@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_DDR2_HUMAN: (2014-10-12 )
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE
Atome Classification :
(13 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550....---...560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670-...---......680-........690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIL
I
P
R
M
L
L
V
L
F
L
L
L
P
I
L
S
SAKAQVNPAICRYPLGMSGGQIPDEDITASSQW
S
E
S
T
A
A
KYGRLDSEEGDGAWCPEIPV
E
P
D
D
L
K
E
F
L
Q
I
D
L
H
T
L
H
F
I
T
L
VGTQGRHAGGHG
I
E
F
A
P
M
Y
K
I
N
YSRDG
T
R
W
I
S
WRNRHG
K
Q
VLDGNSN
P
Y
D
I
F
L
KDLE
P
P
I
V
A
R
F
V
R
F
I
PVTDHS
M
N
V
C
M
R
V
E
L
Y
G
C
V
W
L
D
G
L
VSYNAPAG
Q
Q
F
VLPG
G
S
I
I
Y
LNDSVYDGAVG
Y
S
M
T
E
G
L
G
Q
L
T
DGVS
G
L
D
D
F
TQT
H
E
Y
HVWPGYDYVGWRNESATN
G
Y
I
E
I
M
F
E
F
D
RIRN
F
T
T
M
K
V
H
CNN
M
F
A
K
G
V
K
I
F
K
E
V
Q
C
Y
F
RSEASEWEPNAISF
P
L
V
L
DDVNPSA
R
F
V
T
V
P
L
H
H
R
M
A
S
A
I
K
C
Q
Y
HFA
D
T
W
M
M
F
S
E
I
T
FQSDAAMYNNSEALPTSPMAPTTYD
P
M
L
K
VDDSN
T
R
I
L
I
G
C
L
V
A
I
I
F
I
L
L
A
I
I
V
I
I
L
W
R
Q
F
W
Q
K
M
L
E
K
A
S
R
R
MLDDE
M
T
V
S
L
SLPSDSSMFNNNRSSSPSEQGSNSTY
D
R
IFPLRPDYQ
E
P
S
R
L
I
R
KLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEA
D
I
V
N
L
Q
GVTGGN
T
Y
S
V
P
A
V
T
M
D
LLSGKD
V
A
V
E
---
E
F
P
R
K
L
L
T
F
K
E
K
LGEGQFG
E
V
H
L
C
E
VE
G
M
E
KFKDK
D
F
A
L
DVSANQ
P
V
L
V
A
V
K
M
L
R
ADANK
N
A
R
N
D
F
L
K
E
I
K
I
M
S
RLKDP
N
I
I
H
L
L
A
V
CITDD
P
L
C
M
I
T
E
Y
MENG
D
L
N
Q
F
L
S
RHE---PPN---SSSS
D
V
R
T
--
V
S
YT
N
L
K
F
M
A
T
Q
I
A
S
G
M
K
Y
L
S
S
L
N
F
V
H
R
D
LATRNCLVGK
N
Y
T
I
K
I
ADFGMSRNLYSG
D
Y
Y
R
IQG
R
A
V
L
P
I
R
WMSW
E
S
I
LLGKFTTA
S
D
V
W
A
F
G
V
T
L
W
E
T
F
T
F
C
Q
EQPYSQL
S
D
E
Q
V
I
E
N
T
G
E
F
F
R
DQGRQTYLPQPAI
C
P
D
S
V
Y
K
L
M
L
S
C
W
RRDTKNRP
S
F
Q
E
I
H
L
L
L
LQQGDE
2
PsiBlast_PDB
97.81
67%
-116
- C2 -
4BKJ
10
DDR1_HUMAN
A:
[6-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
P
Q
D
L
V
S
L
D
F
P
L
N
V
R
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
LED------------
P
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
----
1
PsiBlast_PDB
95.78
67%
-117
- C2 -
3ZOS
4
DDR1_HUMAN
A:
[6-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
P
Q
D
L
V
S
L
D
F
P
L
N
V
R
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
LED--------
A
A
Q
G
P
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
----
6
PsiBlast_PDB
69.19
46%
-104
- C2 -
4AT3
1
A:
[4-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
-----------
I
L
V
A
V
K
T
L
---
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
---
P
D
A
V
L
M
A
--
N
P
P
T
E
--
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
------
8
PsiBlast_PDB
67.83
46%
-102
- C2 -
4AT5
2
A:
[4-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-----
K
-----------
I
L
V
A
V
K
T
L
K
-
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
---
P
D
A
V
L
M
A
E
G
N
P
P
T
E
--
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
------
7
PsiBlast_PDB
67.59
46%
-106
- C2 -
4AT4
1
A:
[4-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
----
K
-----------
I
L
V
A
V
K
T
L
K
-
D
A
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
---
P
D
A
V
L
M
A
---
P
P
T
E
--
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
------
11
PsiBlast_PDB
66.25
44%
-109
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[33-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
---
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
---
K
-----------
M
L
V
A
V
K
A
L
K
-
E
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
---
P
D
-----------
P
GP
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
-----
T
Q
G
R
E
--
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
------
9
PsiBlast_PDB
63.67
44%
-112
- C2 -
3V5Q
1
NTRK3_HUMAN
A:
[7-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
H
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
E
C
Y
N
L
S
P
T
K
D
K
-----------
M
L
V
A
V
K
A
L
---
P
T
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
---
P
---------
E
L
-----
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
-
Q
P
W
F
Q
L
S
N
T
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
--
18
PsiBlast_PDB
57.76
40%
-88
- C2 -
3NW5
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
EW
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
K
G
V
V
K
D
-------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---
P
E
M
---
E
N
N
P
V
L
A
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
G
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------
19
PsiBlast_PDB
57.66
40%
-87
- C2 -
3NW6
1
A:
[7-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
EW
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
K
G
V
V
K
D
-------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---
P
E
M
---
E
N
N
P
V
L
A
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
G
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------
16
PsiBlast_PDB
56.80
40%
-90
* C2 *
3I81
1
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
EW
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
K
G
V
V
K
D
-------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---
P
E
----
E
N
N
P
V
L
A
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
G
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------
17
PsiBlast_PDB
55.41
40%
-85
- C2 -
2OJ9
1
A:
[5-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
V
Y
V
P
DEW
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
K
G
V
V
K
D
-------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---
P
E
-----------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
G
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------
20
PsiBlast_PDB
54.69
40%
-86
- C2 -
3NW7
1
A:
[8-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
DEW
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
K
G
V
V
K
D
-------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---
P
E
M
---
E
N
N
P
V
L
A
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
G
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------
14
PsiBlast_PDB
51.69
40%
-89
- C2 -
3LVP
2
IGF1R_HUMAN
A:
[39-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
DEW
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
K
G
V
V
K
D
-------
E
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---
P
E
M
---
E
--
P
V
L
A
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
-
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
G
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------