
I
E
D
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
T
N
A
S
P
C
D
P
T
F
I
L
G
C
A
P
C
N
V
I
C
S
V
I
F
H
N
R
F
D
Y
K
D
E
E
F
L
K
L
M
E
S
L
H
E
N
V
E
L
L
G
T
P
-----------
L
D
Y
F
P
G
I
H
K
T
L
L
K
N
A
D
Y
I
K
N
F
I
M
E
K
V
K
E
H
Q
K
L
L
D
V
N
N
P
R
D
F
I
D
C
F
L
I
K
M
E
Q
E
N
N
---
L
E
F
T
L
E
S
L
V
I
A
V
S
D
L
F
G
A
G
T
E
T
T
S
T
T
L
R
Y
S
L
L
L
L
L
K
H
P
E
V
A
A
R
V
Q
E
E
I
E
R
V
I
G
R
H
R
S
P
C
M
Q
D
R
S
R
M
P
Y
T
D
A
V
I
H
E
I
Q
R
F
I
D
L
L
P
T
N
L
P
H
A
V
T
R
D
V
R
F
R
N
Y
F
I
P
K
G
T
D
I
I
T
S
L
T
S
V
L
H
D
E
K
A
F
P
N
P
K
V
F
D
P
G
H
F
L
D
E
S
G
N
F
K
K
S
D
Y
F
M
P
F
S
A
G
K
R
M
C
V
G
E
G
L
A
R
M
E
L
F
L
F
L
T
S
I
L
Q
N
F
K
L
Q
S
L
V
E
P
K
D
L
D
I
T
A
V
V
N
G
F
V
S
V
P
P
S
Y
Q
L
C
F
I
P
I
16
PsiBlast_PDB
85.84
58%
-101
- C4 -
3KOH
2
CP2E1_HUMAN
A:
[10-470]
---------------------------
K
L
P
P
G
P
F
P
L
P
I
I
G
N
L
F
Q
L
E
L
K
N
I
P
K
S
F
T
R
L
A
Q
R
F
G
P
V
F
T
L
Y
V
G
S
Q
R
M
V
V
M
H
G
Y
K
A
V
K
E
A
L
L
D
Y
K
D
E
F
S
G
R
G
D
L
P
-
A
F
H
A
H
R
D
R
G
I
I
F
N
N
G
P
T
W
K
D
I
R
R
F
S
L
T
T
L
R
N
Y
G
M
G
K
Q
G
N
E
S
R
I
Q
R
E
A
H
F
L
L
E
A
L
R
K
T
Q
G
Q
P
F
D
P
T
F
L
I
G
C
A
P
C
N
V
I
A
D
I
L
F
R
K
H
F
D
Y
N
D
E
K
F
L
R
L
M
Y
L
F
N
E
N
F
H
L
L
S
T
P
W
L
Q
L
Y
N
N
F
P
S
F
L
H
Y
L
P
G
S
H
R
K
V
I
K
N
V
A
E
V
K
E
Y
V
S
E
R
V
K
E
H
H
Q
S
L
D
P
N
C
P
R
D
L
T
D
C
L
L
V
E
M
E
K
E
K
H
S
A
E
R
L
Y
T
M
D
G
I
T
V
T
V
A
D
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
I
L
M
K
Y
P
E
I
E
E
K
L
H
E
E
I
D
R
V
I
G
P
S
R
I
P
A
I
K
D
R
Q
E
M
P
Y
M
D
A
V
V
H
E
I
Q
R
F
I
T
L
V
P
S
N
L
P
H
E
A
T
R
D
T
I
F
R
G
Y
L
I
P
K
G
T
V
V
V
P
T
L
D
S
V
L
Y
D
N
Q
E
F
P
D
P
E
K
F
K
P
E
H
F
L
N
E
N
G
K
F
K
Y
S
D
Y
F
K
P
F
S
T
G
K
R
V
C
A
G
E
G
L
A
R
M
E
L
F
L
L
L
C
A
I
L
Q
H
F
N
L
K
P
L
V
D
P
K
D
I
D
L
S
P
I
H
I
G
F
G
C
I
P
P
R
Y
K
L
C
V
I
P
-
13
PsiBlast_PDB
85.08
58%
-103
- C4 -
3E4E
2
CP2E1_HUMAN
A:
[10-470]
---------------------------
K
L
P
P
G
P
F
P
L
P
I
I
G
N
L
F
Q
L
E
L
K
N
I
P
K
S
F
T
R
L
A
Q
R
F
G
P
V
F
T
L
Y
V
G
S
Q
R
M
V
V
M
H
G
Y
K
A
V
K
E
A
L
L
D
Y
K
D
E
F
S
G
R
G
D
L
P
-
A
F
H
A
H
R
D
R
G
I
I
F
N
N
G
P
T
W
K
D
I
R
R
F
S
L
T
T
L
R
N
Y
G
---
Q
G
N
E
S
R
I
Q
R
E
A
H
F
L
L
E
A
L
R
K
T
Q
G
Q
P
F
D
P
T
F
L
I
G
C
A
P
C
N
V
I
A
D
I
L
F
R
K
H
F
D
Y
N
D
E
K
F
L
R
L
M
Y
L
F
N
E
N
F
H
L
L
S
T
P
W
L
Q
L
Y
N
N
F
P
S
F
L
H
Y
L
P
G
S
H
R
K
V
I
K
N
V
A
E
V
K
E
Y
V
S
E
R
V
K
E
H
H
Q
S
L
D
P
N
C
P
R
D
L
T
D
C
L
L
V
E
M
E
K
E
K
H
S
A
E
R
L
Y
T
M
D
G
I
T
V
T
V
A
D
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
L
L
I
L
M
K
Y
P
E
I
E
E
K
L
H
E
E
I
D
R
V
I
G
P
S
R
I
P
A
I
K
D
R
Q
E
M
P
Y
M
D
A
V
V
H
E
I
Q
R
F
I
T
L
V
P
S
N
L
P
H
E
A
T
R
D
T
I
F
R
G
Y
L
I
P
K
G
T
V
V
V
P
T
L
D
S
V
L
Y
D
N
Q
E
F
P
D
P
E
K
F
K
P
E
H
F
L
N
E
N
G
K
F
K
Y
S
D
Y
F
K
P
F
S
T
G
K
R
V
C
A
G
E
G
L
A
R
M
E
L
F
L
L
L
C
A
I
L
Q
H
F
N
L
K
P
L
V
D
P
K
D
I
D
L
S
P
I
H
I
G
F
G
C
I
P
P
R
Y
K
L
C
V
I
P
-
19
PsiBlast_PDB
83.91
50%
-106
- C4 -
4H1N
5
CP2B4_RABIT
A:
[10-470]
---------------------------
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
---
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
Y
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
A
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
--
S
G
V
G
N
V
P
P
S
Y
Q
I
R
F
L
--
40
HHSearch
81.96
51%
-104
- C4 -
1PO5
1
CP2B4_RABIT
A:
[9-471]
--------------------------
G
K
L
P
P
G
P
S
P
L
P
V
L
G
N
L
L
Q
M
D
R
K
G
L
L
R
S
F
L
R
L
R
E
K
Y
G
D
V
F
T
V
Y
L
G
S
R
P
V
V
V
L
C
G
T
D
A
I
R
E
A
L
V
D
Q
A
E
A
F
S
G
R
G
K
I
A
V
V
D
P
I
F
Q
G
Y
G
V
I
F
A
N
G
E
R
W
R
A
L
R
R
F
S
L
A
T
M
R
D
F
G
M
G
K
R
S
V
E
E
R
I
Q
E
E
A
R
C
L
V
E
E
L
R
K
S
K
G
A
L
L
D
N
T
L
L
F
H
S
I
T
S
N
I
I
C
S
I
V
F
G
K
R
F
D
Y
K
D
P
V
F
L
R
L
L
D
L
F
F
Q
S
F
S
L
I
S
S
F
S
S
Q
V
F
E
L
F
S
G
F
L
K
H
F
P
G
T
H
R
Q
I
Y
R
N
L
Q
E
I
N
T
F
I
G
Q
S
V
E
K
H
R
A
T
L
D
P
S
N
P
R
D
F
I
D
V
Y
L
L
R
M
E
K
D
K
S
D
P
S
S
E
F
H
H
Q
N
L
I
L
T
V
L
S
L
F
F
A
G
T
E
T
T
S
T
T
L
R
Y
G
F
L
L
M
L
K
Y
P
H
V
T
E
R
V
Q
K
E
I
E
Q
V
I
G
S
H
R
P
P
A
L
D
D
R
A
K
M
P
Y
T
D
A
V
I
H
E
I
Q
R
L
G
D
L
I
P
F
G
V
P
H
T
V
T
K
D
T
Q
F
R
G
Y
V
I
P
K
N
T
E
V
F
P
V
L
S
S
A
L
H
D
P
R
Y
F
E
T
P
N
T
F
N
P
G
H
F
L
D
A
N
G
A
L
K
R
N
E
G
F
M
P
F
S
L
G
K
R
I
C
L
G
E
G
I
A
R
T
E
L
F
L
F
F
T
T
I
L
Q
N
F
S
I
A
S
P
V
P
P
E
D
I
D
L
T
P
R
E
S
G
V
G
N
V
P
P
S
Y
Q
I
R
F
L
A
-