@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_CSF1R_HUMAN: (2014-10-12 )
MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVGNGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVKDPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQAQEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570-.----------......580.......590.......600.......610.......620.......630.......640.......650...-....660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.....----..910.......920.......930.......940.......950.......960.......970
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGPG
V
L
L
L
L
L
V
A
T
AWHGQGIPVIEPSVP
E
L
V
VKPG
A
T
V
T
L
R
C
VGNGSVEWDGPPSP
H
W
T
L
YSDGSS
S
I
LSTNNATFQNTG
T
Y
RCTEPGDPLGG
S
A
A
I
H
L
Y
VKDPAR
P
W
N
V
L
A
Q
E
V
V
V
FEDQDAL
L
P
C
LLT
D
P
V
L
E
A
G
V
S
L
V
RVRGRPLMRHTNYSFSPWH
G
F
T
I
H
R
A
K
F
IQSQDYQ
C
S
A
LMGG
R
K
V
M
S
I
S
I
R
L
K
V
Q
KVIPGPP
A
L
T
L
V
P
A
E
L
V
R
IRGE
A
A
Q
I
V
C
SAS
S
V
D
V
N
F
D
V
F
L
Q
HNN
T
K
L
AIPQQSDFHNN
R
Y
Q
K
V
L
T
L
NLD
Q
V
D
F
QHAGNY
S
C
V
ASNVQGKH
S
T
S
M
F
F
R
V
V
E
S
A
Y
LNLS
S
E
Q
N
L
I
Q
E
VTVGEGL
N
L
K
V
M
V
E
AYPGLQGF
N
W
T
Y
LGPFSDHQPEPKLANATTKD
T
Y
R
H
T
F
T
LSLPRLKPSEAG
R
Y
S
F
L
ARNPGG
W
R
A
L
T
F
E
L
T
L
RYPP
E
V
S
V
I
W
T
F
INGS
G
T
L
L
C
AASGYPQPN
V
T
W
L
Q
CSGHTDRCD
E
A
Q
V
L
Q
VWDDP
Y
P
E
V
LSQEP
F
H
K
V
T
V
Q
S
L
L
T
V
E
TLEHNQ
T
Y
E
C
R
AHNSVGSG
S
W
A
F
I
P
ISAGAHTHP
P
D
E
F
L
F
T
P
V
V
V
A
C
M
S
I
M
A
L
L
L
L
L
L
L
L
L
L
Y
K
YKQKP
K
Y
Q
V
R
W
K
I
I
E
SYEGN
S
Y
T
F
IDPTQLPYN-E----------KWEFPRNNLQFGKTLGA
G
A
F
G
K
V
V
E
A
T
AFGLGK
E
D
A
V
L
K
V
A
V
K
M
L
K
S
TAHA
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
LGQ
H
E
N
I
V
N
L
L
G
ACTH-G
G
P
V
L
V
I
TEYC
C
Y
G
D
L
L
N
F
L
R
R
K
A
E
A
MLGPSLSPGQDPEGGVDY
K
N
I
H
L
E
K
K
Y
V
RRDSGFSSQGV
D
T
Y
V
E
M
RPVSTSSNDSFSEQDLDKEDGR
P
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
ASKN
C
I
H
R
D
VAAR
N
V
L
LTNG
H
V
A
KIG
D
F
G
L
A
R
D
I
MNDS
N
Y
I
V
KGN
A
R
L
P
V
K
WM
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
LGLNPYP
G
I
L
V
N
S
K
F
Y
K
L
V
KDGYQMAQPAFA
P
K
N
I
Y
S
I
M
Q
A
C
WALEPTHR
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
D
R
R
ERDYTNLPSSSRSGGSGSS
S
S
E
L
EEESSSE
H
L
T
CCEQGDIAQPLLQPNNYQFC
2
PsiBlast_PDB
92.60
82%
-115
- C2 -
2I0V
1
A:
[10-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
Y
Q
V
R
W
K
I
I
E
S
Y
E
G
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
D
A
V
L
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
------------------------------------------------------------
Q
---------
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
--------------------------------------------------------
3
PsiBlast_PDB
90.94
82%
-122
- C2 -
2I0Y
1
A:
[14-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
W
K
I
I
E
S
Y
E
--
S
Y
T
F
I
---------
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
D
A
V
L
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
------------------------------------------------------------
Q
---------
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
--------------------------------------------------------
4
PsiBlast_PDB
90.57
81%
-110
- C2 -
2I1M
1
A:
[13-332]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
R
W
K
I
I
E
S
Y
--
N
S
Y
T
F
I
D
P
T
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
D
A
V
L
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
V
L
------------------------------------------
E
T
D
-------
S
T
A
S
T
-------------
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
----
S
F
L
Q
E
Q
A
Q
E
D
R
R
E
R
---------------------------------------------------
1
PsiBlast_PDB
86.54
87%
-120
- C2 -
4HW7
1
A:
[36-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
L
P
Y
N
-
E
----------
K
W
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
L
G
K
E
D
A
V
L
K
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
E
A
M
L
G
P
S
------------------------------------------------------------
G
R
P
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
----
S
F
L
Q
E
Q
A
----------------------------------------------------------
7
PsiBlast_PDB
80.21
60%
-105
- C2 -
4HVS
1
A:
[10-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
Y
E
V
Q
W
K
V
V
E
E
S
N
G
N
N
Y
S
Y
I
D
P
T
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
I
K
S
D
A
A
M
T
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
T
H
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
--------------------------------
R
D
S
F
H
S
S
-------
D
T
S
P
A
S
M
------------
E
D
D
E
N
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
----
Q
D
I
E
K
Q
I
S
E
--------------------------------------------------------
16
PsiBlast_PDB
74.48
47%
-107
- C2 -
3VHK
2
A:
[11-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
E
HCERLPYDAS
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-
P
Y
K
-------------------------------------------------------
Y
K
D
---
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------
17
PsiBlast_PDB
74.47
48%
-112
* C2 *
3VHE
1
A:
[9-359]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-
P
Y
K
-----------------------------------------------------
D
L
Y
K
D
---
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
--
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
---------------------------------------------------------
15
PsiBlast_PDB
71.29
47%
-120
- C2 -
1Y6B
1
A:
[14-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLPYDAS---
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
--
G
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
K
--
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-
P
Y
--------------------------------------------------------------
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
----------------------------------------------------------
14
PsiBlast_PDB
70.41
47%
-123
- C2 -
1Y6A
1
A:
[15-362]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPYDAS----
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
----
Q
V
I
E
A
D
A
F
G
I
D
K
T
A
T
C
R
T
V
A
V
K
M
L
----
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
-
P
Y
----------------------------------------------------------
D
---
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
--------------------
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
-----------------------------------------------------------
18
PsiBlast_PDB
66.04
46%
-105
- C2 -
3U6J
1
A:
[5-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
--
A
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
A
P
--------------------------------------------------
E
D
L
Y
K
D
F
---
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
D
P
D
Y
V
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
19
PsiBlast_PDB
63.12
46%
-108
- C2 -
3EWH
2
A:
[5-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
Y
D
A
S
----------
K
W
E
F
P
R
D
R
L
K
L
G
K
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
I
D
---
T
C
R
T
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
G
P
L
M
V
I
T
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
N
E
F
V
P
Y
K
V
A
P
--------------------------------------------------
E
D
L
Y
K
D
F
---
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
P
D
Y
V
R
-----
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
Q
Q
D
R
------------------------------------------------------
9
PsiBlast_PDB
56.12
50%
-70
- C2 -
3G0E
1
A:
[4-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
Y
L
Q
K
P
M
Y
E
V
Q
W
K
V
V
E
E
I
N
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
D
A
A
M
T
V
A
V
K
M
L
K
P
S
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
-
L
G
N
H
M
---------
N
I
V
N
L
L
--
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
I
C
S
K
T
S
P
A
I
M
E
D
D
E
L
A
L
D
L
E
D
L
L
S
-------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
10
PsiBlast_PDB
52.14
50%
-69
- C2 -
3G0F
1
KIT_HUMAN
A:
[25-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
D
A
A
M
T
V
A
V
K
M
L
K
P
S
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
-
L
G
N
H
M
---------
N
I
V
N
L
L
--
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
----------------
L
D
L
E
D
L
L
S
-------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
H
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------
13
PsiBlast_PDB
51.97
50%
-71
- C2 -
1T46
1
A:
[1-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
N
Y
V
Y
I
D
P
T
Q
L
P
Y
D
-
H
----------
K
W
E
F
P
R
N
R
L
S
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Y
G
L
I
K
S
D
A
A
M
T
V
A
V
K
M
L
K
P
S
A
----------------
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
-
L
G
N
---------
H
M
N
I
V
N
L
L
--
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
-
D
L
L
N
F
-
L
R
R
K
---
R
D
S
F
--------------
L
A
L
D
L
E
D
L
L
S
-------------------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
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K
F
Y
K
M
I
K
E
G
F
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M
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H
A
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A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
----
Q
L
I
E
K
Q
I
S
E
--------------------------------------------------------