@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00433_AKT3_H: (2014-09-06 )
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.....-..160.......170........180.......190.......200-........210.......220.......230.......-240.......250.......260....--...270.......280........290.......300..--.....310.......320--........330.......340-.....--..350.......360-----........370.......380.......390.......400.......---410.......420.......430.......440.......450.......460.......470.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
D
V
T
I
V
K
E
G
W
V
Q
K
R
G
E
Y
I
K
NWR
P
R
Y
F
L
L
KTDGSFIGYKEKPQDVDLPYPLNNF
S
V
A
K
C
Q
L
MKTERPKP
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
TFHVDT
P
E
E
R
E
E
W
T
E
A
I
Q
A
V
A
D
R
L
Q
R
Q
E
E
E
RMNCSP
T
S
Q
I
DNI
G
E
E
EMDASTTHHKRKTM
N
D
F
D
Y
L
K
L
LGKG-TFG
K
V
I
L
V
R
EKAS-G
K
Y
Y
A
M
K
I
L
K
K
E
V
I
I
A
K
D
E
V
A
H
T
L
T
E
S
R
V
LK--NTRHP
F
L
T
S
L
K
Y
SFQTKD
R
L
C
F
V
M
E
YVNG
G
E
L
F
F
H
L
S
R
-
E
RVFSE
D
R
T
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
HSG
K
--
I
V
Y
R
D
L
K
L
E
N
L
M
LD-KDG
H
I
K
I
T
D
F
G
L
C
KEGIT
D
A
A
T
M
K
--
T
FCG
T
P
E
Y
L
A
P
E
VLEDN---DYGR
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
CG-RLPFY--NQ
D
H
E
K
L
F
E
L
I
L
M
E------DIKFPR
T
L
S
S
D
A
K
S
L
L
S
G
LLIKDPNKRLGGG
P
D
D
A
K
E
I
M
R
H
S
FFSGV
N
---
W
Q
D
V
YDKKLVPPFKPQVTSETDTRYFDEEFTA
Q
T
I
T
ITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
1
PsiBlast_PDB
97.51
83%
-112
- C1 -
3O96
1
AKT1_HUMAN
A:
[5-432]
-
S
D
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
Q
D
V
--
E
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
---
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
L
K
K
Q
------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
----------
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
----------------
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----------------------------------------------------
2
PsiBlast_PDB
97.23
82%
-108
- C1 -
4EJN
3
AKT1_HUMAN
A:
[4-438]
---
V
A
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
K
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
------
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
T
V
A
D
G
---------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-------------
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
--------------------------------------------
10
PsiBlast_PDB
84.74
85%
-108
- C1 -
4GV1
5
AKT1_HUMAN
A:
[4-337]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
16
PsiBlast_PDB
84.55
82%
-109
- C1 -
3E87
2
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
--------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-
17
PsiBlast_PDB
83.43
82%
-110
- C1 -
3E88
2
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
----------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-
15
PsiBlast_PDB
82.69
83%
-110
- C1 -
1O6K
2
AKT2_HUMAN
A:
[3-334]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
------------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
--
18
PsiBlast_PDB
82.46
82%
-111
- C1 -
3E8D
2
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
---------------------
H
F
P
Q
F
D
Y
S
A
S
I
R
-
3
PsiBlast_PDB
82.44
85%
-106
- C1 -
3OCB
2
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
---------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
---
8
PsiBlast_PDB
82.17
85%
-104
- C1 -
4EKK
2
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
6
PsiBlast_PDB
82.09
85%
-105
- C1 -
3QKL
2
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
---
19
PsiBlast_PDB
81.78
82%
-108
- C1 -
3D0E
1
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
D
-------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-
12
PsiBlast_PDB
81.61
85%
-105
- C1 -
3MV5
2
AKT1_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
--------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
---
20
PsiBlast_PDB
81.56
81%
-110
- C1 -
1O6L
2
AKT2_HUMAN
A:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
----
7
PsiBlast_PDB
81.52
85%
-106
- C1 -
3QKM
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
13
PsiBlast_PDB
81.40
85%
-104
- C1 -
3MVH
2
AKT1_HUMAN
A:
[7-338]
----------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
----------------------
R
P
H
F
P
Q
F
D
Y
S
A
----
9
PsiBlast_PDB
81.20
85%
-103
- C1 -
4EKL
1
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-------
S
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
4
PsiBlast_PDB
80.99
85%
-104
- C1 -
3OW4
2
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
---
11
PsiBlast_PDB
80.70
85%
-107
- C1 -
3CQW
2
AKT1_HUMAN
A:
[6-339]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
------------------
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
5
PsiBlast_PDB
80.38
85%
-102
- C1 -
3QKK
2
AKT1_HUMAN
A:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
----------
M
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
29
PsiBlast_CBE
60.62
81%
-66
- C1 -
2JDO
3
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
---------------------
M
F
E
D
F
D
Y
I
A
----
21
PsiBlast_CBE
60.33
85%
-64
- C1 -
4EKK
2
AKT1_HUMAN
B:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
---
24
PsiBlast_CBE
60.27
82%
-64
- C1 -
3E8D
3
AKT2_HUMAN
B:
[3-335]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
-------------------
Q
R
T
H
F
P
Q
F
D
Y
S
A
S
I
R
-
25
PsiBlast_CBE
60.02
81%
-68
- C1 -
2XH5
2
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
----
27
PsiBlast_CBE
59.69
81%
-64
- C1 -
2UW9
2
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
----
22
PsiBlast_CBE
59.26
85%
-62
- C1 -
3OW4
2
AKT1_HUMAN
B:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
-------------------
R
P
H
F
P
Q
F
D
Y
S
A
S
---
26
PsiBlast_CBE
59.08
81%
-65
- C1 -
2X39
2
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
----
40
Fugue
58.52
40%
-90
- C1 -
1CDK
3
KAPCA_PIG
A:
[8-350]
-------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
-------------------
H
--
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
K
E
T
G-
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V--
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
--
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
--
G
--
R
TW
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-KGY--
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y-
P
P
F
F
AD--
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
PS------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
---TT
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-------------
N
E
K
C
G
K
E
F
S
E
F
--------
28
PsiBlast_CBE
58.24
81%
-62
- C1 -
2JDR
2
AKT2_HUMAN
A:
[8-340]
-----------------------------------------------------------------------------------------------------------------------------------------------
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
--
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
--
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
R
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
-------------------
Q
E
M
F
E
D
F
D
Y
I
A
----
23
PsiBlast_CBE
56.95
85%
-58
- C1 -
3OCB
2
AKT1_HUMAN
B:
[5-338]
---------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
K
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
--
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
---
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
-----------------
R
P
H
F
P
Q
F
D
Y
S
A
S
---