@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00089_TM11D_: (2014-08-23 )
MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......---170.......180.......190.......200...-.----.-----.----.210.......220......-.--230-----.......240..----..----.---------..---------250.-..-.....260..------..--..---.--270.......280---........290..---....---.300........310......-.-320.--------......330.......340-------..---.-.....350.......360........370.-...-.---..380.......390..-.......400.......410......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYRPARVT
S
T
S
RFL
N
P
Y
V
V
C
F
I
V
V
A
G
V
V
I
L
A
V
T
I
A
L
L
V
Y
F
L
A
FDQKS
Y
F
Y
RS
S
F
Q
L
L
N
V
E
YNSQLNSP
A
T
Q
E
Y
R
T
L
S
G
R
I
E
S
L
I
T
K
T
F
K
ES
N
L
R
N
Q
F
I
R
A
H
V
A
K
L
RQDGSG
V
R
A
D
V
V
M
K
F
Q
F
TRNNNG
A
S
M
K
S
R
I
E
S
V
L
R
Q
M
LNNSG
N
L
E
INPSTE
I
T
S
L
T
D
Q
A
A
A
N
W
L
---
I
N
ECGAGP
D
L
I
T
LSEQRILGGTEAEEGSW
P
W
Q
V
S
L
R
-L----N-----N----AHHC
G
G
S
L
I
N
N
M
W
I
L
T
A
A
H
C
-F--RSN-----SNPR
D
W
I
ATSGI----ST----
T
---------
F
P
---------
K
-
L
R
-
M
R
-
V
R
N
I
L
I
HNNY------KS--AT---H--EN
D
I
A
L
V
R
LENS----
V
T
F
T
K
D
I
H
S
V
CL
P
---
A
ATQ---NIP-PGS
T
A
Y
V
T
GWG
A
Q
EYAG-H-T
V
P
E
--------LRQG
Q
V
R
I
I
SNDVCNAPH--------SY---
N
-
G
A
I
L
S
G
M
L
CAGVPQGG-VDACQGDSGGPLV-QED-S---
R
R
L
W
F
I
V
G
IVSWG--DQ-CGLPDKPG
V
Y
T
R
V
T
A
Y
L
D
W
I
R
Q
QTGI-
30
HHSearch
87.61
50%
-110
- C2 -
2OQ5
1
TM11E_HUMAN
A:
[1-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
E
V
E
E
G
E
W
P
W
Q
A
S
L
Q
-
W
----
D
-----
G
----
S
H
R
C
G
A
T
L
I
N
A
T
W
L
V
S
A
A
H
C
-
F
--
T
T
Y
-----
K
N
P
A
R
W
T
A
S
F
G
V
----
T
I
----
K
---------
P
S
---------
K
-
M
K
-
R
G
-
L
R
R
I
I
V
H
E
K
Y
------
K
H
--
P
S
---
H
--
D
Y
D
I
S
L
A
E
L
S
S
P
----
V
P
Y
T
N
A
V
H
R
V
C
L
P
---
D
A
S
Y
---
E
F
Q
-
P
G
D
V
M
F
V
T
G
F
G
A
L
K
N
D
G
-
Y
-
S
Q
N
H
--------
L
R
Q
A
Q
V
T
L
I
D
A
T
T
C
N
E
P
Q
--------
A
Y
---
N
-
D
A
I
T
P
R
M
L
C
A
G
S
L
E
G
K
-
T
D
A
C
Q
G
D
S
G
G
P
L
V
-
S
S
D
-
A
---
R
D
I
W
Y
L
A
G
I
V
S
W
G
--
D
E
-
C
A
K
P
N
K
P
G
V
Y
T
R
V
T
A
L
R
D
W
I
T
S
K
T
G
I
-
5
PsiBlast_PDB
83.41
46%
-112
- C2 -
1O5F
1
?
H:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
R
D
T
S
L
G
R
W
P
W
Q
V
S
L
R
-
Y
----
D
-----
G
----
A
H
L
C
G
G
S
L
L
S
G
D
W
V
L
T
A
A
H
C
-
F
PE
R
N
R
-----
V
L
S
R
W
R
V
F
A
G
A
V
----
A
Q
----
A
---------
S
P
---------
H
G
L
Q
-
L
G
-
V
Q
A
V
V
Y
H
G
G
Y
LPF------------
N
--
S
N
D
I
A
L
V
H
L
S
S
P
----
L
P
L
T
E
Y
I
Q
P
V
C
L
P
---
A
A
G
Q
---
A
L
V
-
D
G
K
I
C
T
V
T
G
W
G
N
T
Q
Y
Y
G
-
Q
-
Q
A
G
V
--------
L
Q
E
A
R
V
P
I
I
S
N
D
V
C
N
G
A
D
--------
F
Y
---
G
-
N
Q
I
K
P
K
M
F
C
A
G
Y
P
E
G
G
-
I
D
A
C
Q
G
D
S
G
G
P
F
V
-
C
E
D
-
S
ISR
T
P
R
W
R
L
C
G
I
V
S
W
G
--
T
G
-
C
A
L
A
Q
K
P
G
V
Y
T
K
V
S
D
F
R
E
W
I
F
Q
-----
2
PsiBlast_PDB
83.12
43%
-111
- C2 -
1Z8G
2
?
A:
[88-357]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
S
V
C
D
C
P
R
G
R
F
L
A
A
I
C
Q
D
C
G
R
----
R
K
L
P
---
I
V
G
G
R
D
T
S
L
G
R
W
P
W
Q
V
S
L
R
-
Y
----
D
-----
G
----
A
H
L
C
G
G
S
L
L
S
G
D
W
V
L
T
A
A
H
C
-
F
PE
R
N
R
-----
V
L
S
R
W
R
V
F
A
G
A
V
----
A
Q
----
A
---------
S
P
---------
H
G
L
Q
-
L
G
-
V
Q
A
V
V
Y
H
G
G
Y
LPFRDP
N
S
--
E
E
---
N
--
S
N
D
I
A
L
V
H
L
S
S
P
----
L
P
L
T
E
Y
I
Q
P
V
C
L
P
---
A
A
G
Q
---
A
L
V
-
D
G
K
I
C
T
V
T
G
W
G
N
T
Q
Y
Y
G
-
Q
-
Q
A
G
V
--------
L
Q
E
A
R
V
P
I
I
S
N
D
V
C
N
G
A
D
--------
F
Y
---
G
-
N
Q
I
K
P
K
M
F
C
A
G
Y
P
E
G
G
-
I
D
A
C
Q
G
D
S
G
G
P
F
V
-
C
E
D
-
S
ISR
T
P
R
W
R
L
C
G
I
V
S
W
G
--
T
G
-
C
A
L
A
Q
K
P
G
V
Y
T
K
V
S
D
F
R
E
W
I
F
Q
-----
6
PsiBlast_PDB
81.17
46%
-113
- C2 -
1P57
1
?
B:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
R
D
T
S
L
G
R
W
P
W
Q
V
S
L
R
-
Y
----
D
-----
G
----
A
H
L
C
G
G
S
L
L
S
G
D
W
V
L
T
A
A
H
C
-
F
PE
R
N
R
-----
V
L
S
R
W
R
V
F
A
G
A
V
----
A
Q
----
A
---------
S
P
---------
H
G
L
Q
-
L
G
-
V
Q
A
V
V
Y
H
G
G
Y
LPF------------
N
--
S
N
D
I
A
L
V
H
L
S
S
P
----
L
P
L
T
E
Y
I
Q
P
V
C
L
P
---
A
A
G
Q
---
A
L
V
-
D
G
K
I
C
T
V
T
G
W
G
N
T
Q
Y
Y
G
-
Q
-
Q
A
G
V
--------
L
Q
E
A
R
V
P
I
I
S
N
D
V
C
N
G
A
D
--------
F
Y
---
G
-
N
Q
I
K
P
K
M
F
C
A
G
Y
P
E
G
G
-
I
D
A
C
Q
G
D
S
G
G
P
F
V
-
C
E
D
-
S
ISR
T
P
R
W
R
L
C
G
I
V
S
W
G
--
T
G
-
C
A
L
A
Q
K
P
G
V
Y
T
K
V
S
D
F
R
E
W
I
F
Q
-----
4
PsiBlast_PDB
80.62
46%
-109
- C2 -
1O5E
1
HEPS_HUMAN
H:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
R
D
T
S
L
G
R
W
P
W
Q
V
S
L
R
-
Y
----
D
-----
G
----
A
H
L
C
G
G
S
L
L
S
G
D
W
V
L
T
A
A
H
C
-
F
PE
R
N
R
-----
V
L
S
R
W
R
V
F
A
G
A
V
----
A
Q
----
A
---------
S
P
---------
H
G
L
Q
-
L
G
-
V
Q
A
V
V
Y
H
G
G
Y
LPF------------
N
--
S
N
D
I
A
L
V
H
L
S
S
P
----
L
P
L
T
E
Y
I
Q
P
V
C
L
P
---
A
A
G
Q
---
A
L
V
-
D
G
K
I
C
T
V
T
G
W
G
N
T
Q
Y
Y
G
-
Q
-
Q
A
G
V
--------
L
Q
E
A
R
V
P
I
I
S
N
D
V
C
N
G
A
D
--------
F
Y
---
G
-
N
Q
I
K
P
K
M
F
C
A
G
Y
P
E
G
G
-
I
D
A
C
Q
G
D
S
G
G
P
F
V
-
C
E
D
-
S
ISR
T
P
R
W
R
L
C
G
I
V
S
W
G
--
T
G
-
C
A
L
A
Q
K
P
G
V
Y
T
K
V
S
D
F
R
E
W
I
F
Q
-----
14
PsiBlast_PDB
80.13
39%
-107
- C2 -
3P8F
1
A:
[1-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
T
D
A
D
E
G
E
W
P
W
Q
V
S
L
H
A
L
----
G
-----
Q
----
G
H
I
C
G
A
S
L
I
S
P
N
W
L
V
S
A
A
H
C
-
Y
--
I
D
D
RGFRY
S
D
P
T
Q
W
T
A
F
L
G
L
----
H
D
QSQR
S
---------
A
P
---------
G
-
V
Q
E
R
R
-
L
K
R
I
I
S
H
P
F
F
------
N
D
--
F
T
---
F
--
D
Y
D
I
A
L
L
E
L
E
K
P
----
A
E
Y
S
S
M
V
R
P
I
C
L
P
---
D
A
S
H
---
V
F
P
-
A
G
K
A
I
W
V
T
G
W
G
H
T
Q
Y
G
G
-
T
-
G
A
L
I
--------
L
Q
K
G
E
I
R
V
I
Q
Q
T
T
C
E
--
N
--------
L
L
---
P
-
Q
Q
I
T
P
R
M
M
C
V
G
F
L
S
G
G
-
V
D
S
C
Q
G
D
S
G
G
P
L
S
-
S
V
E
-
A
---
D
G
R
I
F
Q
A
G
V
V
S
W
G
--
D
G
-
C
A
Q
R
N
K
P
G
V
Y
T
R
L
P
L
F
R
D
W
I
K
E
N
T
G
V
-
11
PsiBlast_PDB
80.08
39%
-104
- C2 -
4JZ1
1
?
A:
[1-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
T
D
A
D
E
G
E
W
P
W
Q
V
S
L
H
A
L
----
G
-----
Q
----
G
H
I
C
G
A
S
L
I
S
P
N
W
L
V
S
A
A
H
C
-
Y
--
I
D
D
RGFRY
S
D
P
T
Q
W
T
A
F
L
G
L
----
H
D
QSQR
S
---------
A
P
---------
G
-
V
Q
E
R
R
-
L
K
R
I
I
S
H
P
F
F
------
N
D
--
F
T
---
F
--
D
Y
D
I
A
L
L
E
L
E
K
P
----
A
E
Y
S
S
M
V
R
P
I
C
L
P
---
D
A
S
H
---
V
F
P
-
A
G
K
A
I
W
V
T
G
W
G
H
T
Q
Y
G
G
-
T
-
G
A
L
I
--------
L
Q
K
G
E
I
R
V
I
N
Q
T
T
C
E
--
N
--------
L
L
---
P
-
Q
Q
I
T
P
R
M
M
C
V
G
F
L
S
G
G
-
V
D
S
C
Q
G
D
S
G
G
P
L
S
-
S
V
E
-
A
---
D
G
R
I
F
Q
A
G
V
V
S
W
G
--
D
G
-
C
A
Q
R
N
K
P
G
V
Y
T
R
L
P
L
F
R
D
W
I
K
E
N
T
G
V
-
51
HHSearch
79.95
43%
-102
- C2 -
1FIW
4
ACRO_SHEEP
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
Q
D
A
A
H
G
A
W
P
W
M
V
S
L
Q
-
I
F
TYH
N
-----
N
R
R
--
Y
H
V
C
G
G
S
L
L
N
S
Q
W
L
L
T
A
A
H
C
-
F
--
R
I
K
-----
K
K
V
T
D
W
R
L
I
F
G
A
----
K
E
----
V
E
W
GTN
K
P
V
K
P
P
---------
L
-
Q
E
-
R
Y
-
V
E
K
I
I
I
H
E
K
Y
------
S
A
--
S
S
---
E
--
A
N
D
I
A
L
M
K
I
T
P
P
----
V
T
C
G
H
F
I
G
P
G
C
L
P
---
Q
F
R
A
---
G
P
P
R
V
P
Q
T
C
W
V
A
G
W
G
F
L
Q
E
N
A
-
R
R
T
S
P
M
--------
L
Q
E
A
R
V
D
L
I
D
L
G
L
C
N
S
T
R
--------
W
Y
---
N
-
G
R
I
R
S
T
N
V
C
A
G
Y
P
E
G
K
-
I
D
T
C
Q
G
D
S
G
G
P
L
M
-
C
K
D
S
A
---
E
N
S
Y
V
V
V
G
I
T
S
W
G
--
V
G
-
C
A
R
A
K
R
P
G
V
Y
T
S
T
W
S
Y
L
N
W
I
A
S
K
I
G
--
8
PsiBlast_PDB
79.78
39%
-105
- C2 -
1EAX
1
A:
[1-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
T
D
A
D
E
G
E
W
P
W
Q
V
S
L
H
A
L
----
G
-----
Q
----
G
H
I
C
G
A
S
L
I
S
P
N
W
L
V
S
A
A
H
C
-
Y
--
I
D
D
RGFRY
S
D
P
T
Q
W
T
A
F
L
G
L
----
H
D
QSQR
S
---------
A
P
---------
G
-
V
Q
E
R
R
-
L
K
R
I
I
S
H
P
F
F
------
N
D
--
F
T
---
F
--
D
Y
D
I
A
L
L
E
L
E
K
P
----
A
E
Y
S
S
M
V
R
P
I
C
L
P
---
D
A
S
H
---
V
F
P
-
A
G
K
A
I
W
V
T
G
W
G
H
T
Q
Y
G
G
-
T
-
G
A
L
I
--------
L
Q
K
G
E
I
R
V
I
N
Q
T
T
C
E
--
N
--------
L
L
---
P
-
Q
Q
I
T
P
R
M
M
C
V
G
F
L
S
G
G
-
V
D
S
C
Q
G
D
S
G
G
P
L
S
-
S
V
E
-
A
---
D
G
R
I
F
Q
A
G
V
V
S
W
G
--
D
G
-
C
A
Q
R
N
K
P
G
V
Y
T
R
L
P
L
F
R
D
W
I
K
E
N
T
G
V
-
10
PsiBlast_PDB
79.33
39%
-107
- C2 -
2GV7
1
A:
[1-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
T
D
A
D
E
G
E
W
P
W
Q
V
S
L
H
A
L
----
G
-----
Q
----
G
H
I
C
G
A
S
L
I
S
P
N
W
L
V
S
A
A
H
C
-
Y
--
I
D
D
RGFRY
S
D
P
T
Q
W
T
A
F
L
G
L
----
H
D
QSQR
S
---------
A
P
---------
G
-
V
Q
E
R
R
-
L
K
R
I
I
S
H
P
F
F
------
N
D
--
F
T
---
F
--
D
Y
D
I
A
L
L
E
L
E
K
P
----
A
E
Y
S
S
M
V
R
P
I
C
L
P
---
D
A
S
H
---
V
F
P
-
A
G
K
A
I
W
V
T
G
W
G
H
T
Q
Y
G
G
-
T
-
G
A
L
I
--------
L
Q
K
G
E
I
R
V
I
N
Q
T
T
C
E
--
N
--------
L
L
---
P
-
Q
Q
I
T
P
R
M
M
C
V
G
F
L
S
G
G
-
V
D
S
C
Q
G
D
S
G
G
P
L
S
-
S
V
E
-
A
---
D
G
R
I
F
Q
A
G
V
V
S
W
G
--
D
G
-
C
A
Q
R
N
K
P
G
V
Y
T
R
L
P
L
F
R
D
W
I
K
E
N
T
G
V
-
12
PsiBlast_PDB
79.21
39%
-106
- C2 -
4JZI
1
?
A:
[1-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
T
D
A
D
E
G
E
W
P
W
Q
V
S
L
H
A
L
----
G
-----
Q
----
G
H
I
C
G
A
S
L
I
S
P
N
W
L
V
S
A
A
H
C
-
Y
--
I
D
D
RGFRY
S
D
P
T
Q
W
T
A
F
L
G
L
----
H
D
QSQR
S
---------
A
P
---------
G
-
V
Q
E
R
R
-
L
K
R
I
I
S
H
P
F
F
------
N
D
--
F
T
---
F
--
D
Y
D
I
A
L
L
E
L
E
K
P
----
A
E
Y
S
S
M
V
R
P
I
C
L
P
---
D
A
S
H
---
V
F
P
-
A
G
K
A
I
W
V
T
G
W
G
H
T
Q
Y
G
G
-
T
-
G
A
L
I
--------
L
Q
K
G
E
I
R
V
I
N
Q
T
T
C
E
--
N
--------
L
L
---
P
-
Q
Q
I
T
P
R
M
M
C
V
G
F
L
S
G
G
-
V
D
S
C
Q
G
D
S
G
G
P
L
S
-
S
V
E
-
A
---
D
G
R
I
F
Q
A
G
V
V
S
W
G
--
D
G
-
C
A
Q
R
N
K
P
G
V
Y
T
R
L
P
L
F
R
D
W
I
K
E
N
T
G
V
-
13
PsiBlast_PDB
78.77
39%
-105
- C2 -
3P8G
5
A:
[1-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
T
D
A
D
E
G
E
W
P
W
Q
V
S
L
H
A
L
----
G
-----
Q
----
G
H
I
C
G
A
S
L
I
S
P
N
W
L
V
S
A
A
H
C
-
Y
--
I
D
D
RGFRY
S
D
P
T
Q
W
T
A
F
L
G
L
----
H
D
QSQR
S
---------
A
P
---------
G
-
V
Q
E
R
R
-
L
K
R
I
I
S
H
P
F
F
------
N
D
--
F
T
---
F
--
D
Y
D
I
A
L
L
E
L
E
K
P
----
A
E
Y
S
S
M
V
R
P
I
C
L
P
---
D
A
S
H
---
V
F
P
-
A
G
K
A
I
W
V
T
G
W
G
H
T
Q
Y
G
G
-
T
-
G
A
L
I
--------
L
Q
K
G
E
I
R
V
I
Q
Q
T
T
C
E
--
N
--------
L
L
---
P
-
Q
Q
I
T
P
R
M
M
C
V
G
F
L
S
G
G
-
V
D
S
C
Q
G
D
S
G
G
P
L
S
-
S
V
E
-
A
---
D
G
R
I
F
Q
A
G
V
V
S
W
G
--
D
G
-
C
A
Q
R
N
K
P
G
V
Y
T
R
L
P
L
F
R
D
W
I
K
E
N
T
G
V
-
17
PsiBlast_PDB
77.63
39%
-105
- C2 -
4IS5
3
A:
[1-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
T
D
A
D
E
G
E
W
P
W
Q
V
S
L
H
A
L
----
G
-----
Q
----
G
H
I
C
G
A
S
L
I
S
P
N
W
L
V
S
A
A
H
C
-
Y
--
I
D
D
RGFRY
S
D
P
T
Q
W
T
A
F
L
G
L
----
H
D
QSQR
S
---------
A
P
---------
G
-
V
Q
E
R
R
-
L
K
R
I
I
S
H
P
F
F
------
N
D
--
F
T
---
F
--
D
Y
D
I
A
L
L
E
L
E
K
P
----
A
E
Y
S
S
M
V
R
P
I
C
L
P
---
D
A
S
H
---
V
F
P
-
A
G
K
A
I
W
V
T
G
W
G
H
T
Q
Y
G
G
-
T
-
G
A
L
I
--------
L
Q
K
G
E
I
R
V
I
Q
Q
T
T
C
E
--
N
--------
L
L
---
P
-
Q
Q
I
T
P
R
M
M
C
V
G
F
L
S
G
G
-
V
D
S
C
Q
G
D
A
G
G
P
L
S
-
S
V
E
-
A
---
D
G
R
I
F
Q
A
G
V
V
S
W
G
--
D
G
-
C
A
Q
R
N
K
P
G
V
Y
T
R
L
P
L
F
R
D
W
I
K
E
N
T
G
V
-
9
PsiBlast_PDB
76.88
39%
-104
- C2 -
2GV6
1
A:
[1-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
T
D
A
D
E
G
E
W
P
W
Q
V
S
L
H
A
L
----
G
-----
Q
----
G
H
I
C
G
A
S
L
I
S
P
N
W
L
V
S
A
A
H
C
-
Y
--
I
D
D
RGFRY
S
D
P
T
Q
W
T
A
F
L
G
L
----
H
D
QSQR
S
---------
A
P
---------
G
-
V
Q
E
R
R
-
L
K
R
I
I
S
H
P
F
F
------
N
D
--
F
T
---
F
--
D
Y
D
I
A
L
L
E
L
E
K
P
----
A
E
Y
S
S
M
V
R
P
I
C
L
P
---
D
A
S
H
---
V
F
P
-
A
G
K
A
I
W
V
T
G
W
G
H
T
Q
Y
G
G
-
T
-
G
A
L
I
--------
L
Q
K
G
E
I
R
V
I
N
Q
T
T
C
E
--
N
--------
L
L
---
P
-
Q
Q
I
T
P
R
M
M
C
V
G
F
L
S
G
G
-
V
D
S
C
Q
G
D
S
G
G
P
L
S
-
S
V
E
-
A
---
D
G
R
I
F
Q
A
G
V
V
S
W
G
--
D
G
-
C
A
Q
R
N
K
P
G
V
Y
T
R
L
P
L
F
R
D
W
I
K
E
N
T
G
V
-
53
HHSearch
74.95
38%
-115
- C2 -
1BRU
1
CEL2A_PIG
P:
[1-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
R
P
N
S
W
P
W
Q
V
S
L
Q
-
Y
----
D
-----
S
SGQW
R
H
T
C
G
G
T
L
V
D
Q
S
W
V
L
T
A
A
H
C
-
I
--
S
--------
S
S
R
T
Y
R
V
V
L
G
R
----
H
S
----
L
STNE-----
P
G
---------
S
-
L
A
-
V
K
-
V
S
K
L
V
V
H
Q
D
W
------
N
S
--
N
Q
---
L
SN
G
N
D
I
A
L
L
K
L
A
S
P
----
V
S
L
T
D
K
I
Q
L
G
C
L
P
---
A
A
G
T
---
I
L
P
-
N
N
Y
V
C
Y
V
T
G
W
G
R
L
Q
T
N
G
-
A
-
S
P
D
I
--------
L
Q
Q
G
Q
L
L
V
V
D
Y
A
T
C
S
K
P
G
--------
W
W
---
G
-
S
T
V
K
T
N
M
I
C
A
G
G
D
-
G
I
-
I
S
S
C
N
G
D
S
G
G
P
L
N
-
C
Q
G
-
A
---
N
G
Q
W
Q
V
H
G
I
V
S
F
G
SS
L
G
-
C
N
Y
Y
H
K
P
S
V
F
T
R
V
S
N
Y
I
D
W
I
N
S
V
I
---
44
HHSearch
74.64
37%
-100
- C2 -
3MHW
1
?
U:
[1-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
G
G
E
F
T
T
I
E
N
Q
P
W
F
A
A
I
Y
-
R
----
R
HRGGS
V
----
T
Y
V
C
G
G
S
L
I
S
P
C
W
V
I
S
A
T
H
C
-
F
--
I
D
Y
-----
P
K
K
E
D
Y
I
V
Y
L
G
R
----
S
R
----
L
NSNT-----
Q
G
---------
E
-
M
K
-
F
E
-
V
E
N
L
I
L
H
K
D
Y
------
S
A
--
D
-LA-
H
--
H
N
D
I
A
L
L
K
I
R
S
K
EGRC
A
Q
P
S
R
T
I
Q
T
I
S
L
P
---
S
M
Y
N
---
D
P
Q
-
F
G
T
S
C
E
I
T
G
F
G
K
E
N
S
T
D
Y
L
-
Y
P
E
Q
--------
L
K
M
T
V
V
K
L
I
S
H
R
E
C
Q
Q
P
H
--------
Y
Y
---
G
-
S
E
V
T
T
K
M
L
C
A
A
D
P
Q
W
K
-
T
D
S
C
Q
G
D
S
G
G
P
L
V
-
C
S
L
-----
Q
G
R
M
T
L
T
G
I
V
S
W
G
--
R
G
-
C
A
L
K
D
K
P
G
V
Y
T
R
V
S
H
F
L
P
W
I
R
S
H
T
K
--
23
Fugue
74.12
45%
-121
- C2 -
1A0L
1
TRYB2_HUMAN
A:
[1-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
Q
E
A
P
R
S
K
W
P
W
Q
V
S
L
R
-
V
----
H
GPY--
W
----
M
H
F
C
G
G
S
L
I
H
P
Q
W
V
L
T
A
A
H
C
-
V
--
G
P
D
-----------
V
K
D
L
A
A
-----
L
----
R
---------
V
Q
L
R
EQHLYYQ
D
-
Q
L
-
L
P
-
V
S
R
I
I
V
H
P
Q
F
------
Y
T
----AQI---
G
A
D
I
A
L
L
E
L
E
--EP--
V
K
V
S
S
H
V
H
T
V
T
L
P
P
AS---
E
---
T
F
P
-
P
G
M
P
C
W
V
T
G
W
G
D
V
D
N
D
--------ERLPPPF
P
L
K
Q
V
K
V
P
I
M
E
N
H
I
C
D
A
-
K
Y
H
LGAYTG
D
D
---
V
-
R
I
V
R
D
D
M
L
C
A
G
N
T
---R
R
D
S
C
Q
G
D
S
G
G
P
L
V
C
K
V
N
------
G
T
W
L
Q
A
G
V
V
S
W
G
--
E
-G
C
A
Q
P
N
R
P
G
I
Y
T
R
V
T
Y
Y
L
D
W
I
H
H
Y
V
P
K
K
7
PsiBlast_PDB
73.64
40%
-105
- C2 -
1EKB
2
?
B:
[1-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
S
D
S
R
E
G
A
W
P
W
V
V
A
L
Y
-
F
----
D
-----
D
----
Q
Q
V
C
G
A
S
L
V
S
R
D
W
L
V
S
A
A
H
C
V
Y
--
G
R
N
-----
M
E
P
S
K
W
K
A
V
L
G
L
HMAS
N
L
----
T
---------
S
P
---------
Q
-
I
E
-
T
R
L
I
D
Q
I
V
I
N
P
H
Y
------
N
K
--
R
R
---
K
--
N
N
D
I
A
M
M
H
L
E
M
K
----
V
N
Y
T
D
Y
I
Q
P
I
C
L
P
---
E
E
N
Q
---
V
F
P
-
P
G
R
I
C
S
I
A
G
W
G
A
L
I
Y
Q
G
-
S
-
T
A
D
V
--------
L
Q
E
A
D
V
P
L
L
S
N
E
K
C
Q
Q
Q
M
P-------
E
Y
---
N
---
I
T
E
N
M
V
C
A
G
Y
E
A
G
G
-
V
D
S
C
Q
G
D
S
G
G
P
L
M
-
C
Q
E
-
N
---
N
R
-
W
L
L
A
G
V
T
S
F
G
--
Y
Q
-
C
A
L
P
N
R
P
G
V
Y
A
R
V
P
R
F
T
E
W
I
Q
------
50
HHSearch
71.54
35%
-102
- C2 -
2WPH
3
?
S:
[1-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
G
G
E
D
A
K
P
G
Q
F
P
W
Q
V
V
L
N
-
G
----
K
-----
V
----
D
A
F
C
G
G
S
I
V
N
E
K
W
I
V
T
A
A
H
C
-
V
--
E
--------
T
G
V
K
I
T
V
V
A
G
E
----
H
N
----
I
EETE-----
H
T
---------
E
-
Q
K
-
R
N
-
V
I
R
I
I
P
H
H
N
F
------
N
A
AI
N
T
---
Y
--
N
H
D
I
A
L
L
E
L
D
E
P
----
L
V
L
N
S
Y
V
T
P
I
C
I
A
---
D
K
E
Y
TNI
F
L
K
-
F
G
S
-
G
Y
V
S
G
W
G
R
V
F
H
K
G
-
R
-
S
A
L
V
--------
L
Q
Y
L
R
V
P
L
V
D
R
A
T
C
L
R
S
----------
T
---
K
-
F
T
I
T
N
N
M
F
C
A
G
F
H
E
G
G
-
R
D
S
C
Q
G
D
S
G
G
P
H
V
-
T
E
V
-----
E
G
T
S
F
L
T
G
I
I
S
W
G
--
E
E
-
C
A
M
K
G
K
Y
G
I
Y
T
K
V
S
R
Y
V
N
W
I
K
E
K
T
K
L
-
45
HHSearch
71.54
37%
-99
- C2 -
4JZE
4
?
H:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
K
V
C
P
K
G
E
C
P
W
Q
V
L
L
L
-
V
----
N
-----
G
----
A
Q
L
C
G
G
T
L
I
N
T
I
W
V
V
S
A
A
H
C
-
F
--
D
K
I
-----
K
N
W
R
N
L
I
A
V
L
G
E
----
H
D
----
L
SEHD-----
G
D
---------
E
-
Q
S
-
R
R
-
V
A
Q
V
I
I
P
S
T
Y
------
V
P
--
G
T
---
T
--
N
H
D
I
A
L
L
R
L
H
Q
P
----
V
V
L
T
D
H
V
V
P
L
C
L
P
---
E
R
T
F
SER
T
L
A
-
F
V
R
F
S
L
V
S
G
W
G
Q
L
L
D
R
G
-
A
-
T
A
L
E
--------
L
M
V
L
N
V
P
R
L
M
T
Q
D
C
L
Q
Q
S
--------
R
K
VGD
S
-
P
N
I
T
E
Y
M
F
C
A
G
Y
S
D
G
S
-
K
D
S
C
K
G
D
S
G
G
P
H
A
-
T
H
Y
-----
R
G
T
W
Y
L
T
G
I
V
S
W
G
--
Q
G
-
C
A
T
V
G
H
F
G
V
Y
T
R
V
S
Q
Y
I
E
W
L
Q
K
L
M
R
--
38
HHSearch
70.11
41%
-98
- C2 -
3BG8
1
A:
[1-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
G
G
T
A
S
V
R
G
E
W
P
W
Q
V
T
L
H
-
T
----
T
SP
T
--
Q
----
R
H
L
C
G
G
S
I
I
G
N
Q
W
I
L
T
A
A
H
C
-
F
--
Y
G
V
-----
E
S
P
K
I
L
R
V
Y
S
G
I
----
L
N
----
Q
SEIK-----
E
D
---------
T
-
S
F
-
F
G
-
V
Q
E
I
I
I
H
D
Q
Y
------
K
M
--
A
E
---
S
--
G
Y
D
I
A
L
L
K
L
E
T
T
----
V
N
Y
T
D
S
Q
R
P
I
S
L
P
---
S
K
G
E
---
R
N
V
-
I
Y
T
D
C
W
V
T
G
W
G
Y
R
K
L
R
D
-
K
-
I
Q
N
T
--------
L
Q
K
A
K
I
P
L
V
T
N
E
E
C
Q
K
R
----------
Y
---
R
G
H
K
I
T
H
K
M
I
C
A
G
Y
R
E
G
G
-
K
D
A
C
K
G
D
S
G
G
P
L
S
-
C
K
H
-----
N
E
V
W
H
L
V
G
I
T
S
W
G
--
E
G
-
C
A
Q
R
E
R
P
G
V
Y
T
N
V
V
E
Y
V
D
W
I
L
E
K
T
Q
--