@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00072_PDE8B_: (2014-08-21 )
MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASGPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS
Atome Classification :
(16 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760..----....---.770.......780.......790.......800.......810.......820.......830.......840.......850-..--...--...860.......870.......880...-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGCAP
S
I
H
VSQS
G
V
I
Y
C
RDSDESSSPRQTTSVSQGPAAPLP
G
L
F
V
QTDAADAIPPSRASG
P
P
S
V
A
R
V
R
R
A
R
T
ELGSGSSAGSAAPAATTSRG
R
R
R
HCCSSAEA
E
T
Q
T
C
Y
T
S
V
K
QVSSA
E
V
R
IG
P
M
RLTQDP
I
Q
V
L
L
I
F
AKEDSQSDG
F
W
W
A
CDRAG
Y
R
C
NIART
P
E
S
A
L
E
C
F
L
DKHH
E
I
I
V
I
DHRQTQNF
D
A
E
A
V
C
R
S
I
RATNPSEH
T
V
I
L
A
V
V
S
R
VSDD
H
E
E
A
S
V
L
P
L
L
H
AGFNRRFMENS
S
I
I
A
C
Y
N
E
L
I
QIE
H
G
E
V
R
S
Q
F
K
L
R
A
C
N
S
V
F
T
A
L
D
H
C
H
E
A
IEITSD
D
H
V
I
Q
YV
N
P
A
F
E
R
M
M
G
Y
H
K
G
E
L
L
G
K
E
L
A
DLPKSDK
N
R
A
D
L
L
D
T
I
N
T
C
I
KKGKEWQ
G
V
Y
Y
A
RRKSGD
S
I
Q
Q
H
V
K
I
T
P
V
IGQGG
K
I
R
H
F
V
S
L
K
K
L
CCTTDNNK
Q
I
H
K
I
HRDSGDNSQTEPHSFRYKNRRKESI
D
V
K
S
I
SSRGSDAPSLQNRRYP
S
M
A
R
I
H
S
M
T
IE
A
P
I
T
K
V
I
N
I
I
N
A
AQENSPV
T
V
A
E
A
L
D
R
V
L
E
I
L
R
T
TELYSPQLGTKDEDP
H
T
S
D
L
V
G
G
L
M
T
D
G
L
R
RLSGN
E
Y
V
F
TKNVHQSHS
H
L
A
M
P
I
T
INDV
P
P
C
I
S
Q
L
LDNEESWD
F
N
I
F
E
L
E
AITHKRP
L
V
Y
L
G
L
K
V
F
S
RF
G
V
C
E
FLNC
S
E
T
T
L
R
A
W
F
Q
V
I
E
ANYHSSNAYHNST
H
A
A
D
V
L
H
A
T
A
F
F
L
G
K
E
R
VKG
S
L
D
Q
L
D
E
V
A
A
L
I
A
A
T
V
HDVDHPGRTN
S
F
L
CNAG
S
E
L
A
V
L
YN
D
T
A
V
LESHH
T
A
L
A
F
Q
L
T
V
KDTK
C
N
I
F
K
NI
D
R
N
H
Y
R
T
L
R
Q
A
I
I
D
M
V
L
A
T
E
M
T
K
H
F
E
H
V
N
K
F
V
N
SINKP
M
A
A
E
IEGSDCECNPAGKN----FP
E
N
---
Q
I
L
I
K
R
M
M
I
K
C
ADVANPC
R
P
L
D
L
C
I
E
W
A
G
RI
S
E
E
Y
F
AQT
D
E
E
K
RQGL
P
V
V
M
P
V
FDRNTCSI
P
K
S
Q
I
S
F
I
D
Y
F
I
T
D
M
F
D
A
W
D
A
F
--
A
H
--
L
P
A
--
L
M
Q
H
L
A
D
N
Y
K
H
W
K
T
L
D
DLKCKSLRLPSDS-----
2
PsiBlast_PDB
93.74
77%
-99
- C1 -
3ECN
1
PDE8A_HUMAN
A:
[1-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
V
P
P
R
I
A
R
A
M
E
N
E
E
Y
W
D
F
D
I
F
E
L
E
A
A
T
H
N
R
P
L
I
Y
L
G
L
K
M
F
A
R
F
G
I
C
E
F
L
H
C
S
E
S
T
L
R
S
W
L
Q
I
I
E
A
N
Y
H
S
S
N
P
Y
H
N
S
T
H
S
A
D
V
L
H
A
T
A
Y
F
L
S
K
E
R
I
K
E
T
L
D
P
I
D
E
V
A
A
L
I
A
A
T
I
H
D
V
D
H
P
G
R
T
N
S
F
L
C
N
A
G
S
E
L
A
I
L
Y
N
D
T
A
V
L
E
S
H
H
A
A
L
A
F
Q
L
T
T
G
D
D
K
C
N
I
F
K
N
M
E
R
N
D
Y
R
T
L
R
Q
G
I
I
D
M
V
L
A
T
E
M
T
K
H
F
E
H
V
N
K
F
V
N
S
I
N
K
P
L
A
T
L
E
E
N
G
E
T
D
K
N
Q
E
V
I
N
T
M
L
R
T
P
E
N
---
R
T
L
I
K
R
M
L
I
K
C
A
D
V
S
N
P
C
R
P
L
Q
Y
C
I
E
W
A
A
R
I
S
E
E
Y
F
S
Q
T
D
E
E
K
Q
Q
G
L
P
V
V
M
P
V
F
D
R
N
T
C
S
I
P
K
S
Q
I
S
F
I
D
Y
F
I
T
D
M
F
D
A
W
D
A
F
--
V
D
--
L
P
D
--
L
M
Q
H
L
D
N
N
F
K
Y
W
K
G
L
D
E
M
----------------
21
PsiBlast_CBE
92.99
77%
-98
- C1 -
3ECN
1
B:
[1-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
V
P
P
R
I
A
R
A
M
E
N
E
E
Y
W
D
F
D
I
F
E
L
E
A
A
T
H
N
R
P
L
I
Y
L
G
L
K
M
F
A
R
F
G
I
C
E
F
L
H
C
S
E
S
T
L
R
S
W
L
Q
I
I
E
A
N
Y
H
S
S
N
P
Y
H
N
S
T
H
S
A
D
V
L
H
A
T
A
Y
F
L
S
K
E
R
I
K
E
T
L
D
P
I
D
E
V
A
A
L
I
A
A
T
I
H
D
V
D
H
P
G
R
T
N
S
F
L
C
N
A
G
S
E
L
A
I
L
Y
N
D
T
A
V
L
E
S
H
H
A
A
L
A
F
Q
L
T
T
G
D
D
K
C
N
I
F
K
N
M
E
R
N
D
Y
R
T
L
R
Q
G
I
I
D
M
V
L
A
T
E
M
T
K
H
F
E
H
V
N
K
F
V
N
S
I
N
K
P
L
A
T
L
E
E
N
G
E
T
D
K
N
Q
E
V
I
N
TMLR
T
P
E
N
---
R
T
L
I
K
R
M
L
I
K
C
A
D
V
S
N
P
C
R
P
L
Q
Y
C
I
E
W
A
A
R
I
S
E
E
Y
F
S
Q
T
D
E
E
K
Q
Q
G
L
P
V
V
M
P
V
F
D
R
N
T
C
S
I
P
K
S
Q
I
S
F
I
D
Y
F
I
T
D
M
F
D
A
W
D
A
F
--
V
D
--
L
P
D
--
L
M
Q
H
L
D
N
N
F
K
Y
W
K
G
L
D
E
M
----------------
22
Fugue
71.03
32%
-86
- C1 -
1F0J
3
PDE4B_HUMAN
A:
[1-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
S
R
F
G
V
N
-
T
E
N
E
D
H
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
-
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
S
S
-------
G
V
L
L
L
D
----
N
Y
T
D
---
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
R
G
M
E
I
-
S
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
Q
PD
A
Q
D
--
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
A
N
R
D
C
Q
G
L
M
E
K
F
QF
16
PsiBlast_PDB
69.57
32%
-99
- C1 -
1XOR
1
PDE4D_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
----------
K
V
T
---
V
L
----
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
H
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
--------------------
12
PsiBlast_PDB
69.46
35%
-93
- C1 -
3G45
1
PDE4B_HUMAN
A:
[94-411]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
--------
S
L
L
A
D
L
K
T
M
V
E
T
K
--
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
Q
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
-------------------
34
HHSearch
69.23
31%
-92
- C1 -
1Y2K
13
PDE4D_HUMAN
A:
[22-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
Q
E
D
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
-------
K
V
T
S
S
G
V
L
L
L
D
----
N
Y
S
D
---
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
-
S
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
V
H
P
D
--
A
Q
D
--
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
T
I
------------------
17
PsiBlast_PDB
68.96
32%
-94
- C1 -
1Y2B
13
PDE4D_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
----------
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
H
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
--------------------
14
PsiBlast_PDB
68.96
32%
-98
- C1 -
1XON
15
PDE4D_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
----------
K
V
----
V
L
----
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
H
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
--------------------
13
PsiBlast_PDB
68.82
32%
-94
- C1 -
1XOM
9
PDE4D_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
----------
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
H
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
--------------------
15
PsiBlast_PDB
68.46
32%
-94
- C1 -
1XOQ
11
PDE4D_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
----------
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
H
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
--------------------
18
PsiBlast_PDB
68.45
32%
-94
- C1 -
1Y2C
11
PDE4D_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
----------
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
H
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
--------------------
19
PsiBlast_PDB
68.30
32%
-93
- C1 -
1Y2D
12
PDE4D_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
----------
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
H
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
--------------------
20
PsiBlast_PDB
68.08
32%
-96
- C1 -
1Y2E
9
PDE4D_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
A
K
E
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
E
T
K
----------
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
N
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
H
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
--------------------
6
PsiBlast_PDB
68.08
35%
-97
- C1 -
1XMY
1
PDE4B_HUMAN
B:
[36-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
--------
S
L
L
A
D
L
K
T
M
V
E
T
K
--
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
Q
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
-------------------
4
PsiBlast_PDB
66.78
35%
-94
- C1 -
1XM4
1
PDE4B_HUMAN
A:
[36-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
--------
S
L
L
A
D
L
K
T
M
V
E
T
K
--
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
Q
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
-------------------
5
PsiBlast_PDB
66.73
35%
-96
- C1 -
1XMU
1
PDE4B_HUMAN
A:
[36-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
E
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
R
P
L
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
-
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
--------
S
L
L
A
D
L
K
T
M
V
E
T
K
--
K
V
T
S
S
G
V
L
----
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
R
G
M
E
I
S
-
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
L
--
V
Q
--
P
D
A
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
-------------------