@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00233_PDE9A_: (2014-09-02 )
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260..---.....------270.....-..280.......290.......300.....-..310.......320.......330.......340.......350.......360.......370....---...380.......390.......400.......410.......420.......430.......-440.--------......450.......460.......470.......480.......490.......500......-.510.......520.......530.-.......540.......550.......560.......570.......-580.......590.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGSGSSSYR
P
K
A
I
Y
L
DIDG
R
I
Q
K
V
I
F
S
KYCNSSD
I
M
D
L
F
C
I
ATGLPRN
T
T
I
S
L
L
TTD
D
A
M
V
S
IDPTMPANSERT
P
Y
K
VR
P
V
A
I
K
Q
L
SAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREP
Q
G
C
Y
QEGQRIPP
E
R
E
E
L
I
Q
S
V
L
A
Q
V
A
E
Q
F
S
R
A
F
K
I
N
E
L
K
A
E
V
A
N
H
L
A
V
L
E
K
R
VELEG
L
K
V
V
E
I
E
K
C
K
S
D
I
K
K
M
R
E
E
L
A
ARSSRTNC
P
C
K
Y
SFLDNHKKLTPRRDVPTY
P
K
Y
LL
S
P
E
T
I
E
A
L
RKPT
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
LGL
V
R
DFSI
N
P
V
T
L
R
R
W
L
F
C
VHDNYR-NN
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
FSQT
D
I
L
I
L
M
T
A
A
I
C
HDLDHPGYNN
T
Y
Q
I
N
A
R
T
E
L
A
V
R
YN---DISPLENHH
C
A
V
A
F
Q
I
LAEPECNIFSNIP
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-ENFD--------YS
N
E
E
H
M
T
L
L
K
M
I
L
I
K
CCDISNEVR
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
QSDREKSEGLPVAPFMD
R
D
K
V
T
-
K
A
T
AQI
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
ES
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
K
T
D
SLTSGAT
E
K
S
R
-
E
R
SRDVKNSEGDCA
7
PsiBlast_PDB
98.97
100%
-139
- C5 -
4GH6
1
PDE9A_HUMAN
A:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
K
----------------------------
29
PsiBlast_CBE
98.72
100%
-137
- C5 -
4G2L
1
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
24
PsiBlast_CBE
98.48
100%
-139
- C5 -
4GH6
2
PDE9A_HUMAN
B:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
K
----------------------------
3
PsiBlast_PDB
98.45
100%
-140
- C5 -
2YY2
1
PDE9A_HUMAN
A:
[8-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
K
----------------------------
8
PsiBlast_PDB
98.44
99%
-141
- C5 -
3N3Z
1
PDE9A_HUMAN
A:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
A
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
K
----------------------------
4
PsiBlast_PDB
98.32
100%
-138
- C5 -
2HD1
1
PDE9A_HUMAN
A:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
K
----------------------------
27
PsiBlast_CBE
98.30
100%
-142
- C5 -
2HD1
1
PDE9A_HUMAN
B:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
K
----------------------------
35
PsiBlast_CBE
98.29
100%
-139
- C5 -
3DYQ
1
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
14
PsiBlast_PDB
98.28
100%
-140
- C5 -
3JSI
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
13
PsiBlast_PDB
98.10
100%
-140
- C5 -
3DYS
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
33
PsiBlast_CBE
98.06
100%
-140
- C5 -
3JSI
1
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
18
PsiBlast_PDB
98.04
100%
-141
- C5 -
4G2L
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
9
PsiBlast_PDB
98.01
100%
-140
- C5 -
3DY8
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
30
PsiBlast_CBE
98.00
100%
-140
- C5 -
4G2J
1
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
32
PsiBlast_CBE
97.87
100%
-141
- C5 -
3JSW
1
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
28
PsiBlast_CBE
97.83
99%
-139
- C5 -
3N3Z
1
PDE9A_HUMAN
B:
[1-326]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
A
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
K
----------------------------
34
PsiBlast_CBE
97.79
100%
-138
- C5 -
3DYS
2
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
15
PsiBlast_PDB
97.78
100%
-141
- C5 -
3JSW
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
16
PsiBlast_PDB
97.77
100%
-141
- C5 -
4E90
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
37
PsiBlast_CBE
97.69
100%
-142
- C5 -
3DYL
2
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
17
PsiBlast_PDB
97.65
100%
-141
- C5 -
4G2J
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
36
PsiBlast_CBE
97.54
100%
-137
- C5 -
3DYN
2
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
50
HHSearch
97.52
99%
-140
- C5 -
3DYN
1
PDE9A_HUMAN
A:
[2-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
49
HHSearch
97.51
100%
-140
- C5 -
3QI3
1
PDE9A_HUMAN
A:
[181-505]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
E
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
38
PsiBlast_CBE
97.49
100%
-138
- C5 -
3DY8
2
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
10
PsiBlast_PDB
97.47
100%
-140
- C5 -
3DYL
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
31
PsiBlast_CBE
97.45
100%
-139
- C5 -
4E90
1
PDE9A_HUMAN
B:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
12
PsiBlast_PDB
97.12
100%
-139
- C5 -
3DYQ
1
PDE9A_HUMAN
A:
[5-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
23
PsiBlast_CBE
96.85
100%
-139
- C5 -
2YY2
1
PDE9A_HUMAN
B:
[8-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
Q
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
------------------------------
2
PsiBlast_PDB
94.96
84%
-139
- C5 -
3QI4
1
PDE9A_HUMAN
A:
[181-505]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
E
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
21
PsiBlast_CBE
94.67
84%
-136
- C5 -
3QI4
1
PDE9A_HUMAN
B:
[181-505]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
E
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
22
PsiBlast_CBE
94.51
84%
-137
- C5 -
3QI3
1
PDE9A_HUMAN
B:
[181-505]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Y
P
K
Y
L
L
S
P
E
T
I
E
A
L
R
K
P
T
F
D
V
W
---
L
W
E
P
N
------
E
M
L
S
C
L
E
H
-
M
Y
H
D
L
G
L
V
R
D
F
S
I
N
P
V
T
L
R
R
W
L
F
C
V
H
D
N
Y
R
-
N
N
P
F
H
N
F
R
H
C
F
C
V
A
Q
M
M
Y
S
M
V
W
L
C
S
L
Q
E
K
F
S
Q
T
D
I
L
I
L
M
T
A
A
I
C
H
D
L
D
H
P
G
Y
N
N
T
Y
Q
I
N
A
R
T
E
L
A
V
R
Y
N
---
D
I
S
P
L
E
N
H
H
C
A
V
A
F
Q
I
L
A
E
P
E
C
N
I
F
S
N
I
P
P
D
G
F
K
Q
I
R
Q
G
M
I
T
L
I
L
A
T
D
M
A
R
H
A
E
I
M
D
S
F
K
E
K
M
-
E
N
F
D
--------
Y
S
N
E
E
H
M
T
L
L
K
M
I
L
I
K
C
C
D
I
S
N
E
V
R
P
M
E
V
A
E
P
W
V
D
C
L
L
E
E
Y
F
M
Q
S
D
R
E
K
S
E
G
L
P
V
A
P
F
M
D
R
D
K
V
T
-
K
A
T
A
E
I
G
F
I
K
F
V
L
I
P
M
F
E
T
V
T
K
-
L
F
-
P
M
V
E
E
I
M
L
Q
P
L
W
E
S
R
D
R
Y
E
E
L
K
R
I
D
D
A
M
K
E
L
Q
K
-----------------------------
53
HHSearch
75.68
30%
-107
- C5 -
1F0J
3
PDE4B_HUMAN
A:
[2-357]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
R
F
G
V
N
T
E
N
E
D
H
L
A
K
E
-
L
E
D
L
N
K
W
G
L
N
I
F
N
V
A
G
Y
S
H
N
------
R
P
L
T
C
I
M
Y
A
I
F
Q
E
R
D
L
L
K
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
H
Y
H
S
D
V
A
Y
H
N
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
E
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
H
C
D
I
F
M
N
L
T
K
K
Q
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
-
E
T
K
K
V
T
SSG
V
L
L
L
D
N
Y
T
D
R
I
Q
V
L
R
N
M
V
H
C
A
D
L
S
N
P
T
K
S
L
E
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
Q
Q
G
D
K
E
R
E
R
G
M
E
I
S
P
M
C
D
K
H
T
A
S
-
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
-
L
V
Q
P
D
A
Q
-
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
S
M
I
P
Q
A
P
A
------
N
--
R
D
C
Q
G
L
M
E
K
F
Q
F--------------
54
HHSearch
75.62
31%
-123
- C5 -
1Y2K
13
PDE4D_HUMAN
A:
[22-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
Q
E
D
V
L
A
K
E
-
L
E
D
V
N
K
W
G
L
H
V
F
R
I
A
E
L
S
G
N
------
R
P
L
T
V
I
M
H
T
I
F
Q
E
R
D
L
L
K
T
F
K
I
P
V
D
T
L
I
T
Y
L
M
T
L
E
D
H
Y
H
A
D
V
A
Y
H
N
N
I
H
A
A
D
V
V
Q
S
T
H
V
L
L
S
T
P
A
L
E
A
V
F
T
D
L
E
I
L
A
A
I
F
A
S
A
I
H
D
V
D
H
P
G
V
S
N
Q
F
L
I
N
T
N
S
E
L
A
L
M
Y
N
---
D
S
S
V
L
E
N
H
H
L
A
V
G
F
K
L
L
Q
E
E
N
C
D
I
F
Q
N
L
T
K
K
Q
R
Q
S
L
R
K
M
V
I
D
I
V
L
A
T
D
M
S
K
H
M
N
L
L
A
D
L
K
T
M
V
-
E
T
K
K
V
T
SSG
V
L
L
L
D
N
Y
S
D
R
I
Q
V
L
Q
N
M
V
H
C
A
D
L
S
N
P
T
K
P
L
Q
L
Y
R
Q
W
T
D
R
I
M
E
E
F
F
R
Q
G
D
R
E
R
E
R
G
M
E
I
S
P
M
C
D
K
H
N
A
S
-
V
E
K
S
Q
V
G
F
I
D
Y
I
V
H
P
L
W
E
T
W
A
D
-
L
V
H
P
D
A
-
Q
D
I
L
D
T
L
E
D
N
R
E
W
Y
Q
S
T
I
P
---------------------------------------
63
HHSearch
70.42
30%
-121
- C5 -
2R8Q
1
?
A:
[40-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
G
F
N
L
F
---
E
V
R
E
K
YSE
P
M
D
A
A
A
G
V
V
Y
N
-
L
L
W
N
S
G
L
P
E
K
F
G
C
R
E
Q
T
L
L
N
F
I
L
Q
C
R
R
R
Y
R
-
R
V
P
Y
H
N
F
Y
H
V
V
D
V
C
Q
T
L
H
T
Y
L
Y
T
G
K
A
S
E
L
L
T
E
L
E
C
Y
V
L
L
V
T
A
L
V
H
D
L
D
H
M
G
V
N
N
S
F
Y
L
K
T
D
S
P
L
G
I
L
S
S
A
S
G
N
N
S
V
L
E
V
H
H
C
S
L
A
I
E
I
L
S
D
P
A
A
D
V
F
E
G
L
S
G
Q
D
V
A
Y
A
Y
R
A
L
I
D
C
V
L
A
T
D
M
A
K
H
A
D
A
L
S
R
F
T
E
L
A
T
S
G
F
E
--------
K
D
N
D
T
H
R
R
L
V
M
E
T
L
I
K
A
G
D
V
S
N
V
T
K
P
F
E
T
S
R
M
W
A
M
A
V
T
E
E
F
Y
R
Q
G
D
M
E
K
E
K
G
V
E
V
L
P
M
F
D
R
S
K
N
N
E
L
A
R
G
Q
I
G
F
I
D
F
V
A
G
K
F
F
R
D
I
V
G
N
L
F
-
H
G
M
-
Q
W
C
V
D
T
V
N
S
N
R
A
K
W
Q
E
I
L
D
---------------------------------------