@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_ST17A_: (2014-08-19 )
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90....-----...-------.----100--.........110.......120.......130--.........140.......150.......160.......170.......180.......190......-.200.......210......-.220.......230....------...240.......250.......260.......270--.........280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPP
P
P
Q
A
R
G
L
L
T
E
I
R
A
V
V
RTEPFQDGYSLCPGRELGR
G
K
F
A
V
V
R
K
C
I
KKDS
G
K
E
F
A
A
K
F
M
R
K
R-----RKG-------
Q
----
D
----
C
R
M
E
I
I
H
E
I
A
V
L
E
LAQDN
P
W
V
I
N
L
H
E
V
Y
E
T
----
A
S
E
M
I
L
V
L
E
YAA
G
G
E
I
F
D
Q
C
V
A
D
R
E
E
A
F
K
E
K
D
V
Q
R
L
M
R
Q
I
L
E
G
V
H
F
LHTR
D
V
V
H
L
DLKP
Q
N
I
L
LTSES-PLG
D
I
K
I
V
D
F
G
L
S
R
I
LK
N
S
E
-
E
L
R
E
I
MGTP
E
Y
VA
P
E
ILS------YDP
I
S
M
A
T
D
M
W
S
I
G
V
L
T
Y
V
M
L
TGI
S
P
FLGNDKQ
E
----
T
F
L
N
I
S
Q
MNLSY
S
E
E
E
F
D
V
L
S
E
S
A
V
D
F
I
R
T
L
L
VKKPED
R
A
T
A
E
E
C
L
KHPWLTQSSIQEP
S
F
R
M
E
K
A
L
E
E
A
N
A
L
QEGHSVPEINSDTD
K
S
E
T
K
E
SIVT
E
E
L
I
V
V
T
S
Y
T
L
G
Q
C
R
Q
S
E
K
E
K
M
E
Q
K
A
I
S
K
RFKFEE
P
L
L
Q
EIPGEFIY
1
PsiBlast_PDB
80.31
60%
-115
- C1 -
3LM0
2
ST17B_HUMAN
A:
[24-302]
----------------------------------------------------
E
N
F
N
N
F
Y
I
L
-
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
-----
R
R
G
-------
Q
----
D
----
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
A
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
L
G
D
I
K
I
V
D
F
G
M
S
R
K
I
----------
M
G
T
P
E
Y
L
A
P
E
I
L
N
------
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
----
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
-
E
N
L
F
H
P
---------------------------------------------------------------------------------
10
PsiBlast_PDB
78.06
45%
-114
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[2-278]
-----------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.49
60%
-118
- C1 -
3LM5
1
ST17B_HUMAN
A:
[24-299]
----------------------------------------------------
E
N
F
N
N
F
Y
I
L
-
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
-----
R
R
G
-------
Q
----
D
----
C
R
A
E
I
L
H
E
I
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
-
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
L
G
D
I
K
I
V
D
F
G
M
S
R
K
I
----------
M
G
T
P
E
Y
L
A
P
E
I
L
N
------
Y
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
----
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
Q
Q
W
D
F
-
E
N
L
------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.56
45%
-101
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[2-291]
-----------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
-----------------------------------------------------------------------------
18
PsiBlast_PDB
76.09
46%
-107
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[2-275]
-----------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------
35
HHSearch
75.53
47%
-104
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[3-281]
------------------------------------------------
V
F
R
Q
E
N
V
D
D
Y
Y
D
T
--
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
SRRG
V
----
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
--
L
A
E
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
---------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.21
46%
-114
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[4-275]
-------------------------------------------------
F
R
Q
E
N
V
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
---------------------------------------------------------------------------------------------
5
PsiBlast_PDB
72.70
45%
-99
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[7-293]
--------------------------------------------------
R
Q
E
N
V
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
-----------------------------------------------------------------------------
17
PsiBlast_PDB
71.28
44%
-98
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[2-291]
-----------------------------------------------
T
V
F
R
Q
E
N
V
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
-----------------------------------------------------------------------------
4
PsiBlast_PDB
67.14
43%
-94
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[6-296]
--------------------------------------------------
K
Q
Q
K
V
E
D
F
Y
D
I
--
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
QSRAS
R
R
G
-------
V
---------
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
--
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
-------------------------------------------------------------------------
49
HHSearch
64.72
38%
-106
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-290]
------------------------------------------------------
F
Y
E
N
Y
E
P
--
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
-----
G
G
G
SFS
A
E
E
V
Q
----
E
----
L
R
E
A
T
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
--
L
T
E
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
----
M
N
I
K
L
T
D
F
G
F
S
C
Q
L
D
P
G
E
-
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
DN
H
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
----
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
Q
Q
Y
------------------------------------------------------------------------------------------
34
HHSearch
59.62
38%
-95
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[65-352]
-----------------------------
D
I
P
A
P
P
A
P
F
D
H
R
I
V
T
A
-----
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
-------
G
-------
M
----
K
----
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
-
I
I
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
--
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
-
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
----
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
---------------------------------------------------------------------------------------
44
HHSearch
55.09
34%
-113
* C1 *
3LIJ
1
?
A:
[31-297]
--------------------------------------------------
K
K
G
H
L
S
E
M
Y
Q
R
--
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
---------------------
S
----
S
N
S
K
L
L
E
E
V
A
V
L
K
L
L
-
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
----
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
--
H
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
-
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
------
K
-
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
----
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
-------------------------------------------------------------------------------------------
50
HHSearch
53.29
35%
-95
- C1 -
3NYV
1
?
A:
[21-288]
---------------------------------------------------
T
A
I
F
S
D
R
Y
K
G
--
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
-----
Q
V
K
-------
Q
K---
T
----
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
--
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
-
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
------
G
-
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
----
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
------------------------------------------------------------------------------------------
12
PsiBlast_PDB
51.32
45%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
----------------------------------------------------
E
N
V
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
-------------------
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
-------------
E
F
V
A
P
E
I
V
N
------
Y
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
--------------------------------------------------------------------------------------------
45
HHSearch
44.08
33%
-94
- C1 -
3MWU
1
?
A:
[18-283]
----------------------------------------------------
G
T
F
A
E
R
Y
N
I
--
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
-----
S
A
K
-------
N
----
K
----
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
--
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
------
G
-
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
----
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
------------------------------------------------------------------------------------------
48
HHSearch
43.14
30%
-102
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[54-328]
-------------------------------------------------
I
K
K
N
A
I
I
D
D
Y
K
V
T
-
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
---------------------------
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
LYAG
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
------------
P
Y
Y
V
A
P
E
V
L
G
------
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
ISPG
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
------------------------------------------------------------------------------------------
42
HHSearch
42.38
33%
-98
- C1 -
3SOA
1
KCC2A_HUMAN
A:
[7-273]
----------------------------------------------------
T
R
F
T
E
E
Y
Q
L
--
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
-----
K
L
S
-------
A
----
R
----
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
--
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
L
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
D
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
----
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
H
P
W
I
S
H
-------------------------------------------------------------------------------------------