@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_KLKB1_: (2014-08-23 )
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410..--.....420.......430......-----.440.......450.......460........470.....--..--480.......490----.......500.......---510--.........520.....-----.----.-530.-........540.......550-..--------.....560......---.570.......580....--...590.......600.......610.......620.......630......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
L
F
KQ
A
T
Y
F
I
S
L
F
A
T
V
S
C
G
C
L
T
Q
L
Y
E
N
A
FFRGG
D
V
A
S
MYTPNA
Q
Y
C
Q
M
R
C
TFH
P
R
C
L
L
F
SFLPASS
I
N
D
M
E
K
R
F
G
C
F
L
K
DSVTGTLPKVHRTGAVSGH
S
L
K
Q
C
G
H
Q
I
S
A
C
H
R
D
I
Y
KGVDMRGVNF
N
V
S
K
V
S
S
V
E
E
C
Q
K
RCTNNI
R
C
Q
F
F
S
Y
A
T
Q
T
F
H
K
A
E
YRN
N
C
L
L
K
YSPGGT
P
T
A
I
K
V
L
S
N
V
ESGFSLKP
C
A
L
S
EIG
C
H
M
N
I
F
Q
H
L
AFSDV
D
V
A
R
VLTP
D
A
F
V
C
R
T
I
C
TYHP
N
C
L
F
F
T
F
YT
N
V
W
K
IESQR
N
V
C
L
L
KTSESGTPSSSTPQENTIS
G
Y
S
L
L
T
CKRTLPEPCHSKIYPGVDFGGE
E
L
N
V
T
F
V
K
G
V
N
V
C
Q
E
T
C
T
K
M
I
R
C
Q
F
F
T
YSLL
P
E
D
C
K
E
E
K
C
K
C
F
L
R
LSMDGSP
T
R
I
A
YGTQGSS
G
Y
S
L
R
L
CNTGDN
S
V
C
TTKT
S
T
R
I
VGGTNSSWGEW
P
W
Q
V
S
L
Q
V
K
L
T
A
--QRHLCGGSLIG
H
Q
W
V
L
T
A
A
H
CFDG-----L
P
L
Q
D
V
W
R
I
Y
S
G
I
L
N
L
S
D
ITKD-T
P
F
S
Q
I
K
E
I
I
IHQN
Y
K
V--SE--GNH
D
I
A
L
I
K
L
QAP----L
N
Y
T
E
FQKPICLPSKGD---T----
S
T
I
Y
T
N
C
W
V
TGWGFSKE-----K----
G
-
E
--
I
-
Q
N
I
L
Q
KVNIPLVT
N
E
E
C
Q
K
R
Y
-
Q
D
--------
Y
K
I
T
Q
R
M
V
CAGYKE---GGKDACKGDSG
G
P
L
V
C
KH--NG
M
W
R
L
V
G
ITSW
G
E
G
CARREQP
G
V
Y
T
K
V
A
E
Y
M
D
W
I
L
E
KTQSSDGKAQMQSPA
11
PsiBlast_PDB
64.88
67%
-103
- C2 -
3BG8
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
E
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
7
PsiBlast_PDB
64.59
67%
-99
- C2 -
1ZSL
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
4
PsiBlast_PDB
64.43
67%
-100
- C2 -
1ZHM
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
C
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
9
PsiBlast_PDB
64.05
67%
-100
- C2 -
3SOR
2
A:
[1-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
------------
18
PsiBlast_PDB
63.76
66%
-96
- C2 -
1ZMJ
2
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
15
PsiBlast_PDB
63.72
66%
-99
- C2 -
1ZPB
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
19
PsiBlast_PDB
63.69
66%
-98
- C2 -
1ZML
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
20
PsiBlast_PDB
63.66
66%
-97
- C2 -
1ZMN
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
13
PsiBlast_PDB
63.65
66%
-96
- C2 -
1ZLR
2
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
16
PsiBlast_PDB
63.59
66%
-97
- C2 -
1ZPC
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
2
PsiBlast_PDB
63.58
67%
-96
- C2 -
4NA8
3
?
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
C
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
10
PsiBlast_PDB
63.54
67%
-98
- C2 -
3SOS
3
A:
[1-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
------------
17
PsiBlast_PDB
63.37
66%
-99
- C2 -
2FDA
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
14
PsiBlast_PDB
63.31
66%
-98
- C2 -
1ZHR
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
1
PsiBlast_PDB
63.30
67%
-97
- C2 -
4NA7
1
?
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
K
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
C
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
6
PsiBlast_PDB
63.28
67%
-95
- C2 -
1ZRK
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
12
PsiBlast_PDB
62.45
66%
-95
- C2 -
1ZHP
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
A
E
I
K
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
A
D
S
Q
R
P
I
C
L
P
S
K
G
D
---
R
----
N
V
I
Y
T
D
C
W
V
T
G
W
G
Y
R
A
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
5
PsiBlast_PDB
61.43
67%
-89
- C2 -
1ZPZ
1
A:
[1-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
T
T
S
P
T
--
Q
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
F
Y
G
-----
V
E
S
P
K
I
L
R
V
Y
S
G
I
L
N
Q
S
E
I
A
E
D
-
T
S
F
F
G
V
Q
E
I
I
I
H
D
Q
Y
K
M
--
A
E
--
S
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
S
L
P
S
K
G
D
---
R
--------
T
D
C
W
V
T
G
W
G
Y
R
K
L
-----
R
----
D
-
K
--
I
-
Q
N
T
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
Y
-
R
G
--------
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
---
G
G
K
D
A
C
K
G
D
S
G
G
P
L
S
C
K
H
--
N
E
V
W
H
L
V
G
I
T
S
W
G
E
G
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
A
-----------
39
HHSearch
55.57
39%
-88
- C2 -
4JZE
4
?
H:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
V
N
-----
G
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
F
D
K
-----
I
K
N
W
R
N
L
I
A
V
L
G
E
H
D
L
S
E
H
D
G
D
-
E
Q
S
R
R
V
A
Q
V
I
I
P
S
T
Y
V
P
--
G
T
--
T
N
H
D
I
A
L
L
R
L
H
Q
P
----
V
V
L
T
D
H
V
V
P
L
C
L
P
E
R
T
F
SER
T
----
L
A
F
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
-----
R
----
G
-
A
--
T
-
A
L
E
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
-
R
K
VGDS----
P
N
I
T
E
Y
M
F
C
A
G
Y
S
D
---
G
S
K
D
S
C
K
G
D
S
G
G
P
H
A
T
H
Y
--
R
G
T
W
Y
L
T
G
I
V
S
W
G
Q
G
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
S
E
P
R
P
-------
46
HHSearch
54.08
40%
-84
- C2 -
2F9N
4
TRYB1_HUMAN
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
A
P
R
S
K
W
P
W
Q
V
S
L
R
V
R
D
R
Y
--
W
M
H
F
C
G
G
S
L
I
H
P
Q
W
V
L
T
A
A
H
C
V
G
P
D----
V
K
D
L
A
T
L
R
V
Q
L
R
E
Q
H
L
Y
Y
---
Q
-
D
Q
L
L
P
V
S
R
I
I
V
H
P
Q
F
Y
I
--
I
Q
--
T
G
A
D
I
A
L
L
E
L
E
E
P
----
V
N
I
S
S
R
V
H
T
V
M
L
P
P
A
S
E
---
T
----
F
P
P
G
M
P
C
W
V
T
G
W
G
D
V
D
N
-----
D
----
E
-
P
LP
P
-
P
F
P
L
K
Q
V
K
V
P
I
M
E
N
H
I
C
D
A
K
Y
-
H
L
GAYTGDDV
R
I
I
R
D
D
M
L
C
A
G
N
S
Q
-----
R
D
S
C
Q
G
D
S
G
G
P
L
V
C
K
V
--
N
G
T
W
L
Q
A
G
V
V
S
W
G
E
G
C
A
Q
P
N
R
P
G
I
Y
T
R
V
T
Y
Y
L
D
W
I
H
H
Y
V
P
K
-----------
47
HHSearch
54.05
40%
-81
- C2 -
2WPH
3
?
S:
[1-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
N
G
K
-----
V
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
V
E
T
--------
G
V
K
I
T
V
V
A
G
E
H
N
I
E
E
T
E
H
T
-
E
Q
K
R
N
V
I
R
I
I
P
H
H
N
F
N
A
AI
N
T
--
Y
N
H
D
I
A
L
L
E
L
D
E
P
----
L
V
L
N
S
Y
V
T
P
I
C
I
A
D
K
E
Y
---
T
NIF-
L
K
F
G
S
-
G
Y
V
S
G
W
G
R
V
F
H
-----
K
----
G
-
R
--
S
-
A
L
V
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
T
-
K
---------
F
T
I
T
N
N
M
F
C
A
G
F
H
E
---
G
G
R
D
S
C
Q
G
D
S
G
G
P
H
V
T
E
V
--
E
G
T
S
F
L
T
G
I
I
S
W
G
E
E
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
-----------
41
HHSearch
52.65
41%
-82
- C2 -
2OQ5
1
TM11E_HUMAN
A:
[1-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
E
V
E
E
G
E
W
P
W
Q
A
S
L
Q
W
D
-----
G
S
H
R
C
G
A
T
L
I
N
A
T
W
L
V
S
A
A
H
C
F
T
T
-----
Y
K
N
P
A
R
W
T
A
S
F
G
V
T
I
K
----
P
S
-
K
M
K
R
G
L
R
R
I
I
V
H
E
K
Y
K
H
--
P
S
--
H
D
Y
D
I
S
L
A
E
L
S
S
P
----
V
P
Y
T
N
A
V
H
R
V
C
L
P
D
A
S
Y
---
E
----
F
Q
P
G
D
V
M
F
V
T
G
F
G
A
L
K
N
-----
D
----
G
-
Y
--
S
-
Q
N
H
L
R
Q
A
Q
V
T
L
I
D
A
T
T
C
N
E
P
Q
A
Y
N
--------
D
A
I
T
P
R
M
L
C
A
G
S
L
E
---
G
K
T
D
A
C
Q
G
D
S
G
G
P
L
V
S
S
D
A-
R
D
I
W
Y
L
A
G
I
V
S
W
G
D
E
C
A
K
P
N
K
P
G
V
Y
T
R
V
T
A
L
R
D
W
I
T
S
K
T
G
------------
48
HHSearch
52.32
33%
-86
- C2 -
3MHW
1
?
U:
[1-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
R
R
H
R
G
GS
V
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
F
I
D
-----
Y
P
K
K
E
D
Y
I
V
Y
L
G
R
S
R
L
N
S
N
T
Q
G
-
E
M
K
F
E
V
E
N
L
I
L
H
K
D
Y
S
A
--
D
-LA
H
H
N
D
I
A
L
L
K
I
R
S
K
EGRC
A
Q
P
S
R
T
I
Q
T
I
S
L
P
S
M
Y
N
---
D
----
P
Q
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
-----
T
----
D
Y
L
--
Y
-
P
E
Q
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
Y
Y
G
--------
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
---
W
K
T
D
S
C
Q
G
D
S
G
G
P
L
V
C
S
L
--
Q
G
R
M
T
L
T
G
I
V
S
W
G
R
G
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
------------
59
HHSearch
51.59
37%
-77
- C2 -
1AUT
1
PROC_HUMAN
C:
[1-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
G
K
M
T
R
R
G
D
S
P
W
Q
V
V
L
L
D
--
S
K
--
K
K
L
A
C
G
A
V
L
I
H
P
S
W
V
L
T
A
A
H
C
M
D
E
--------
S
K
K
L
L
V
R
L
G
E
Y
D
L
R
R
W
E
K
W
-
E
L
D
L
D
I
K
E
V
F
V
H
P
N
Y
S
K
--
S
T
--
T
D
N
D
I
A
L
L
H
L
A
Q
P
----
A
T
L
S
Q
T
I
V
P
I
C
L
P
D
S
G
L
---
A
EREL
N
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
REKEA
K
----
R
-
N
--
R
-
T
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
-
S
N
---------
M
V
S
E
N
M
L
C
A
G
I
L
G
---
D
R
Q
D
A
C
E
G
D
S
G
G
P
M
V
A
S
F
--
H
G
T
W
F
L
V
G
L
V
S
W
G
E
G
C
G
L
L
H
N
Y
G
V
Y
T
K
V
S
R
Y
L
D
W
I
H
G
H
I
R
D
-----------
37
HHSearch
49.16
39%
-67
- C2 -
3NXP
5
THRB_HUMAN
A:
[162-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
G
R
I
V
E
G
S
D
A
E
I
G
M
S
P
W
Q
V
M
L
F
R
K
S
P
---
Q
E
L
L
C
G
A
S
L
I
S
D
R
W
V
L
T
A
A
H
C
L
L
Y
PPWD
K
N
F
T
E
N
D
L
L
V
R
I
G
K
H
S
R
T
R
Y
E
R
N
I
E
K
I
S
M
L
E
K
I
Y
I
H
P
R
Y
N
W
R-
E
N
--
L
D
R
D
I
A
L
M
K
L
K
K
P
----
V
A
F
S
D
Y
I
H
P
V
C
L
P
D
R
E
T
---
A
A
S
L
-
L
Q
A
G
Y
K
G
R
V
T
G
W
G
N
L
K
E
-----
T
W
T
A
N------Q
P
S
V
L
Q
V
V
N
L
P
I
V
E
R
P
V
C
K
D
S
T
-
R
---------
I
R
I
T
D
N
M
F
C
A
G
Y
K
P
DEG
K
R
G
D
A
C
E
G
D
S
G
G
P
F
V
M
K
S
PF
N
N
R
W
Y
Q
M
G
I
V
S
W
G
E
G
C
D
R
D
G
K
Y
G
F
Y
T
H
V
F
R
L
K
K
W
I
Q
K
V
I
D
Q
F
----------