@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07686_UFO_HUMAN: (2014-10-12 )
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Atome Classification :
(17 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530-........540.......550...-....-560.......570.......580.......590.......600.......610.......620.......630.......640....-...650.......660.......670.......680.......690.......700.--......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAWRCPRMGR
V
P
L
A
W
C
L
A
L
CGWACMAPRGTQAEESPFVGNPGNITGARGL
T
G
T
L
R
C
Q
L
Q
VQGEPP
E
V
H
WLRDG
Q
I
L
E
LADSTQTQVPLGEDEQD
D
W
I
V
V
S
Q
L
R
I
T
S
L
Q
LSDTG
Q
Y
Q
C
L
V
F
LG
H
Q
T
F
VSQPGYVGLEGL
P
Y
F
LEEPED
R
T
VAANTP
F
N
L
S
CQAQGPPEP
V
D
L
L
W
LQDAVPLATAPGHGPQRSLHVPGLNKTS
S
F
S
C
EAHNAKG
V
T
TS
R
T
A
T
I
T
VLPQQPR
N
L
H
L
VSRQP
T
E
L
E
V
A
WTPGLSGI
Y
P
L
T
H
C
T
L
Q
A
V
L
SNDGMGIQAGEPDPPEEPLTSQASV
P
P
H
Q
L
R
LGSLHPHT
P
Y
H
I
R
V
A
C
TSSQGPSSW
T
H
W
L
PVETPEGVPLGPPENISATRNG
S
Q
A
F
V
H
WQEPRAPLQG
T
L
L
G
Y
R
L
A
YQGQD
T
P
E
V
L
M
D
IGLR
Q
E
V
T
L
E
L
QGDGSV
S
N
L
T
V
C
V
A
A
Y
TAAGDGPWSLPV
P
L
EAWRPGQ
A
Q
P
V
H
Q
L
V
KEPSTPAFS
W
P
W
W
Y
V
L
L
G
A
V
V
A
A
A
C
V
L
I
L
A
L
F
L
V
H
RRKKETRYGEVFEPTVERG
E
L
V
V
R
Y
R
V
R
K
S
YSRRT
T
E
A
T
L
N
SLGI
S
E
E
L
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
LGKTLGEGEF
G
A
VMEGQL-NQD
D
-
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
EFDH
P
N
V
M
R
L
I
G
V
CFQGSERESFPA
P
V
V
I
L
P
FMKHG
D
L
H
S
F
L
L
Y
S
RLGDQPVY
L
P
T
-
Q
M
L
V
K
F
M
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
RNCMLNENM
S
V
C
VADFGLS
K
K
IYNG
D
Y
Y--RQGRIAKM
P
V
K
W
I
A
I
E
S
L
A
D
R
VYTSKSDV
W
S
FG
V
T
M
W
E
I
ATRGQTPYPGVE
N
S
E
I
Y
D
Y
L
R
QGNRLK
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
CWELNPQDRP
S
F
T
E
L
R
E
D
L
E
N
T
L
K
ALPPAQEPD
E
I
L
Y
V
NMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCL
T
A
AEVHPA
G
R
Y
V
L
CPSTTPSPAQPADRGSPAAPGQEDGA
2
PsiBlast_PDB
97.69
69%
-124
- C1 -
3BPR
1
MERTK_HUMAN
A:
[24-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
-
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
-
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
-----------------------------------------------------------------------------------
1
PsiBlast_PDB
96.96
69%
-126
- C1 -
2P0C
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
G
K
I
L
G
--
E
F
G
S
V
M
E
G
N
L
-
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
--------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
-
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.45
69%
-127
- C1 -
3TCP
1
MERTK_HUMAN
A:
[26-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
E
G
N
L
-
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
-
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
83.58
61%
-128
- C1 -
3QUP
1
A:
[16-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
--
P
---
F
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
--------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
---
P
F
N
L
P
L
-
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
-------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
H
-------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.65
61%
-122
- C1 -
4FEQ
1
A:
[22-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
T
L
G
R
M
L
G
K
G
---
S
V
R
E
A
Q
L
-
K
--
D
G
S
F
V
K
V
A
V
K
M
L
------------
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
-----------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
-------
P
L
-
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
----------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
G
H
L
------------------------------------------------------------------------------------
8
PsiBlast_PDB
58.43
43%
-108
- C1 -
3VW8
1
A:
[32-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
GP
S
S
L
I
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
-----
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
18
PsiBlast_PDB
53.84
45%
-113
- C1 -
3U6I
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
--------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
15
PsiBlast_PDB
52.87
45%
-109
- C1 -
2WD1
3
A:
[24-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
12
PsiBlast_PDB
52.06
45%
-106
- C1 -
3RHK
1
MET_HUMAN
A:
[50-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
13
PsiBlast_PDB
51.02
45%
-119
- C1 -
4EEV
1
A:
[49-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
-------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.98
45%
-113
- C1 -
3U6H
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
---------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
20
PsiBlast_PDB
50.78
45%
-110
- C1 -
4DEH
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.37
45%
-112
- C1 -
4DEG
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
-------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
16
PsiBlast_PDB
47.13
45%
-112
- C1 -
3I5N
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
SV
H
-----
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
10
PsiBlast_PDB
43.32
45%
-104
* C1 *
4GG7
1
A:
[51-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
9
PsiBlast_PDB
41.35
45%
-105
- C1 -
4GG5
1
A:
[51-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
N
D
G
-
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
----
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
------
R
N
E
T
H
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
-----------------------------------------------------------------------------------------------
6
PsiBlast_PDB
28.51
61%
-108
- C1 -
4FF8
1
A:
[80-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
D
H
P
H
V
A
K
L
V
-----------------
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
I
-------
P
L
-
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
-------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
--
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
N
I
L
---------------------------------------------------------------------------------------