@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00088_SUIS_H: (2014-08-22 )
MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDSTSTPATTRVTTNPSDSGKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSLIPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRFKITDPNNRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIGPLVYSDQYLQISTRLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYGHQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQVVQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYMEDKKDFTYDQVAFNGLPQFVQDLHDHGQKYVIILDPAISIGRRANGTTYATYERGNTQHVWINESDGSTPIIGEVWPGLTVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNEVSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSMAIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLEFSLFGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLVKSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEFLWGPALLITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADKIGLHLRGGYIIPIQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNNTLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMNAHSNFTYDASNQVLLIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGCVWRTGSSLSKAPECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRVEVKYHKNDMLQFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRSSGRVIWDSWLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPPGYKLNSYGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGPTPEVATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDIDYMERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVFVKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREIVDFYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTICMEAEQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWGGHWLGDNYARWDNMDKSIIGMMEFSLFGMSYTGADICGFFNNSEYHLCTRWMQLGAFYPYSRNHNIANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRPLLHEFFDEKPTWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVRGQFQTFNASYDTINLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFWDDGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNAVTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINWS
Atome Classification :
(8 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-..-120--..-......130.......140.......150.......160.......170.......180.-------......190.-......200.......210......------.220.......230..--.....240.......250.......260.......270.......280....--...290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400....--...410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520--.......530...--....540.......550.-......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770--.......780.......790.......800.......810.......820.......830.......840........850....----...860.......870.......880....--...890.......900.......910--.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARKKFSG
L
E
I
S
L
I
V
L
F
V
I
V
T
I
I
A
I
A
L
I
V
V
LATKTPAVDEISDSTSTPA
T
T
R
V
TTNPSDSGKCPNVLNDP
V
N
V
R
I
N
CIPEQFPTEGICAQRGCCWRPWNDSL
I
P
W
C
F
F
VDNHGYN
V
Q
-
D
M
-
T
T---TS-IG
V
E
A
KLNRIPSPTLFGNDIN
S
V
L
F
TTQNQTP
N
R
F
R
F
K
ITDPNNR
R
Y
EV
P
H
Q
Y
V
K
E
FTGP-------TVSD
T
L
Y
D
V
K
-VAQNP
F
S
I
Q
V
I
RKSNG
K
T
L
F
DTSIG------
P
L
V
YSD
Q
Y
L
Q
I
S
TRLP--
S
D
Y
I
Y
G
I
G
E
Q
V
H
K
R
F
R
HDLSWKT
W
P
I
F
TRDQLPGDNNNNLYG
H
Q
T
F
F
M
C
I
ED--TSG
K
S
F
G
V
F
L
MNSN
A
M
E
I
F
I
QPT
P
I
V
T
Y
R
VTGG
I
L
D
F
Y
I
L
LGD
T
P
E
Q
V
V
Q
Q
Y
Q
Q
L
VGLPAM
P
A
Y
W
NLG
F
Q
L
SRWNY
K
S
L
D
V
V
K
E
V
V
RRNREAGIPFDTQVTDIDYMEDKKDF
T
Y
D
Q
V
A
FN--
G
L
P
Q
F
V
Q
D
L
H
DHG
Q
K
Y
V
I
I
LDPAISIGRRANG
T
T
Y
A
T
Y
ERGN
T
Q
H
V
W
I
NESDGST
P
I
I
G
EVWPG
L
T
VYPDFTNP
N
C
I
D
W
W
A
N
E
C
S
I
F
H
Q
EVQYD
G
L
W
I
D
M
N
E
V
S
S
F
I
QGSTKGCNV--NKLNYPPF
T
P
D
I
L
--
D
K
L
M
Y
S
K
T
I
C
M
D
A
V
Q
N
W
G
-KQYDV
H
S
LYG
Y
S
M
A
I
A
T
E
Q
A
V
Q
K
VFPNK
R
S
F
I
L
T
RSTFAGSGRH
A
A
H
WLGDNTAS
W
E
Q
M
E
W
S
I
T
G
M
L
E
F
S
L
FGIPLV
G
A
D
I
C
G
F
V
A
E
T
T
E
E
L
C
R
R
W
M
QLGAFYPFSRNHNSDGYEHQDPAFFGQN
S
L
L
V
KSSR
Q
Y
L
T
I
R
Y
T
L
L
P
F
L
Y
T
L
F
Y
K
A
H
VF
G
E
T
V
A
R
P
V
L
H
E
F
Y
E
D
T
N
S
W
I
EDTEFLWG
P
A
L
L
I
T
P
V
L
KQGA
D
T
V
S
A
YIPD
A
I
W
YDYESGAKRP--
W
R
K
QR
V
D
M
Y
LPAD
K
I
G
L
H
L
RG
G
Y
I
I
PIQEPDVTTTASRKNP
L
G
L
I
V
A
LGENNTAKG
D
F
F
WDDGETKDTI-QNG
N
Y
I
L
Y
T
F
S
VSNN----
T
L
D
I
V
CTHSSYQEG
T
T
L
A
F
Q
T
V
K
I
LGLTDS--
V
T
E
V
R
VAENNQPMNAHS
N
F
T
YDASN
Q
--
V
L
L
I
A
D
L
K
L
NLGRN
F
S
V
Q
W
N
Q
IFSENERFNCYPDADLA
T
E
Q
K
C
TQRG
C
V
WRTGSSLSKAPECYFPRQDNSYSVNS
A
R
YSSM
G
I
T
A
D
L
Q
L
NTA
N
A
R
I
KLPSDPI
S
T
L
R
V
E
V
K
YHKND
M
L
Q
F
K
IYDPQK
K
R
YEVPVPLNIPTTPISTYED
R
L
Y
D
V
E
IKENP
F
G
I
Q
I
R
RRSSG
R
V
I
WDSWLPGFAFND
Q
F
I
Q
I
STRL
P
S
E
Y
I
Y
GFGEV
E
H
T
A
F
KRDLNWNTWGMFTRDQPPGYKLNSYGFH
P
Y
Y
M
A
L
EEEGNA
H
G
V
F
L
LNSN
A
M
D
V
T
FQPTP
A
L
T
Y
R
T
V
G
G
I
L
D
F
Y
M
FLGPTP
E
V
A
T
K
Q
Y
H
E
V
IGHP
V
M
P
A
Y
W
A
L
G
F
Q
L
C
RYGYA
N
T
S
E
V
R
E
L
Y
D
A
M
V
AANIPYD
V
Q
YT
D
I
D
Y
M
E
R
Q
LD
F
T
I
G
E
A
F
Q
D
L
P
Q
F
V
D
K
IRGEG
M
R
Y
I
I
I
LDPAISGNETKTYPAFERGQQN
D
V
F
V
KWPNTNDI
C
W
A
K
VWPDLPNITIDKTLTEDEAVNASRAHVAF
P
D
F
F
RT
S
T
A
E
W
W
A
R
E
I
V
D
F
Y
N
EKMKFD
G
L
W
I
DMNEP
S
S
FVNGTTTNQCRNDELNYPPY
F
P
E
L
TKRTDGL
H
F
R
T
I
C
M
E
A
E
Q
I
L
SDGT
S
V
L
H
Y
D
V
H
N
LYGWSQMK
P
T
H
D
A
L
Q
KTTGKR
G
I
V
I
SRSTYPTSGRWGGHWLGDN
Y
A
R
WDNM
D
K
S
I
I
G
M
M
E
F
S
L
FGMSYTGA
D
I
C
G
FFNNS
E
Y
H
L
C
T
R
W
M
Q
LGAFYPYSRNHNIANTRRQDPA
S
W
N
E
T
F
A
E
M
S
R
N
I
L
N
I
R
Y
T
L
L
P
Y
F
Y
T
Q
M
H
EIHANG
G
T
V
I
R
P
L
L
H
E
F
FDEKP
T
W
D
I
F
K
Q
F
LWGP
A
F
M
V
T
P
V
L
E
P
Y
V
Q
T
V
N
AYVPNA
R
W
F
DYHTGKDIGV
R
G
Q
F
Q
T
FNASY
D
T
I
N
L
H
V
RG
G
H
ILPCQEP
A
Q
N
T
F
Y
S
RQ
K
H
M
K
L
I
V
AADDNQMAQG
S
L
F
WDDGESIDTY
E
R
D
L
Y
L
S
V
Q
F
NLN
Q
T
T
L
T
S
T
I
L
K
RGYINKSETRLG
S
L
H
V
WGKGTT
P
V
N
A
V
T
L
T
YNGNKNSLPFNEDTT
N
M
I
L
R
I
D
L
T
THN
V
T
LEE
P
I
EINWS
38
HHSearch
86.06
59%
-83
- C3 -
3L4Y
9
MGA_HUMAN
A:
[7-869]
--------------------------------------------------------------------
V
N
E
L
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
-
G
N
L
V
N
---
T
N
-
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
E
Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
N
N
S
S
S
S
K
-
P
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
I
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
G
-
K
Q
Y
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
A
A
K
T
V
F
P
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
G
K
F
A
A
H
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
V
-
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
T
-
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
S
-
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
85.90
59%
-82
- C3 -
2QMJ
13
MGA_HUMAN
A:
[7-870]
--------------------------------------------------------------------
V
N
E
L
E
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
-
G
N
-
L
V
---
N
T
N
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
E
Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
N
N
S
S
S
S
K
P
-
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
I
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
G
-
K
Q
Y
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
A
A
K
T
V
F
P
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
G
K
F
A
A
H
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
V
-
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
T
-
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
-
S
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
A
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.53
59%
-84
- C3 -
3L4Z
8
MGA_HUMAN
A:
[7-868]
------------------------------------------------------------------
V
N
E
L
E
--
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
-
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
E
Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
-
N
N
S
S
S
S
K
P
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
I
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
G
-
K
Q
Y
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
A
A
K
T
V
F
P
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
G
K
F
A
A
H
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
V
-
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
-
T
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
S
-
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.41
59%
-82
- C3 -
3L4U
4
MGA_HUMAN
A:
[7-868]
------------------------------------------------------------------
V
N
E
L
E
--
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
-
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
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Y
L
E
L
I
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R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
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V
V
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R
N
R
A
A
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L
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Y
D
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Q
H
A
D
I
D
Y
M
D
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R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
-
N
N
S
S
S
S
K
P
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
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T
P
L
I
G
E
V
W
P
G
Q
T
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D
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T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
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N
Q
V
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D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
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-
K
Q
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N
L
Y
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A
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A
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A
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A
A
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N
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I
L
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A
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F
A
A
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W
L
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D
N
T
A
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N
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A
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L
L
L
N
S
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L
L
P
Y
L
Y
T
L
F
F
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A
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A
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L
L
H
E
F
Y
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D
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S
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P
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L
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V
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A
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A
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--
W
R
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Q
K
V
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M
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L
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T
K
D
T
V
-
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
-
T
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
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P
T
V
T
Y
D
S
N
L
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--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.21
59%
-83
- C3 -
3L4X
7
MGA_HUMAN
A:
[7-868]
------------------------------------------------------------------
V
N
E
L
E
--
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
-
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
E
Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
-
N
N
S
S
S
S
K
P
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
I
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
G
-
K
Q
Y
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
A
A
K
T
V
F
P
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
G
K
F
A
A
H
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
V
-
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
-
T
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
S
-
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.06
59%
-83
- C3 -
3L4W
9
MGA_HUMAN
A:
[7-868]
------------------------------------------------------------------
V
N
E
L
E
--
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
-
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
S
N
A
M
E
V
V
L
Q
P
A
P
A
I
T
Y
R
T
I
G
G
I
L
D
F
Y
V
F
L
G
N
T
P
E
Q
V
V
Q
E
Y
L
E
L
I
G
R
P
A
L
P
S
Y
W
A
L
G
F
H
L
S
R
Y
E
Y
G
T
L
D
N
M
R
E
V
V
E
R
N
R
A
A
Q
L
P
Y
D
V
Q
H
A
D
I
D
Y
M
D
E
R
R
D
F
T
Y
D
S
V
D
F
K
--
G
F
P
E
F
V
N
E
L
H
N
N
G
Q
K
L
V
I
I
V
D
P
A
I
S
-
N
N
S
S
S
S
K
P
Y
G
P
Y
D
R
G
S
D
M
K
I
W
V
N
S
S
D
G
V
T
P
L
I
G
E
V
W
P
G
Q
T
V
F
P
D
Y
T
N
P
N
C
A
V
W
W
T
K
E
F
E
L
F
H
N
Q
V
E
F
D
G
I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
T
L
C
M
D
A
V
Q
H
W
G
-
K
Q
Y
D
I
H
N
L
Y
G
Y
S
M
A
V
A
T
A
E
A
A
K
T
V
F
P
N
K
R
S
F
I
L
T
R
S
T
F
A
G
S
G
K
F
A
A
H
W
L
G
D
N
T
A
T
W
D
D
L
R
W
S
I
P
G
V
L
E
F
N
L
F
G
I
P
M
V
G
P
D
I
C
G
F
A
L
D
T
P
E
E
L
C
R
R
W
M
Q
L
G
A
F
Y
P
F
S
R
N
H
N
G
Q
G
Y
K
D
Q
D
P
A
S
F
G
A
D
S
L
L
L
N
S
S
R
H
Y
L
N
I
R
Y
T
L
L
P
Y
L
Y
T
L
F
F
R
A
H
S
R
G
D
T
V
A
R
P
L
L
H
E
F
Y
E
D
N
S
T
W
D
V
H
Q
Q
F
L
W
G
P
G
L
L
I
T
P
V
L
D
E
G
A
E
K
V
M
A
Y
V
P
D
A
V
W
Y
D
Y
E
T
G
S
Q
V
R
--
W
R
K
Q
K
V
E
M
E
L
P
G
D
K
I
G
L
H
L
R
G
G
Y
I
F
P
T
Q
Q
P
N
T
T
T
L
A
S
R
K
N
P
L
G
L
I
I
A
L
D
E
N
K
E
A
K
G
E
L
F
W
D
D
G
E
T
K
D
T
V
-
A
N
K
V
Y
L
L
C
E
F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
G
-
T
E
E
--
P
S
N
V
T
V
K
H
N
G
V
P
S
-
T
S
P
T
V
T
Y
D
S
N
L
K
--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.89
59%
-83
- C3 -
3L4V
4
MGA_HUMAN
A:
[7-868]
------------------------------------------------------------------
V
N
E
L
E
--
R
I
N
C
I
P
D
Q
P
P
T
K
A
T
C
D
Q
R
G
C
C
W
N
P
Q
G
A
V
S
V
P
W
C
Y
Y
S
K
N
H
S
Y
H
V
E
G
N
L
-
V
N
---
T
N
-
A
G
F
T
A
R
L
K
N
L
P
S
S
P
V
F
G
S
N
V
D
N
V
L
L
T
A
E
Y
Q
T
S
N
R
F
H
F
K
L
T
D
Q
T
N
N
R
F
E
V
P
H
E
H
V
Q
S
F
S
G
N
-------
A
A
A
S
L
T
Y
Q
V
E
-
I
S
R
Q
P
F
S
I
K
V
T
R
R
S
N
N
R
V
L
F
D
S
S
I
G
------
P
L
L
F
A
D
Q
F
L
Q
L
S
T
R
L
P
--
S
T
N
V
Y
G
L
G
E
H
V
H
Q
Q
Y
R
H
D
M
N
W
K
T
W
P
I
F
N
R
D
T
T
P
N
G
N
G
T
N
L
Y
G
A
Q
T
F
F
L
C
L
E
D
--
A
S
G
L
S
F
G
V
F
L
M
N
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N
A
M
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A
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A
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Y
R
T
I
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G
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L
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V
F
L
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N
T
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V
V
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L
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L
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A
L
P
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Y
W
A
L
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F
H
L
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Y
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T
L
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V
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R
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A
A
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A
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M
D
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D
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--
G
F
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F
V
N
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L
H
N
N
G
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L
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I
I
V
D
P
A
I
S
-
N
N
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S
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P
Y
D
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D
M
K
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L
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G
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N
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A
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K
E
F
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I
W
I
D
M
N
E
V
S
N
F
V
D
G
S
V
S
G
C
S
T
--
N
N
L
N
N
P
P
F
T
P
R
I
L
--
D
G
Y
L
F
C
K
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-
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A
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A
A
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D
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A
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L
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L
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Y
L
Y
T
L
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F
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A
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L
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N
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P
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W
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L
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K
D
T
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-
A
N
K
V
Y
L
L
C
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F
S
V
T
Q
N
----
R
L
E
V
N
I
S
Q
S
T
Y
K
D
P
N
N
L
A
F
N
E
I
K
I
L
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-
T
E
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--
P
S
N
V
T
V
K
H
N
G
V
P
S
-
T
S
P
T
V
T
Y
D
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N
L
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--
V
A
I
I
T
D
I
D
L
L
L
G
E
A
Y
T
V
E
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
70.82
36%
-76
- C3 -
3W37
10
?
A:
[39-909]
-----------------------------------------------------------------------------------------------------------
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