@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00641_MDM4_H: (2014-09-13 )
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTSFSTSAQCSTSDS
A
C
RISPGQINQVRPKL
P
L
L
K
I
L
H
AAGAQG
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
YDQQE
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
LGRQSFSVKDP
S
P
L
Y
D
M
L
R
K
N
L
V
T
L
ATATT
D
A
A
Q
T
L
A
LAQDHSMDIP
S
Q
D
Q
L
K
Q
S
A
E
ESSTSRKRTTEDDIPTLPTSEHKCIHSR
E
D
E
D
L
I
E
N
L
A
Q
D
E
T
S
RLDLGFEEWDVAG
L
P
W
W
F
L
GNLRSNYTPRSNGSTDLQTNQDV
G
T
A
IVSDTTDD
L
W
F
L
N
E
S
V
S
E
QLGV
G
I
K
V
E
AADT
E
Q
T
S
E
E
VGKVSD
K
K
V
I
EVGKNDDLEDSKSLSDDT
D
V
E
VTSEDEWQ
C
T
E
C
KKFNSP
S
K
R
Y
C
F
R
C
W
A
L
R
K
D
W
Y
S
D
C
S
K
L
T
H
SLSTSDITAIPEKENEGND
V
P
D
C
R
R
TISAPVVRPK
D
A
Y
I
KKENSKLFDPCNS
V
E
F
L
DLAHSS
E
S
Q
E
T
I
S
S
M
G
E
Q
L
D
N
L
S
E
QRTDTE
N
M
E
D
C
Q
N
L
L
K
P
C
S
L
C
E
KRPRDG
N
I
IHGRTGH
L
V
T
C
F
H
C
A
R
R
L
K
KAGASCP
I
C
K
K
E
I
Q
L
V
I
K
V
FIA
8
PsiBlast_PDB
93.49
100%
-132
- C2 -
3JZQ
1
MDM4_HUMAN
A:
[3-86]
------------------------
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
93.29
100%
-134
- C2 -
3JZQ
1
MDM4_HUMAN
B:
[3-89]
------------------------
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
L
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
93.13
100%
-136
- C2 -
3DAB
2
MDM4_HUMAN
G:
[2-88]
----------------------
Q
I
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
92.16
100%
-138
- C2 -
3DAB
1
MDM4_HUMAN
C:
[2-86]
----------------------
Q
I
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
91.71
100%
-135
- C2 -
3DAB
1
MDM4_HUMAN
E:
[2-86]
----------------------
Q
I
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
91.68
100%
-134
- C2 -
3DAB
1
MDM4_HUMAN
A:
[2-88]
----------------------
Q
I
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
91.49
100%
-131
- C2 -
3FDO
1
MDM4_HUMAN
A:
[2-90]
----------------------
Q
I
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
L
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
91.20
100%
-135
- C2 -
3JZO
1
MDM4_HUMAN
A:
[1-87]
----------------------
Q
I
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.63
98%
-138
- C2 -
3FEA
3
MDM4_HUMAN
A:
[15-97]
-------------------------
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.57
100%
-133
- C2 -
3JZP
1
MDM4_HUMAN
A:
[1-87]
----------------------
Q
I
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.75
100%
-132
- C2 -
3LBJ
2
MDM4_HUMAN
E:
[4-86]
------------------------
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
Q
Q
E
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
87.09
96%
-132
- C2 -
3EQY
3
MDM4_HUMAN
B:
[2-85]
------------------------
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
A
A
A
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
85.47
96%
-129
- C2 -
3EQY
2
MDM4_HUMAN
A:
[2-85]
------------------------
N
Q
V
R
P
K
L
P
L
L
K
I
L
H
A
A
G
A
Q
G
E
M
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
V
K
Q
L
Y
D
A
A
A
Q
H
M
V
Y
C
G
G
D
L
L
G
E
L
L
G
R
Q
S
F
S
V
K
D
P
S
P
L
Y
D
M
L
R
K
N
L
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
84.59
69%
-120
- C2 -
4N5T
1
MDM4_DANRE
A:
[1-90]
-------------------
L
P
G
E
G
T
Q
V
H
P
R
A
P
L
L
Q
I
L
K
V
A
G
A
Q
E
E
V
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
M
K
Q
L
Y
D
K
Q
R
Q
H
I
V
H
C
H
D
D
P
L
G
E
L
L
E
V
G
S
F
S
V
K
N
P
S
P
L
Y
E
M
L
K
R
N
L
V
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
82.96
57%
-121
- C2 -
2Z5S
2
MDM4_DANRE
M:
[13-106]
---------------
K
I
R
T
L
--
E
G
T
Q
V
H
P
R
A
P
L
L
Q
I
L
K
V
A
G
A
Q
E
E
V
F
T
L
K
E
V
M
H
Y
L
G
Q
Y
I
M
M
K
Q
L
Y
D
K
Q
R
Q
H
I
V
H
C
H
D
D
P
L
G
E
L
L
E
V
G
S
F
S
V
K
N
P
S
P
V
Y
E
M
L
K
R
N
L
V
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.24
61%
-127
- C2 -
2Z5T
3
MDM4_DANRE
M:
[18-106]
--------------------
P
G
E
G
T
Q
V
H
P
R
A
P
L
L
Q
I
L
K
V
A
G
A
Q
E
E
V
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
M
K
Q
L
Y
D
K
Q
R
Q
H
I
V
H
C
H
D
D
P
L
G
E
L
L
E
V
G
S
F
S
V
K
N
P
S
P
L
Y
E
M
L
K
R
N
L
V
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.13
61%
-124
- C2 -
3DAC
2
MDM4_DANRE
M:
[23-107]
------------------------
T
Q
V
H
P
R
A
P
L
L
Q
I
L
K
V
A
G
A
Q
E
E
V
F
T
V
K
E
V
M
H
Y
L
G
Q
Y
I
M
M
K
Q
L
Y
D
K
Q
R
Q
H
I
V
H
C
H
D
D
P
L
G
E
L
L
E
V
G
S
F
S
V
K
N
P
S
P
L
Y
E
M
L
K
R
N
L
V
I
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.29
55%
-119
- C2 -
3VZV
2
MDM2_HUMAN
A:
[3-86]
-----------------------
E
T
L
V
R
P
K
P
E
L
L
K
L
L
K
S
V
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Y
L
G
Q
Y
I
M
T
K
R
L
Y
D
E
K
Q
Q
H
I
V
Y
C
S
N
D
L
L
G
D
L
F
G
V
P
S
F
S
V
K
E
H
R
K
I
Y
T
M
I
Y
R
N
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
77.23
49%
-114
- C2 -
2AXI
2
MDM2_HUMAN
A:
[7-98]
---------------------
E
Q
E
T
L
V
R
P
K
P
L
L
L
K
L
L
K
S
V
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Y
L
G
Q
Y
I
M
T
K
R
L
Y
D
E
K
Q
Q
H
I
V
Y
C
S
N
D
L
L
G
D
L
F
G
V
P
S
F
S
V
K
E
H
R
K
I
Y
T
M
I
Y
R
N
L
V
V
V
N
Q
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.02
58%
-122
- C2 -
1RV1
3
MDM2_HUMAN
A:
[4-84]
--------------------------
V
R
P
K
P
E
L
L
K
L
L
K
S
V
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Y
L
G
Q
Y
I
M
T
K
R
L
Y
D
E
K
Q
Q
H
I
V
Y
C
S
N
D
L
L
G
D
L
F
G
V
P
S
F
S
V
K
E
H
R
K
I
Y
T
M
I
Y
R
N
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.60
55%
-120
- C2 -
3W69
1
MDM2_HUMAN
A:
[3-86]
-----------------------
E
T
L
V
R
P
K
P
E
L
L
K
L
L
K
S
V
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Y
L
G
Q
Y
I
M
T
K
R
L
Y
D
E
K
Q
Q
H
I
V
Y
C
S
N
D
L
L
G
D
L
F
G
V
P
S
F
S
V
K
E
H
R
K
I
Y
T
M
I
Y
R
N
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
76.57
55%
-113
- C2 -
1YCR
1
MDM2_HUMAN
A:
[9-93]
-----------------------
E
T
L
V
R
P
K
P
L
L
L
K
L
L
K
S
V
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Y
L
G
Q
Y
I
M
T
K
R
L
Y
D
E
K
Q
Q
H
I
V
Y
C
S
N
D
L
L
G
D
L
F
G
V
P
S
F
S
V
K
E
H
R
K
I
Y
T
M
I
Y
R
N
L
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.20
56%
-121
- C2 -
3LBK
1
MDM2_HUMAN
A:
[12-94]
--------------------------
V
R
P
K
P
E
L
L
K
L
L
K
S
V
G
A
Q
K
D
T
Y
T
M
K
E
V
L
F
Y
L
G
Q
Y
I
M
T
K
R
L
Y
D
E
K
Q
Q
H
I
V
Y
C
S
N
D
L
L
G
D
L
F
G
V
P
S
F
S
V
K
E
H
R
K
I
Y
T
M
I
Y
R
N
L
V
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
76.08
51%
-110
* C2 *
1YCQ
1
MDM2_XENLA
A:
[9-96]
-----------------------
E
K
L
V
Q
P
T
P
L
L
L
S
L
L
K
S
A
G
A
Q
K
E
T
F
T
M
K
E
V
I
Y
H
L
G
Q
Y
I
M
A
K
Q
L
Y
D
E
K
Q
Q
H
I
V
H
C
S
N
D
P
L
G
E
L
F
G
V
Q
E
F
S
V
K
E
P
R
R
L
Y
A
M
I
S
R
N
L
V
S
A
N
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
74.26
54%
-107
- C2 -
4J74
2
MDM2_XENLA
A:
[2-86]
-----------------------
E
K
L
V
Q
P
T
P
L
L
L
S
L
L
K
S
A
G
A
Q
K
E
T
F
T
M
K
E
V
L
Y
H
L
G
Q
Y
I
M
A
K
Q
L
Y
D
E
K
Q
Q
H
I
V
H
C
S
N
D
P
L
G
E
L
F
G
V
Q
E
F
S
V
K
E
H
R
R
I
Y
A
M
I
S
R
N
L
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------