@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_FA9_HU: (2014-08-23 )
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240..--..--...250.......260.......270------.---.---.......280......-.290.......300.......310.......320.......330.......340-..-...-..350.......360.-.-.....370.......380.....-.-----.390.......400--........410.......--420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Q
R
V
N
M
I
MAESPG
L
I
T
I
C
L
L
G
Y
L
LSA
E
C
T
V
F
L
DHE
N
A
N
K
I
LNRPKRYNS
G
K
L
E
E
F
V
Q
G
N
L
E
R
E
C
M
E
E
KC
S
F
E
E
A
R
E
V
F
EN
T
E
R
T
T
E
F
W
K
QYVDGDQCESNPCLNGGSCKDDINS
Y
E
C
WCPFGFEGKN
C
E
L
D
V
T
C
NIKN
G
R
C
E
Q
F
C
KNSAD
N
K
V
V
C
SCTEG
Y
R
LAENQKSCEPAVPFPCGRVS
V
S
QTSKLTRAETVFPDVDYVNST
E
A
E
T
I
L
D
N
I
T
Q
S
T
Q
S
F
N
D
F
T
R
V
VGGEDAKPGQF
P
W
Q
V
V
L--NG--KV
D
A
FCGGSIVNE
K
W
I
V
T
A
A
H
C
V
E--------T---G---
V
K
I
T
V
V
AGEHNIE
E
T
E
-
H
T
E
Q
KR
N
V
I
R
I
IPHHNYN
A
A
INKYNH
D
I
A
L
L
ELDE
P
L
V
LNSYVT
P
I
C
IADKE
Y
T
-
N
I
-
F
L
K
-FGSG
Y
V
S
G
W
G
R
V
F
HK
G
-
R
-
S
A
L
V
L
Q
Y
L
RVPLV
D
R
A
T
C
LRS
T
K
-
F
-----
T
I
YN
N
M
F
C
AGFHE---GGRDSCQGDSGGP
H
V
T
EV--E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
AMKGKY
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
TKLT
5
PsiBlast_PDB
94.87
99%
-108
- C1 -
2WPI
1
?
S:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
Y
N
A
A
I
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
3
PsiBlast_PDB
94.75
100%
-106
- C1 -
3LC5
1
?
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
Y
N
A
A
I
N
K
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
Y
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
9
PsiBlast_PDB
94.29
98%
-108
- C1 -
2WPL
1
?
S:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
A
A
I
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
7
PsiBlast_PDB
94.20
98%
-106
- C1 -
2WPJ
1
?
S:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
A
A
I
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
10
PsiBlast_PDB
94.09
98%
-104
- C1 -
2WPM
1
?
S:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
A
A
I
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
A
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
34
HHSearch
93.59
99%
-108
- C1 -
2WPH
3
?
S:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
A
A
I
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
8
PsiBlast_PDB
93.30
98%
-106
- C1 -
2WPK
2
?
S:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
A
A
I
N
T
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
2
PsiBlast_PDB
92.81
100%
-107
- C1 -
3LC3
2
?
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
Y
N
A
A
I
N
K
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
Y
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
1
PsiBlast_PDB
92.31
100%
-107
- C1 -
1RFN
2
FA9_HUMAN
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
Y
N
A
A
I
N
K
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
Y
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
21
PsiBlast_CBE
90.30
100%
-104
- C1 -
3LC3
2
?
C:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
--
N
G
--
K
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
--------
T
---
G
---
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
-
H
T
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
Y
N
A
A
I
N
K
Y
N
H
D
I
A
L
L
E
L
D
E
P
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
Y
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
11
PsiBlast_PDB
87.18
88%
-103
- C1 -
1PFX
1
FA9_PIG
C:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
E
N
A
K
P
G
Q
F
P
W
Q
V
L
L
--
N
G
--
K
I
D
A
F
C
G
G
S
I
I
N
E
K
W
V
V
T
A
A
H
C
I
E
--------
P
---
G
---
V
K
I
T
V
V
A
G
E
Y
N
T
E
E
T
E
-
P
T
E
Q
R
R
N
V
I
R
A
I
P
H
H
S
Y
N
A
T
V
N
K
Y
S
H
D
I
A
L
L
E
L
D
E
P
L
T
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
N
R
G
-
R
-
S
A
T
I
L
Q
Y
L
K
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
Y
S
N
M
F
C
A
G
F
H
E
---
G
G
K
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
V
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
12
PsiBlast_PDB
85.30
88%
-102
- C1 -
1X7A
1
?
C:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
E
N
A
K
P
G
Q
F
P
W
Q
V
L
L
--
N
G
--
K
I
D
A
F
C
G
G
S
I
I
N
E
K
W
V
V
T
A
A
H
C
I
E
--------
P
---
G
---
V
K
I
T
V
V
A
G
E
Y
N
T
E
E
T
E
-
P
T
E
Q
R
R
N
V
I
R
A
I
P
H
H
S
Y
N
A
T
V
N
K
Y
S
H
D
I
A
L
L
E
L
D
E
P
L
T
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
T
-
N
I
-
F
L
K
-
F
G
S
G
Y
V
S
G
W
G
R
V
F
N
R
G
-
R
-
S
A
T
I
L
Q
Y
L
K
V
P
L
V
D
R
A
T
C
L
R
S
T
K
-
F
-----
T
I
Y
S
N
M
F
C
A
G
F
H
E
---
G
G
K
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
V
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
T
19
PsiBlast_PDB
75.27
43%
-99
- C1 -
1F0R
1
A:
[1-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
-
N
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
---
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
-
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
-
R
-
Q
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--
18
PsiBlast_PDB
74.84
43%
-102
- C1 -
1EZQ
1
?
A:
[1-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
-
N
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
---
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
-
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
-
R
-
Q
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--
20
PsiBlast_PDB
73.98
43%
-97
- C1 -
1F0S
1
?
A:
[1-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
-
N
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
---
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
-
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
-
R
-
Q
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--
15
PsiBlast_PDB
72.36
43%
-94
- C1 -
2BQ7
1
?
B:
[16-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
-
N
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
---
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
-
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
-
R
-
Q
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--
37
HHSearch
71.59
41%
-98
- C1 -
4JZE
4
?
H:
[1-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
--
L
V
--
N
G
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
D
--------
K
---
I
KNW
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
-
G
D
E
Q
S
R
R
V
A
Q
V
I
I
P
S
T
Y
V
P
G
T
--
T
N
H
D
I
A
L
L
R
L
H
Q
P
V
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
S
-
E
R
T
L
A
F
-
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
R
G
-
A
-
T
A
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
R
-
K
VGDSP
N
I
T
E
Y
M
F
C
A
G
Y
S
D
---
G
S
K
D
S
C
K
G
D
S
G
G
P
H
A
T
H
Y
--
R
G
T
W
Y
L
T
G
I
V
S
W
G
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
-
16
PsiBlast_PDB
71.28
43%
-96
- C1 -
2BQW
1
?
B:
[16-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
-
N
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
---
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
-
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
-
R
-
Q
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--
14
PsiBlast_PDB
70.08
43%
-92
- C1 -
2BQ6
1
?
B:
[16-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
C
K
D
G
E
C
P
W
Q
A
L
L
I
-
N
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
---
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
K
--
E
T
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
C
L
P
E
R
D
W
A
E
S
T
-
L
M
T
-
Q
K
T
G
I
V
S
G
F
G
R
T
H
E
K
G
-
R
-
Q
S
T
R
L
K
M
L
E
V
P
Y
V
D
R
N
S
C
K
L
S
S
S
-
F
-----
I
I
T
Q
N
M
F
C
A
G
Y
D
T
---
K
Q
E
D
A
C
Q
G
D
S
G
G
P
H
V
T
R
F
--
K
D
T
Y
F
V
T
G
I
V
S
W
G
E
G
C
A
R
K
G
K
Y
G
I
Y
T
K
V
T
A
F
L
K
W
I
D
R
S
M
K
--
53
HHSearch
70.05
38%
-95
- C1 -
3BG8
1
A:
[1-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
-
T
T
SP
T
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
--------
G
VES
P
---
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
-
E
D
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
E
R
----
N
V
I
-
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
R
D
-
K
-
I
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
R
G
H
-----
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
--
45
HHSearch
69.21
38%
-93
- C1 -
3RM2
5
?
H:
[1-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
FR
K
S
--
P
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
YPPWDKNF
T
---
E
---
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R
-
E
N
L
D
R
D
I
A
L
M
K
L
K
K
P
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
A
-
A
S
-
L
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
T
---G
Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
R
-
I
-----
R
I
T
D
N
M
F
C
A
G
Y
K
P
DEG
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
--
50
HHSearch
67.64
42%
-92
- C1 -
1FXY
2
TRY1_HUMAN
A:
[1-225]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Y
N
C
K
D
G
E
V
P
W
Q
A
L
L
I
-
N
E
--
E
N
E
G
F
C
G
G
T
I
L
S
E
F
Y
I
L
T
A
A
H
C
L
Y
--------
Q
---
A
---
K
R
F
K
V
R
V
G
D
R
N
T
E
Q
E
E
-
G
G
E
A
V
H
E
V
E
V
V
I
K
H
N
R
F
T
K
E
T
--
Y
D
F
D
I
A
V
L
R
L
K
T
P
I
T
F
R
M
N
V
A
P
A
S
L
P
T
A
P
P
------
A
T
-
G
T
K
C
L
I
S
G
W
G
N
T
A
S
S
G
A
D
-
Y
P
D
E
L
Q
C
L
D
A
P
V
L
S
Q
A
K
C
E
A
S
Y
P
-
G
-----
K
I
T
S
N
M
F
C
V
G
F
L
E
---
G
G
K
D
S
C
Q
G
D
S
G
G
P
V
V
C
----
N
G
--
Q
L
Q
G
V
V
S
W
G
D
G
C
A
Q
K
N
K
P
G
V
Y
T
K
V
Y
N
Y
V
K
W
I
K
N
T
I
A
--