@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00273_ALBU_R: (2014-09-03 )
MKWVTFLLLLFISGSAFSRGVFRREAHKSEIAHRFKDLGEQHFKGLVLIAFSQYLQKCPYEEHIKLVQEVTDFAKTCVADENAENCDKSIHTLFGDKLCAIPKLRDNYGELADCCAKQEPERNECFLQHKDDNPNLPPFQRPEAEAMCTSFQENPTSFLGHYLHEVARRHPYFYAPELLYYAEKYNEVLTQCCTESDKAACLTPKLDAVKEKALVAAVRQRMKCSSMQRFGERAFKAWAVARMSQRFPNAEFAEITKLATDVTKINKECCHGDLLECADDRAELAKYMCENQATISSKLQACCDKPVLQKSQCLAEIEHDNIPADLPSIAADFVEDKEVCKNYAEAKDVFLGTFLYEYSRRHPDYSVSLLLRLAKKYEATLEKCCAEGDPPACYGTVLAEFQPLVEEPKNLVKTNCELYEKLGEYGFQNAVLVRYTQKAPQVSTPTLVEAARNLGRVGTKCCTLPEAQRLPCVEDYLSAILNRLCVLHEKTPVSEKVTKCCSGSLVERRPCFSALTVDETYVPKEFKAETFTFHSDICTLPDKEKQIKKQTALAELVKHKPKATEDQLKTVMGDFAQFVDKCCKAADKDNCFATEGPNLVARSKEALA
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270........280.......290.-......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
W
V
T
F
L
L
L
L
F
ISG
S
A
FS
R
G
V
F
R
R
E
A
H
K
S
E
I
A
H
R
F
K
D
L
G
E
Q
H
F
K
G
L
V
L
I
A
F
S
Q
Y
L
Q
KC
P
Y
E
E
H
I
K
L
V
Q
E
V
T
D
F
A
K
T
CVADE
N
A
E
N
C
D
K
S
I
H
T
L
FGDKLCAI
P
K
L
R
D
N
Y
G
E
L
A
D
C
CAKQEPERN
E
C
F
L
Q
HKDDNPNLPPFQRP
E
A
E
A
M
C
T
S
FQEN
P
T
S
F
L
G
H
Y
L
H
E
V
A
R
RHPYFY
A
P
E
L
L
Y
Y
A
E
K
Y
N
E
V
L
T
Q
CCTESDKAACLTP
K
L
D
A
V
K
E
K
A
L
V
A
A
V
R
Q
R
M
K
C
S
S
M
Q
R
F
G
E
R
A
F
K
A
W
A
V
A
R
M
S
Q
RFPN
A
E
F
A
E
I
T
K
L
A
T
D
V
T
K
I
N
K
E
CC-HG
D
L
L
E
C
AD
D
R
A
E
L
A
K
Y
M
CENQ
A
-
T
I
S
S
K
L
Q
A
C
CDKP
V
L
Q
K
S
Q
C
L
A
E
I
EHDNIPA
D
L
P
S
I
A
A
D
F
V
E
D
K
E
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
T
F
L
Y
E
Y
SRRHPD
Y
S
V
S
L
L
L
R
L
A
K
K
Y
E
A
T
L
E
K
C
CAEGDP
P
A
C
Y
G
T
V
L
A
E
F
Q
P
L
V
EE
P
K
N
L
V
K
T
N
C
E
L
Y
E
K
L
G
EYGFQ
N
A
V
L
V
R
YTQKAPQVST
P
T
L
V
E
A
A
R
N
L
G
R
VGTKCCTLP
E
A
QRL
P
C
V
E
D
Y
L
S
A
I
L
N
R
L
C
V
LHEKT
P
V
S
E
K
V
T
K
CCSGSLVERRPCF
S
A
L
TVDETYVPKEFKA
E
T
F
T
F
HSDICTLP
D
K
E
K
Q
I
K
K
Q
T
A
L
A
E
L
V
KHKPKA
T
E
D
Q
L
K
T
V
M
G
D
F
A
Q
F
V
D
K
C
C
KAADKDNCFATEGP
N
L
V
AR
S
K
E
ALA
7
PsiBlast_PDB
99.22
73%
-96
- C6 -
1E7H
7
ALBU_HUMAN
A:
[3-583]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
-
18
PsiBlast_PDB
99.20
73%
-96
- C6 -
1HK4
8
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
5
PsiBlast_PDB
99.05
73%
-97
- C6 -
1E7G
8
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
12
PsiBlast_PDB
98.93
73%
-97
- C6 -
1H9Z
7
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
10
PsiBlast_PDB
98.87
73%
-96
- C6 -
1E7C
12
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
3
PsiBlast_PDB
98.85
73%
-95
- C6 -
1E7E
10
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
21
PsiBlast_CBE
98.58
73%
-96
- C6 -
4BKE
7
?
A:
[27-608]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
14
PsiBlast_PDB
98.55
73%
-95
- C6 -
1GNI
7
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
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K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
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Y
A
R
R
H
P
D
Y
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V
V
L
L
L
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L
A
K
T
Y
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T
L
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C
C
A
A
A
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C
Y
A
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F
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L
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Q
N
L
I
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Q
N
C
E
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F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
4
PsiBlast_PDB
98.53
73%
-99
- C6 -
1E7F
8
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
13
PsiBlast_PDB
98.46
73%
-98
- C6 -
1HA2
7
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
19
PsiBlast_PDB
98.43
73%
-94
- C6 -
1N5U
6
ALBU_HUMAN
A:
[2-584]
-------------------------
A
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
50
PsiBlast_CBE
98.38
73%
-96
- C6 -
3B9M
9
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
15
PsiBlast_PDB
98.35
73%
-96
- C6 -
1GNJ
8
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
59
PsiBlast_CBE
98.14
73%
-93
- C6 -
2XW0
2
ALBU_HUMAN
A:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
---------
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
6
PsiBlast_PDB
98.11
73%
-99
- C6 -
1E7I
7
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
39
PsiBlast_CBE
98.07
73%
-96
- C6 -
3UIV
6
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
38
PsiBlast_CBE
98.04
73%
-97
- C6 -
3UIV
8
ALBU_HUMAN
H:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
22
PsiBlast_CBE
98.04
73%
-97
- C6 -
4LB9
5
ALBU_HUMAN
A:
[2-584]
-------------------------
A
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
51
PsiBlast_CBE
97.88
73%
-94
- C6 -
3B9L
9
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
54
PsiBlast_CBE
97.66
73%
-93
- C6 -
2YDF
4
ALBU_HUMAN
B:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
------------
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
31
PsiBlast_CBE
97.65
73%
-95
- C6 -
4L8U
6
ALBU_HUMAN
A:
[2-584]
-------------------------
A
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
57
PsiBlast_CBE
97.55
73%
-92
- C6 -
2XW1
1
ALBU_HUMAN
A:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
---------
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
53
PsiBlast_CBE
97.49
73%
-96
- C6 -
3A73
8
ALBU_HUMAN
A:
[2-584]
-------------------------
A
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
-------
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
9
PsiBlast_PDB
97.49
73%
-91
- C6 -
1E7B
3
ALBU_HUMAN
A:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
62
PsiBlast_CBE
97.41
73%
-90
- C6 -
2XVQ
1
ALBU_HUMAN
B:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
------------
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
52
PsiBlast_CBE
97.28
73%
-98
- C6 -
3A73
7
ALBU_HUMAN
B:
[2-584]
-------------------------
A
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
-------
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
40
PsiBlast_CBE
97.24
73%
-90
- C6 -
3TDL
6
ALBU_HUMAN
A:
[3-584]
--------------------------
H
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
----
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
L
G
55
PsiBlast_CBE
97.17
73%
-90
- C6 -
2YDF
4
ALBU_HUMAN
A:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
---------
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
63
PsiBlast_CBE
97.08
73%
-92
- C6 -
2XVQ
1
ALBU_HUMAN
A:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
---------
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
8
PsiBlast_PDB
96.64
73%
-92
- C6 -
1E7A
2
ALBU_HUMAN
A:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
56
PsiBlast_CBE
96.63
73%
-91
- C6 -
2XW1
1
ALBU_HUMAN
B:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
------------
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
16
PsiBlast_PDB
96.63
73%
-94
- C6 -
1O9X
7
ALBU_HUMAN
A:
[4-582]
---------------------------
K
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
R
E
T
Y
G
E
M
A
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
58
PsiBlast_CBE
96.37
73%
-91
- C6 -
2XW0
2
ALBU_HUMAN
B:
[5-582]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
------------
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
G
K
K
L
V
A
A
S
Q
A
A
--
60
PsiBlast_CBE
95.33
73%
-91
* C6 *
2XVU
2
ALBU_HUMAN
B:
[5-571]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
----------
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
-------------
61
PsiBlast_CBE
94.85
73%
-93
- C6 -
2XVU
2
ALBU_HUMAN
A:
[5-579]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
V
A
T
L
---------
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
E
Q
L
K
A
V
M
D
D
F
A
A
F
V
E
K
C
C
------
T
C
F
A
E
E
G
K
K
L
V
A
A
S
-----
17
PsiBlast_PDB
94.72
73%
-92
- C6 -
1HK1
4
ALBU_HUMAN
A:
[5-569]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
------------
D
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
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A
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R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
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C
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A
A
D
K
A
A
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L
L
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A
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A
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A
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A
R
L
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F
P
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A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
R
A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
K
E
C
C
E
K
P
L
L
E
K
S
H
C
I
A
E
V
E
N
D
E
M
P
A
D
L
P
S
L
A
A
D
F
V
E
S
K
D
V
C
K
N
Y
A
E
A
K
D
V
F
L
G
M
F
L
Y
E
Y
A
R
R
H
P
D
Y
S
V
V
L
L
L
R
L
A
K
T
Y
E
T
T
L
E
K
C
C
A
A
A
D
P
H
E
C
Y
A
K
V
F
D
E
F
K
P
L
V
E
E
P
Q
N
L
I
K
Q
N
C
E
L
F
E
Q
L
G
E
Y
K
F
Q
N
A
L
L
V
R
Y
T
K
K
V
P
Q
V
S
T
P
T
L
V
E
V
S
R
N
L
G
K
V
G
S
K
C
C
K
H
P
E
A
K
R
M
P
C
A
E
D
Y
L
S
V
V
L
N
Q
L
C
V
L
H
E
K
T
P
V
S
D
R
V
T
K
C
C
T
E
S
L
V
N
R
R
P
C
F
S
A
L
E
V
D
E
T
Y
V
P
K
E
F
N
A
E
T
F
T
F
H
A
D
I
C
T
L
S
E
K
E
R
Q
I
K
K
Q
T
A
L
V
E
L
V
K
H
K
P
K
A
T
K
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Q
L
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A
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M
D
D
F
A
A
F
V
E
K
C
C
K
A
D
D
K
E
T
C
F
A
---------------
37
PsiBlast_CBE
94.50
73%
-87
- C6 -
4E99
2
ALBU_HUMAN
A:
[5-571]
----------------------------
S
E
V
A
H
R
F
K
D
L
G
E
E
N
F
K
A
L
V
L
I
A
F
A
Q
Y
L
Q
Q
C
P
F
E
D
H
V
K
L
V
N
E
V
T
E
F
A
K
T
C
V
A
D
E
S
A
E
N
C
D
K
S
L
H
T
L
F
G
D
K
L
C
T
-------------
C
C
A
K
Q
E
P
E
R
N
E
C
F
L
Q
H
K
D
D
N
P
N
L
P
R
L
V
R
P
E
V
D
V
M
C
T
A
F
H
D
N
E
E
T
F
L
K
K
Y
L
Y
E
I
A
R
R
H
P
Y
F
Y
A
P
E
L
L
F
F
A
K
R
Y
K
A
A
F
T
E
C
C
Q
A
A
D
K
A
A
C
L
L
P
K
L
D
E
L
R
D
E
G
K
A
S
S
A
K
Q
R
L
K
C
A
S
L
Q
K
F
G
E
R
A
F
K
A
W
A
V
A
R
L
S
Q
R
F
P
K
A
E
F
A
E
V
S
K
L
V
T
D
L
T
K
V
H
T
E
C
C
-
H
G
D
L
L
E
C
A
D
D
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A
D
L
A
K
Y
I
C
E
N
Q
D
-
S
I
S
S
K
L
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C
C
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L
L
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A
E
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D
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M
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A
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L
A
A
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Y
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F
L
Y
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Y
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L
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T
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T
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R
N
L
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V
G
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C
C
K
H
P
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A
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M
P
C
A
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D
Y
L
S
V
V
L
N
Q
L
C
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L
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K
T
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C
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N
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R
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A
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L
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D
D
F
A
A
F
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E
K
C
C
K
A
D
D
K
E
T
C
F
A
E
E
-------------
66
Fugue
47.22
75%
-87
- C6 -
1BJ5
3
?
?:
[198-389]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
C
A
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---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------