@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00433_KPCE_H: (2014-09-07 )
MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLMP
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...-....310.......320.......------------330---.-------.......340---------.....-----------------...350.......360....-...370.......380.......390.......400.......410.....-..420.....---.---.430........440.....-..450.......460...-....470.......480.......490.......500.----.......510.......520..-.-....530.......540........550....---...560....-...570.......580--.-----.......590.......600.-....---.--.---610---........620------.--....---..630.......640.......650.......660.......670---.......680.......690---.........700...-....710.......720-.........730.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
V
FN
G
L
L
K
I
K
I
C
E
AVSLKPT
A
W
S
L
R
HAVGPRP
Q
T
F
L
LD
P
Y
I
A
L
NV
D
D
SRIGQTATKQKTNSPA
W
H
D
E
F
V
T
D
VCNG
R
K
I
E
L
A
V
F
HDAPI
G
Y
D
D
F
V
A
N
C
T
I
Q
F
E
E
L
L
QNG
S
R
H
F
E
D
W
IDLEPEG
R
V
Y
V
I
I
D
LSGSSGEAPKD
N
E
E
R
V
F
R
E
RMR
P
R
K
R
Q
G
A
V
R
R
R
V
H
QVNG
H
K
F
M
A
T
Y
LRQP
T
Y
C
S
H
C
R
D
F
I
W
G
V
IGKQG
Y
Q
C
Q
V
C
T
C
V
V
H
K
R
C
H
E
L
I
I
T
K
CAGLKKQE
T
P
D
Q
VGS
Q
R
F
SVNMPHKFGIHNYKV
P
T
F
C
D
H
C
G
S
L
L
W
G
L
L
RQGL
Q
C
K
V
C
KMNVHRRCETNVAPNCGV
D
A
R
G
I
A
K
V
L
A
D-LGV
T
P
D
KITN
S
G
Q
R
R
K
K
L
IAGAES------------PQ----P-------ASGSSPS
E
E
----------DRSKS-----------------APTS
P
C
D
Q
E
I
K
E
L
E
N
N
I
R
K
A
-LSFDNRGEEHRAASSPDGQLMSPGENGEVRQG
Q
A
KRLGLDEF
N
F
I
K
V
LGKG-SFGK
V
M
L
A
EL---K---GK-D
E
V
Y
A
V
K
V
LKKD
V
I
LQD-DDVD
C
T
M
T
E
K
R
I
L
A
L
A
RK-H
P
Y
L
T
Q
L
Y
C
C
FQTK
D
R
L
F
F
V
M
E
YVNGG
D
L
M
F
Q
I
Q
R
-SR----KFD
E
P
R
S
R
F
Y
A
A
E
V
T
S
A
L
M
F
L
H
-Q-HG
V
I
Y
R
D
L
K
L
D
N
I
L
LD-AEG
H
C
KL
A
D
F
G
M
C
K
E
---
G
I
LNGVTTTT-FCGT
P
D
Y
I
A
P
E
I
L
Q
E
---L-----EYGPS
V
D
W
W
A
L
G
V
L
M
Y
E
M
MAG-QPPF---E--A---D
N
----
E
D
D
L
F
E
S
I
L
HD------D--VLY
P
---
V
WL
S
K
E
A
V
S
I
L
K
A
F
MTKNPHKRL
G
C
V
ASQN
G
E
D
A
I
K
QHP
F
F
K
E
I
D
---
W
V
L
LEQKKIKPPFKPRIK-----TKRDVNNFDQDFTRE-E
P
V
L
T
L
V
D
E
A
I
V
K
Q
I
---
N
Q
E
E
FK
G
F
S
YFGEDLMP
30
HHSearch
89.93
52%
-82
- C1 -
3PFQ
1
KPCB_RAT
A:
[102-668]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
K
F
K
I
H
T
Y
S
S
P
T
F
C
D
H
C
G
S
L
L
Y
G
L
I
H
Q
G
M
K
C
D
T
C
M
M
N
V
H
K
R
C
V
M
N
V
P
S
L
C
G
T
D
H
T
E
R
R
G
R
I
Y
I
Q
A
H
I
D
R
E
V
L
I
V
V
V
R
D
A
K
N
L
V
P
M
D
P
N
GLSD
P
Y
V
K
L
K
L
I
P
D
PKSE
S
K
Q
K
T
K
T
I
K
S
S
L
N
P
E
W
N
E
T
F
R
F
QLKES
D
K
D
R
R
L
S
V
E
I
W
D
W
D
LTSR
N
D
F
M
G
S
L
S
F
G
I
S
E
L
Q
K
-
A
G
V
D
G
W
F
K
L
L
S
Q
E
E
G
E
Y
F
N
V
P
V
P
P
----------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
S
E
R
---
K
---
G
T
-
D
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
A
L
P
G
K
-
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
----
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
-
S
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
---
N
I
W
D
G
V
T
T
K
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
---
Q
-----
P
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
-
Q
A
P
F
---
E
--
G
---
E
D
----
E
D
E
L
F
Q
S
I
M
E
H
------
N
--
V
A
Y
P
---
K
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
C
G
--
P
E
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
-----
G
R
-
N
A
E
N
F
D
R
F
F
T
R
H
-
P
P
V
L
T
P
P
D
Q
E
V
I
R
N
I
---
D
Q
S
E
F
E
G
F
S
F
V
N
S
E
F
L
-
31
HHSearch
67.76
72%
-101
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
---
E
T
-
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
-
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
----
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
---
G
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
---
M
-----
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
---
E
--
A
---
E
N
----
E
D
D
L
F
E
A
I
L
N
D
------
E
--
V
V
Y
P
---
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
T
-
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
-----
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
-
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
---
N
Q
D
E
F
R
N
F
E
Y
V
S
P
----
10
PsiBlast_PDB
67.30
53%
-105
- C1 -
3A8W
1
KPCI_HUMAN
A:
[3-341]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
-
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
---
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
---
E
-----
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
---
D
--------
T
---
E
D
Y
L
F
Q
V
I
L
E
K
------
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
-----
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
-
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
---
D
Q
S
E
F
E
G
F
E
Y
-------
35
HHSearch
66.49
54%
-102
- C1 -
4DC2
2
KPCI_MOUSE
A:
[49-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
-
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
---
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
---
E
-----
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
---
D
--
I
VGS
N
T
----
E
D
Y
L
F
Q
V
I
L
E
K
------
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
-----
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
-
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
---
D
Q
S
E
F
E
G
F
E
Y
I
N
P
----
9
PsiBlast_PDB
66.36
53%
-107
- C1 -
3ZH8
4
KPCI_HUMAN
A:
[2-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
---
K
T
-
D
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
-
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
----
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
---
G
L
R
P
G
D
T
T
S
T
-
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
---
E
-----
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
---
D
IV------
N
T
--
E
D
Y
L
F
Q
V
I
L
E
K
------
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
-
H
P
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
-----
G
E
----------------
Q
L
T
P
D
D
D
D
I
V
R
K
I
---
D
Q
S
E
F
E
G
F
E
Y
I
N
P
L
L
M
-
14
PsiBlast_PDB
65.54
46%
-104
- C1 -
2JDO
3
AKT2_HUMAN
A:
[6-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
-
S
I
T
------------------
M
F
E
D
F
D
Y
I
A
D
----
13
PsiBlast_PDB
65.15
46%
-102
- C1 -
1O6L
2
AKT2_HUMAN
A:
[1-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
-
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
----
34
HHSearch
64.11
47%
-101
- C1 -
4GV1
5
AKT1_HUMAN
A:
[3-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
-
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
K
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
S
--
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
-----
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
-
M
I
T
I
T
P
----
S
M
E
C
V
DSE
R
R
P
H
F
P
Q
F
D
Y
S
A
S
----
18
PsiBlast_PDB
64.08
46%
-100
- C1 -
2XH5
2
AKT2_HUMAN
A:
[6-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
-
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
----
16
PsiBlast_PDB
64.07
46%
-99
- C1 -
2UW9
2
AKT2_HUMAN
A:
[6-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
-
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
----
17
PsiBlast_PDB
63.84
46%
-101
- C1 -
2X39
2
AKT2_HUMAN
A:
[6-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
-
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
----
15
PsiBlast_PDB
62.84
46%
-100
- C1 -
2JDR
2
AKT2_HUMAN
A:
[6-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
-
S
I
T
----------------
Q
E
M
F
E
D
F
D
Y
I
A
D
----
38
HHSearch
60.85
36%
-97
- C1 -
4AW2
3
MRCKA_RAT
A:
[69-408]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
---
K
---
N
A
-
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
-
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
----
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
-
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
---
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
---
M
E
GGKG
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
---
Y
--
A
---
E
S
----
L
V
E
T
Y
G
K
I
M
N
H
------
K
ER
F
Q
F
P
TQV
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
G
Q
----
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
-----
S
P
T
D
T
S
N
F
D
V
D
------------------
S
G
---
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
--
5
PsiBlast_PDB
59.23
54%
-111
- C1 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
---
K
T
-
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
-
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
----
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
---
N
M
L
G
D
A
K
T
N
T
-
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
---
Q
-----
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
---
H
--
G
---
Q
D
----
E
E
E
L
F
H
S
I
R
M
D
------
N
--
P
F
Y
P
---
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
-----------------------------------------------
Q
N
M
F
R
N
F
S
F
-------
19
PsiBlast_PDB
58.37
49%
-103
- C1 -
3E87
2
AKT2_HUMAN
A:
[1-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
--------------------------------------
20
PsiBlast_PDB
57.74
49%
-103
- C1 -
3E88
2
AKT2_HUMAN
A:
[1-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
E
---
K
---
A
T
-
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
L
Q
N
T
R
--
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
----
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
-
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
---
G
I
S
D
G
A
T
M
K
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
---
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
---
Y
--
N
---
Q
D
----
H
E
R
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
P
S
D
A
K
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
-----
S
E
V
D
T
R
Y
F
D
D
E
F
T
--------------------------------------
42
HHSearch
56.72
40%
-88
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[37-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
---
E
S
-
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
-
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
--
K
-
G
R
T
W
T
-
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
---
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
---
F
--
A
---
D
Q
----
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
--
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
-
E
I
R
V
S
I
N
E
------
K
---
C
G
K
E
F
T
E
F
---------
41
HHSearch
54.79
41%
-101
- C1 -
4L42
1
KS6B1_HUMAN
A:
[13-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
VTG
A
---
N
T
-
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
---
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
---
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
---
T
--
G
---
E
N
----
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
--
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
---------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
----
44
HHSearch
49.92
36%
-90
- C1 -
3C4Z
1
RK_BOVIN
A:
[180-510]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
-
G
F
G
E
V
F
A
C
Q
M
---
K
---
A
T
-
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
-
H
-
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
-
V
D
ED
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
---
L
K
A
G
Q
T
K
T
K
G
-
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
---
E
-----
E
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
-
R
G
P
F
---
R
--
A
---
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
------
A
--
V
T
Y
P
---
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
--
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
TVYAK
N
----
G
A
F
S
-------
G
V
A
F
E
K
--------
A
---
D
T
E
F
F
Q
E
F
A
S
G
T
-----
27
Fugue
47.96
37%
-81
- C1 -
1CDK
3
KAPCA_PIG
A:
[8-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
-
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------
H
--
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
---
K
---
E
T
G-
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
--N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
----
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
--
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
VKG-
R
T
-----
W
T
-
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
KGY--------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y-
P
P
F
FAD--------
Q
----
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
PS-----------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
--
N
L
K
D
G
V
N
D
I
K
N
H
K
W
F
A
---TT
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
-----
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
--------
N
E
K
---
C
G
K
E
F
S
E
F
---------
51
HHSearch
46.74
42%
-96
* C1 *
4L3J
1
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
---
V
TGA
N
T
-
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
-
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
----
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
---
S
I
H
D
G
T
V
T
H
T
-
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
---
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
---
T
--
G
---
E
N
----
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
P
--
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-----
S
--------------------------------------------------
37
HHSearch
45.93
45%
-109
- C1 -
2R5T
1
SGK1_HUMAN
A:
[33-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
---
A
E
-
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
N
V
K
-
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
----
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
---
N
I
E
H
N
S
T
T
S
T
-
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
---
Q
-----
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
---
Y
--
S
---
R
N
----
T
A
E
M
Y
D
N
I
L
N
K
------
P
--
L
Q
L
K
---
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
---
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
-----
G
--------------------------------------------------