@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00294_ADK_TO: (2014-09-04 )
MAVDSSNSATGPMRVFAIGNPILDLVAEVPSSFLDEFFLKRGDATLATPEQMRIYSTLDQFNPTSLPGGSALNSVRVVQKLLRKPGSAGYMGAIGDDPRGQVLKELCDKEGLATRFMVAPGQSTGVCAVLINEKERTLCTHLGACGSFRLPEDWTTFASGALIFYATAYTLTATPKNALEVAGYAHGIPNAIFTLNLSAPFCVELYKDAMQSLLLHTNILFGNEEEFAHLAKVHNLVAAEKTALSTANKEHAVEVCTGALRLLTAGQNTGATKLVVMTRGHNPVIAAEQTADGTVVVHEVGVPVVAAEKIVDTNGAGDAFVGGFLYALSQGKTVKQCIMCGNACAQDVIQHVGFSLSFTSLPC
Atome Classification :
(16 SA)
.........10........20........30........40........50.......-.60...-.....70........80.....-...90........100.......110.......120-.......130.......140.......150---.-.----.......160.......170.......180.......190........200.......210.......220.......230.......240.......250.......260.......270........280......--.290.......300.......310.......320.......330.......340.......350.......360.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAVDSSNSATG
P
M
R
V
F
AIG
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
KRGDATLA
T
P
E
Q
M
R
I
Y
S
T
L
-DQFNPT-SLPG
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
RKPG-SAGYMGAIGDD
P
R
G
Q
V
L
K
E
L
CDKEGL
A
T
R
F
M
VAPGQ-ST
G
V
C
A
V
L
INEK
E
R
T
L
C
T
H
LGACGSFRL-----P-E----
D
W
T
T
FAS
G
A
L
I
F
Y
A
T
A
Y
T
L
TATPK
N
A
L
E
V
AGYAHGIPN-
A
I
F
T
L
NLSA
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
HTNILFG
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
A
A
E
K
T
A
LSTAN
K
E
H
A
V
E
V
C
T
G
A
L
R
L
L
TAGQNTG-
A
T
K
L
V
V
M
TRGHN
P
V
I
A
A
E--QTAD
G
T
V
V
V
H
EVGV
P
V
V
A
A
E
K
I
VDTNGA
G
D
A
F
V
G
G
F
L
Y
A
LSQ
G
K
T
V
K
Q
C
I
M
CG
N
A
C
A
Q
D
V
I
Q
HVGF
S
L
SFTSLPC
7
PsiBlast_PDB
97.87
99%
-133
- C1 -
2A9Y
2
ADK_TOXGO
A:
[30-379]
---------
T
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
V
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
L
-----
P
-
E
----
D
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
L
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
A
A
E
K
T
A
L
S
T
A
N
K
E
H
A
V
E
V
C
T
G
A
L
R
L
L
T
A
G
Q
N
T
S
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
A
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
T
----
6
PsiBlast_PDB
97.16
99%
-140
- C1 -
2ABS
1
ADK_TOXGO
A:
[30-379]
---------
T
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
V
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
L
-----
P
-
E
----
D
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
L
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
----------
N
K
E
H
A
V
E
V
C
T
G
A
L
R
L
L
T
A
G
Q
N
T
S
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
A
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
T
----
8
PsiBlast_PDB
96.98
99%
-133
- C1 -
2A9Z
2
ADK_TOXGO
A:
[30-379]
---------
T
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
V
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
L
-----
P
-
E
----
D
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
L
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
A
A
E
K
T
A
L
S
T
A
N
K
E
H
A
V
E
V
C
T
G
A
L
R
L
L
T
A
G
Q
N
T
S
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
A
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
T
----
9
PsiBlast_PDB
96.65
99%
-130
- C1 -
2AA0
2
ADK_TOXGO
A:
[30-379]
---------
T
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
V
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
L
-----
P
-
E
----
D
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
L
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
A
A
E
K
T
A
L
S
T
A
N
K
E
H
A
V
E
V
C
T
G
A
L
R
L
L
T
A
G
Q
N
T
S
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
A
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
T
----
10
PsiBlast_PDB
96.40
99%
-131
- C1 -
2AB8
2
ADK_TOXGO
A:
[30-379]
---------
T
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
V
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
L
-----
P
-
E
----
D
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
L
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
A
A
E
K
T
A
L
S
T
A
N
K
E
H
A
V
E
V
C
T
G
A
L
R
L
L
T
A
G
Q
N
T
S
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
A
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
T
----
1
PsiBlast_PDB
95.12
99%
-132
- C1 -
1DGM
2
ADK_TOXGO
A:
[10-363]
---------
T
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
V
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
L
-----
P
-
E
----
D
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
F
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
--------
T
A
N
K
E
H
A
V
E
V
C
T
G
A
L
R
L
L
T
A
G
Q
N
T
G
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
A
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
T
S
L
P
C
4
PsiBlast_PDB
91.55
98%
-126
- C1 -
1LIJ
2
ADK_TOXGO
A:
[11-358]
----------
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
T
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
I
-----
P
-
E
----
N
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
L
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
---
K
V
A
L
S
V
A
N
K
E
H
A
V
---------------
T
G
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
G
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
-----
3
PsiBlast_PDB
91.00
98%
-121
- C1 -
1LII
2
ADK_TOXGO
A:
[11-358]
----------
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
T
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
I
-----
P
-
E
----
N
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
L
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
A
--
K
V
A
L
S
V
A
N
K
E
H
A
V
E
---------------
G
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
G
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
-----
5
PsiBlast_PDB
90.39
98%
-123
- C1 -
1LIK
2
ADK_TOXGO
A:
[11-358]
----------
G
P
M
R
V
F
A
I
G
N
P
I
L
D
L
V
A
E
V
P
S
S
F
L
D
E
F
F
L
K
R
G
D
A
T
L
A
T
P
E
Q
M
R
I
Y
S
T
L
-
D
Q
F
N
P
T
-
S
L
P
G
G
S
A
L
N
S
V
R
V
V
Q
K
L
L
R
K
P
G
-
S
A
G
Y
M
G
A
I
G
D
D
P
R
G
Q
V
L
K
E
L
C
D
K
E
G
L
A
T
R
F
M
V
A
P
G
Q
-
S
T
G
T
C
A
V
L
I
N
E
K
E
R
T
L
C
T
H
L
G
A
C
G
S
F
R
I
-----
P
-
E
----
N
W
T
T
F
A
S
G
A
L
I
F
Y
A
T
A
Y
T
L
T
A
T
P
K
N
A
L
E
V
A
G
Y
A
H
G
I
P
N
-
A
I
F
T
L
N
L
S
A
P
F
C
V
E
L
Y
K
D
A
M
Q
S
L
L
L
H
T
N
I
L
F
G
N
E
E
E
F
A
H
L
A
K
V
H
N
L
V
---
K
V
A
L
S
V
A
N
K
E
H
A
V
---------------
T
G
-
A
T
K
L
V
V
M
T
R
G
H
N
P
V
I
A
A
E
--
Q
T
A
D
G
T
V
V
V
H
E
V
G
V
P
V
V
A
A
E
K
I
V
D
T
N
G
A
G
D
A
F
V
G
G
F
L
Y
G
L
S
Q
G
K
T
V
K
Q
C
I
M
C
G
N
A
C
A
Q
D
V
I
Q
H
V
G
F
S
L
S
F
-----
33
HHSearch
66.76
30%
-110
- C1 -
3VAS
1
?
A:
[23-360]
----------
S
E
G
Y
V
F
G
M
G
N
P
L
L
D
I
I
V
D
A
D
D
F
M
Y
R
K
Y
N
L
K
K
D
N
I
V
L
A
E
E
K
H
M
T
I
Y
D
E
I
Q
K
K
K
K
L
N
-
Y
I
A
G
G
A
T
L
N
T
V
K
M
I
Q
W
I
I
Q
K
P
F
-
V
C
S
Y
V
G
C
I
G
A
D
I
Q
G
K
Y
I
K
N
D
C
S
A
L
D
L
V
T
E
F
Q
I
A
E
E
P
L
M
T
G
K
V
A
V
L
V
S
E
K
L
R
S
M
V
T
Y
L
G
A
A
C
D
L
S
L
-----
A
-
H
I
E
Q
P
H
V
W
S
L
V
E
K
A
Q
V
Y
Y
I
A
G
F
V
I
N
T
C
Y
E
G
M
L
K
I
A
K
H
S
L
E
-
N
E
-
K
L
F
C
F
N
L
S
A
P
F
L
S
Q
F
N
T
K
E
V
D
E
M
I
S
Y
S
N
I
V
F
G
N
E
S
E
A
E
A
Y
G
E
V
H
G
L
L
E
D
T
V
H
-----------
A
T
A
R
Y
I
A
D
L
--
P
F
A
D
G
K
K
R
K
R
L
V
I
I
T
R
G
K
N
P
L
L
Y
T
D
SS
D
S
--
E
---
I
H
Q
F
M
V
E
Q
F
K
D
D
Q
I
I
D
T
N
G
A
G
D
A
F
A
A
G
F
I
A
D
Y
I
R
G
K
P
M
I
T
S
L
H
A
A
V
K
A
A
A
Y
I
I
C
R
S
G
F
S
L
G
S
-----
32
HHSearch
66.15
33%
-106
- C1 -
3LOO
1
?
A:
[21-357]
---------
L
R
D
G
M
L
V
G
L
G
N
P
L
L
D
I
S
A
V
V
E
K
D
L
L
N
K
Y
D
M
Q
P
N
N
A
I
L
A
E
E
K
H
M
P
M
Y
Q
E
L
I
E
K
Y
Q
A
E
-
Y
I
A
G
G
S
V
Q
N
S
L
R
V
A
Q
W
I
L
Q
R
P
R
-
T
A
I
F
F
G
C
V
G
Q
D
E
Y
A
R
I
L
E
E
R
A
T
S
N
G
V
N
V
Q
Y
Q
R
S
A
T
S
-
P
T
G
T
C
A
V
L
V
T
G
T
Q
R
S
L
C
A
N
L
A
A
A
N
D
F
T
P
-----
E
-
H
L
R
S
D
G
N
R
A
Y
L
Q
G
A
Q
F
F
Y
V
S
G
F
F
F
T
V
S
F
E
S
A
L
S
V
A
K
E
A
A
A
-
T
G
-
R
M
F
M
M
N
L
S
A
P
F
V
P
Q
F
Y
K
N
N
L
E
E
I
F
P
Y
V
D
V
L
F
G
N
E
T
E
A
I
A
L
A
K
E
F
N
Y
G
T
E
D
L
R
E
I
-----------
G
K
R
I
A
A
L
--
P
K
E
N
G
K
-
R
K
R
I
V
I
I
T
Q
G
S
D
P
V
L
L
I
E
--
A
G
T
-
D
N
--
V
R
E
F
P
V
Q
K
L
A
------
T
N
G
A
G
D
A
F
V
G
G
F
L
A
Q
L
L
Q
S
R
T
V
D
V
C
I
K
C
G
I
W
A
A
R
E
I
I
Q
R
S
G
C
T
F
E
G
-----
29
HHSearch
64.88
32%
-107
- C1 -
1BX4
2
ADK_HUMAN
A:
[4-339]
---------
V
R
E
N
I
L
F
G
M
G
N
P
L
L
D
I
S
A
V
V
D
K
D
F
L
D
K
Y
S
L
K
P
N
D
Q
I
L
A
E
D
K
H
K
E
L
F
D
E
L
V
K
K
F
K
V
E
-
Y
H
A
G
G
S
T
Q
N
S
I
K
V
A
Q
W
M
I
Q
Q
P
H
K
A
A
T
F
F
G
C
I
G
I
D
K
F
G
E
I
L
K
R
K
A
A
E
A
H
V
D
A
H
Y
Y
E
Q
N
E
Q
-
P
T
G
T
C
A
A
C
I
T
G
D
N
R
S
L
I
A
N
L
A
A
A
N
C
Y
K
K
-----
E
K
H
LDL
E
K
N
W
M
L
V
E
K
A
R
V
C
Y
I
A
G
F
F
L
T
V
S
P
E
S
V
L
K
V
A
H
H
A
S
E
-
N
N
-
R
I
F
T
L
N
L
S
A
P
F
I
S
Q
F
Y
K
E
S
L
M
K
V
M
P
Y
V
D
I
L
F
G
N
E
T
E
A
A
T
F
A
R
E
Q
G
F
E
T
K
D
I
K
E
-----------
I
A
K
K
T
Q
A
--
L
P
K
M
N
S
K
-
R
Q
R
I
V
I
F
T
Q
G
R
D
D
T
I
M
A
T
--
E
---
S
E
--
V
T
A
F
A
V
L
D
Q
D
Q
K
E
I
I
D
T
N
G
A
G
D
A
F
V
G
G
F
L
S
Q
L
V
S
D
K
P
L
T
E
C
I
R
A
G
H
Y
A
A
S
I
I
I
R
R
T
G
C
T
F
P
------
18
PsiBlast_PDB
64.75
30%
-111
- C1 -
3UQ9
2
?
A:
[29-360]
--------------
V
F
G
M
G
N
P
L
L
D
I
I
V
D
A
D
D
F
M
Y
R
K
Y
N
L
K
K
D
N
I
V
L
A
E
E
K
H
M
T
I
Y
D
E
I
-
Q
K
K
K
K
L
N
Y
I
A
G
G
A
T
L
N
T
V
K
M
I
Q
W
I
I
Q
K
P
F
-
V
C
S
Y
V
G
C
I
G
A
D
I
Q
G
K
Y
I
K
N
D
C
S
A
L
D
L
V
T
E
F
Q
I
A
E
E
P
L
M
T
G
K
V
A
V
L
V
S
E
K
L
R
S
M
V
T
Y
L
G
A
A
C
D
L
S
L
A
H
I
E
Q
P
-
H
----
V
W
-
S
L
V
E
K
A
Q
V
Y
Y
I
A
G
F
V
I
N
T
C
Y
E
G
M
L
K
I
A
K
--
H
S
L
E
N
E
K
L
F
C
F
N
L
S
A
P
F
L
S
Q
F
N
T
K
E
V
D
E
M
I
S
Y
S
N
I
V
F
G
N
E
S
E
A
E
A
Y
G
E
V
H
G
L
L
--
E
D
T
V
H
A
T
A
R
Y
I
A
D
L
P
F
A
D
G
K
K
R
-----------
K
R
L
V
I
I
T
R
G
K
N
P
L
L
Y
T
D
---
S
S
D
S
E
--
I
H
Q
F
M
V
E
Q
F
K
D
D
Q
I
I
D
T
N
G
A
G
D
A
F
A
A
G
F
I
A
D
Y
I
R
G
K
P
M
I
T
S
L
H
A
A
V
K
A
A
A
Y
I
I
C
R
S
G
F
S
L
-------
15
PsiBlast_PDB
64.69
30%
-112
- C1 -
3VAQ
1
?
A:
[29-360]
--------------
V
F
G
M
G
N
P
L
L
D
I
I
V
D
A
D
D
F
M
Y
R
K
Y
N
L
K
K
D
N
I
V
L
A
E
E
K
H
M
T
I
Y
D
E
I
-
Q
K
K
K
K
L
N
Y
I
A
G
G
A
T
L
N
T
V
K
M
I
Q
W
I
I
Q
K
P
F
-
V
C
S
Y
V
G
C
I
G
A
D
I
Q
G
K
Y
I
K
N
D
C
S
A
L
D
L
V
T
E
F
Q
I
A
E
E
P
L
M
T
G
K
V
A
V
L
V
S
E
K
L
R
S
M
V
T
Y
L
G
A
A
C
D
L
S
L
A
H
I
E
Q
P
-
H
----
V
W
-
S
L
V
E
K
A
Q
V
Y
Y
I
A
G
F
V
I
N
T
C
Y
E
G
M
L
K
I
A
K
--
H
S
L
E
N
E
K
L
F
C
F
N
L
S
A
P
F
L
S
Q
F
N
T
K
E
V
D
E
M
I
S
Y
S
N
I
V
F
G
N
E
S
E
A
E
A
Y
G
E
V
H
G
L
L
--
E
D
T
V
H
A
T
A
R
Y
I
A
D
L
P
F
A
D
G
K
K
R
-----------
K
R
L
V
I
I
T
R
G
K
N
P
L
L
Y
T
D
---
S
S
D
S
E
--
I
H
Q
F
M
V
E
Q
F
K
D
D
Q
I
I
D
T
N
G
A
G
D
A
F
A
A
G
F
I
A
D
Y
I
R
G
K
P
M
I
T
S
L
H
A
A
V
K
A
A
A
Y
I
I
C
R
S
G
F
S
L
-------
16
PsiBlast_PDB
64.62
30%
-113
- C1 -
4DC3
1
?
A:
[29-360]
--------------
V
F
G
M
G
N
P
L
L
D
I
I
V
D
A
D
D
F
M
Y
R
K
Y
N
L
K
K
D
N
I
V
L
A
E
E
K
H
M
T
I
Y
D
E
I
-
Q
K
K
K
K
L
N
Y
I
A
G
G
A
T
L
N
T
V
K
M
I
Q
W
I
I
Q
K
P
F
-
V
C
S
Y
V
G
C
I
G
A
D
I
Q
G
K
Y
I
K
N
D
C
S
A
L
D
L
V
T
E
F
Q
I
A
E
E
P
L
M
T
G
K
V
A
V
L
V
S
---
R
S
M
V
T
Y
L
G
A
A
C
D
L
S
L
A
H
I
E
Q
P
-
H
----
V
W
-
S
L
V
E
K
A
Q
V
Y
Y
I
A
G
F
V
I
N
T
C
Y
E
G
M
L
K
I
A
K
--
H
S
L
E
N
E
K
L
F
C
F
N
L
S
A
P
F
L
S
Q
F
N
T
K
E
V
D
E
M
I
S
Y
S
N
I
V
F
G
N
E
S
E
A
E
A
Y
G
E
V
H
G
L
L
--
E
D
T
V
H
A
T
A
R
Y
I
A
D
L
P
F
A
D
G
K
K
R
-----------
K
R
L
V
I
I
T
R
G
K
N
P
L
L
Y
T
D
---
S
S
D
S
E
--
I
H
Q
F
M
V
E
Q
F
K
D
D
Q
I
I
D
--
G
A
G
D
A
F
A
A
G
F
I
A
D
Y
I
R
G
K
P
M
I
T
S
L
H
A
A
V
K
A
A
A
Y
I
I
C
R
S
G
F
S
L
-------
17
PsiBlast_PDB
64.37
30%
-109
- C1 -
3UQ6
2
?
A:
[29-360]
--------------
V
F
G
M
G
N
P
L
L
D
I
I
V
D
A
D
D
F
M
Y
R
K
Y
N
L
K
K
D
N
I
V
L
A
E
E
K
H
M
T
I
Y
D
E
I
-
Q
K
K
K
K
L
N
Y
I
A
G
G
A
T
L
N
T
V
K
M
I
Q
W
I
I
Q
K
P
F
-
V
C
S
Y
V
G
C
I
G
A
D
I
Q
G
K
Y
I
K
N
D
C
S
A
L
D
L
V
T
E
F
Q
I
A
E
E
P
L
M
T
G
K
V
A
V
L
V
S
E
K
L
R
S
M
V
T
Y
L
G
A
A
C
D
L
S
L
A
H
I
E
Q
P
-
H
----
V
W
-
S
L
V
E
K
A
Q
V
Y
Y
I
A
G
F
V
I
N
T
C
Y
E
G
M
L
K
I
A
K
--
H
S
L
E
N
E
K
L
F
C
F
N
L
S
A
P
F
L
S
Q
F
N
T
K
E
V
D
E
M
I
S
Y
S
N
I
V
F
G
N
E
S
E
A
E
A
Y
G
E
V
H
G
L
L
--
E
D
T
V
H
A
T
A
R
Y
I
A
D
L
P
F
A
D
G
K
K
R
-----------
K
R
L
V
I
I
T
R
G
K
N
P
L
L
Y
T
D
---
S
S
D
S
E
--
I
H
Q
F
M
V
E
Q
F
K
D
D
Q
I
I
D
T
N
G
A
G
D
A
F
A
A
G
F
I
A
D
Y
I
R
G
K
P
M
I
T
S
L
H
A
A
V
K
A
A
A
Y
I
I
C
R
S
G
F
S
L
-------