@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_MCR_RA: (2014-08-25 )
METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYDQQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAIVKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIITDQLPKVESGNAKPLYFHRK
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730--.......740.......750.......760.......770.......780.......790.......800.......810.......820---.......830.......-840.......850.......860.......870......--.880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
METKGYHSLPEGL
D
M
E
R
R
W
S
Q
V
S
Q
T
L
E
RSSLGPAERTTENN
Y
M
E
I
V
N
V
S
C
VSGAIPNNSTQGSSK
E
K
H
E
LL
P
Y
I
QQDNSRSGIL
P
S
D
I
K
T
E
L
E
S
K
E
L
S
A
T
V
A
E
S
M
G
L
Y
M
D
SVRDAEYTYDQQNQQGSL
S
P
T
K
I
Y
Q
N
M
E
Q
L
V
K
F
Y
K
ENGHRS
S
T
L
S
A
M
S
R
P
L
R
S
FMPDSAASMNG
G
A
L
R
A
I
V
KS
P
I
I
CHEKSSSVSS
P
L
N
M
A
S
S
VCSPVGINSMSSSTTSFGSFPVHSPITQGT
S
L
T
CSPSVENRGSRSHSPTHASNVGS
P
L
S
S
P
L
S
S
M
KSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNS
R
C
SVSSPSNNTNNRSTLSSP
T
A
S
T
VGSIGS
P
I
S
N
A
F
S
YATSGASAGA
G
A
I
Q
DVVPSPDTHEKGAHDVPFP
K
T
E
E
V
E
K
A
I
SNGVT
G
P
L
N
I
V
Q
Y
I
KSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSY
F
S
FMDDKDYYSLSGILGPPVPGFDGSCEDSAFPVGIKQEPDDGSYYPEASIPS
S
A
I
V
G
VNSGG
Q
S
F
H
Y
R
IGA
Q
G
T
I
S
LSRSPR
D
Q
S
F
Q
H
L
SSFP
P
V
N
T
L
V
E
SWKPHGDLSSRRSDGY
P
V
L
E
Y
IPENVSS
S
T
L
R
SVSTGSSRP
S
K
I
C
L
V
CGDEASG
C
H
Y
G
V
V
T
CG
S
C
K
V
F
F
K
R
A
VEGQH
N
Y
L
CAGRN
D
C
I
I
D
K
I
RRKNC
P
A
C
R
L
Q
K
C
L
Q
AGMNLG
A
R
K
S
K
K
L
G
K
LKGLHEEQPQQPPPPPPQSPEEG
T
T
Y
I
APTKEPSVN
S
A
L
V
P
Q
L
T
S
I
T
HALT--P
S
P
A
M
I
LENIEP
E
T
V
Y
AGYDNSKP
D
T
A
E
S
L
L
S
T
L
N
R
L
A
A
K
Q
M
I
Q
V
V
K
W
A
K
VLPGFKNLPLED
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
SYKHTN
S
Q
---
L
L
Y
FAPDLVF
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
R
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
S
I
M
K
V
L
L
L
L
STV--PKDGL
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
KCPNSS
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
FRES
Q
A
L
K
V
E
F
P
A
M
L
V
E
I
I
T
D
QLPKVESGNAK
P
L
Y
FHRK
11
PsiBlast_PDB
97.55
92%
-116
- C4 -
3VHV
4
A:
[3-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
-----
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
24
PsiBlast_CBE
97.31
92%
-115
- C4 -
2AA6
1
B:
[13-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
3
PsiBlast_PDB
97.03
92%
-117
- C4 -
2AA7
3
A:
[18-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
----
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
5
PsiBlast_PDB
96.70
92%
-113
- C4 -
2AA6
1
MCR_HUMAN
A:
[13-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
-
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
1
PsiBlast_PDB
96.53
92%
-118
- C4 -
2AA2
4
A:
[18-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
-----
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
2
PsiBlast_PDB
96.51
92%
-113
- C4 -
2AA5
1
MCR_HUMAN
A:
[13-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
22
PsiBlast_CBE
96.13
92%
-116
- C4 -
2AB2
1
B:
[14-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
-
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
7
PsiBlast_PDB
96.02
92%
-111
- C4 -
2AB2
1
MCR_HUMAN
A:
[14-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
-
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
21
PsiBlast_CBE
95.86
92%
-114
- C4 -
2AA5
1
B:
[14-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
-----
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
8
PsiBlast_PDB
95.44
91%
-109
- C4 -
3WFF
1
A:
[18-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
9
PsiBlast_PDB
95.28
91%
-108
- C4 -
3WFG
14
A:
[26-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
-
72
HHSearch
95.01
92%
-117
- C4 -
3VHU
1
A:
[38-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
S
R
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
------
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
12
PsiBlast_PDB
94.51
94%
-113
- C4 -
2A3I
2
A:
[2-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
--
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
26
PsiBlast_CBE
92.76
93%
-120
- C4 -
2ABI
1
MCR_HUMAN
B:
[9-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
----
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
14
PsiBlast_PDB
92.38
93%
-123
- C4 -
1YA3
1
MCR_HUMAN
A:
[8-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
-----
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
29
PsiBlast_CBE
92.02
93%
-115
- C4 -
1Y9R
1
B:
[8-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
----------
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
13
PsiBlast_PDB
91.96
93%
-119
- C4 -
1Y9R
1
MCR_HUMAN
A:
[8-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
10
PsiBlast_PDB
91.91
93%
-128
- C4 -
2ABI
1
MCR_HUMAN
A:
[9-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
-------
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
---------
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
27
PsiBlast_CBE
91.86
93%
-121
- C4 -
1YA3
1
C:
[8-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
---
V
Y
A
G
Y
D
S
---
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
28
PsiBlast_CBE
91.71
93%
-124
- C4 -
1YA3
1
MCR_HUMAN
B:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
-------
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
25
PsiBlast_CBE
91.27
93%
-119
- C4 -
2ABI
1
C:
[9-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
----
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
18
PsiBlast_PDB
87.76
69%
-108
- C4 -
3RY9
2
?
A:
[2-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
S
T
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
---
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
-
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
K
17
PsiBlast_PDB
86.99
71%
-105
- C4 -
4FN9
6
?
A:
[6-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
--
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
35
PsiBlast_CBE
86.83
71%
-107
- C4 -
4FN9
3
?
B:
[6-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
--
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
--
20
PsiBlast_PDB
86.09
61%
-113
- C4 -
4E2J
3
?
A:
[4-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
-
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
75
HHSearch
85.95
57%
-112
- C4 -
3MNP
4
A:
[10-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
--
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
--
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
19
PsiBlast_PDB
85.23
61%
-110
- C4 -
3GN8
2
?
A:
[2-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
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A
I
V
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R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
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-
V
N
K
S
L
S
V
E
F
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M
L
A
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I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
76
HHSearch
82.15
56%
-105
- C4 -
1SQN
1
PRGR_HUMAN
A:
[10-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
--
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
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D
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I
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L
I
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Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
-
S
S
F
Y
S
L
C
L
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M
W
Q
I
P
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F
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M
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V
L
L
L
L
N
T
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--
P
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M
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Y
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A
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-
G
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V
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S
S
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F
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L
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L
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N
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D
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Q
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Y
C
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A
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F
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M
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A
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L
P
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I
L
A
G
M
V
K
P
L
L
F
H
K
-
74
HHSearch
81.35
50%
-101
- C4 -
1T7R
2
A:
[19-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
--
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
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E
R
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W
A
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M
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L
M
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A
M
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T
N
V
N
S
R
---
M
L
Y
F
A
P
D
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V
F
N
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Y
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M
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K
-
S
R
M
Y
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A
L
L
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--
P
V
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A
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F
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Q
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L
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K
V
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P
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Y
F
H
T
-
62
Fugue
78.98
51%
-97
- C4 -
1A28
1
PRGR_HUMAN
A:
[5-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
---------------------
V
I
Y
A
GH
D
N
-------
T
K
P
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------------
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L
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H
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S
G
-QML
Y
F
A
--
P
D
L
I
L
N
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Q
R
M
K
-E
S
S
F
Y
S
L
C
L
T
M
W
Q
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F
V
K
L
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Q
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E
F
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L
L
L
N
T
I
PL--
E
G
L
R
S
Q
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F
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M
R
S
S
Y
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L
I
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A
I
G
L
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L
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-