@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01909_TDT_HU: (2014-09-28 )
MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMTGKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCEFRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLVSCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQLLQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSSWQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKTKRIFLKAESEEEIFAHLGLDYIEPWERNA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350......-.360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDPPRASHLSPRKKRPRQTG
A
L
MASSPQD
I
K
F
Q
D
L
V
V
F
I
L
E
K
KMG
T
T
R
R
A
F
L
M
E
L
A
R
RKGFRVENELSDS
V
T
H
I
V
AENNS
G
S
D
V
L
E
W
L
Q
A
QKVQVSSQP
E
L
L
D
V
S
W
L
I
E
C
I
RAGKPVEMTGK
H
Q
L
V
V
R
RDYSDSTNPGPPKTP
P
I
A
V
Q
K
I
S
Q
Y
A
C
Q
RRTTLN
N
C
N
Q
I
F
T
D
A
F
D
I
L
A
ENCEFRENE
D
S
C
V
T
F
M
R
A
A
S
V
L
K
SLP
F
T
I
I
S
MKDTEGIPC
L
G
S
K
V
K
G
I
I
E
E
I
I
EDGES
S
E
V
K
A
V
L
N
D
E
R
Y
Q
S
F
K
L
F
T
S
V
F
GVGLK
T
S
E
K
W
F
R
M
G
F
R
T
L
S
K
VRSDKSL
K
F
T
RMQKA
G
F
L
Y
Y
E
D
L
V
S
C
V
T
R
A
E
A
E
A
V
S
V
L
V
K
E
A
V
W
A
FLP
D
A
F
V
T
MTGGFRRGKKMGHDV
D
F
L
I
TSPGST
E
D
E
E
-
Q
L
L
Q
K
V
M
N
L
W
E
KKG
L
L
L
Y
Y
D
L
V
E
S
T
F
E
K
LRLPSR
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
F
KL
P
R
Q
RVDSDQSSWQEGK
T
W
K
A
I
R
V
D
L
V
LCPYER
R
A
F
A
L
LGWTG
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
ILDNH
A
L
Y
D
K
T
K
R
I
F
L
KAESE
E
E
I
F
A
H
LG
L
D
Y
IEPWERNA
4
PsiBlast_PDB
98.97
81%
-114
- C2 -
4I27
2
TDT_MOUSE
A:
[36-400]
-------------------------------------------------------------------------------------------------------------------------------------------------
A
V
K
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
----
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
S
G
Q
Q
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
16
PsiBlast_PDB
98.15
81%
-116
- C2 -
4I2J
1
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
----
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
-----
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
14
PsiBlast_PDB
97.96
81%
-118
- C2 -
4I2H
2
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
----------------
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
------
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
15
PsiBlast_PDB
97.92
81%
-116
- C2 -
4I2I
1
TDT_MOUSE
A:
[38-400]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
-------------------
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
------
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
13
PsiBlast_PDB
97.50
81%
-110
- C2 -
4I2G
1
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
----
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
10
PsiBlast_PDB
97.47
81%
-111
- C2 -
4I2D
1
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
-----
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
2
PsiBlast_PDB
97.23
81%
-114
- C2 -
4IQT
1
TDT_MOUSE
A:
[20-381]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
--
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
----
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
18
PsiBlast_PDB
97.05
81%
-111
- C2 -
4IQV
2
TDT_MOUSE
A:
[19-381]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
D
A
A
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
----
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
17
PsiBlast_PDB
97.03
81%
-110
- C2 -
4IQW
2
TDT_MOUSE
A:
[20-381]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
-
D
A
A
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
----
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
8
PsiBlast_PDB
97.01
81%
-110
- C2 -
4I2B
2
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
---
Q
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
9
PsiBlast_PDB
96.93
81%
-111
- C2 -
4I2C
2
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
---
Q
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
11
PsiBlast_PDB
96.86
81%
-112
- C2 -
4I2E
2
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
-
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
-----
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
5
PsiBlast_PDB
96.80
81%
-114
- C2 -
4I28
1
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
-----
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
-----
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
3
PsiBlast_PDB
96.76
81%
-113
- C2 -
4IQU
1
TDT_MOUSE
A:
[20-381]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
----
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
12
PsiBlast_PDB
96.62
81%
-111
- C2 -
4I2F
1
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
----
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
7
PsiBlast_PDB
96.50
81%
-109
- C2 -
4I2A
1
TDT_MOUSE
A:
[39-400]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
S
--
Q
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
6
PsiBlast_PDB
96.24
81%
-112
- C2 -
4I29
1
TDT_MOUSE
A:
[39-399]
----------------------------------------------------------------------------------------------------------------------------------------------------
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
K
V
-
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
S
G
----
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
-
19
PsiBlast_PDB
95.68
82%
-111
- C2 -
1KDH
1
TDT_MOUSE
A:
[1-363]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
K
F
K
Q
P
S
R
----
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
S
---
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
20
PsiBlast_PDB
94.97
82%
-104
- C2 -
1KEJ
1
TDT_MOUSE
A:
[1-363]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
K
I
S
Q
Y
A
C
Q
R
R
T
T
L
N
N
Y
N
Q
L
F
T
D
A
L
D
I
L
A
E
N
D
E
L
R
E
N
E
G
S
C
L
A
F
M
R
A
S
S
V
L
K
S
L
P
F
P
I
T
S
M
K
D
T
E
G
I
P
C
L
G
D
K
V
K
S
I
I
E
G
I
I
E
D
G
E
S
S
E
A
K
A
V
L
N
D
E
R
Y
K
S
F
K
L
F
T
S
V
F
G
V
G
L
K
T
A
E
K
W
F
R
M
G
F
R
T
L
S
K
I
Q
S
D
K
S
L
R
F
T
Q
M
Q
K
A
G
F
L
Y
Y
E
D
L
V
S
C
V
N
R
P
E
A
E
A
V
S
M
L
V
K
E
A
V
V
T
F
L
P
D
A
L
V
T
M
T
G
G
F
R
R
G
K
M
T
G
H
D
V
D
F
L
I
T
S
P
E
A
T
E
D
E
E
Q
Q
L
L
H
K
V
T
D
F
W
K
Q
Q
G
L
L
L
Y
C
D
I
L
E
S
T
F
E
---
Q
P
S
R
K
V
D
A
L
D
H
F
Q
K
C
F
L
I
L
K
L
D
H
G
R
V
H
S
E
K
S
---
E
G
K
G
W
K
A
I
R
V
D
L
V
M
C
P
Y
D
R
R
A
F
A
L
L
G
W
T
G
S
R
Q
F
E
R
D
L
R
R
Y
A
T
H
E
R
K
M
M
L
D
N
H
A
L
Y
D
R
T
K
R
V
F
L
E
A
E
S
E
E
E
I
F
A
H
L
G
L
D
Y
I
E
P
W
E
R
N
A
32
HHSearch
80.10
45%
-100
- C2 -
4LZG
4
?
A:
[12-356]
-----------------------------------------------------------------------------------------------------------------------------------------------------
M
P
A
Y
A
C
Q
R
P
T
P
L
T
H
H
N
T
G
L
S
E
A
L
E
I
L
A
E
A
A
G
F
E
G
S
E
G
R
L
L
T
F
C
R
A
A
S
V
L
K
A
L
P
S
P
V
T
T
L
S
Q
L
Q
G
L
P
H
F
G
E
H
S
S
R
V
V
Q
E
L
L
E
H
G
V
C
E
E
V
E
R
V
R
R
S
E
R
Y
Q
T
M
K
L
F
T
Q
I
F
G
V
G
V
K
T
A
D
R
W
Y
R
E
G
L
R
T
L
D
D
L
R
E
Q
P
Q
-
K
L
T
Q
Q
Q
K
A
G
L
Q
H
H
Q
D
L
S
T
P
V
L
R
S
D
V
D
A
L
Q
Q
V
V
E
E
A
V
G
Q
A
L
P
G
A
T
V
T
L
T
G
G
F
R
R
G
K
L
Q
G
H
D
V
D
F
L
I
T
H
P
K
E
G
Q
-
E
A
-
G
L
L
P
R
V
M
C
R
L
Q
D
Q
G
L
I
L
Y
H
Q
---------------------
F
E
R
S
F
C
I
F
R
L
P
Q
P
------------
G
S
W
K
A
V
R
V
D
L
V
V
A
P
V
S
Q
F
P
F
A
L
L
G
W
T
G
S
K
L
F
Q
R
E
L
R
R
F
S
R
K
E
K
G
L
W
L
N
S
H
G
L
F
D
P
E
Q
K
T
F
F
Q
A
A
S
E
E
D
I
F
R
H
L
G
L
E
Y
L
P
P
E
Q
R
N
A