@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00433_KS6A4_: (2014-09-07 )
MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
Atome Classification :
(27 SA)
-------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40.-.......50........60........70..-......80........90....--....100.......110.......120......----.--130........140.......150.-.-.....160.......170.......180.......190...-....200.......210---..---......220.......230.....------..240.......250.....------.--.260---.......270.......280......-.-290.......300...---....310.......320...---------....330.......340........-----.--350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------------------------------------------------------------------------------MGDEDDDE
S
C
A
V
E
L
R
I
T
EANLTGHEEKVSVEN
F
E
L
L
K
V
LGTG-AY
G
K
V
F
L
V
R
KAGGH
D
A
G
K
L
Y
A
M
K
V
L
R
K
A
A
L
V
-
Q
R
A
K
T
Q
E
HT
R
T
E
R
S
V
L
E
L
V
R
QA--
P
F
L
V
T
L
H
Y
A
FQTD
A
K
L
H
L
I
L
D
YVSG
G
E
M
F
T
H
L
Y
----
Q
--
R
Q
-
Y
F
K
EA
E
V
R
V
YGG
E
I
V
L
A
L
E
H
L
H
-
K
-
L
G
I
I
Y
R
D
L
K
L
E
N
V
L
LDSEG
H
I
V
L
T
DFGL
S
K
E
F
L
T
E
E
K
E
R
T
F
-
S
F
CG
T
I
E
Y
M
A
P
E
I
I
RS----KT---GHGK
A
V
D
W
W
S
L
G
I
L
L
F
E
L
LTGAS
P
------
F
T
LEGERN
T
Q
A
E
V
S
R
R
I
LKC------S--PPFP---PR
I
G
P
V
A
Q
D
L
L
Q
R
L
LCK
D
P
K
K
RLGAG-P-Q
G
A
Q
E
V
RNHPFFQG
L
D
---
W
V
A
L
A
A
R
KIPAPF
R
P
Q
I
R
SE---------LDV
G
N
F
A
E
E
F
T
RLEP--VYSPPGSP-----P--PGDP
R
I
FQ
G
Y
S
FV
A
P
S
I
L
FDHNN
A
V
MTDGLEAPGAGDRP
G
R
A
A
V
A
R
S
A
MMQDSP
F
F
Q
Q
Y
ELDLREPALGQG
S
F
S
V
C
R
R
C
R
QRQS
G
Q
E
F
A
V
K
I
L
S
R
R
LEAN
T
Q
R
E
V
A
A
L
R
L
C
Q
SHP
N
V
V
N
L
H
E
V
H
H
D
Q
L
H
T
Y
L
V
L
E
L
LRG
G
E
L
L
E
H
I
R
K
KRHF
S
E
S
E
A
S
Q
I
L
R
S
L
V
S
A
V
S
F
M
H
E
EAG
V
V
HRDLKPE
N
I
L
YADDTPGA
P
V
K
I
I
DFG
F
A
RLRPQSPGVPMQT
P
C
F
T
L
QYA
A
P
E
L
L
A
QQGYDESC
D
L
W
S
L
G
V
I
L
Y
M
M
LSGQVPFQGASGQGG
Q
S
Q
A
A
E
I
M
C
KIREG
R
F
SLD
G
E
A
WQ
G
V
S
E
E
A
K
E
L
V
R
G
L
LTVDP
A
K
R
L
K
LEGLRGSSWLQDGSARSSPPLR
T
P
D
V
LESS
G
P
A
V
R
SGL
N
A
T
F
M
AFNRGKRE
G
F
F
L
KSVENA
P
L
A
K
R
R
K
Q
K
L
R
S
A
T
ASRRGSPAPANPGRAPVASKGAPRRANGPLPPS
6
PsiBlast_PDB
82.27
50%
-102
- C1 -
4L46
1
KS6B1_HUMAN
A:
[9-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
----
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---
E
---------
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
--
V
-------------------
Q
V
F
L
G
F
T
Y
V
A
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.72
50%
-100
- C1 -
4L43
1
KS6B1_HUMAN
A:
[10-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
-------------
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
---------
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
--
V
----------------
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
78.26
51%
-103
- C1 -
4L42
1
KS6B1_HUMAN
A:
[13-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
-
H
--
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
-
I
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
----
N
R
K
K
T
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
----------------------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.13
50%
-92
- C1 -
4L44
1
KS6B1_HUMAN
A:
[10-346]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
-----
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
---------
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
----------------
S
--
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
77.53
43%
-98
* C1 *
4GV1
5
AKT1_HUMAN
A:
[3-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
E
---
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
K
D
E
-
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
R
-
H
--
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
----
R
--
E
R
-
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
-
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
-
I
K
D
G
A
T
M
K
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
---
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
------
F
Y
N
----
Q
D
H
E
K
L
F
E
L
I
L
M
E
------
E
--
I
R
F
P
---
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
G
-
S
-
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
---------
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
--
T
I
T
P
----SMECV
D
--
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
76.39
40%
-94
- C1 -
4DC2
2
KPCI_MOUSE
A:
[49-387]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
L
---
K
K
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
------
I
D
W
V
Q
T
E
K
H
V
F
E
Q
A
S
N
H
--
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
----
R
--
Q
R
-
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
-
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
-
R
P
G
D
T
T
S
-
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
-----
G
E
---
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
------
F
D
I
V
G
S
-
N
T
E
D
Y
L
F
Q
V
I
L
E
K
------
Q
--
I
R
I
P
---
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
H
P
Q
-
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
---------
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
--
Q
L
T
P
D
D
D
D
I
V
---
R
--
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
73.14
41%
-93
- C1 -
1RDQ
4
KAPCA_MOUSE
E:
[34-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
H
---
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
N
-
F
--
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
----
R
--
I
G
-
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
----
K
G
R
T
W
-
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
-----
S
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
------
F
F
A
----
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
------
K
--
V
R
F
P
---
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
N
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
71.94
32%
-76
- C1 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDLIPEVP
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
GPCKDLF
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
------
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
-
G
F
G
E
V
C
A
C
Q
V
---
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
-
K
R
-
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
-
S
--
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
----
H
MG
Q
A
-
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
-
R
-
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
--
P
E
G
Q
T
I
K
-
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-----
N
E
---
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
------
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
------
P
--
E
E
Y
S
---
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
-
G
-
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
---
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
----------
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
--
T
G
S
V
---
P
-----
I
--
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
70.31
36%
-91
- C1 -
4AW2
3
MRCKA_RAT
A:
[69-413]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
L
---
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
-
K
R
A
E
-
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
-
S
--
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
----
K
F
-
E
D
-
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
-
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
-
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GG
K
G
---
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
T
P
------
F
Y
A
E
----
S
L
V
E
T
Y
G
K
I
M
N
H
------
K
ER
F
Q
F
P
TQV
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
G
Q
----
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
---------
T
D
T
S
N
F
D
V
D
------------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
69.52
53%
-104
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[7-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
-
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
--------
D
I
L
V
E
V
N
-
H
--
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
------
K
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
----
D
R
K
E
T
M
T
M
I
L
K
A
------
K
--
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
69.38
41%
-95
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
V
---
K
E
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
-
Q
D
D
-
D
V
E
C
T
M
T
E
K
R
I
L
S
L
A
R
N
H
--
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
----
K
--
S
R
-
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
-
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
-
I
C
----------
G
T
P
D
Y
I
A
P
E
I
L
Q
-----
E
M
---
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
------
F
E
A
E
----
N
E
D
D
L
F
E
A
I
L
N
D
------
E
--
V
V
Y
P
---
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
L
-
T
Q
G
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
---------
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
--
V
L
T
P
I
D
E
G
-----
H
LP
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
69.24
32%
-72
- C1 -
3C4Z
1
RK_BOVIN
A:
[31-533]
----------------RD
R
K
Y
L
A
R
LKLPPLSKC
E
A
L
R
E
S
LDLGFEGMCLEQ
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
EQH
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
ADDAL
R
P
Q
K
A
Q
A
L
R
A
A
YLEPQAQLFCSFLD
A
E
T
V
A
R
A
R
AGGLF
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
--
A
Q
P
M
G
E
D
W
F
L
D
F
R
V
L
G
R
G
-
G
F
G
E
V
F
A
C
Q
M
K
A
---
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
-
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
---
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
NVDE
D
--
N
P
-
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
-
Q
-
R
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
-
L
K
A
G
Q
T
K
T
K
-
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
G
----
E
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
------
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
E
Q
------
A
--
V
T
Y
P
---
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
-
D
-
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
YAKNGAFSG
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
SG
T
C
P
I
P
W
Q
E
-----
E
--
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.17
50%
-107
- C1 -
3G51
1
KS6A3_MOUSE
A:
[5-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------
I
K
E
I
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
-----------
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
-------------
T
V
E
Y
M
A
P
E
V
V
-
N
----
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
--
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.59
51%
-92
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
-
M
----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.45
51%
-88
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[14-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
-
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
-
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
-
M
----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.92
51%
-89
- C1 -
4NW6
1
?
A:
[15-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
--
T
K
M
E
R
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
----
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
--
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.84
51%
-88
- C1 -
4NW5
1
?
A:
[15-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
--
T
K
M
E
R
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
----
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
--
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.69
51%
-100
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
----------
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
----
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
--
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.64
51%
-100
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[8-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
A
I
T
H
H
V
K
E
G
H
E
-
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
R
D
R
V
R
-------
D
I
L
V
E
V
N
H
---
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
K
-
K
A
Y
-
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
-
N
----
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
M
I
L
K
A
------
K
--
L
G
M
P
---
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
G
-
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.21
51%
-103
- C1 -
3A62
1
KS6B1_HUMAN
A:
[13-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
---------------
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
-----------
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
-
M
----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
65.64
38%
-97
- C1 -
1XJD
1
A:
[16-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
F
---
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
-
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
--
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
----
S
--
C
H
-
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
-
G
D
A
K
T
N
-
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
-----
G
Q
---
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
------
F
H
G
Q
----
D
E
E
E
L
F
H
S
I
R
M
D
------
N
--
P
F
Y
P
---
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
------
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
------------------------------------------------------
Q
N
M
F
R
N
F
S
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
64.81
43%
-107
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
H
---
K
A
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
---------------
V
L
L
K
N
V
K
H
--
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
----
R
--
E
R
-
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
-
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
-
E
H
N
S
T
T
S
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
---
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
------
F
Y
S
----
R
N
T
A
E
M
Y
D
N
I
L
N
K
------
P
--
L
Q
L
K
---
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
-
D
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
63.38
51%
-105
- C1 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
----------------
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
61.71
49%
-108
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
---------------------
I
L
A
D
V
N
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
----
R
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
L
I
L
K
A
------
K
--
L
G
M
P
---
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
60.47
49%
-102
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
-
V
-------------
I
L
A
D
V
N
H
---
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
----
K
--
E
V
-
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
G
T
V
E
Y
M
A
P
E
V
V
-
N
----
R
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
------
F
Q
G
K
D
R
K
E
T
M
T
----
L
I
L
K
A
------
K
--
L
G
M
P
---
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
G
-
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.18
51%
-96
- C1 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
------------
K
A
E
R
N
I
L
E
E
V
K
H
---
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
----
R
--
E
G
-
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
---------------
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
---
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
------
F
T
G
E
N
R
K
K
T
----
I
D
K
I
L
K
C
------
K
--
L
N
L
P
---
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
G
-
P
-
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
59.67
38%
-91
- C1 -
1CDK
3
KAPCA_PIG
A:
[8-350]
--------------------------------------------------------------------------------------------------------------------------------K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------
H
--
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
K
--
E
T
G
-
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
--
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V
---NF
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
----
R
---
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
--
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
--
G
--
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
------KGY--
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
---YPPFFA
D
-------
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
PS-----------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
-
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
---TT
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
---------
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
--
V
S
I
----------
N
--
E
K
C
G
K
E
F
S
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------