@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01471_MMP24_: (2014-09-24 )
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVPGRLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCNQKEVERRKERRLPQDDVDIMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV
Atome Classification :
(13 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250-.........260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380--.--......390.......400.......410.......420.......430...-....440.-.......450.......460...-....470.--.--.....480.......490.......500.......510..-.-.-...520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPRSRGGRAAPGPPPPPPPPGQAPRWSRWRVP
G
R
L
L
L
L
L
L
P
A
L
CCLPG
A
A
R
A
A
A
AAAGAGN
R
A
A
V
A
V
A
V
ARADEAEAPFA
G
Q
N
W
L
K
SYGYLLPYD
S
R
A
S
A
L
H
S
A
K
A
L
Q
S
A
V
S
T
M
Q
Q
F
YGIPVTGVL
D
Q
T
T
I
E
W
MKKPRCGVPDHP
H
L
S
R
R
RRNKRYALT
G
Q
K
W
R
QK
H
I
T
Y
S
IHNYTPKVGE
L
D
T
R
K
A
I
R
Q
A
F
D
V
W
Q
KVTPLTFEEV
P
Y
H
E
I
KSDRKEA
D
I
M
I
F
F
ASGFHGDSSPFDGEG
G
F
L
A
H
A
YFPGP---GIGGDTHFDSDEPWTLGNANHDGN
D
L
F
L
V
A
V
H
E
L
G
H
A
LGLEHSSD
P
S
A
I
M
A
P
F
Y
Q
Y
M
E
THNFKL
P
Q
D
D
L
Q
G
I
Q
K
I
YGPPAEPLEPTRPLPTL
P
V
RRIHSP
S
E
RKHERQPRPPRPPLGDRPSTPGTKPNICDG--N--F
N
T
V
A
L
FRG
E
M
F
V
F
KD
R
W
F
W
R
LRNNRVQEGY
P
M
Q
I
E
Q
F
W
KGLP
A
R
I
D
A
A
Y
ER-ADG
R
F
V
-
F
-
F
KGD
K
Y
W
V
F
K
E
V
T
VEPGYPH
S
L
G
-
E
L
G
S
CLPR--E--GIDT
A
L
R
W
EPVGK
T
Y
F
F
KG
E
R
Y
W
R
Y
S
E
ERRATDPGYPKP
I
-
T
-
V
-WKGIPQAPQG
A
F
ISKEG
Y
Y
T
Y
F
YKG
R
D
Y
W
K
FDN
Q
K
L
SVEPGY
P
R
N
I
L
R
D
W
MGC
N
Q
K
E
V
E
R
R
K
E
RRLPQDD
V
D
I
M
V
T
I
NDVPGS
V
N
A
V
A
V
V
I
P
C
I
L
S
L
C
I
L
V
L
V
Y
T
I
F
Q
FKNKTGPQP
V
T
Y
Y
K
R
P
V
Q
EWV
34
HHSearch
72.55
41%
-97
- C1 -
4FVL
14
?
A:
[6-368]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
L
K
W
S
K
M
N
L
T
Y
R
I
V
N
Y
T
P
D
M
T
H
S
E
V
E
K
A
F
K
K
A
F
K
V
W
S
D
V
T
P
L
N
F
T
R
L
H
-------
D
G
I
A
D
I
M
I
S
F
G
I
K
E
H
G
D
F
Y
P
F
D
G
P
S
G
L
L
A
H
A
F
P
P
G
P
---
N
Y
G
G
D
A
H
F
D
D
D
E
T
W
T
S
S
---
S
K
G
Y
N
L
F
L
V
A
A
H
A
F
G
H
S
L
G
L
D
H
S
K
D
P
G
A
L
M
F
P
I
Y
T
Y
T
G
K
S
H
F
M
L
P
D
D
D
V
Q
G
I
Q
S
L
Y
G
P
G
D
E
D
-----
P
N
---------------------
P
-
K
-----
H
P
----
K
T
P
D
K
C
D
P
--
S
LS
L
D
A
I
T
S
L
R
G
E
T
M
I
F
K
D
R
F
F
W
R
L
H
P
Q
-
Q
V
D
A
E
L
F
L
T
K
S
F
W
P
E
L
P
N
R
I
D
A
A
Y
E
H
P
S
H
D
L
I
F
-
I
-
F
R
G
R
K
F
W
A
L
N
G
Y
D
I
L
E
G
Y
P
K
K
I
S
-
E
L
--
G
L
P
K
EV
K
--
K
I
S
A
A
V
H
F
E
D
T
G
K
T
L
L
F
S
G
N
Q
V
W
R
Y
D
D
T
N
H
I
M
D
K
D
Y
P
R
L
I
-
E
E
D
-
F
P
G
I
G
D
K
V
D
A
V
Y
E
K
--
N
G
Y
I
Y
F
F
N
G
P
I
Q
F
E
Y
S
I
W
S
N
R
I
V
R
V
M
---
P
A
N
S
I
L
W
C
----------------------------------------------------------------------------
33
HHSearch
67.66
45%
-93
- C1 -
3BA0
1
MMP12_HUMAN
A:
[1-365]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
N
-------
T
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
D
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
T
H
---
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
N
Q
----
R
---------------------
L
-
P
N
P
----
D
----
N
S
E
P
A
L
C
D
P
--
N
LS
F
D
A
V
T
T
V
G
N
K
I
F
F
F
K
D
R
F
F
W
L
K
V
S
E
-
R
P
K
T
S
V
N
L
I
S
S
L
W
P
T
L
P
S
G
I
E
A
A
Y
E
I
E
A
R
N
Q
V
F
-
L
-
F
K
D
D
K
Y
W
L
I
S
N
L
R
P
E
P
N
Y
P
K
S
I
H
-
S
F
--
G
F
P
N
FV
K
--
K
I
D
A
A
V
F
N
P
R
F
Y
R
T
Y
F
F
V
D
N
Q
Y
W
R
Y
D
E
R
R
Q
M
M
D
P
G
Y
P
K
L
I
T
K
-
N
-
F
Q
G
I
G
P
K
I
D
A
V
F
Y
S
K
-
N
K
Y
Y
Y
F
F
Q
G
S
N
Q
F
E
Y
D
F
L
L
Q
R
I
T
---
K
T
L
K
S
N
S
W
F
G
C
----------------------------------------------------------------------------
13
PsiBlast_PDB
66.07
39%
-84
- C1 -
4G0D
11
MMP13_HUMAN
A:
[9-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
S
K
M
N
L
T
Y
R
I
V
N
Y
T
P
D
M
T
H
S
E
V
E
K
A
F
K
K
A
F
K
V
W
S
D
V
T
P
L
N
F
T
R
L
--
H
D
-----
G
I
A
D
I
M
I
S
F
G
I
K
E
H
G
D
F
Y
P
F
D
G
P
S
G
L
L
A
H
A
F
P
P
G
P
---
N
Y
G
G
D
A
H
F
D
D
D
E
T
W
T
---
S
S
S
K
G
Y
N
L
F
L
V
A
A
H
A
F
G
H
S
L
G
L
D
H
S
K
D
P
G
A
L
M
F
P
I
Y
T
Y
T
G
K
S
H
F
M
L
P
D
D
D
V
Q
G
I
Q
S
L
Y
G
P
G
D
E
D
P
N
P
------------------
K
H
P
K
T
P
D
K
C
D
P
S
L
------------------
S
--
L
D
A
I
T
S
L
R
G
E
T
M
I
F
K
D
R
F
F
W
R
L
H
P
Q
Q
V
-
D
A
E
L
F
L
T
K
S
F
W
P
E
L
P
N
R
I
D
A
A
Y
E
H
-
P
S
H
D
L
I
-
F
I
F
R
G
R
K
F
W
A
L
N
G
Y
D
I
L
E
G
Y
P
K
K
I
S
-
E
L
G
--
L
P
K
--
E
VK
K
I
S
A
A
V
H
F
E
D
T
G
K
T
L
L
F
S
G
N
Q
V
W
R
Y
D
D
T
N
H
I
M
D
K
D
Y
P
R
L
I
-
E
-
E
D
F
P
G
I
G
D
K
V
D
A
V
Y
-
E
K
N
G
-
Y
I
Y
F
F
N
G
--------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.05
40%
-81
- C1 -
1FBL
1
MMP1_PIG
A:
[9-349]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
E
N
T
H
L
T
Y
R
I
E
N
Y
T
P
D
L
S
R
E
D
V
D
R
A
I
E
K
A
F
Q
L
W
S
N
V
S
P
L
T
F
T
K
V
S
-------
E
G
Q
A
D
I
M
I
S
F
V
R
G
D
H
R
D
N
S
P
F
D
G
P
G
G
N
L
A
H
A
F
Q
P
G
P
---
G
I
G
G
D
A
H
F
D
E
D
E
R
W
T
---
K
N
F
R
D
Y
N
L
Y
R
V
A
A
H
E
L
G
H
S
L
G
L
S
H
S
T
D
I
G
A
L
M
Y
P
N
Y
I
Y
--
T
G
D
V
Q
L
S
Q
D
D
I
D
G
I
Q
A
I
Y
G
P
S
E
N
P
V
Q
P
S
G
P
------------------------------------
Q
T
P
Q
V
C
D
S
KL
T
--
F
D
A
I
T
T
L
R
G
E
L
M
F
F
K
D
R
F
Y
M
R
T
-
N
S
F
Y
P
E
V
E
L
N
F
I
S
V
F
W
P
Q
V
P
N
G
L
Q
A
A
Y
E
I
-
A
D
R
D
E
V
R
F
-
F
K
G
N
K
Y
W
A
V
R
G
Q
D
V
L
Y
G
Y
P
K
D
I
H
R
S
F
G
F
P
S
T
V
--
K
--
N
I
D
A
A
V
F
E
E
D
T
G
K
T
Y
F
F
V
A
H
E
C
W
R
Y
D
E
Y
K
Q
S
M
D
T
G
Y
P
K
M
I
-
A
E
E
-
F
P
G
I
G
N
K
V
D
A
V
F
-
Q
K
D
G
-
F
L
Y
F
F
H
G
T
R
Q
Y
Q
F
D
-------------------------------------------------------------------------------------------------
46
HHSearch
47.61
85%
-90
- C1 -
1RM8
1
MMP16_HUMAN
A:
[1-169]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
W
Q
H
K
H
I
T
Y
S
I
K
N
V
T
P
K
V
G
D
P
E
T
R
K
A
I
R
R
A
F
D
V
W
Q
N
V
T
P
L
T
F
E
E
V
P
Y
S
E
L
E
N
G
K
R
D
V
D
I
T
I
I
F
A
S
G
F
H
G
D
S
S
P
F
D
G
E
G
G
F
L
A
H
A
Y
F
P
G
P
---
G
I
G
G
D
T
H
F
D
S
D
E
P
W
T
L
G
N
P
N
H
D
G
N
D
L
F
L
V
A
V
H
E
L
G
H
A
L
G
L
E
H
S
N
D
P
T
A
I
M
A
P
F
Y
Q
Y
M
E
T
D
N
F
K
L
P
N
D
D
L
Q
G
I
Q
K
I
Y
G
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
39.15
52%
-75
- C1 -
2WO9
1
MMP12_HUMAN
A:
[2-163]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
-------
N
T
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
---
T
H
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
39.11
52%
-76
- C1 -
2WO8
1
MMP12_HUMAN
A:
[2-163]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
-------
N
T
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
---
T
H
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
38.67
54%
-73
- C1 -
3AYU
1
MMP2_HUMAN
A:
[3-165]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
F
P
R
K
P
K
W
D
K
N
Q
I
T
Y
R
I
I
G
Y
T
P
D
L
D
P
E
T
V
D
D
A
F
A
R
A
F
Q
V
W
S
D
V
T
P
L
R
F
S
R
I
H
D
-------
G
E
A
D
I
M
I
N
F
G
R
W
E
H
G
D
G
Y
P
F
D
G
K
D
G
L
L
A
H
A
F
A
P
G
T
---
G
V
G
G
D
S
H
F
D
D
D
E
L
W
T
L
G
K
G
--
V
G
Y
S
L
F
L
V
A
A
H
A
F
G
H
A
M
G
L
E
H
S
Q
D
P
G
A
L
M
A
P
I
Y
T
Y
--
T
K
N
F
R
L
S
Q
D
D
I
K
G
I
Q
E
L
Y
G
A
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
38.67
52%
-73
- C1 -
2WOA
1
MMP12_HUMAN
A:
[2-163]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
W
R
K
H
Y
I
T
Y
R
I
N
N
Y
T
P
D
M
N
R
E
D
V
D
Y
A
I
R
K
A
F
Q
V
W
S
N
V
T
P
L
K
F
S
K
I
-------
N
T
G
M
A
D
I
L
V
V
F
A
R
G
A
H
G
D
F
H
A
F
D
G
K
G
G
I
L
A
H
A
F
G
P
G
S
---
G
I
G
G
D
A
H
F
D
E
D
E
F
W
T
---
T
H
S
G
G
T
N
L
F
L
T
A
V
H
E
I
G
H
S
L
G
L
G
H
S
S
D
P
K
A
V
M
F
P
T
Y
K
Y
V
D
I
N
T
F
R
L
S
A
D
D
I
R
G
I
Q
S
L
Y
G
D
P
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
38.11
52%
-80
- C1 -
1I76
1
MMP8_HUMAN
A:
[2-163]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
G
N
P
K
W
E
R
T
N
L
T
Y
R
I
R
N
Y
T
P
Q
L
S
E
A
E
V
E
R
A
I
K
D
A
F
E
L
W
S
V
A
S
P
L
I
F
T
R
I
S
-------
Q
G
E
A
D
I
N
I
A
F
Y
Q
R
D
H
G
D
N
S
P
F
D
G
P
N
G
I
L
A
H
A
F
Q
P
G
Q
---
G
I
G
G
D
A
H
F
D
A
E
E
T
W
T
N
T
S
---
A
N
Y
N
L
F
L
V
A
A
H
E
F
G
H
S
L
G
L
A
H
S
S
D
P
G
A
L
M
Y
P
N
Y
A
F
R
E
T
S
N
Y
S
L
P
Q
D
D
I
D
G
I
Q
A
I
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
36.53
50%
-70
* C1 *
4H1Q
2
MMP9_HUMAN
A:
[3-160]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
L
K
W
H
H
H
N
I
T
Y
W
I
Q
N
Y
S
E
D
L
P
R
A
V
I
D
D
A
F
A
R
A
F
A
L
W
S
A
V
T
P
L
T
F
T
R
V
Y
S
-------
R
D
A
D
I
V
I
Q
F
G
V
A
E
H
G
D
G
Y
P
F
D
G
K
D
G
L
L
A
H
A
F
P
P
G
P
---
G
I
Q
G
D
A
H
F
D
D
D
E
L
W
S
L
G
K
--
G
Q
G
Y
S
L
F
L
V
A
A
H
Q
F
G
H
A
L
G
L
D
H
S
S
V
P
E
A
L
M
Y
P
M
Y
R
F
T
--
E
G
P
P
L
H
K
D
D
V
N
G
I
R
H
L
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
34.86
42%
-76
- C1 -
4IN9
6
?
A:
[1-165]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
L
Q
G
S
K
W
N
K
T
T
L
K
Y
Y
I
Y
N
----
L
T
T
T
E
R
E
N
A
I
R
S
A
F
A
L
W
S
D
K
S
T
L
S
F
I
Q
V
Y
N
------
P
N
Q
A
D
I
K
I
K
W
E
K
G
N
H
G
D
G
Y
P
F
D
G
N
T
G
I
L
A
H
A
F
Y
P
P
P
AGG
N
Y
A
G
H
L
H
F
D
D
D
E
N
W
S
I
N
---
G
S
G
I
D
L
I
T
V
A
A
H
E
I
G
H
L
L
G
I
E
H
S
N
V
S
S
A
L
M
Y
P
Y
Y
T
G
I
K
R
---
Q
L
D
N
D
D
C
L
A
V
W
D
L
Y
G
Y
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
34.64
47%
-74
- C1 -
1HV5
1
MMP11_MOUSE
A:
[2-162]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
L
S
G
G
R
W
E
K
T
D
L
T
Y
R
I
L
R
F
P
W
Q
L
V
R
E
Q
V
R
Q
T
V
A
E
A
L
Q
V
W
S
E
V
T
P
L
T
F
T
E
V
H
E
-------
G
R
A
D
I
M
I
D
F
A
R
Y
W
H
G
D
N
L
P
F
D
G
P
G
G
I
L
A
H
A
F
F
P
K
T
---
H
R
E
G
D
V
H
F
D
Y
D
E
T
W
T
I
G
D
N
--
Q
G
T
D
L
L
Q
V
A
A
H
E
F
G
H
V
L
G
L
Q
H
T
T
A
A
K
A
L
M
S
P
F
Y
T
F
--
R
Y
P
L
S
L
S
P
D
D
R
R
G
I
Q
H
L
Y
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------