@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_ERR2_H: (2014-08-25 )
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQEQLRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSPTPLNERGRQISPSTRTPGGQGKHLWLTM
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220....----------...230.......240.......250.......260.......270.......280.......290...--....300.......310-....--...320...-....330.......340.......350......-.360.......370......--.380---.--......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
D
D
R
H
L
G
S
S
C
G
S
FIKTEPSSPSS
G
I
D
A
LSHHSPSGSSDASG
G
F
G
L
A
LGTHANGLDSPP
M
F
AGAGLGGT
P
C
R
K
S
Y
E
D
C
A
S
G
IMEDS
A
I
K
C
E
Y
M
L
N
A
I
P
K
R
L
C
L
V
C
G
D
IASGYHYGVA
S
C
E
A
C
K
A
F
F
K
R
TIQGN
I
E
YSCPAT
N
E
C
E
I
T
K
R
R
R
K
S
C
Q
A
C
R
F
M
K
C
L
K
V
G
M
L
K
EGVR
L
D
R
VRG
G
R
Q
K
Y
K
R
RLDSESS
P
Y
L
S
L
Q
ISPPAKK
P
L
T
K
I
V
S
Y
L
L
VAEPD
K
L
Y
A----------MPPPGMPE
G
D
I
K
A
L
T
T
L
C
D
LADR
E
L
V
V
I
I
GWAKHIPGFSSLSL
G
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
I
V
Y
R
SLPY--DD
K
L
V
Y
A
E
DYIM
D
E
E
H
S
-
R
L
A
G
--
L
L
E
L
Y
R
A
I
L
-
Q
L
V
R
R
Y
K
K
LKV
E
K
E
E
F
V
T
L
K
A
L
A
LANSDS
M
Y
I
E
-
D
L
E
A
V
Q
K
L
Q
D
L
L
H
E
A
L
Q
D
Y
E
--
L
S
Q
R
---H--EEPWRT
G
K
L
L
L
T
L
P
L
L
R
Q
T
A
A
K
A
V
Q
H
F
Y
S
V
K
LQGKV
P
M
H
K
L
F
L
E
M
L
E
A
KV
G
Q
E
Q
LRGSPKDERMSSHDGKCPFQSAAFTSRDQSNSPGIPNPRPSSPTP
L
N
ERGRQISPSTRTPGGQ
G
K
H
L
W
L
TM
13
PsiBlast_PDB
88.76
79%
-133
- C5 -
2P7G
1
ERR3_HUMAN
A:
[28-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
2
PsiBlast_PDB
88.60
77%
-133
- C5 -
2ZAS
2
ERR3_HUMAN
A:
[17-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
---------------------------------------------------------------------------
11
PsiBlast_PDB
88.15
79%
-136
- C5 -
1TFC
1
ERR3_HUMAN
A:
[26-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
---------------------------------------------------------------------------
29
PsiBlast_CBE
88.13
79%
-133
- C5 -
1TFC
1
ERR3_HUMAN
B:
[26-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
----------------------------------------------------------------------------
1
PsiBlast_PDB
87.70
77%
-133
- C5 -
2E2R
4
ERR3_HUMAN
A:
[17-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
---------------------------------------------------------------------------
17
PsiBlast_PDB
87.68
79%
-134
- C5 -
2EWP
1
ERR3_HUMAN
A:
[1-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
12
PsiBlast_PDB
87.61
79%
-133
- C5 -
2P7A
1
ERR3_HUMAN
A:
[27-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
36
PsiBlast_CBE
87.36
79%
-133
- C5 -
2EWP
1
ERR3_HUMAN
B:
[1-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
26
PsiBlast_CBE
87.24
79%
-133
- C5 -
2GPP
1
B:
[5-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
34
PsiBlast_CBE
87.18
79%
-130
- C5 -
2EWP
1
ERR3_HUMAN
D:
[3-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
------------------------------------------------------------------------------
7
PsiBlast_PDB
87.05
79%
-131
- C5 -
2GPP
2
ERR3_HUMAN
A:
[5-229]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
----------------------------------------------------------------------------
8
PsiBlast_PDB
86.98
79%
-134
- C5 -
2GPU
1
A:
[6-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
------------------------------------------------------------------------------
35
PsiBlast_CBE
86.17
79%
-131
- C5 -
2EWP
1
ERR3_HUMAN
C:
[2-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
27
PsiBlast_CBE
85.82
79%
-129
- C5 -
1KV6
1
B:
[7-228]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
33
PsiBlast_CBE
85.81
79%
-138
- C5 -
2EWP
1
E:
[5-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
------------
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
------------------------------------------------------------------------------
30
PsiBlast_CBE
85.75
79%
-127
- C5 -
1S9P
1
D:
[3-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
---------------------------------------------------------------------------
9
PsiBlast_PDB
85.61
79%
-127
- C5 -
2GPV
2
ERR3_HUMAN
A:
[4-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
------------------------------------------------------------------------------
25
PsiBlast_CBE
85.16
79%
-126
- C5 -
2GPV
3
ERR3_HUMAN
B:
[5-227]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
------------------------------------------------------------------------------
24
PsiBlast_CBE
85.14
79%
-126
- C5 -
2GPV
2
ERR3_HUMAN
C:
[5-227]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
------------------------------------------------------------------------------
32
PsiBlast_CBE
84.67
79%
-125
- C5 -
1S9P
1
ERR3_MOUSE
B:
[3-219]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
-----------------------------------------------------------------------------------
15
PsiBlast_PDB
83.65
79%
-127
- C5 -
1S9Q
2
ERR3_MOUSE
A:
[25-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
-
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
31
PsiBlast_CBE
83.03
79%
-124
- C5 -
1S9P
1
ERR3_MOUSE
C:
[3-221]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
---------------------------------------------------------------------------------
16
PsiBlast_PDB
82.10
79%
-125
- C5 -
1S9P
1
ERR3_MOUSE
A:
[2-216]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
--------------------------------------------------------------------------------------
18
PsiBlast_PDB
81.84
64%
-140
- C5 -
3D24
1
ERR1_HUMAN
A:
[24-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
----------
M
P
----------
A
V
A
T
L
C
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
--
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
-
R
A
A
G
--
L
G
E
L
G
A
A
L
L
-
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
H
I
E
-
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
AG-----------
E
R
R
R
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
57
HHSearch
81.19
64%
-127
- C5 -
3K6P
1
ERR1_HUMAN
A:
[14-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
Q
G
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
----------
M
P
-------
H
L
P
A
V
A
T
L
C
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
--
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
-
R
A
A
G
--
L
G
E
L
G
A
A
L
L
-
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
H
I
E
-
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
--
A
G
R
-----GG
A
E
R
R
-
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
-
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
----------------------------------------------------------------------------
19
PsiBlast_PDB
81.14
64%
-142
- C5 -
1XB7
1
ERR1_HUMAN
A:
[17-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
----------
M
-----------
A
V
A
T
L
C
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
--
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
-
R
A
A
G
--
L
G
E
L
G
A
A
L
L
-
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
H
I
E
-
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
A
G------------
R
R
R
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
-----------------------------------------------------------------------------
14
PsiBlast_PDB
80.53
79%
-123
- C5 -
2P7Z
1
ERR3_HUMAN
A:
[28-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
--------------------------------------------------------------------------------------------
28
PsiBlast_CBE
79.79
79%
-124
- C5 -
1VJB
1
ERR3_HUMAN
B:
[26-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
-------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.75
79%
-126
- C5 -
1VJB
1
ERR3_HUMAN
A:
[27-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
----------
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
--
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
-
K
L
A
G
--
L
L
D
L
N
N
A
I
L
-
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
-
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
--
A
G
Q
H
---
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
--------------------------------------------------------------------------------------------
54
HHSearch
70.77
32%
-119
- C5 -
1YYE
2
ESR2_HUMAN
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
-
L
----------
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
--
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
--
I
L
E
I
F
D
M
L
L
-
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
--
A
K
S
G
IS
S
Q
--
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
--------------------------------------------------------------------------
68
HHSearch
68.10
31%
-122
- C5 -
3PLZ
2
NR5A2_HUMAN
A:
[16-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
--------
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
GK
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
-
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
-
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
--
M
C
N
Y
---
P
--
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
-----------------------------------------------------------------------------
63
HHSearch
64.30
31%
-116
- C5 -
2P1T
2
RXRA_HUMAN
A:
[7-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
--
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
G
--
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
-
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
--
K
H
K
Y
---
P
--
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
----------------------------------------------------------------------------