@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_FAK2_HUMAN: (2014-10-12 )
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
Atome Classification :
(17 SA)
.........10........20........30........40...-.....50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..-.....290.......300.......310....--...320.......330.......340.......350.......360.......370.......380.......390.......400......--.410.......420.......430.......440.......450.......460.....-..470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
G
V
S
E
P
L
S
R
VKLGTLRRPEGPAE
P
M
V
V
V
PVDVEKED
V
R
I
L
K
V
C
-
F
YSNSFNPGK
N
F
K
L
V
K
C
T
V
Q
T
E
I
R
E
I
I
T
S
I
L
LSGRIGPN
I
R
L
A
E
CYG
L
R
L
KHMKSDE
I
H
W
LHPQM
T
V
G
E
V
QDK
Y
E
C
L
H
V
E
A
E
W
R
Y
D
L
Q
I
R
YL
P
E
D
F
M
E
S
L
K
ED
R
T
T
L
L
Y
F
Y
Q
Q
L
R
N
D
Y
M
Q
R
Y
A
S
K
V
SEG
M
A
L
Q
L
G
C
L
E
L
R
R
F
F
K
DMPHNALDKKS
N
F
E
L
L
E
K
EVGLDLF
F
P
K
Q
M
Q
ENL
K
P
K
Q
F
R
K
M
I
Q
Q
T
F
Q
Q
Y
A
S
L
R
E
E
E
C
V
M
K
F
F
N
T
L
A
G
FANIDQE
T
Y
R
C
E
L
I
QGW
N
I
T
V
D
L
V
IG
P
K
-
G
I
R
Q
L
T
SQDAK
P
T
C
L
A
E
F
K
Q
I
RS
I
R
C
L
PLEEG--
Q
A
V
L
Q
LGIEGAP
Q
A
L
S
I
K
T
S
S
LA
E
A
E
N
M
A
D
L
I
D
G
Y
C
RLQGEHQ
G
S
L
I
I
H
PRKDGEKRNSLPQIPML
N
L
E
A
R
R
S
H
L
S
E
SCSIES
D
I
Y
AEI
P
D
E
--
T
LRRPGGPQYGI
A
R
E
D
V
V
L
N
R
I
L
GE
G
F
F
G
E
V
Y
E
G
V
YTNHKG
E
K
I
N
V
A
V
K
TCKKDCTLD
N
-
K
E
K
F
M
S
E
A
V
I
M
KNLD
H
P
H
I
V
K
L
I
G
I
IEEEP
T
W
I
I
M
E
LYPY
G
E
L
G
H
Y
L
E
RNKN
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
LVASP
E
C
V
K
L
G
DF
G
L
S
R
YIEDE
D
Y
Y
KASVTRL
P
I
K
WMSPESIN
F
R
R
FTT
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
FGKQ
P
F
F
W
LENK
D
V
I
G
V
LEKGDRLPKPDL
C
P
P
V
L
Y
T
L
M
T
R
CWDYDPSDR
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
M
E
Q
ERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAP
K
L
Q
F
QVPEGLCASSPTLTSPMEYPSPVNSLHTPPL
H
R
H
N
V
F
K
R
HSMR
E
E
DFIQPS
S
R
E
E
A
Q
Q
L
W
E
A
E
K
V
K
M
R
Q
I
L
D
K
Q
Q
K
Q
M
V
E
D
Y
Q
W
L
R
Q
E
EKSLD
P
M
V
Y
MNDKSPLTPEKEV
G
Y
L
E
FTGPPQKPPRLGAQSIQPTANLDRTDD
L
V
Y
L
N
V
M
E
L
V
R
A
V
L
E
L
K
N
E
L
CQLPPE
G
Y
V
V
V
V
KNV
G
L
T
L
R
K
L
I
G
S
V
D
D
L
L
PSLPSSSRTEI
E
G
T
Q
K
L
L
N
K
D
L
A
E
L
I
N
K
M
R
L
A
Q
Q
N
A
V
T
S
L
S
E
E
C
K
R
Q
M
LTAS
H
T
L
A
V
D
A
K
N
L
L
D
A
V
D
Q
A
K
V
L
A
N
LAHPPAE
2
PsiBlast_PDB
96.88
51%
-119
- C1 -
2J0J
1
FAK1_CHICK
A:
[5-654]
--------------------------------------
R
V
L
K
V
F
H
Y
F
E
N
S
S
E
P
T
T
W
A
S
I
I
R
H
G
D
A
T
D
V
R
G
I
I
Q
K
I
V
D
C
H
K
V
----
K
N
V
A
C
Y
G
L
R
L
S
H
L
Q
S
E
E
V
H
W
L
H
L
D
M
G
V
S
N
V
R
E
K
F
E
L
A
H
P
P
E
E
W
K
Y
E
L
R
I
R
Y
L
P
K
G
F
L
N
Q
F
T
E
D
K
P
T
L
N
F
F
Y
Q
Q
V
K
N
D
Y
M
L
E
I
A
D
Q
V
D
Q
E
I
A
L
K
L
G
C
L
E
I
R
R
S
Y
G
E
M
R
G
N
A
L
E
K
K
S
N
Y
E
V
L
E
K
D
V
G
L
R
R
F
F
P
K
S
L
L
D
S
V
K
A
K
T
L
R
K
L
I
Q
Q
T
F
R
Q
F
A
N
L
N
R
E
E
S
I
L
K
F
F
E
I
L
S
P
V
Y
R
F
D
K
E
C
F
K
C
A
L
G
S
S
W
I
I
S
V
E
L
A
I
G
P
E
E
G
I
S
Y
L
T
D
K
G
A
N
P
T
H
L
A
D
F
N
Q
V
Q
T
I
Q
Y
S
N
S
E
D
K
DR
K
G
M
L
Q
L
K
I
A
G
A
P
E
P
L
T
V
T
A
P
S
L
T
I
A
E
N
M
A
D
L
I
D
G
Y
C
R
L
V
N
G
A
T
Q
S
F
I
I
R
P
--------------------------------
T
D
D
Y
A
E
I
I
D
E
ED
T
Y
T
M
P
S
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
----------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.41
51%
-126
- C1 -
2J0K
1
FAK1_CHICK
A:
[5-654]
--------------------------------------
R
V
L
K
V
F
H
Y
F
E
N
S
S
E
P
T
T
W
A
S
I
I
R
H
G
D
A
T
D
V
R
G
I
I
Q
K
I
V
D
C
H
K
V
----
K
N
V
A
C
Y
G
L
R
L
S
H
L
Q
S
E
E
V
H
W
L
H
L
D
M
G
V
S
N
V
R
E
K
F
E
L
A
H
P
P
E
E
W
K
Y
E
L
R
I
R
Y
L
P
K
G
F
L
N
Q
F
T
E
D
K
P
T
L
N
F
F
Y
Q
Q
V
K
N
D
Y
M
L
E
I
A
D
Q
V
D
Q
E
I
A
L
K
L
G
C
L
E
I
R
R
S
Y
G
E
M
R
G
N
A
L
E
K
K
S
N
Y
E
V
L
E
K
D
V
G
L
R
R
F
F
P
K
S
L
L
D
S
V
K
A
K
T
L
R
K
L
I
Q
Q
T
F
R
Q
F
A
N
L
N
R
E
E
S
I
L
K
F
F
E
I
L
S
P
V
Y
R
F
D
K
E
C
F
K
C
A
L
G
S
S
W
I
I
S
V
E
L
A
I
G
P
E
E
G
I
S
Y
L
T
D
K
G
A
N
P
T
H
L
A
D
F
N
Q
V
Q
T
I
Q
Y
S
N
S
E
D
K
DR
K
G
M
L
Q
L
K
I
A
G
A
P
E
P
L
T
V
T
A
P
S
L
T
I
A
E
N
M
A
D
L
I
D
G
Y
C
R
L
V
N
G
A
T
Q
S
F
I
I
R
P
--------------------------------
T
D
D
Y
A
E
I
I
D
E
--------
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
N
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
---------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.87
100%
-125
- C1 -
3FZS
1
A:
[5-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
-----------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
56.74
100%
-120
- C1 -
3FZP
1
A:
[4-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
---------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
56.52
99%
-126
- C1 -
4H1M
1
A:
[21-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
---------------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.00
99%
-120
- C1 -
4H1J
1
A:
[20-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
---
D
E
------
V
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
55.64
100%
-120
- C1 -
3FZT
1
A:
[5-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
---
D
E
---------
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.59
100%
-117
- C1 -
3FZR
1
A:
[4-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
54.54
100%
-118
- C1 -
3ET7
1
A:
[4-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
A
R
E
D
V
V
L
N
R
I
L
G
E
G
F
F
G
E
V
Y
E
G
V
Y
T
N
H
K
G
E
K
I
N
V
A
V
K
T
C
K
K
D
C
T
L
D
N
-
K
E
K
F
M
S
E
A
V
I
M
K
N
L
D
H
P
H
I
V
K
L
I
G
I
I
E
E
E
P
T
W
I
I
M
E
L
Y
P
Y
G
E
L
G
H
Y
L
E
R
N
K
N
S
L
K
V
L
T
L
V
L
Y
S
L
Q
I
C
K
A
M
A
Y
L
E
S
I
N
C
V
H
R
D
I
A
V
R
N
I
L
V
A
S
P
E
C
V
K
L
G
D
F
G
L
S
R
------------
T
R
L
P
I
K
W
M
S
P
E
S
I
N
F
R
R
F
T
T
A
S
D
V
W
M
F
A
V
C
M
W
E
I
L
S
F
G
K
Q
P
F
F
W
L
E
N
K
D
V
I
G
V
L
E
K
G
D
R
L
P
K
P
D
L
C
P
P
V
L
Y
T
L
M
T
R
C
W
D
Y
D
P
S
D
R
P
R
F
T
E
L
V
C
S
L
S
D
V
Y
Q
M
E
K
D
I
A
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
47.11
59%
-124
- C1 -
4KAB
1
FAK1_HUMAN
A:
[5-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
45.79
59%
-123
* C1 *
4GU9
1
FAK1_HUMAN
A:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
45.19
60%
-119
- C1 -
4KAO
1
FAK1_HUMAN
A:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
---
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
45.17
60%
-119
- C1 -
3PXK
1
FAK1_HUMAN
A:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
45.11
60%
-117
- C1 -
2ETM
1
FAK1_HUMAN
A:
[7-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
----------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
43.47
59%
-117
- C1 -
4K8A
1
FAK1_HUMAN
A:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
--
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
43.16
60%
-108
- C1 -
4GU6
1
FAK1_HUMAN
A:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
--
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
T
Y
Y
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
42.67
59%
-109
- C1 -
4K9Y
1
A:
[8-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
S
P
E
N
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
T
Y
Y
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
E
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------