@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00856_EHMT2_: (2014-09-17 )
MRGLPRGRGLMRARGRGRAAPTGGRGRGRGGAHRGRGRPRSLLSLPRAQASWAPQLPAGLTGPPVPCLPSQGEAPAEMGALLLEKEPRGAAERVHSSLGDTPQSEETLPKANPDSLEPAGPSSPASVTVTVGDEGADTPVGAASLIGDEPESLEGDGGRIVLGHATKSFPSSPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAGPEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPIPEKRPPEVQHFRMSDDMHLGKVTSDVAKRRKLNSGSLSEDLGSAGGSGDIILEKGEPRPLEEWETVVGDDFSLYYDAYSVDERVDSDSKSEVEALAEQLSEEEEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRRKAKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSSGPSEYMEVPLGSLELPSEGTLSPNHAGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKCMATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTFLECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPIGTAAPALPPLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPPGPGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDCVLLFLSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDPHPELLPDLSSLPPINT
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030.......1040......1050..--....1060......1070......1080......1090......1100......1110......1120......1130------......1140..-....1150........1160......1170-.......1180......1190......1200......1210......1220......1230......1240......1250......1260
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRGLPRGRG
L
M
RARGRGRAAPTGGRGRGRGGAHRGRGR
P
R
S
L
L
SLPRAQASWAPQLPAGLTGPPVPCLPSQGEA
P
A
E
M
G
A
L
L
LEKEPR
G
A
A
E
R
V
H
S
SLGDTPQSEETLPKANPDSLEPAGPSSP
A
S
V
T
V
T
VGDEGADTPV
G
A
A
S
LIGDEPESLEGDG
G
R
I
V
LGHATKSFPSSPSKGGACPSR
A
K
M
S
MTGAGKSPP
S
V
Q
S
L
A
M
R
L
L
SMPGAQGAATAGPEPSPATTAAQEGQ
P
K
V
H
R
A
R
K
TMSKPSNGQPPIPEKRPPEV
Q
H
F
RMSDDMH
L
G
K
V
T
S
D
V
A
K
R
RKLNSGS
L
S
E
D
L
GSAGGSG
D
I
I
L
EKGEPR
P
L
E
E
W
E
T
V
VGDD
F
S
L
Y
Y
D
AYSVDERVDSD
S
K
S
E
V
E
A
L
A
E
Q
L
S
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
E
EEEDEESGNQSDRSGSSG
R
R
K
A
K
K
KWRKDSPWVK
P
S
R
K
RRKREPPRAKEPRGVNGVGSSGP
S
E
Y
M
EVPLGSLELPSEGTLSPNHAGVSNDTSSL
E
T
ERGFEELPLCSCRMEAPKI
D
R
I
S
E
RAG
H
K
C
MATESVDGELLGC
N
A
A
I
L
K
RETMRPSS
R
V
A
L
M
V
L
C
E
A
H
R
A
R
M
V
K
HHCCPGCGYFCTAG
T
F
L
E
CHP
D
F
R
V
A
H
R
F
H
K
A
C
V
S
QLN
G
M
V
FCPHCGE
D
A
SEA
Q
E
V
T
IPRGDGGTPPIGTAAPALPPLAHDAPGRADTSQP
S
A
RMRGHGEPRRPPC
D
P
L
A
D
T
IDSSGP
S
L
TLPNGG
C
L
SAVGLPPGP
G
R
E
A
L
E
K
A
L
V
I
Q
E
S
E
R
R
K
K
LRFH
P
R
Q
L
Y
L
S
VKQG
E
L
Q
K
V
I
L
M
L
L
DNLDPNFQSDQQSKRTP
L
H
A
A
AQKG
S
V
E
I
C
H
V
L
L
QAGANINAV
D
K
Q
Q
R
T
P
L
M
E
A
V
V
N
N
H
L
E
V
A
R
Y
M
V
Q
LG
G
C
V
YSKEEDG
S
T
C
L
H
H
A
A
KIG
N
L
E
M
V
S
L
L
L
STG
Q
V
D
V
NAQDSGG
W
T
P
I
I
W
AAEH
K
H
I
D
V
I
R
M
L
L
TRGA
D
V
T
L
TDNEE
N
I
C
L
H
WASFT
G
S
A
A
I
A
E
V
L
L
NAQC
D
L
H
A
V
NYHGDT
P
L
H
I
A
ARESY
H
D
C
V
L
L
F
L
SRGANPELRNKEGDTAWDLTPERS
D
V
W
F
A
L
QLN
R
K
L
RLGVGNR
A
V
R
T
E
K
I
I
C
R
D
V
A
RGYENVPIPCVNGVDGEPC
P
E
D
Y
K
Y
I
S
ENCETSTMNIDRNI
T
H
L
QHCT
C
V
DD-CSSSN
C
L
C
G
Q
L
S
I
R
C
W
YDKD
G
R
L
--
L
Q
E
F
N
KIEP
P
L
I
F
EC
N
Q
A
C
S
C
W
R
S
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
TAKMGWG
V
R
A
L
Q
TIPQ
G
T
F
I
C
E
Y
V
G
E
L
I
S
DAEADVR------EDD
S
Y
L
F
D
LDNK-DG
E
V
Y
--
C
I
D
A
R
YYG
N
I
S
R
F
I
N
HLCDPN
I
--
I
P
V
R
V
F
M
LHQDLRF
P
R
I
A
F
F
SSRDIRT
G
E
E
LGFDYG
D
R
F
W
D
I
K
S
K
Y
F
T
C
QCG
S
E
K
C
KH
S
A
E
A
I
A
L
E
Q
S
R
L
ARLDP
H
P
E
L
L
P
D
L
SSLPPINT
23
PsiBlast_CBE
97.59
99%
-96
- C2 -
2O8J
1
EHMT2_HUMAN
B:
[10-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
L
A
R
L
------------------
2
PsiBlast_PDB
97.36
99%
-99
- C2 -
3K5K
2
EHMT2_HUMAN
A:
[7-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
D
N
K
---
E
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
L
A
--------------------
26
PsiBlast_CBE
96.49
99%
-103
- C2 -
4NVQ
2
?
B:
[10-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
-----
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
D
------
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
L
A
--------------------
25
PsiBlast_CBE
96.38
99%
-99
- C2 -
3K5K
2
B:
[9-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
D
N
----
E
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
L
A
--------------------
3
PsiBlast_PDB
94.99
99%
-98
- C2 -
3RJW
2
EHMT2_HUMAN
A:
[8-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
--
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
-----------------------
22
PsiBlast_CBE
93.60
99%
-102
- C2 -
2O8J
1
EHMT2_HUMAN
C:
[10-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
------
E
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
K
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
R
----------------------
4
PsiBlast_PDB
93.41
99%
-100
- C2 -
4NVQ
2
?
A:
[8-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
T
E
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
-----
G
E
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
I
K
S
-
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
I
A
L
E
Q
S
-----------------------
1
PsiBlast_PDB
92.98
99%
-103
- C2 -
2O8J
1
EHMT2_HUMAN
A:
[8-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
D
-----
E
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
D
----
Y
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
-----------------------------
21
PsiBlast_CBE
92.57
99%
-104
- C2 -
2O8J
1
D:
[10-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
R
D
V
A
R
G
Y
E
N
V
P
I
P
C
V
N
G
V
D
G
E
P
C
P
E
D
Y
K
Y
I
S
E
N
C
E
T
S
T
M
N
I
D
R
N
I
T
H
L
Q
H
C
T
C
V
D
D
-
C
S
S
S
N
C
L
C
G
Q
L
S
I
R
C
W
Y
D
K
D
G
R
L
--
L
Q
E
F
N
K
I
E
P
P
L
I
F
E
C
N
Q
A
C
S
C
W
R
N
C
K
N
R
V
V
Q
S
G
I
K
V
R
L
Q
L
Y
R
T
A
K
M
G
W
G
V
R
A
L
Q
T
I
P
Q
G
T
F
I
C
E
Y
V
G
E
L
I
S
D
A
E
A
D
V
R
------
E
D
D
S
Y
L
F
D
L
-------
V
Y
--
C
I
D
A
R
Y
Y
G
N
I
S
R
F
I
N
H
L
C
D
P
N
I
--
I
P
V
R
V
F
M
L
H
Q
D
L
R
F
P
R
I
A
F
F
S
S
R
D
I
R
T
G
E
E
L
G
F
D
Y
G
D
R
F
W
------
F
T
C
Q
C
G
S
E
K
C
K
H
S
A
E
A
-----------------------------
51
HHSearch
89.82
74%
-93
- C2 -
3HNA
2
EHMT1_HUMAN
A:
[1-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
N
S
Q
V
W
S
A
L
Q
M
S
K
A
L
-------
P
S
P
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
38
PsiBlast_CBE
87.78
74%
-97
- C2 -
3HNA
2
B:
[28-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
14
PsiBlast_PDB
87.61
78%
-99
- C2 -
3FPD
2
EHMT1_HUMAN
A:
[1-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
13
PsiBlast_PDB
87.51
74%
-97
- C2 -
4I51
5
EHMT1_HUMAN
A:
[26-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
A
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
6
PsiBlast_PDB
87.51
74%
-97
- C2 -
2RFI
2
EHMT1_HUMAN
A:
[25-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
31
PsiBlast_CBE
86.98
74%
-99
- C2 -
3MO5
1
EHMT1_HUMAN
B:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
---
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
10
PsiBlast_PDB
86.53
74%
-93
- C2 -
3SWC
2
EHMT1_HUMAN
A:
[25-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
30
PsiBlast_CBE
86.43
74%
-98
- C2 -
3MO5
2
EHMT1_HUMAN
C:
[25-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
----
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
36
PsiBlast_CBE
86.20
74%
-103
- C2 -
2RFI
2
B:
[28-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
-------
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
11
PsiBlast_PDB
86.14
74%
-95
- C2 -
3SW9
2
EHMT1_HUMAN
A:
[25-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
34
PsiBlast_CBE
86.11
74%
-96
- C2 -
3MO2
1
EHMT1_HUMAN
B:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
---
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
29
PsiBlast_CBE
85.72
74%
-100
- C2 -
3MO5
2
D:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
-----
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
33
PsiBlast_CBE
85.63
74%
-100
- C2 -
3MO2
2
EHMT1_HUMAN
C:
[25-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
----
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
40
PsiBlast_CBE
85.48
78%
-94
- C2 -
3FPD
2
B:
[2-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
32
PsiBlast_CBE
85.48
74%
-95
- C2 -
3MO2
2
D:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
-----
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
5
PsiBlast_PDB
85.20
74%
-98
- C2 -
2IGQ
1
EHMT1_HUMAN
A:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
-------
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
---
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
37
PsiBlast_CBE
85.05
74%
-100
- C2 -
2IGQ
1
B:
[26-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
-----
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
--
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
39
PsiBlast_CBE
84.80
74%
-97
- C2 -
4I51
5
B:
[24-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
------
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
A
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
27
PsiBlast_CBE
84.29
74%
-96
- C2 -
3SWC
2
B:
[25-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
28
PsiBlast_CBE
84.24
74%
-93
- C2 -
3SW9
2
B:
[25-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
8
PsiBlast_PDB
84.07
74%
-102
- C2 -
3MO2
1
EHMT1_HUMAN
A:
[28-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
----
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
9
PsiBlast_PDB
83.86
74%
-100
- C2 -
3MO5
1
EHMT1_HUMAN
A:
[28-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
----
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
7
PsiBlast_PDB
79.33
74%
-91
- C2 -
3MO0
2
EHMT1_HUMAN
A:
[27-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
-------
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
W
Y
D
K
D
G
R
L
--
L
P
E
F
N
M
A
E
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
---------------------------------
35
PsiBlast_CBE
76.20
74%
-93
- C2 -
3MO0
4
B:
[28-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
R
D
I
A
R
G
Y
E
R
I
P
I
P
C
V
N
A
V
D
S
E
P
C
P
S
N
Y
K
Y
V
S
Q
N
C
V
T
S
P
M
N
I
D
R
N
I
T
H
L
Q
Y
C
V
C
I
D
D
-
C
S
S
S
N
C
M
C
G
Q
L
S
M
R
C
------------------
P
P
L
I
F
E
C
N
H
A
C
S
C
W
R
N
C
R
N
R
V
V
Q
N
G
L
R
A
R
L
Q
L
Y
R
T
R
D
M
G
W
G
V
R
S
L
Q
D
I
P
P
G
T
F
V
C
E
Y
V
G
E
L
I
S
D
S
E
A
D
V
R
------
E
E
D
S
Y
L
F
D
L
D
N
K
-
D
G
E
V
Y
--
C
I
D
A
R
F
Y
G
N
V
S
R
F
I
N
H
H
C
E
P
N
L
--
V
P
V
R
V
F
M
A
H
Q
D
L
R
F
P
R
I
A
F
F
S
T
R
L
I
E
A
G
E
Q
L
G
F
D
Y
G
E
R
F
W
D
I
K
G
K
L
F
S
C
R
C
G
S
P
K
C
R
H
S
--------------------------------
20
PsiBlast_PDB
51.52
34%
-71
- C2 -
3BO5
3
SETMR_HUMAN
A:
[16-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
A
C
G
Q
E
N
L
P
---
V
G
A
W
P
P
G
A
A
P
A
P
F
Q
Y
T
P
D
H
V
V
G
P
G
A
D
I
D
P
T
Q
I
T
F
P
G
C
I
C
V
K
T
P
C
L
P
G
T
C
S
C
L
R
H
G
E
N
--
Y
D
D
N
S
C
L
RD-----
K
Y
A
E
P
-
V
F
E
C
N
V
L
C
R
C
S
D
H
C
R
N
R
V
V
Q
K
G
L
Q
F
H
F
Q
V
F
K
T
H
K
K
G
W
G
L
R
T
L
E
F
I
P
K
G
R
F
V
C
E
Y
A
G
E
V
L
G
F
S
E
V
Q
R
R
I
H
L
QTK
S
D
S
N
Y
I
I
A
I
R
E
H
V----
M
E
T
F
V
D
P
T
Y
I
G
N
I
G
R
F
L
N
H
S
C
E
P
N
L
L
M
I
P
V
R
I
-----
D
S
M
V
P
K
L
A
L
F
A
A
K
D
I
V
P
E
E
E
L
S
Y
D
Y
S
G
R
Y
L
N
L
-------------------------------------------------