@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00183_HSP90_: (2014-08-30 )
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
Atome Classification :
(42 SA)
.........10........20........30........40........50.......-----.60........70........80........90........100.......110-.----.-.....120.......130.......140.......150.......160....-----...170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MADAKV
E
T
H
E
F
T
A
E
I
S
Q
L
M
S
L
I
I
N
T
VYS
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
QALS
D
P
S
Q
-----LESEP
E
L
F
I
R
I
IPQKD
Q
K
V
L
E
I
RDSGIG
M
T
K
A
D
L
V
N
N
L
G
T
I
A
K
S
G
T
K
S
F
M
E
A
L
S-A----G-A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
H
V
Q
V
I
S
KHNDDE
Q
Y
V
W
ESNAG
G
K
F
T
V
T
LDET-----
N
E
RLGR
G
T
M
L
R
L
F
L
K
E
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
V
K
KHSEF
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
K
EVPETEEEDKAAEEDDKKP
K
L
E
E
VKDE
E
D
E
K
K
E
K
K
T
K
T
V
K
E
E
V
T
E
T
E
ELNKTKPLWTRNPSDI
T
Q
D
E
Y
N
A
F
Y
K
S
ISNDWEDP
L
A
V
K
H
F
S
VE
G
Q
L
E
F
R
A
I
L
F
VPKRAP
F
D
A
F
E
S
KKKKN
N
I
K
L
Y
V
R
R
V
F
ITD
D
A
E
E
L
I
P
E
W
L
S
F
I
K
G
VVDSEDLP
L
N
L
S
R
E
M
L
Q
Q
N
K
I
L
K
V
I
R
K
N
I
V
K
K
M
I
E
T
F
N
E
I
S
E
D
Q
E
Q
F
N
Q
F
Y
T
A
F
SKN
I
K
L
G
IHE
D
A
Q
N
R
Q
S
L
A
K
L
L
R
F
YSTKSS
E
E
M
T
S
L
S
D
Y
V
T
RMPEHQK
N
I
Y
Y
ITGE
S
I
K
AVEKSP
F
L
D
A
L
KAKN
F
E
V
L
F
M
VDP
I
D
E
Y
A
M
T
Q
L
K
E
FEDK
K
L
V
DITKDFELEES
D
E
E
K
A
A
R
E
K
E
I
K
E
Y
E
P
L
T
K
A
L
K
D
I
L
G
D
Q
V
E
K
V
V
V
S
Y
K
LVDAPAAIRTGQFGW
S
A
N
M
E
R
I
M
K
A
Q
A
L
R
D
T
T
M
S
S
Y
MSSK
K
T
F
E
ISPS
S
P
I
I
K
E
L
K
K
K
VETDGAED
K
T
V
K
D
L
T
T
L
L
F
D
T
A
L
LTSGFTLDEP
S
N
F
A
H
R
I
N
R
L
I
A
L
GLNIDDDSEETAVEPEATTTASTDEPA
G
E
S
A
M
E
EVD
48
PsiBlast_CBE
49.50
88%
-87
- C2 -
2VW5
1
HSP82_YEAST
C:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
49.40
88%
-86
- C2 -
2VW5
1
HSP82_YEAST
D:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
49.04
88%
-83
- C2 -
2BRE
1
HSP82_YEAST
B:
[4-218]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
K
E
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
48.97
88%
-83
- C2 -
2VW5
1
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
48.87
88%
-81
- C2 -
1AH8
1
HSP82_YEAST
A:
[4-216]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
48.86
88%
-82
- C2 -
2VW5
1
HSP82_YEAST
B:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
48.83
87%
-82
- C2 -
3C11
3
HSP82_YEAST
A:
[24-234]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
A
A
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
48.62
88%
-82
- C2 -
1AMW
1
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
48.51
88%
-81
- C2 -
1A4H
1
HSP82_YEAST
A:
[14-224]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
48.46
87%
-81
- C2 -
2WEQ
3
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
I
V
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
48.42
88%
-80
- C2 -
2BRC
1
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
48.41
88%
-80
- C2 -
1AH8
3
HSP82_YEAST
B:
[4-218]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
K
E
V
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
48.29
87%
-82
- C2 -
2WER
1
HSP82_YEAST
A:
[3-214]
-----
S
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
I
V
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
48.23
88%
-80
- C2 -
1AM1
1
HSP82_YEAST
A:
[3-213]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
48.08
87%
-84
- C2 -
2WER
1
HSP82_YEAST
B:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
I
V
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
48.05
88%
-78
- C2 -
1ZWH
1
HSP82_YEAST
A:
[24-234]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
48.04
88%
-81
- C2 -
1BGQ
1
HSP82_YEAST
A:
[15-225]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
48.03
88%
-85
- C2 -
4ASB
1
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
48.03
88%
-84
- C2 -
4ASG
1
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
47.95
88%
-82
- C2 -
2XX5
2
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
---
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
47.91
88%
-80
- C2 -
1ZW9
1
HSP82_YEAST
A:
[24-234]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
-------
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
47.89
87%
-80
- C2 -
2WEP
1
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
I
V
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
47.80
88%
-81
- C2 -
2FXS
6
HSP82_YEAST
A:
[24-234]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
47.66
88%
-81
- C2 -
4ASA
1
HSP82_YEAST
A:
[4-214]
------
E
T
F
E
F
Q
A
E
I
T
Q
L
M
S
L
I
I
N
T
V
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
K
S
L
S
D
P
K
Q
-----
L
E
T
E
P
D
L
F
I
R
I
T
P
K
P
E
Q
K
V
L
E
I
R
D
S
G
I
G
M
T
K
A
E
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
S
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
L
F
L
V
A
D
R
V
Q
V
I
S
K
S
N
D
D
E
Q
Y
I
W
E
S
N
A
G
G
S
F
T
V
T
L
D
E
V
-----
N
E
R
I
G
R
G
T
I
L
R
L
F
L
K
D
D
Q
L
E
Y
L
E
E
K
R
I
K
E
V
I
K
R
H
S
E
F
V
A
Y
P
I
Q
L
V
V
T
K
E
V
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
47.25
49%
-51
- C2 -
3PEH
1
?
A:
[21-281]
---
E
S
M
E
S
H
Q
Y
Q
T
E
V
T
R
L
M
D
I
I
V
N
S
L
Y
T
Q
K
E
V
F
L
R
E
L
I
S
N
A
A
D
A
L
E
K
I
R
F
L
S
L
S
D
E
S
V
-----
L
G
E
E
K
K
L
E
I
R
I
S
A
N
K
E
K
N
I
L
S
I
T
D
T
G
I
G
M
T
K
V
D
L
I
N
N
L
G
T
I
A
K
S
G
T
S
N
F
L
E
A
I
S
K
S
----
G
-
G
D
M
S
L
I
G
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
Y
T
K
N
N
D
D
E
Q
Y
I
W
E
S
T
A
D
A
K
F
T
I
Y
K
D
P
R
-----
G
A
T
L
K
R
G
T
R
I
S
L
H
L
K
E
D
A
T
N
L
L
N
D
K
K
L
M
D
L
I
S
K
Y
S
Q
F
I
Q
F
P
I
Y
L
L
H
E
N
V
Y
T
E
E
V
L
A
D
I
A
K
D
M
V
N
D
P
N
Y
D
S
V
K
V
E
E
T
D
D
P
-----
N
K
K
T
R
T
V
E
K
K
V
K
K
W
T
L
M
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
46.44
71%
-79
- C2 -
2JKI
1
?
C:
[12-223]
------
E
T
F
A
F
Q
A
E
I
N
Q
L
L
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
F
E
S
L
T
D
K
S
K
-----
L
D
A
Q
P
E
L
F
I
H
I
I
P
D
K
A
T
S
T
L
T
I
V
D
S
G
I
G
M
T
K
S
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
E
F
M
E
A
L
A
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
R
V
V
V
T
T
K
H
N
D
D
E
Q
Y
V
W
E
S
Q
A
G
G
S
F
T
V
T
R
D
T
S
-----
G
E
Q
L
G
R
G
T
K
M
V
L
Y
L
K
D
D
Q
M
E
Y
L
E
E
R
R
I
K
D
L
V
K
R
H
S
E
F
I
S
Y
P
I
S
L
W
T
E
K
T
T
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
46.40
71%
-81
- C2 -
3BMY
1
HS90A_HUMAN
A:
[7-213]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
46.21
71%
-78
- C2 -
2JKI
1
?
A:
[12-223]
------
E
T
F
A
F
Q
A
E
I
N
Q
L
L
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
F
E
S
L
T
D
K
S
K
-----
L
D
A
Q
P
E
L
F
I
H
I
I
P
D
K
A
T
S
T
L
T
I
V
D
S
G
I
G
M
T
K
S
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
E
F
M
E
A
L
A
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
R
V
V
V
T
T
K
H
N
D
D
E
Q
Y
V
W
E
S
Q
A
G
G
S
F
T
V
T
R
D
T
S
-----
G
E
Q
L
G
R
G
T
K
M
V
L
Y
L
K
D
D
Q
M
E
Y
L
E
E
R
R
I
K
D
L
V
K
R
H
S
E
F
I
S
Y
P
I
S
L
W
T
E
K
T
T
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
46.07
71%
-78
- C2 -
3RKZ
1
HS90A_HUMAN
A:
[7-214]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
46.04
71%
-79
* C2 *
3O0I
1
HS90A_HUMAN
A:
[36-243]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
46.01
71%
-82
- C2 -
2YI7
1
HS90A_HUMAN
A:
[16-224]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
46.00
71%
-79
- C2 -
3NMQ
1
HS90B_HUMAN
A:
[14-225]
---
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
K
I
D
I
I
P
N
P
Q
E
R
T
L
T
L
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
V
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
A
D
H
------
G
E
P
I
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
V
K
E
V
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
Y
L
E
K
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
45.95
71%
-82
- C2 -
3QTF
2
HS90A_HUMAN
A:
[7-213]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
45.90
71%
-80
- C2 -
3R92
1
HS90A_HUMAN
A:
[7-214]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
45.85
71%
-77
- C2 -
2JKI
1
?
B:
[12-223]
------
E
T
F
A
F
Q
A
E
I
N
Q
L
L
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
F
E
S
L
T
D
K
S
K
-----
L
D
A
Q
P
E
L
F
I
H
I
I
P
D
K
A
T
S
T
L
T
I
V
D
S
G
I
G
M
T
K
S
D
L
V
N
N
L
G
T
I
A
R
S
G
T
K
E
F
M
E
A
L
A
-
A
----
G
-
A
D
V
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
R
V
V
V
T
T
K
H
N
D
D
E
Q
Y
V
W
E
S
Q
A
G
G
S
F
T
V
T
R
D
T
S
-----
G
E
Q
L
G
R
G
T
K
M
V
L
Y
L
K
D
D
Q
M
E
Y
L
E
E
R
R
I
K
D
L
V
K
R
H
S
E
F
I
S
Y
P
I
S
L
W
T
E
K
T
T
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
HHSearch
45.82
71%
-81
- C2 -
1YC1
1
HS90A_HUMAN
A:
[43-252]
---
E
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
T
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
T
------
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
45.68
71%
-79
- C2 -
3BM9
1
HS90A_HUMAN
A:
[7-213]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
45.68
71%
-82
- C2 -
3R91
1
HS90A_HUMAN
A:
[7-213]
-----
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
45.62
71%
-81
- C2 -
3MNR
1
HS90A_HUMAN
P:
[16-224]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
45.60
50%
-74
- C2 -
1QY5
2
ENPL_CANFA
A:
[4-269]
----
K
S
E
K
F
A
F
Q
A
E
V
N
R
M
M
K
L
I
I
N
S
L
Y
K
N
K
E
I
F
L
R
E
L
I
S
N
A
S
D
A
L
D
K
I
R
L
I
S
L
T
D
E
N
A
-----
L
A
G
N
E
E
L
T
V
K
I
K
C
D
K
E
K
N
L
L
H
V
T
D
T
G
V
G
M
T
R
E
E
L
V
K
N
L
G
T
I
A
K
S
G
T
S
E
F
L
N
K
M
T
-
E
A
Q
E
D
G
Q
S
T
S
E
L
I
G
Q
F
G
V
G
F
Y
S
A
F
L
V
A
D
K
V
I
V
T
S
K
H
N
N
D
T
Q
H
I
W
E
S
D
-
S
N
E
F
S
V
I
A
D
P
R
-----
G
N
T
L
G
R
G
T
T
I
T
L
V
L
K
E
E
A
S
D
Y
L
E
L
D
T
I
K
N
L
V
K
K
Y
S
Q
F
I
N
F
P
I
Y
V
W
S
S
K
T
-------------------------------------------
K
T
V
W
D
W
E
L
M
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
45.57
71%
-78
- C2 -
3D0B
1
HS90A_HUMAN
A:
[16-223]
----
E
V
E
T
F
A
F
Q
A
E
I
A
Q
L
M
S
L
I
I
N
T
F
Y
S
N
K
E
I
F
L
R
E
L
I
S
N
S
S
D
A
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
-----
L
D
S
G
K
E
L
H
I
N
L
I
P
N
K
Q
D
R
T
L
T
I
V
D
T
G
I
G
M
T
K
A
D
L
I
N
N
L
G
T
I
A
K
S
G
T
K
A
F
M
E
A
L
Q
-
A
----
G
-
A
D
I
S
M
I
G
Q
F
G
V
G
F
Y
S
A
Y
L
V
A
E
K
V
T
V
I
T
K
H
N
D
D
E
Q
Y
A
W
E
S
S
A
G
G
S
F
T
V
R
T
D
-
T
-----
G
E
P
M
G
R
G
T
K
V
I
L
H
L
K
E
D
Q
T
E
Y
L
E
E
R
R
I
K
E
I
V
K
K
H
S
Q
F
I
G
Y
P
I
T
L
F
V
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
HHSearch
43.45
46%
-81
- C2 -
3IED
1
?
A:
[21-271]
--
G
S
P
V
E
K
Y
N
F
K
A
E
V
N
K
V
M
D
I
I
V
N
S
L
Y
T
D
K
D
V
F
L
R
E
L
I
S
N
A
S
D
A
C
D
K
K
R
I
I
L
E
N
N
K
L
I
K
D
A
EV-
N
D
I
K
K
L
I
I
K
I
K
P
D
K
E
K
K
T
L
T
I
T
D
N
G
I
G
M
D
K
S
E
L
I
N
N
L
G
T
I
A
Q
S
G
T
A
K
F
L
K
Q
I
E
-
E
----
G
K
A
D
S
N
L
I
G
Q
F
G
V
G
F
Y
S
S
F
L
V
S
N
R
V
E
V
Y
T
K
K
-
E
D
Q
I
Y
R
W
S
S
D
L
K
G
S
F
S
V
N
E
I
K
K
YDQEY--
I
K
G
S
G
T
K
I
I
L
H
L
K
E
E
C
D
E
Y
L
E
D
Y
K
L
K
E
L
I
K
K
Y
S
E
F
I
K
F
P
I
E
I
W
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------