@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00069_WNK1_HUMAN: (2014-08-20 )
MSGGAAEKQSSTPGSLFLSPPAPAPKNGSSSDSSVGEKLGAAAADAVTGRTEEYRRRRHTMDKDSRGAAATTTTTEHRFFRRSVICDSNATALELPGLPLSLPQPSIPAAVPQSAPPEPHREETVTATATSQVAQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKEPQEERSQQQDDIEELETKAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEETGVRVELAEEDDGEKIAIKLWLRIEDIKKLKGKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVSLIKRKREQRQLVREEQEKKKQEESSLKQQVEQSSASQTGIKQLPSASTGIPTASTTSASVSTQVEPEEPEADQHQQLQYQQPSISVLSDGTVDSGQGSSVFTESRVSSQQTVSYGSQHEQAHSTGTVPGHIPSTVQAQSQPHGVYPPSSVAQGQSQGQPSSSSLTGVSSSQPIQHPQQQQGIQQTAPPQQTVQYSLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQPSVVPVHSGAHFLPVGQPLPTPLLPQYPVSQIPISTPHVSTAQTGFSSLPITMAAGITQPLLTLASSATTAAIPGVSTVVPSQLPTLLQPVTQLPSQVHPQLLQPAVQSMGIPANLGQAAEVPLSSGDVLYQGFPPRLPPQYPGDSNIAPSSNVASVCIHSTVLSPPMPTEVLATPGYFPTVVQPYVESNLLVPMGGVGGQVQVSQPGGSLAQAPTTSSQQAVLESTQGVSQVAPAEPVAVAQTQATQPTTLASSVDSAHSDVASGMSDGNENVPSSSGRHEGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKGDRVVECQLETHNRKMVTFKFDLDGDNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSEDVSVEPEGDQGLESLQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGIPTSSLTQVVHSAGRRFIVSPVPESRLRESKVFPSEITDTVAASTAQSPGMNLSHSASSLSLQQAFSELRRAQMTEGPNTAPPNFSHTGPTFPVVPPFLSSIAGVPTTAAATAPVPATSSPPNDISTSVIQSEVTVPTEEGIAGVATSTGVVTSGGLPIPPVSESPVLSSVVSSITIPAVVSISTTSPSLQVPTSTSEIVVSSTALYPSVTVSATSASAGGSTATPGPKPPAVVSQQAAGSTTVGATLTSVSTTTSFPSTASQLCIQLSSSTSTPTLAETVVVSAHSLDKTSHSSTTGLAFSLSAPSSSSSPGAGVSSYISQPGGLHPLVIPSVIASTPILPQAAGPTSTPLLPQVPSIPPLVQPVANVPAVQQTLIHSQPQPALLPNQPHTHCPEVDSDTQPKAPGIDDIKTLEEKLRSLFSEHSSSGAQHASVSLETSLVIESTVTPGIPTTAVAPSKLLTSTTSTCLPPTNLPLGTVALPVTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQPLEDLDAQLRRTLSPEMITVTSAVGPVSMAAPTAITEAGTQPQKGVSQVKEGPVLATSSGAGVFKMGRFQVSVAADGAQKEGKNKSEDAKSVHFESSTSESSVLSSSSPESTLVKPEPNGITIPGISSDVPESAHKTTASEAKSDTGQPTKVGRFQVTTTANKVGRFSVSKTEDKITDTKKEGPVASPPFMDLEQAVLPAVIPKKEKPELSEPSHLNGPSSDPEAAFLSRDVDDGSGSPHSPHQLSSKSLPSQNLSQSLSNSFNSSYMSSDNESDIEDEDLKLELRRLRDKHLKEIQDLQSRQKHEIESLYTKLGKVPPAVIIPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQSAASVLHPQQTLHPPGNIPESGQNQLLQPLKPSPSSDNLYSAFTSDGAISVPSLSAPGQGTSSTNTVGATVNSQAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLSGRRGSKGHMNYEGPGMARKFSAPGQLCISMTSNLGGSAPISAASATSLGHFTKSMCPPQQYGFPATPFGAQWSGTGGPAPQPLGQFQPVGTASLQNFNISNLQKSISNPPGSNLRTT
Atome Classification :
(11 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.----.----.....320.......330.......340.......350.......360.......370...-....380.......390...----...----.400.......410.......420.......430.......440......--.---450........460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340......2350......2360......2370......2380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSGGAAEKQSSTPG
S
L
F
LSPPAPAPKNGSSS
D
S
S
V
G
E
K
LGAA
A
A
D
AVTGR
T
E
E
Y
R
R
R
RHTMDKDSRGAAATTTT
T
E
H
R
F
F
R
R
S
VICDSNA
T
A
L
ELPGLPLSLPQPSIPAAVPQSAPPEPHREE
T
V
T
A
T
A
T
S
Q
V
AQQPPAAAAPGEQAVAGPAPSTVPSSTSKDRPVSQPSLVGSKEEPPPARSGSGGGSAKE
P
Q
E
E
R
S
Q
Q
Q
D
D
I
E
E
L
E
T
K
AVGMSNDG
R
F
L
K
F
D
I
E
IGRG
S
F
K
T
V
Y
KGLDTE
T
T
V
E
V
A
W
C
ELQDRKL
T
K
S
E
R
Q
R
F
K
E
E
A
E
M
L
K
GLQHP
N
I
V
R
F
Y
D
S
W
E
STVKG
K
K
C
I
V
L
V
T
E
L
MTS
G
T
L
K
T
Y
L
----
K
----
R
F
K
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
HTRTP
P
I
I
H
RDLKCD
N
I
F
I
TGPTG
S
V
K
IG
D
L
G
L
A
T
L
K
-
R
A
S
F
A
K
S
VIGTPEFM
A
P
E
M
Y
----
E
E
K
----YDES
V
D
V
Y
A
F
G
M
C
M
L
E
MATSEY
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
TSGVKPASFDKVA--
I
---
P
E
-
V
K
E
I
I
E
G
C
I
RQNKDERY
S
I
K
D
L
L
N
H
A
F
F
QEETG
V
R
V
E
L
AEEDDG
E
K
I
A
I
K
L
W
L
R
I
E
D
I
K
K
L
KGKYKDN
E
A
I
E
F
S
FDLERDV
P
E
D
V
A
Q
E
M
V
ESG
Y
V
CEG
D
H
K
T
M
A
K
A
I
K
D
R
V
S
L
I
K
R
K
R
E
Q
R
Q
L
V
R
E
E
Q
E
K
K
K
Q
E
E
S
S
L
K
Q
Q
V
E
Q
SSASQT
G
I
K
QLPSASTGIPTASTTSAS
V
S
TQVEPEEPEA
D
Q
H
Q
Q
L
Q
YQQP
S
I
S
V
LSDGTVDSGQGSS
V
F
TESRVSSQQTVSYGSQ
H
E
QAHSTGTVPGHIPSTVQAQSQPHGVYPP
S
S
VAQGQSQGQPSSSSLTGVSSSQPIQH
P
Q
Q
QQGIQQTAPP
Q
Q
T
V
Q
Y
SLSQTSTSSEATTAQPVSQPQAPQVLPQVSAGKQLPVSQPVPTIQGEPQIPVATQP
S
V
V
P
VHSGA
H
F
L
PVGQPLPTPLLPQYPVSQIPISTPHV
S
T
A
QTGFSSLP
I
T
M
AAGIT
Q
P
L
L
T
L
ASSATTAAIPGVSTVV
P
S
Q
L
P
T
L
L
Q
P
V
T
Q
L
P
S
QV
H
P
Q
L
L
Q
P
A
V
Q
SMGIPANLGQAAEVPLSSG
D
V
L
YQGFPPRLPPQYPGDSNIAPSS
N
V
A
S
V
C
I
H
S
TVLSPPMP
T
E
VLATPGY
F
P
T
V
V
Q
P
Y
VESN
L
L
V
PMGGVG
G
Q
V
Q
VSQPGGSLAQAPTT
S
S
Q
Q
A
V
L
E
STQGVSQVAPAE
P
V
A
V
A
QTQATQP
T
T
L
A
S
S
V
D
S
A
H
S
D
V
A
SGMSDGNENVPSSSGRHEG
R
T
T
K
R
H
Y
R
K
S
V
R
SRSRHEKTSRP
K
L
R
I
L
N
VSNKG
D
R
V
V
E
C
Q
L
ETHN
R
K
M
V
T
F
K
F
DLDGD
N
P
E
E
I
A
T
I
M
VNN
D
F
I
L
A
I
E
R
E
S
F
V
D
Q
V
R
E
I
I
E
K
A
D
E
M
L
S
EDVSVEPEGDQ
G
L
E
S
LQGKDDYGFSGSQKLEGEFKQPIPASSMPQQIGI
P
T
S
S
L
T
Q
V
V
H
SAG
R
R
F
I
VSPV
P
E
S
R
L
R
ESKV
F
P
S
E
I
T
D
T
V
A
ASTAQSPGMNLSHSASS
L
S
L
Q
Q
A
F
S
E
L
R
R
A
Q
MTEGPNTAPPNFSHTGPTFPVV
P
P
F
L
S
S
IAGVPTTAAATAPVPATSSPPND
I
S
T
S
V
I
QSEVTVPTEEGIAGVATST
G
V
V
TSGGLPIPPVSES
P
V
L
S
S
V
V
S
SITI
P
A
V
V
S
I
STTSP
S
L
Q
VPTST
S
E
I
V
V
S
STALYP
S
V
T
V
S
A
TSASAGGSTATPGPKP
P
A
V
V
S
QQAAGS
T
T
V
G
A
T
L
T
S
V
STTTSFP
S
T
A
S
Q
L
C
I
QLSSSTSTP
T
L
A
E
T
V
V
V
S
A
HSLDKTSHSSTT
G
L
A
F
S
LSAPSSSSSPGA
G
V
S
S
Y
ISQPGGLHP
L
V
I
P
S
V
IASTPILPQAAGPTSTPLLPQVPSIP
P
L
V
Q
PVAN
V
P
A
V
Q
Q
T
L
I
HSQPQPALLPNQPHTHCPEVDSDTQPKAPGI
D
D
I
K
T
L
E
E
K
L
R
S
L
F
S
EHSSSGA
Q
H
A
S
V
S
L
E
T
S
L
V
I
E
STVTPGIPTTAVA
P
S
K
L
L
TSTTSTCLPPTNLPL
G
T
V
ALPVTPVVTPGQVSTPVSTTTSGVKPGTAPSKPPLTKAPVLPVGTELPAGTLPSEQLPPFPGPSLTQSQQ
P
L
E
D
L
D
A
Q
L
R
R
TLSP
E
M
I
T
V
TSAVGPVSMAAP
T
A
ITEAGTQ
P
Q
K
G
V
S
Q
V
KEG
P
V
L
ATSSGA
G
V
F
K
M
G
R
F
Q
V
S
V
AADGAQKEGKNKSEDA
K
S
V
H
FESSTSESSVLSSSSPES
T
L
VKPEPN
G
I
T
IPGISSDVPESAHKTTASEAKSDTGQP
T
K
V
G
R
F
Q
V
T
TTANKVGRFSVSKTEDKITDTKKEGPVASP
P
F
M
D
L
E
Q
A
V
L
P
AVIPKKEKPELSEPSHLNGPSSDP
E
A
A
F
LSRDVDDGSGSPHSPHQLSSKSL
P
S
Q
N
L
S
Q
S
L
S
N
SFNSSYMSSDNESDIE
D
E
D
L
K
L
E
L
R
R
L
R
D
K
H
L
K
E
I
Q
D
L
Q
S
R
Q
K
H
E
I
E
S
L
Y
T
K
LGKVP
P
A
V
I
IPPAAPLSGRRRRPTKSKGSKSSRSSSLGNKSPQLSGNLSGQ
S
A
A
S
VLHPQQTLHPPGNIPESG
Q
N
QLLQPLKPSPSSDNL
Y
S
A
FTSDGAISVPSLSAPGQGTSST
N
T
V
G
A
TVNSQAAQAQPPAMTSSRKGT
F
T
D
D
L
H
K
L
V
D
N
W
A
R
D
A
MNLSGRRGSKGHMNYEGPGMARKFSAPG
Q
L
C
I
S
M
T
SNLGGSAPISAASAT
S
L
G
H
F
T
K
SMC
P
P
Q
QYGFPATPFGAQWSGTGGPAPQPLGQFQPVGTASLQNF
N
I
S
N
L
Q
K
S
ISNPPGSNLRTT
1
PsiBlast_PDB
94.62
96%
-71
- C1 -
3FPQ
4
WNK1_RAT
A:
[17-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
----
K
----
R
F
K
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
K
-
R
A
S
F
A
K
A
V
I
G
T
P
E
F
M
A
P
E
M
Y
----
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
--
I
---
P
E
-
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
Y
S
I
K
D
L
L
N
H
A
F
F
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.89
34%
-52
- C1 -
4H58
1
BRAF_HUMAN
A:
[16-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
----
K
F
E
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S---------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.19
34%
-47
- C1 -
3PSB
1
BRAF_HUMAN
A:
[44-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
----
K
F
E
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.81
34%
-54
- C1 -
3PRF
1
BRAF_HUMAN
A:
[44-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
----
K
F
E
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
60.44
34%
-36
- C1 -
3C4C
1
BRAF_HUMAN
A:
[19-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
--
S
T
---
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASET
K
F
E
M
K
K
L
I
D
I
---
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
--------------
S
G
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.00
34%
-46
- C1 -
3II5
1
BRAF_HUMAN
A:
[43-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
----
K
F
E
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
--------
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.87
34%
-45
- C1 -
3D4Q
1
BRAF_HUMAN
A:
[44-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
----
K
F
E
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
58.56
34%
-49
- C1 -
3PRI
1
BRAF_HUMAN
A:
[44-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
----
K
F
E
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
58.47
34%
-42
- C1 -
4JVG
1
BRAF_HUMAN
B:
[23-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
--
S
T
---
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASE
T
K
F
E
M
K
K
L
I
D
I
---
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-------------
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.62
33%
-45
- C1 -
3OG7
1
BRAF_HUMAN
A:
[31-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
--
S
T
A
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
AS---
F
E
M
K
K
L
I
D
I
---
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
---------------
G
S
I
L
W
M
A
P
E
V
I
----
R
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.32
34%
-42
- C1 -
4FK3
1
BRAF_HUMAN
A:
[31-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
G
S
G
S
F
G
T
V
Y
K
G
---
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
--
S
T
---
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASE
T
K
F
E
M
K
K
L
I
D
I
---
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
--------------
S
G
S
I
L
W
M
A
P
E
V
I
----
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------