@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00648_CAN1_R: (2014-09-13 )
MAEELITPVYCTGVSAQVQKQRDKELGLGRHENAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDSRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKILDTDLDGVVTFDLFKWLQLTMFA
Atome Classification :
(13 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320...-...-.330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEELIT
P
V
Y
CTGV
S
A
Q
V
Q
K
Q
R
D
KELGLGR
H
E
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
QN
G
V
L
FQDDAFPPVSHSLGFKELGPNSS
K
T
Y
G
I
K
WK
R
P
T
E
LLSNP
Q
F
I
VDGA
T
R
T
D
I
C
QG
A
L
G
D
C
W
L
L
A
A
I
A
S
LTL
N
E
T
I
L
H
R
VVPY
G
Q
S
F
Q
E
GYA
G
I
F
H
F
Q
L
WQFG
E
W
V
D
V
V
V
D
D
LLPTKDG
K
L
V
F
V
HSAQG
N
E
F
W
S
A
L
L
E
K
A
Y
A
KVNGSYEALSGGC
T
S
E
A
F
E
D
FTGG
V
T
E
W
Y
D
L
QKA
P
S
D
L
Y
Q
I
I
L
K
A
L
ERG
S
L
L
G
C
S
I
N
I
S
D
IR
D
L
E
A
I
T
F
K
N
L
VRGHAYSVTDA
K
Q
V
T
YQG
Q
R
V
N
L
I
R
MRNPWGE
V
E
WKGPWSDNSYEWNKVDPY
E
R
E
Q
L
-
R
V
K-MED
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
CNL
T
P
D
A
L
K
S
R
TLRNWNTTFYEGTWRRGSTAGGCRNY
P
A
T
F
W
VNP
Q
F
K
I
R
L
E
EVDDADDYD
S
R
E
S
G
C
S
F
L
L
A
L
M
Q
K
H
R
R
R
E
R
R
FGR
D
M
E
T
I
G
F
A
V
Y
Q
V
P
R
E
LAGQ
P
V
H
L
K
R
D
F
F
LANASRAQSE
H
F
I
N
L
R
E
V
SNRIRLPPG
E
Y
I
V
VPSTFEPNKEG
D
F
L
L
R
F
F
S
EKKA
G
T
Q
E
L
D
D
Q
I
QANLPDEKVL
S
E
E
E
I
D
D
N
F
K
T
L
F
S
K
LAGDD
M
E
I
S
V
K
E
L
Q
T
I
L
N
R
I
I
S
K
HKDLRTNGF
S
L
E
S
C
R
S
M
V
N
L
MDRDGNG
K
L
G
L
V
E
F
N
I
L
W
N
R
I
R
N
Y
L
T
I
F
R
KFDLDKSGSM
S
A
Y
E
M
R
M
A
I
E
AAGF
K
L
N
K
K
L
H
E
L
I
I
T
RYSEP
D
L
A
V
D
F
D
N
F
V
C
C
L
V
R
L
E
T
M
F
R
F
F
K
I
L
DTDLD
G
V
V
T
F
D
L
F
K
W
L
Q
L
TMFA
4
PsiBlast_PDB
60.41
99%
-86
- C1 -
1TLO
1
CAN1_RAT
A:
[8-329]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
60.16
99%
-86
- C1 -
2R9F
3
CAN1_RAT
A:
[8-329]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
60.14
99%
-87
- C1 -
2NQG
1
CAN1_RAT
A:
[8-329]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.51
99%
-84
- C1 -
2G8J
1
CAN1_RAT
A:
[8-329]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.38
99%
-82
- C1 -
2G8E
2
CAN1_RAT
A:
[8-331]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
P
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
59.37
99%
-83
- C1 -
1TL9
1
CAN1_RAT
A:
[8-328]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.32
99%
-84
- C1 -
2R9C
3
CAN1_RAT
A:
[8-329]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.10
99%
-85
- C1 -
2NQI
1
CAN1_RAT
A:
[8-329]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
N
L
R
A
R
C
L
Q
N
G
V
L
F
Q
D
D
A
F
P
P
V
S
H
S
L
G
F
K
E
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
T
I
L
H
R
V
V
P
Y
G
Q
S
F
Q
E
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
T
K
D
G
K
L
V
F
V
H
S
A
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
C
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
D
L
Q
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
N
I
S
D
I
R
D
L
E
A
I
T
F
K
N
L
V
R
G
H
A
Y
S
V
T
D
A
K
Q
V
T
Y
Q
G
Q
R
V
N
L
I
R
M
R
N
P
W
G
E
V
E
W
K
G
P
W
S
D
N
S
Y
E
W
N
K
V
D
P
Y
E
R
E
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
I
R
E
F
T
K
L
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
58.03
87%
-87
- C1 -
2ARY
2
CAN1_HUMAN
B:
[24-345]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
Q
L
R
V
R
C
L
Q
S
G
T
L
F
R
D
E
A
F
P
P
V
P
Q
S
L
G
Y
K
D
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
D
T
L
L
H
R
V
V
P
H
G
Q
S
F
Q
N
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
I
K
D
G
K
L
V
F
V
H
S
A
E
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
S
T
S
E
G
F
E
D
F
T
G
G
V
T
E
W
Y
E
L
R
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
D
I
S
S
V
L
D
M
E
A
I
T
F
K
K
L
V
K
G
H
A
Y
S
V
T
G
A
K
Q
V
N
Y
R
G
Q
V
V
S
L
I
R
M
R
N
P
W
G
E
V
E
W
T
G
A
W
S
D
S
S
S
E
W
N
N
V
D
P
Y
E
R
D
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
M
R
E
F
T
R
L
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.34
87%
-83
- C1 -
1ZCM
1
CAN1_HUMAN
A:
[1-321]
--------------------------------
N
A
I
K
Y
L
G
Q
D
Y
E
Q
L
R
V
R
C
L
Q
S
G
T
L
F
R
D
E
A
F
P
P
V
P
Q
S
L
G
Y
K
D
L
G
P
N
S
S
K
T
Y
G
I
K
W
K
R
P
T
E
L
L
S
N
P
Q
F
I
V
D
G
A
T
R
T
D
I
C
Q
G
A
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
D
T
L
L
H
R
V
V
P
H
G
Q
S
F
Q
N
G
Y
A
G
I
F
H
F
Q
L
W
Q
F
G
E
W
V
D
V
V
V
D
D
L
L
P
I
K
D
G
K
L
V
F
V
H
S
A
E
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
V
N
G
S
Y
E
A
L
S
G
G
S
T
S
E
A
F
E
D
F
T
G
G
V
T
E
W
Y
E
L
R
K
A
P
S
D
L
Y
Q
I
I
L
K
A
L
E
R
G
S
L
L
G
C
S
I
D
I
S
S
V
L
D
M
E
A
I
T
F
K
K
L
V
K
G
H
A
Y
S
V
T
G
A
K
Q
V
N
Y
R
G
Q
V
V
S
L
I
R
M
R
N
P
W
G
E
V
E
W
T
G
A
W
S
D
S
S
S
E
W
N
N
V
D
P
Y
E
R
D
Q
L
-
R
V
K
-
M
E
D
G
E
F
W
M
S
F
R
D
F
M
R
E
F
T
R
L
E
I
C
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
52.44
67%
-84
- C1 -
2NQA
2
CAN2_HUMAN
A:
[3-322]
--------------------------------
N
A
L
K
Y
L
G
Q
D
F
K
T
L
R
Q
Q
C
L
D
S
G
V
L
F
K
D
P
E
F
P
A
C
P
S
A
L
G
Y
---------
T
Q
G
I
I
W
K
R
P
T
E
L
C
P
S
P
Q
F
I
V
G
G
A
T
R
T
D
I
C
Q
G
G
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
E
E
L
L
Y
R
V
V
P
R
D
Q
D
F
Q
E
N
Y
A
G
I
F
H
F
Q
F
W
Q
Y
G
E
W
V
E
V
V
I
D
D
R
L
P
T
K
N
G
Q
L
L
F
L
H
S
E
Q
G
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
L
N
G
C
Y
E
A
L
A
G
G
S
T
V
E
G
F
E
D
F
T
G
G
I
S
E
F
Y
D
L
K
K
P
P
A
N
L
Y
Q
I
I
R
K
A
L
C
A
G
S
L
L
G
C
S
I
D
V
Y
S
A
A
E
A
E
A
I
T
S
Q
K
L
V
K
S
H
A
Y
S
V
T
G
V
E
E
V
N
F
Q
G
H
P
E
K
L
I
R
L
R
N
P
W
G
E
-
E
W
S
G
A
W
S
D
D
A
P
E
W
N
H
I
D
P
R
R
K
E
E
L
-
D
K
K
-
V
E
D
G
E
F
W
M
S
L
S
D
F
V
R
Q
F
S
R
L
E
I
C
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
49.38
59%
-79
- C1 -
2P0R
2
CAN9_HUMAN
A:
[19-330]
--------------------------------------
G
Q
S
F
E
Q
M
R
Q
E
C
L
Q
R
G
T
L
F
E
D
A
D
F
P
A
S
N
S
S
L
F
Y
S
E
-----
R
P
Q
I
P
F
V
W
K
R
P
G
E
I
V
K
N
P
E
F
I
L
G
G
A
T
R
T
D
I
C
Q
G
E
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
Q
K
A
L
A
R
V
I
P
Q
D
Q
S
F
G
P
G
Y
A
G
I
F
H
F
Q
F
W
Q
H
S
E
W
L
D
V
V
I
D
D
R
L
P
T
F
R
D
R
L
V
F
L
H
S
A
D
H
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
L
N
G
S
Y
E
A
L
K
G
G
S
A
I
E
A
M
E
D
F
T
G
G
V
A
E
T
F
Q
T
K
E
A
P
E
N
F
Y
E
I
L
E
K
A
L
K
R
G
S
L
L
G
C
F
I
D
T
R
S
A
A
E
S
E
A
R
T
P
F
G
L
I
K
G
H
A
Y
S
V
T
G
I
D
Q
V
S
F
R
G
Q
R
I
E
L
I
R
I
R
N
P
W
G
Q
V
E
W
N
G
S
W
S
D
S
S
P
E
W
R
S
V
G
P
A
E
Q
K
R
L
C
H
T
A
-
L
D
D
G
E
F
W
M
A
F
K
D
F
K
A
H
F
D
K
V
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
47.55
59%
-89
- C1 -
1ZIV
2
CAN9_HUMAN
A:
[20-329]
----------------------------------------
S
F
E
Q
M
R
Q
E
C
L
Q
R
G
T
L
F
E
D
A
D
F
P
A
S
N
S
S
L
F
Y
S
--
P
Q
I
P
-----
F
V
W
K
R
P
G
E
I
V
K
N
P
E
F
I
L
G
G
A
T
R
T
D
I
C
Q
G
E
L
G
D
C
W
L
L
A
A
I
A
S
L
T
L
N
Q
K
A
L
A
R
V
I
P
Q
D
Q
S
F
G
P
G
Y
A
G
I
F
H
F
Q
F
W
Q
H
S
E
W
L
D
V
V
I
D
D
R
L
P
T
F
R
D
R
L
V
F
L
H
S
A
D
H
N
E
F
W
S
A
L
L
E
K
A
Y
A
K
L
N
G
S
Y
E
A
L
K
G
G
S
A
I
E
A
M
E
D
F
T
G
G
V
A
E
T
F
Q
T
K
E
A
P
E
N
F
Y
E
I
L
E
K
A
L
K
R
G
S
L
L
G
C
F
I
D
T
R
S
A
A
E
S
E
A
R
T
P
F
G
L
I
K
G
H
A
Y
S
V
T
G
I
D
Q
V
S
F
R
G
Q
R
I
E
L
I
R
I
R
N
P
W
G
Q
V
E
W
N
G
S
W
S
D
S
S
P
E
W
R
S
V
G
P
A
E
Q
K
R
L
-
C
H
T
A
L
D
D
G
E
F
W
M
A
F
K
D
F
K
A
H
F
D
K
V
E
I
C
N
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------