@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00233_PDE5A_: (2014-09-02 )
MLPFGDKTRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGKKEQMPLTSPRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSKDKFLVSRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCPDSFSRVFQMEWEEVGKSSEPLTREHDANKINYMYAQYVKNTMEPLNIPDVTKDNRFPWTNENMGHINTHCIRSLLCTPIKNGKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNEFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNRQKWQALADQQEKTLLNGESGQAKRD
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630...-....640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLPFG
D
K
T
R
D
M
V
N
A
W
F
S
ERVHNIPV
C
K
E
G
I
R
AHTESCSCSLPQSPHADNTTPGAPARKI
S
A
S
E
FDRPLR
P
I
V
V
KDSEG
T
V
S
FLSDSGKKEQMPLTSPRFDSDE
G
D
Q
C
S
R
L
L
E
L
V
K
D
I
S
SHL
D
V
T
A
L
C
H
K
I
F
L
H
I
H
G
LISAD
R
Y
S
L
F
L
V
CEDSSK
D
K
F
L
V
S
R
L
F
D
VAEGS
T
L
E
E
ASN
N
C
I
R
L
EWNKGI
V
G
H
V
A
AFGEPLNIKDAYEDPRFNAEVDQITGYKT
Q
S
I
L
C
MPIKN
H
R
E
E
V
V
G
V
A
Q
A
I
NKKSGNGGTFTEK
D
E
K
D
F
A
A
Y
L
A
F
C
G
I
V
LHNA
Q
L
Y
E
T
S
L
L
ENK
R
N
Q
V
L
L
D
L
A
S
L
I
F
E
E
Q
Q
S
L
E
V
I
L
K
K
I
A
A
T
I
I
S
F
M
QVQ
K
C
T
I
F
I
VDEDC
P
D
S
F
S
R
V
F
Q
M
E
W
E
E
VGKSSEPLTREHDAN
K
I
N
Y
M
Y
A
Q
Y
V
K
NTMEPLNIPDVTKDNRFPWTNENMGH
I
N
T
H
C
I
R
S
L
L
CTPIKNGKKN
K
V
I
G
V
C
Q
L
V
N
K
M
E
E
KTG
K
I
K
AFNQ
N
D
E
Q
F
L
E
A
F
V
I
F
CGLGIQ
N
T
Q
M
Y
E
A
V
E
R
A
M
A
K
Q
M
V
T
L
E
V
L
S
Y
HAS
A
A
E
E
E
T
R
E
L
Q
A
L
A
A
A
VVPSA
Q
T
L
K
I
T
DFSFSDF
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
KNVAYH
N
W
R
H
AF
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
T
L
A
L
L
I
A
A
L
S
H
D
L
DHRGVN
N
S
Y
I
QRSEH
P
L
A
Q
L
Y
C
-
H
S
T
M
E
H
H
H
F
D
Q
C
L
M
V
LNSP
G
N
Q
I
L
SGL
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
RR
G
E
F
F
E
L
I
R
KNEFSFE
D
P
L
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
AITKPW
P
I
Q
Q
R
I
A
E
L
V
A
A
E
F
F
DQGD
R
E
R
K
ELNME
P
A
D
L
M
N
R
E
K
KNKIPS
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
VS
E
D
C
L
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
D
Q
Q
E
K
TLLNGESGQAKRD
8
PsiBlast_PDB
75.61
96%
-127
- C3 -
3B2R
1
PDE5A_HUMAN
A:
[5-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
----------------
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
-----------------
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
24
PsiBlast_CBE
75.37
96%
-123
- C3 -
3SIE
1
B:
[24-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
-------------------------
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
23
PsiBlast_CBE
74.74
96%
-126
- C3 -
3B2R
1
B:
[8-330]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
-----------------
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
-------------------
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
11
PsiBlast_PDB
73.69
96%
-121
- C3 -
3SIE
1
PDE5A_HUMAN
A:
[25-347]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
-----------------------
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
----
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
15
PsiBlast_PDB
73.41
96%
-123
- C3 -
4G2Y
2
A:
[22-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
-------
P
L
A
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
---------------------
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
7
PsiBlast_PDB
73.21
96%
-113
- C3 -
2H44
1
A:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
L
A
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
12
PsiBlast_PDB
73.15
96%
-119
- C3 -
3TSE
1
A:
[22-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
------------
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
-------------------
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
13
PsiBlast_PDB
73.14
96%
-123
- C3 -
3TSF
1
A:
[23-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
-----------------
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
----------------------
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
----------------
20
PsiBlast_PDB
73.08
95%
-115
- C3 -
1UHO
1
A:
[1-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
-----------
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
6
PsiBlast_PDB
72.79
96%
-111
- C3 -
2H42
1
PDE5A_HUMAN
A:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
L
A
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
21
PsiBlast_CBE
72.53
96%
-112
- C3 -
2H42
1
C:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
---------
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
10
PsiBlast_PDB
72.47
96%
-119
- C3 -
3SHZ
1
A:
[23-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
---------
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
--------------------
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
37
PsiBlast_CBE
72.35
90%
-112
- C3 -
3TGG
1
A:
[3-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
E
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
9
PsiBlast_PDB
72.34
96%
-118
- C3 -
3SHY
1
A:
[23-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
---------
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
-------------------
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
18
PsiBlast_PDB
72.26
95%
-114
- C3 -
1UDT
1
A:
[1-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
-----------
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
14
PsiBlast_PDB
72.20
96%
-121
- C3 -
4G2W
2
A:
[24-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
----------------
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
---------------------
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
17
PsiBlast_PDB
72.01
95%
-116
- C3 -
1RKP
1
A:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
L
A
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
L
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
---------------
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
41
PsiBlast_CBE
71.98
90%
-111
- C3 -
3HC8
1
A:
[1-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
E
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
27
PsiBlast_CBE
71.96
89%
-109
- C3 -
1XOZ
1
A:
[22-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
16
PsiBlast_PDB
71.87
96%
-123
- C3 -
4IA0
1
A:
[22-345]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
----------
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
----------------------
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
36
PsiBlast_CBE
71.86
90%
-109
- C3 -
1T9S
1
PDE5A_HUMAN
A:
[22-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
52
HHSearch
71.79
93%
-116
- C3 -
3BJC
1
PDE5A_HUMAN
A:
[538-863]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
L
A
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
---------------
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
22
PsiBlast_CBE
71.75
96%
-109
- C3 -
2H42
1
PDE5A_HUMAN
B:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
---------
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
26
PsiBlast_CBE
71.46
89%
-108
- C3 -
1XP0
1
A:
[22-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
34
PsiBlast_CBE
71.36
90%
-108
- C3 -
1TBF
2
A:
[22-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
38
PsiBlast_CBE
71.35
90%
-110
- C3 -
3TGE
1
A:
[3-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
E
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
35
PsiBlast_CBE
71.15
90%
-107
- C3 -
1T9S
1
B:
[22-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
40
PsiBlast_CBE
70.63
90%
-108
- C3 -
3HDZ
1
A:
[2-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
E
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
39
PsiBlast_CBE
70.49
90%
-108
- C3 -
2CHM
2
A:
[4-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
D
E
S
V
L
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
E
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
-----------------
25
PsiBlast_CBE
70.17
95%
-114
- C3 -
1UDU
1
B:
[1-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
-----------
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
19
PsiBlast_PDB
69.61
95%
-113
- C3 -
1UDU
1
PDE5A_HUMAN
A:
[1-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
-----------
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
F
D
Q
G
D
R
E
R
K
E
L
N
I
E
P
T
D
L
M
N
R
E
K
K
N
K
I
P
S
M
Q
V
G
F
I
D
A
I
C
L
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
Q
---------------
29
PsiBlast_CBE
69.56
89%
-106
- C3 -
3JWR
4
PDE5A_HUMAN (first)
A:
[7-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
L
A
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
W
E
Q
G
D
L
E
R
T
V
L
Q
Q
Q
P
I
P
M
M
D
R
N
K
R
D
E
L
P
K
L
Q
V
G
F
I
D
F
V
C
T
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
----------------
28
PsiBlast_CBE
69.53
89%
-107
- C3 -
3JWR
3
B:
[5-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
T
R
E
L
Q
S
L
A
A
A
V
V
P
S
A
Q
T
L
K
I
T
D
F
S
F
S
D
F
E
L
S
D
L
E
T
A
L
C
T
I
R
M
F
T
D
L
N
L
V
Q
N
F
Q
M
K
H
E
V
L
C
R
W
I
L
S
V
K
K
N
Y
R
K
N
V
A
Y
H
N
W
R
H
A
F
N
T
A
Q
C
M
F
A
A
L
K
A
G
K
I
Q
N
K
L
T
D
L
E
I
L
A
L
L
I
A
A
L
S
H
D
L
D
H
R
G
V
N
N
S
Y
I
Q
R
S
E
H
P
L
A
Q
L
Y
C
-
H
S
I
M
E
H
H
H
F
D
Q
C
L
M
I
L
N
S
P
G
N
Q
I
L
S
G
L
S
I
E
E
Y
K
T
T
L
K
I
I
K
Q
A
I
L
A
T
D
L
A
L
Y
I
K
R
R
G
E
F
F
E
L
I
R
K
N
Q
F
N
L
E
D
P
H
Q
K
E
L
F
L
A
M
L
M
T
A
C
D
L
S
A
I
T
K
P
W
P
I
Q
Q
R
I
A
E
L
V
A
T
E
F
W
E
Q
G
D
L
E
R
T
V
L
Q
Q
Q
P
I
P
M
M
D
R
N
K
R
D
E
L
P
K
L
Q
V
G
F
I
D
F
V
C
T
Q
L
Y
E
A
L
T
H
V
S
E
D
C
F
P
L
L
D
G
C
R
K
N
R
Q
K
W
Q
A
L
A
E
Q
----------------
57
HHSearch
54.15
38%
-96
- C3 -
2OUR
1
PDE10_HUMAN
A:
[2-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
S
I
C
T
S
E
E
W
Q
G
L
M
---
Q
F
T
L
P
V
R
L
C
K
E
I
E
L
F
H
F
D
I
G
P
F
E
N
M
W
P
G
I
F
-
V
Y
M
V
H
R
--
S
C
G
T
S
C
F
E
L
E
K
L
C
R
F
I
M
S
V
K
K
N
Y
R
-
R
V
P
Y
H
N
W
K
H
A
V
T
V
A
H
C
M
Y
A
I
L
Q
N
N
H
--
T
L
F
T
D
L
E
R
K
G
L
L
I
A
C
L
C
H
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
L
A
A
L
Y
S
-
T
S
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
R
K
A
I
I
A
T
D
L
A
L
Y
F
G
N
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
L
M
M
T
A
C
A
L
C
S
V
T
K
L
W
P
V
T
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
D
E
M
K
-
K
L
G
I
Q
P
I
P
M
M
D
R
D
K
K
D
E
V
P
Q
G
Q
L
G
F
Y
N
A
V
A
I
P
C
Y
T
T
L
T
Q
I
L
P
P
T
E
P
L
L
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
G
E
E
--------------